Pimaricin : Cluster information
Compound
Entry name | Pimaricin |
---|---|
Synonym | Natamycin |
PKS Type | TypeI modular |
Starter Unit | acetyl-CoA |
Chain Length | 13 |
Sugar Unit | mycosamine |
Classification | Polyene Macrolide |
Activity | Antifungal |
Composition | C33H47NO13 |
Original source
Organism | Streptomyces natalensis |
---|---|
Strain | ATCC 27448 (=NBRC 13367) |
Contig | FM864219 AM493721 AJ278573 |
PKS/NRPS Module
Pimar_00160 pimS0 | 0 | ||
Pimar_00170 pimS1 | 1 | malonyl-CoA | |
2 | malonyl-CoA | ||
3 | malonyl-CoA | ||
4 | malonyl-CoA | ||
Pimar_00070 pimS2 | 5 | malonyl-CoA | |
6 | malonyl-CoA | ||
7 | methylmalonyl-CoA | ||
8 | malonyl-CoA | ||
9 | malonyl-CoA | ||
10 | malonyl-CoA | ||
Pimar_00060 pimS3 | 11 | malonyl-CoA | |
Pimar_00050 pimS4 | 12 | malonyl-CoA |
Reference
- The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.
- Aparicio JF, Colina AJ, Ceballos E, Martin JF[PMID: 10187796]J Biol Chem. 274 (1999) 10133-9
- A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.
- Aparicio JF, Fouces R, Mendes MV, Olivera N, Martin JF[PMID: 11094342]Chem Biol. 7 (2000) 895-905
- Identification of PimR as a positive regulator of pimaricin biosynthesis in Streptomyces natalensis.
- Anton N, Mendes MV, Martin JF, Aparicio JF[PMID: 15090496]J Bacteriol. 186 (2004) 2567-75
- Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.
- Mendes MV, Anton N, Martin JF, Aparicio JF[PMID: 15228385]Biochem J. 386 (2005) 57-62
- Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin.
- Mendes MV, Recio E, Anton N, Guerra SM, Santos-Aberturas J, Martin JF, Aparicio JF[PMID: 17379143]Chem Biol. 14 (2007) 279-90
- PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.
- Anton N, Santos-Aberturas J, Mendes MV, Guerra SM, Martin JF, Aparicio JF[PMID: 17768260]Microbiology. 153 (2007) 3174-83
- Enzymology of the polyenes pimaricin and candicidin biosynthesis.
- Martin JF, Aparicio JF[PMID: 19362642]Methods Enzymol. 459 (2009) 215-42
- PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.
- Vicente CM, Santos-Aberturas J, Guerra SM, Payero TD, Martin JF, Aparicio JF[PMID: 19505319]Microb Cell Fact. 8 (2009) 33
- Molecular control of polyene macrolide biosynthesis: direct binding of the regulator PimM to eight promoters of pimaricin genes and identification of binding boxes.
- Santos-Aberturas J, Vicente CM, Guerra SM, Payero TD, Martin JF, Aparicio JF[PMID: 21187288]J Biol Chem. 286 (2011) 9150-61
- Hierarchical Control on Polyene Macrolide Biosynthesis: PimR Modulates Pimaricin Production via the PAS-LuxR Transcriptional Activator PimM.
- Santos-Aberturas J, Vicente CM, Payero TD, Martin-Sanchez L, Canibano C, Martin JF, Aparicio JF[PMID: 22693644]PLoS One. 7 (2012) e38536
- In vivo investigation of the substrate recognition capability and activity affecting amino acid residues of glycosyltransferase FscMI in the biosynthesis of candicidin.
- Lei X, Kong L, Zhang C, Liu Q, Yao F, Zhang W, Deng Z, You D[PMID: 23324745]Mol Biosyst. 9 (2013) 422-30
- Biotechnological production and application of the antibiotic pimaricin: biosynthesis and its regulation.
- Aparicio JF, Barreales EG, Payero TD, Vicente CM, de Pedro A, Santos-Aberturas J[PMID: 26512010]Appl Microbiol Biotechnol. 100 (2016) 61-78
Data download
History
- 2016-12-27[Update]
- 2013-05-28[Update]
- 2013-01-16[Update]
- 2012-10-02[Update]
- 2012-03-28[Release]