Oligomycin : Cluster information
Compound
| Entry name | Oligomycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 17 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Antifungal Toxic Antitumor |
| Composition | A: C45H74O11 |
Original source
| Organism | Streptomyces avermitilis |
|---|---|
| Strain | ATCC 31267 (=NBRC 14893) |
| Contig | AB070940 |
PKS/NRPS Module
| Oligo_00080 olmA1 | 0 |  | malonyl-CoA |
| 1 |  | malonyl-CoA | |
| 2 | | methylmalonyl-CoA | |
| 3 |  | malonyl-CoA | |
| Oligo_00090 olmA2 | 4 | | methylmalonyl-CoA not conserved YASHS |
| 5 | | methylmalonyl-CoA | |
| 6 |  | malonyl-CoA | |
| Oligo_00100 olmA3 | 7 | | ethylmalonyl-CoA |
| 8 | | malonyl-CoA | |
| Oligo_00150 olmA4 | 9 | | malonyl-CoA |
| 10 | | methylmalonyl-CoA not conserved YASHS(S->T) | |
| Oligo_00140 olmA5 | 11 |  | methylmalonyl-CoA |
| Oligo_00110 olmA6 | 12 |  | methylmalonyl-CoA |
| 13 | | methylmalonyl-CoA | |
| 14 | | methylmalonyl-CoA | |
| Oligo_00120 olmA7 | 15 | | methylmalonyl-CoA |
| 16 |  | malonyl-CoA |
Reference
- Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis.
- Ikeda H, Takada Y, Pang CH, Tanaka H, Omura S[PMID: 8384619]J Bacteriol. 175 (1993) 2077-82
- Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites.
- Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, Takahashi Y, Horikawa H, Nakazawa H, Osonoe T, Kikuchi H, Shiba T, Sakaki Y, Hattori M[PMID: 11572948]Proc Natl Acad Sci U S A. 98 (2001) 12215-20
- Functional characterization of CYP107W1 from Streptomyces avermitilis and biosynthesis of macrolide oligomycin A.
- Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D[PMID: 25849761]Arch Biochem Biophys. 575 (2015) 1-7
- Structural Analysis of the Streptomyces avermitilis CYP107W1-Oligomycin A Complex and Role of the Tryptophan 178 Residue.
- Han S, Pham TV, Kim JH, Lim YR, Park HG, Cha GS, Yun CH, Chun YJ, Kang LW, Kim D[PMID: 26883908]Mol Cells. 39 (2016) 211-6
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Oligomycin |
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History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2012-10-02[Update]
- 2012-08-03[Update]
- 2012-03-28[Release]
