Doxorubicin : Cluster information
Compound
Entry name | Doxorubicin |
---|---|
PKS Type | TypeII |
Starter Unit | propionyl-CoA |
Chain Length | 10 |
Sugar Unit | L-daunosamine |
Classification | Anthracycline |
Activity | Antitumor |
Composition | C27H29NO11 |
Original source
Organism | Streptomyces peucetius |
---|---|
Strain | ATCC 29050 (=NBRC 100596) |
Contig | L47163 L37338 U18082 M73758 AF048833 AF006633 M80237 U77891 L35560 L40425 L47164 L76359 |
PKS/NRPS Module
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Reference
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- A bacterial analog of the mdr gene of mammalian tumor cells is present in Streptomyces peucetius, the producer of daunorubicin and doxorubicin.
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- Cloning and characterization of the Streptomyces peucetius dnrQS genes encoding a daunosamine biosynthesis enzyme and a glycosyl transferase involved in daunorubicin biosynthesis.
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- Functional characterization and transcriptional analysis of a gene cluster governing early and late steps in daunorubicin biosynthesis in Streptomyces peucetius.
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- Cloning and sequencing of a gene encoding carminomycin 4-O-methyltransferase from Streptomyces peucetius and its expression in Escherichia coli.
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- The Streptomyces peucetius drrC gene encodes a UvrA-like protein involved in daunorubicin resistance and production.
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- Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine.
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- The Streptomyces peucetius dpsY and dnrX genes govern early and late steps of daunorubicin and doxorubicin biosynthesis.
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- Daunorubicin efflux in Streptomyces peucetius modulates biosynthesis by feedback regulation.
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- Characterization of a novel domain 'GATE' in the ABC protein DrrA and its role in drug efflux by the DrrAB complex.
- Zhang H, Rahman S, Li W, Fu G, Kaur P[PMID: 25721665]Biochem Biophys Res Commun. 459 (2015) 148-53
- Structure of DnmZ, a nitrososynthase in the Streptomyces peucetius anthracycline biosynthetic pathway.
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History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2014-06-25[Update]
- 2013-01-16[Update]
- 2012-10-02[Release]