Rubradirin : Cluster information --- DoBISCUIT

Entry name	Rubradirin
Moiety description	A: prorubransarol B: aminocoumarin moiety
PKS Type	A: TypeI modular B: other
Starter Unit	3-amino-5-hydroxybenzoic acid (AHBA)
Chain Length	A: 7
Sugar Unit	D-rubranitrose
Classification	Ansamycin
Activity	Antibacterial
Composition	C₄₈H₄₆N₄O₂₀

Organism	Streptomyces achromogenes var. rubradiris
Strain	NRRL 3061 (=NBRC 14000)
Contig	AJ871581

A	Rubra_00070 rubA	0
		1	methylmalonyl-CoA
		2	malonyl-CoA
		3	methylmalonyl-CoA
	Rubra_00380 rubB	4	methylmalonyl-CoA
		5	malonyl-CoA
		6	methylmalonyl-CoA
B	Rubra_00400 rubC1	1	tyrosine

A	38..445

PCP	908..982

KS	1002..1378

AT	1537..1855

dh	1904..2085

KR	2304..2484

ACP	2595..2665

KS	2694..3069

AT	3232..3555

ACP	3631..3703

KS	3725..4102

AT	4269..4594

kr	4914..5091

ACP	5196..5266

KS	35..411

AT	564..882

DH	931..1094

KR	1394..1574

ACP	1679..1749

KS	1776..2150

AT	2306..2623

dh	2670..2819

KR	3097..3277

ACP	3376..3450

KS	3472..3833

AT	3982..4302

dh	4349..4494

kr	4712..4914

ACP	4964..5034

A	757..1148

PCP	1235..1301

Identification of a gene cluster of biosynthetic genes of rubradirin substructures in S. achromogenes var. rubradiris NRRL3061.: Sohng JK, Oh TJ, Lee JJ, Kim CG
[PMID: 9387157]Mol Cells. 7 (1997) 674-81
Functional characterization of ketoreductase (rubN6) and aminotransferase (rubN4) genes in the gene cluster of Streptomyces achromogenes var. rubradiris.: Lamichhane J, Liou K, Lee HC, Kim CG, Sohng JK
[PMID: 16614891]Biotechnol Lett. 28 (2006) 545-53
Biosynthesis of rubradirin as an ansamycin antibiotic from Streptomyces achromogenes var. rubradiris NRRL3061.: Kim CG, Lamichhane J, Song KI, Nguyen VD, Kim DH, Jeong TS, Kang SH, Kim KW, Maharjan J, Hong YS, Kang JS, Yoo JC, Lee JJ, Oh TJ, Liou K, Sohng JK
[PMID: 18080113]Arch Microbiol. 189 (2008) 463-73
A unifying nitrososynthase involved in nitrosugar biosynthesis.: Hu Y, Al-Mestarihi A, Grimes CL, Kahne D, Bachmann BO
[PMID: 18983146]J Am Chem Soc. 130 (2008) 15756-7
Adenylate-forming enzymes of rubradirin biosynthesis: RubC1 is a bifunctional enzyme with aminocoumarin acyl ligase and tyrosine-activating domains.: Boll B, Hennig S, Xie C, Sohng JK, Heide L
[PMID: 21448870]Chembiochem. 12 (2011) 1105-14
A domain of RubC1 of rubradirin biosynthesis can functionally replace MbtH-like proteins in tyrosine adenylation.: Boll B, Heide L
[PMID: 23225745]Chembiochem. 14 (2013) 43-4
Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis.: Al-Mestarihi A, Romo A, Liu HW, Bachmann BO
[PMID: 23885759]J Am Chem Soc. 135 (2013) 11457-60