Pyoluteorin : Cluster information
Compound
Entry name | Pyoluteorin |
---|---|
PKS Type | PKS-NRPS hybrid |
Starter Unit | L-proline |
Chain Length | 3 |
Sugar Unit | none |
Classification | Pyrrole Antibiotic |
Activity | Antibacterial Antifungal |
Composition | C11H7Cl2NO3 |
Original source
Organism | Pseudomonas fluorescens |
---|---|
Strain | Pf-5 |
Contig | AF081920 |
PKS/NRPS Module
0 |
| ||
Pyolu_00050 pltB | 1 | malonyl-CoA | |
2 | malonyl-CoA | ||
Pyolu_00060 pltC | 3 | malonyl-CoA |
Reference
- Identification and sequence analysis of the genes encoding a polyketide synthase required for pyoluteorin biosynthesis in Pseudomonas fluorescens Pf-5.
- Nowak-Thompson B, Gould SJ, Loper JE[PMID: 9434161]Gene. 204 (1997) 17-24
- Characterization of the pyoluteorin biosynthetic gene cluster of Pseudomonas fluorescens Pf-5.
- Nowak-Thompson B, Chaney N, Wing JS, Gould SJ, Loper JE[PMID: 10094695]J Bacteriol. 181 (1999) 2166-74
- Conversion of L-proline to pyrrolyl-2-carboxyl-S-PCP during undecylprodigiosin and pyoluteorin biosynthesis.
- Thomas MG, Burkart MD, Walsh CT[PMID: 11880032]Chem Biol. 9 (2002) 171-84
- Dichlorination of a pyrrolyl-S-carrier protein by FADH2-dependent halogenase PltA during pyoluteorin biosynthesis.
- Dorrestein PC, Yeh E, Garneau-Tsodikova S, Kelleher NL, Walsh CT[PMID: 16162666]Proc Natl Acad Sci U S A. 102 (2005) 13843-8
- Reciprocal regulation of pyoluteorin production with membrane transporter gene expression in Pseudomonas fluorescens Pf-5.
- Brodhagen M, Paulsen I, Loper JE[PMID: 16269724]Appl Environ Microbiol. 71 (2005) 6900-9
- Structure and Substrate Sequestration in the Pyoluteorin Type II Peptidyl Carrier Protein PltL.
- Jaremko MJ, Lee DJ, Opella SJ, Burkart MD[PMID: 26340431]J Am Chem Soc. 137 (2015) 11546-9
- Crystal structure of halogenase PltA from the pyoluteorin biosynthetic pathway.
- Pang AH, Garneau-Tsodikova S, Tsodikov OV[PMID: 26416533]J Struct Biol. 192 (2015) 349-57
- The Rare Codon AGA Is Involved in Regulation of Pyoluteorin Biosynthesis in Pseudomonas protegens Pf-5.
- Yan Q, Philmus B, Hesse C, Kohen M, Chang JH, Loper JE[PMID: 27148187]Front Microbiol. 7 (2016) 497
Data download
History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2015-02-12[Update]
- 2013-09-04[Update]
- 2012-03-28[Release]