Phoslactomycin : Cluster information
Compound
| Entry name | Phoslactomycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | cyclohexylcarbonyl-CoA |
| Chain Length | 8 |
| Sugar Unit | none |
| Classification | |
| Activity | Antifungal Antitumor |
| Composition | A: C29H46NO10P |
Original source
| Organism | Streptomyces sp. |
|---|---|
| Strain | HK803 |
| Contig | AY354515 |
PKS/NRPS Module
| Phosl_00180 plm1 | 0 |  | |
| 1 |  | malonyl-CoA | |
| Phosl_00190 plm2-3 | 2 | | malonyl-CoA |
| 3 |  | malonyl-CoA | |
| Phosl_00060 plm4 | 4 | | ethylmalonyl-CoA not conserved XAGHS |
| Phosl_00070 plm5 | 5 | | malonyl-CoA |
| Phosl_00080 plm6 | 6 | | ethylmalonyl-CoA not conserved XAGHS |
| Phosl_00090 plm7 | 7 |  | malonyl-CoA |
Reference
- Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster.
- Palaniappan N, Kim BS, Sekiyama Y, Osada H, Reynolds KA[PMID: 12819191]J Biol Chem. 278 (2003) 35552-7
- The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803.
- Ghatge MS, Reynolds KA[PMID: 16291670]J Bacteriol. 187 (2005) 7970-6
- Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.
- Ghatge M, Palaniappan N, Das Choudhuri S, Reynolds K[PMID: 16609856]J Ind Microbiol Biotechnol. 33 (2006) 589-99
- Modular polyketide synthases and cis double bond formation: establishment of activated cis-3-cyclohexylpropenoic acid as the diketide intermediate in phoslactomycin biosynthesis.
- Alhamadsheh MM, Palaniappan N, Daschouduri S, Reynolds KA[PMID: 17256943]J Am Chem Soc. 129 (2007) 1910-1
- Application of a newly identified and characterized 18-o-acyltransferase in chemoenzymatic synthesis of selected natural and nonnatural bioactive derivatives of phoslactomycins.
- Ghatge MS, Palaniappan N, Alhamadsheh MM, DiBari J, Reynolds KA[PMID: 19304832]Appl Environ Microbiol. 75 (2009) 3469-76
- Structural and stereochemical analysis of a modular polyketide synthase ketoreductase domain required for the generation of a cis-alkene.
- Bonnett SA, Whicher JR, Papireddy K, Florova G, Smith JL, Reynolds KA[PMID: 23790488]Chem Biol. 20 (2013) 772-83
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Phoslactomycin |
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History
- 2016-01-27[Update]
- 2013-09-04[Update]
- 2012-04-26[Release]
