Myxalamid : Cluster information
Compound
| Entry name | Myxalamid |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | Myxalamid A: 2-methylbutyryl-CoA Myxalamid B: isobutyryl-CoA Myxalamid C: propionyl-CoA Myxalamid D: acetyl-CoA |
| Chain Length | 8 |
| Sugar Unit | none |
| Classification | Linear Polyene Peptide-Polyketide Hybrid |
| Activity | Antifungal Antibacterial |
| Composition | Myxalamid A: C26H41NO3 Myxalamid B: C25H39NO3 Myxalamid C: C24H37NO3 Myxalamid D: C23H35NO3 |
Original source
| Organism | Stigmatella aurantiaca |
|---|---|
| Strain | Sga15 |
| Contig | AF319998 |
PKS/NRPS Module
| Myxa_00090 mxaF | 0 |  | |
| 1 |  | 2-methylbutyryl-CoA for Myxalamid A isobutyryl-CoA for Myxalamid B propionyl-CoA for Myxalamid C acetyl-CoA for Myxalamid D methylmalonyl-CoA not conserved YASHS(Y->V) | |
| Myxa_00080 mxaE | 2 |  | methylmalonyl-CoA not conserved YASHS(Y->V) |
| Myxa_00070 mxaD | 3 |  | methylmalonyl-CoA not conserved YASHS(Y->V) |
| Myxa_00060 mxaC | 4 | | malonyl-CoA not conserved HAFHS |
| 5 |  | malonyl-CoA not conserved HAFHS(H->Y) | |
| 6 | | malonyl-CoA | |
| Myxa_00050 mxaB1 | 7 |  | methylmalonyl-CoA not conserved YASHS(Y->V) |
| Myxa_00040 mxaB2 | 7 |  | |
| Myxa_00030 mxaA | 8 |  |
Reference
- Novel features in a combined polyketide synthase/non-ribosomal peptide synthetase: the myxalamid biosynthetic gene cluster of the myxobacterium Stigmatella aurantiaca Sga15.
- Silakowski B, Nordsiek G, Kunze B, Blocker H, Muller R[PMID: 11182319]Chem Biol. 8 (2001) 59-69
- Mutasynthesis-derived myxalamids and origin of the isobutyryl-CoA starter unit of myxalamid B.
- Bode HB, Meiser P, Klefisch T, Cortina NS, Krug D, Gohring A, Schwar G, Mahmud T, Elnakady YA, Muller R[PMID: 17955482]Chembiochem. 8 (2007) 2139-44
- Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols.
- Barajas JF, Phelan RM, Schaub AJ, Kliewer JT, Kelly PJ, Jackson DR, Luo R, Keasling JD, Tsai SC[PMID: 26235055]Chem Biol. 22 (2015) 1018-29
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Myxalamid |
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History
- 2016-01-27[Update]
- 2012-03-28[Release]
