Soraphen : Cluster information
Compound
| Entry name | Soraphen |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | benzoyl-CoA |
| Chain Length | 9 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Antifungal |
| Composition | A: C29H44O8 |
Original source
| Organism | Sorangium cellulosum |
|---|---|
| Strain | So ce26 |
| Contig | U24241 |
PKS/NRPS Module
| Soraph_00070 sorA | 0 |  | |
| 1 |  | malonyl-CoA | |
| 2 |  | malonyl-CoA | |
| 3 | | methoxymalonyl-ACP | |
| Soraph_00080 sorB | 4 |  | malonyl-CoA |
| 5 | | methylmalonyl-CoA | |
| 6 | | methylmalonyl-CoA | |
| 7 | | methoxymalonyl-ACP | |
| 8 |  | methylmalonyl-CoA |
Reference
- Characterization of the biosynthetic gene cluster for the antifungal polyketide soraphen A from Sorangium cellulosum So ce26.
- Ligon J, Hill S, Beck J, Zirkle R, Molnar I, Zawodny J, Money S, Schupp T[PMID: 12039053]Gene. 285 (2002) 257-67
- Heterologous production of the antifungal polyketide antibiotic soraphen A of Sorangium cellulosum So ce26 in Streptomyces lividans.
- Zirkle R, Ligon JM, Molnar I[PMID: 15289572]Microbiology. 150 (2004) 2761-74
- On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of "glycolate" units into ansamitocin and soraphen A.
- Wenzel SC, Williamson RM, Grunanger C, Xu J, Gerth K, Martinez RA, Moss SJ, Carroll BJ, Grond S, Unkefer CJ, Muller R, Floss HG[PMID: 17076505]J Am Chem Soc. 128 (2006) 14325-36
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Soraphen |
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History
- 2012-03-28[Release]
