Epothilone : Cluster information
Compound
| Entry name | Epothilone |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | acetyl-CoA |
| Chain Length | 10 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Antitumor |
| Composition | A: C26H39NO6S |
Original source
| Organism | Sorangium cellulosum |
|---|---|
| Strain | So ce90 |
| Contig | AF210843 |
PKS/NRPS Module
| Epoth_00060 epoA | 0 |  | malonyl-CoA |
| Epoth_00070 epoP | 1 |  | |
| Epoth_00080 epoB | 2 |  | methylmalonyl-CoA not conserved YASHS(Y->V) |
| Epoth_00090 epoC | 3 |  | malonyl-CoA |
| 4 | | malonyl-CoA for Epothilone A methylmalonyl-CoA for Epothilone B | |
| 5 |  | malonyl-CoA | |
| 6 | | methylmalonyl-CoA not conserved YASHS(Y->V) | |
| Epoth_00100 epoD | 7 | | methylmalonyl-CoA not conserved YASHS(Y->V) |
| 8 |  | methylmalonyl-CoA not conserved YASHS(Y->V) | |
| Epoth_00110 epoE | 9 |  | malonyl-CoA |
Reference
- The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90.
- Molnar I, Schupp T, Ono M, Zirkle R, Milnamow M, Nowak-Thompson B, Engel N, Toupet C, Stratmann A, Cyr DD, Gorlach J, Mayo JM, Hu A, Goff S, Schmid J, Ligon JM[PMID: 10662695]Chem Biol. 7 (2000) 97-109
- Studies on the biosynthesis of epothilones: the biosynthetic origin of the carbon skeleton.
- Gerth K, Steinmetz H, Hofle G, Reichenbach H[PMID: 11217802]J Antibiot (Tokyo). 53 (2000) 1373-7
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Epothilone |
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History
- 2016-12-27[Update]
- 2012-03-28[Release]
