Nanchangmycin : Cluster information
Compound
| Entry name | Nanchangmycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 15 |
| Sugar Unit | 4-O-methyl-L-rhodinose |
| Classification | Polyether |
| Activity | Antibacterial Insecticidal Ionophore |
| Composition | C47H78O14 |
Original source
| Organism | Streptomyces nanchangensis |
|---|---|
| Strain | NS3226 |
| Contig | AF521085 |
PKS/NRPS Module
| Nanch_00080 nanA1 | 0 |  | malonyl-CoA |
| 1 |  | methylmalonyl-CoA | |
| Nanch_00090 nanA2 | 2 |  | methylmalonyl-CoA |
| Nanch_00100 nanA3 | 3 |  | malonyl-CoA |
| 4 | | methylmalonyl-CoA | |
| Nanch_00110 nanA4 | 5 | | methylmalonyl-CoA |
| 6 |  | malonyl-CoA | |
| Nanch_00120 nanA5 | 7 | | methylmalonyl-CoA |
| 8 | | malonyl-CoA | |
| Nanch_00130 nanA6 | 9 |  | malonyl-CoA |
| Nanch_00200 nanA7 | 10 |  | methylmalonyl-CoA |
| Nanch_00270 nanA8 | 11 | | methylmalonyl-CoA |
| 12 | | methylmalonyl-CoA | |
| Nanch_00250 nanA9 | 13 |  | |
| Nanch_00220 nanA10 | 13 |  | |
| Nanch_00260 nanA11 | 14 | | methylmalonyl-CoA |
Reference
- A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin.
- Sun Y, Zhou X, Dong H, Tu G, Wang M, Wang B, Deng Z[PMID: 12770825]Chem Biol. 10 (2003) 431-41
- Identification of NanE as the thioesterase for polyether chain release in nanchangmycin biosynthesis.
- Liu T, You D, Valenzano C, Sun Y, Li J, Yu Q, Zhou X, Cane DE, Deng Z[PMID: 16984884]Chem Biol. 13 (2006) 945-55
- Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin.
- Liu T, Lin X, Zhou X, Deng Z, Cane DE[PMID: 18482697]Chem Biol. 15 (2008) 449-58
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Nanchangmycin |
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History
- 2013-05-28[Update]
- 2012-10-02[Update]
- 2012-08-03[Update]
- 2012-04-26[Release]
