FR-008 : Cluster information
Compound
| Entry name | FR-008 |
|---|---|
| Synonym | Candicidin |
| PKS Type | TypeI modular |
| Starter Unit | p-aminobenzoic acid |
| Chain Length | 22 |
| Sugar Unit | mycosamine |
| Classification | Polyene Macrolide |
| Activity | Antifungal |
| Composition | III: C59H84N2O18 |
Original source
| Organism | Streptomyces sp. |
|---|---|
| Strain | FR-008 |
| Contig | AY310323 |
PKS/NRPS Module
| FR008_00130 fscA | 0 |  | |
| 1 |  | malonyl-CoA | |
| FR008_00170 fscB | 2 |  | methylmalonyl-CoA |
| 3 |  | methylmalonyl-CoA | |
| 4 |  | methylmalonyl-CoA | |
| FR008_00160 fscC | 5 |  | malonyl-CoA |
| 6 | | malonyl-CoA | |
| 7 | | malonyl-CoA | |
| 8 | | malonyl-CoA | |
| 9 | | malonyl-CoA | |
| 10 | | malonyl-CoA | |
| FR008_00200 fscD | 11 | | malonyl-CoA |
| 12 | | malonyl-CoA | |
| 13 | | methylmalonyl-CoA not conserved YASHS(S->T) | |
| 14 | | malonyl-CoA | |
| 15 |  | malonyl-CoA | |
| 16 | | malonyl-CoA | |
| FR008_00190 fscE | 17 |  | malonyl-CoA |
| 18 | | malonyl-CoA | |
| 19 | | malonyl-CoA | |
| 20 | | malonyl-CoA | |
| FR008_00180 fscF | 21 |  | malonyl-CoA |
Reference
- Organizational and mutational analysis of a complete FR-008/candicidin gene cluster encoding a structurally related polyene complex.
- Chen S, Huang X, Zhou X, Bai L, He J, Jeong KJ, Lee SY, Deng Z[PMID: 14652074]Chem Biol. 10 (2003) 1065-76
- Incomplete beta-ketone processing as a mechanism for polyene structural variation in the FR-008/candicidin complex.
- Zhou Y, Li J, Zhu J, Chen S, Bai L, Zhou X, Wu H, Deng Z[PMID: 18559273]Chem Biol. 15 (2008) 629-38
- Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in Streptomyces sp. strain FR-008.
- Zhou Y, Meng Q, You D, Li J, Chen S, Ding D, Zhou X, Zhou H, Bai L, Deng Z[PMID: 18836004]Appl Environ Microbiol. 74 (2008) 7235-42
- Tailoring the P450 monooxygenase gene for FR-008/candicidin biosynthesis.
- Chen S, Mao X, Shen Y, Zhou Y, Li J, Wang L, Tao X, Yang L, Wang Y, Zhou X, Deng Z, Wei D[PMID: 19139241]Appl Environ Microbiol. 75 (2009) 1778-81
- Functional characterization of the first two actinomycete 4-amino-4-deoxychorismate lyase genes.
- Zhang Y, Bai L, Deng Z[PMID: 19389784]Microbiology. 155 (2009) 2450-9
- In vivo investigation of the substrate recognition capability and activity affecting amino acid residues of glycosyltransferase FscMI in the biosynthesis of candicidin.
- Lei X, Kong L, Zhang C, Liu Q, Yao F, Zhang W, Deng Z, You D[PMID: 23324745]Mol Biosyst. 9 (2013) 422-30
- Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families.
- Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, Pang X[PMID: 25575546]Microbiology. 161 (2015) 539-52
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 FR-008 |
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History
- 2016-01-27[Update]
- 2013-01-16[Update]
- 2012-10-02[Update]
- 2012-03-28[Release]
