Megalomicin : Cluster information
Compound
| Entry name | Megalomicin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | propionyl-CoA |
| Chain Length | 7 |
| Sugar Unit | L-mycarose D-desosamine L-megosamine |
| Classification | Macrolide |
| Activity | Antibacterial Antiparasitic Antiviral |
| Composition | A: C44H80N2O15 |
Original source
| Organism | Micromonospora megalomicea subsp. nigra |
|---|---|
| Strain | NRRL 3275 (=NBRC 14744) |
| Contig | AF263245 |
PKS/NRPS Module
| Megalo_00120 megAI | 0 |  | |
| 1 |  | methylmalonyl-CoA | |
| 2 | | methylmalonyl-CoA | |
| Megalo_00130 megAII | 3 |  | methylmalonyl-CoA |
| 4 |  | methylmalonyl-CoA | |
| Megalo_00140 megAIII | 5 | | methylmalonyl-CoA |
| 6 |  | methylmalonyl-CoA |
Reference
- Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea.
- Volchegursky Y, Hu Z, Katz L, McDaniel R[PMID: 10972798]Mol Microbiol. 37 (2000) 752-62
- Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli.
- Murli S, Piagentini M, McDaniel R, Hutchinson CR[PMID: 15595843]Biochemistry. 43 (2004) 15884-90
- Production of the potent antibacterial polyketide erythromycin C in Escherichia coli.
- Peiru S, Menzella HG, Rodriguez E, Carney J, Gramajo H[PMID: 15870344]Appl Environ Microbiol. 71 (2005) 2539-47
- In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.
- Rodriguez E, Peiru S, Carney JR, Gramajo H[PMID: 16514147]Microbiology. 152 (2006) 667-73
- Characterization of the heterodimeric MegBIIa:MegBIIb aldo-keto reductase involved in the biosynthesis of L-mycarose from Micromonospora megalomicea.
- Peiru S, Rodriguez E, Tran CQ, Carney JR, Gramajo H[PMID: 17571859]Biochemistry. 46 (2007) 8100-9
- TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.
- Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H[PMID: 20418422]Appl Environ Microbiol. 76 (2010) 3869-77
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Megalomicin |
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History
- 2016-01-27[Update]
- 2013-01-16[Update]
- 2012-10-02[Update]
- 2012-03-28[Release]
