Vicenistatin : Cluster information
Compound
| Entry name | Vicenistatin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | 3-amino-2-methylpropionyl-ACP |
| Chain Length | 9 |
| Sugar Unit | vicenisamine |
| Classification | Macrocyclic Lactam |
| Activity | Antitumor |
| Composition | C30H48N2O4 |
Original source
| Organism | Streptomyces halstedii |
|---|---|
| Strain | HC34 |
| Contig | AB086653 |
PKS/NRPS Module
| 0 |
| ||
| Vicen_00200 vinP1 | 1 |  | malonyl-CoA |
| 2 |  | malonyl-CoA | |
| 3 | | methylmalonyl-CoA | |
| Vicen_00050 vinP2 | 4 | | methylmalonyl-CoA |
| Vicen_00060 vinP3 | 5 | | malonyl-CoA |
| 6 |  | methylmalonyl-CoA | |
| Vicen_00070 vinP4 | 7 | | malonyl-CoA |
| 8 |  | malonyl-CoA |
Reference
- Cloning, sequencing, and functional analysis of the biosynthetic gene cluster of macrolactam antibiotic vicenistatin in Streptomyces halstedii.
- Ogasawara Y, Katayama K, Minami A, Otsuka M, Eguchi T, Kakinuma K[PMID: 15112997]Chem Biol. 11 (2004) 79-86
- Involvement of glutamate mutase in the biosynthesis of the unique starter unit of the macrolactam polyketide antibiotic vicenistatin.
- Ogasawara Y, Kakinuma K, Eguchi T[PMID: 16161486]J Antibiot (Tokyo). 58 (2005) 468-72
- Substrate flexibility of vicenisaminyltransferase VinC involved in the biosynthesis of vicenistatin.
- Minami A, Eguchi T[PMID: 17388594]J Am Chem Soc. 129 (2007) 5102-7
- A natural protecting group strategy to carry an amino acid starter unit in the biosynthesis of macrolactam polyketide antibiotics.
- Shinohara Y, Kudo F, Eguchi T[PMID: 22010945]J Am Chem Soc. 133 (2011) 18134-7
- The crystal structure of the amidohydrolase VinJ shows a unique hydrophobic tunnel for its interaction with polyketide substrates.
- Shinohara Y, Miyanaga A, Kudo F, Eguchi T[PMID: 24530530]FEBS Lett. 588 (2014) 995-1000
- The crystal structure of the adenylation enzyme VinN reveals a unique beta-amino acid recognition mechanism.
- Miyanaga A, Cieslak J, Shinohara Y, Kudo F, Eguchi T[PMID: 25246523]J Biol Chem. 289 (2014) 31448-57
- Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.
- Miyanaga A, Iwasawa S, Shinohara Y, Kudo F, Eguchi T[PMID: 26831085]Proc Natl Acad Sci U S A. 113 (2016) 1802-7
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Vicenistatin |
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History
- 2016-12-27[Update]
- 2015-02-12[Update]
- 2014-03-10[Update]
- 2013-09-04[Update]
- 2012-06-04[Release]
