Cryptophycin 1 : Cluster information
Compound
| Entry name | Cryptophycin 1 |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | trans-cinnamic acid |
| Chain Length | 4 |
| Sugar Unit | none |
| Classification | Peptide-Polyketide Hybrid |
| Activity | Toxic |
| Composition | C35H43ClN2O8 |
Original source
| Organism | Nostoc sp. |
|---|---|
| Strain | ATCC 53789 |
| Contig | EF159954 |
PKS/NRPS Module
| Crypto_00010 crpA | 0 |  | |
| 1 |  | malonyl-CoA | |
| Crypto_00020 crpB | 2 |  | malonyl-CoA |
| 3 |  | malonyl-CoA | |
| Crypto_00030 crpC | 4 |  | L-tyrosine |
| Crypto_00040 crpD | 5 |  | alpha-methyl-beta-alanine |
| 6 |  | 2-keto-isocaproic acid |
Reference
- Cryptophycin anticancer drugs revisited.
- Rohr J[PMID: 17240971]ACS Chem Biol. 1 (2006) 747-50
- Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts.
- Magarvey NA, Beck ZQ, Golakoti T, Ding Y, Huber U, Hemscheidt TK, Abelson D, Moore RE, Sherman DH[PMID: 17240975]ACS Chem Biol. 1 (2006) 766-79
- Characterization of the beta-methylaspartate-alpha-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway.
- Beck ZQ, Burr DA, Sherman DH[PMID: 17600793]Chembiochem. 8 (2007) 1373-5
- Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity.
- Ding Y, Seufert WH, Beck ZQ, Sherman DH[PMID: 18366166]J Am Chem Soc. 130 (2008) 5492-8
- Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module.
- Ding Y, Rath CM, Bolduc KL, Hakansson K, Sherman DH[PMID: 21823639]J Am Chem Soc. 133 (2011) 14492-5
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Cryptophycin 1 |
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History
- 2013-09-04[Update]
- 2012-03-28[Release]
