Mycolactone : Cluster information
Compound
| Entry name | Mycolactone |
|---|---|
| Moiety description | A: mycolactone core B: side chain |
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 18 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Toxic Immunosuppressive |
| Composition | A/B: C44H70O9 |
Original source
| Organism | Mycobacterium ulcerans |
|---|---|
| Strain | Agy99 |
| Contig | BX649209 |
PKS/NRPS Module
| A | MUP_00400 mlsA1 | 0 |  | malonyl-CoA |
|---|---|---|---|---|
| 1 |  | malonyl-CoA | ||
| 2 |  | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 3 |  | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 4 |  | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 5 |  | malonyl-CoA | ||
| 6 | | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 7 | | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 8 | | malonyl-CoA | ||
| MUP_00390 mlsA2 | 9 | | malonyl-CoA | |
| B | MUP_00320 mlsB | 0 | | malonyl-CoA |
| 1 | | malonyl-CoA | ||
| 2 | | malonyl-CoA | ||
| 3 | | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 4 | | malonyl-CoA | ||
| 5 | | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 6 | | methylmalonyl-CoA not conserved YASHS(A->P) | ||
| 7 | | malonyl-CoA |
Reference
- Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.
- Stinear TP, Mve-Obiang A, Small PL, Frigui W, Pryor MJ, Brosch R, Jenkin GA, Johnson PD, Davies JK, Lee RE, Adusumilli S, Garnier T, Haydock SF, Leadlay PF, Cole ST[PMID: 14736915]Proc Natl Acad Sci U S A. 101 (2004) 1345-9
- Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.
- Coutanceau E, Marsollier L, Brosch R, Perret E, Goossens P, Tanguy M, Cole ST, Small PL, Demangel C[PMID: 16008585]Cell Microbiol. 7 (2005) 1187-96
- The unusual macrocycle forming thioesterase of mycolactone.
- Meier JL, Barrows-Yano T, Foley TL, Wike CL, Burkart MD[PMID: 18493665]Mol Biosyst. 4 (2008) 663-71
- History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease).
- Chany AC, Tresse C, Casarotto V, Blanchard N[PMID: 24178858]Nat Prod Rep. 30 (2013) 1527-67
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Mycolactone |
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History
- 2014-03-10[Update]
- 2012-10-02[Update]
- 2012-03-28[Release]
