Daunorubicin : Cluster information
Compound
Entry name | Daunorubicin |
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Synonym | Daunomycin |
PKS Type | TypeII |
Starter Unit | propionyl-CoA |
Chain Length | 10 |
Sugar Unit | L-daunosamine |
Classification | Anthracycline |
Activity | Antitumor |
Composition | C27H29NO10 |
Original source
Organism | Streptomyces sp. |
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Strain | C5 |
Contig | U50973 U43704 L34880 L35154 |
PKS/NRPS Module
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Reference
- Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5.
- Dickens ML, Ye J, Strohl WR[PMID: 7836284]J Bacteriol. 177 (1995) 536-43
- Isolation and sequence analysis of polyketide synthase genes from the daunomycin-producing Streptomyces sp. strain C5.
- Ye J, Dickens ML, Plater R, Li Y, Lawrence J, Strohl WR[PMID: 7928998]J Bacteriol. 176 (1994) 6270-80
- Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
- Dickens ML, Ye J, Strohl WR[PMID: 8655529]J Bacteriol. 178 (1996) 3384-8
- Isolation and characterization of a gene from Streptomyces sp. strain C5 that confers the ability to convert daunomycin to doxorubicin on Streptomyces lividans TK24.
- Dickens ML, Strohl WR[PMID: 8655530]J Bacteriol. 178 (1996) 3389-95
- In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA.
- Dickens ML, Priestley ND, Strohl WR[PMID: 9098063]J Bacteriol. 179 (1997) 2641-50
- Minimal Streptomyces sp. strain C5 daunorubicin polyketide biosynthesis genes required for aklanonic acid biosynthesis.
- Rajgarhia VB, Strohl WR[PMID: 9098068]J Bacteriol. 179 (1997) 2690-6
- Purification, properties, and characterization of recombinant Streptomyces sp. strain C5 DoxA, a cytochrome P-450 catalyzing multiple steps in doxorubicin biosynthesis.
- Walczak RJ, Dickens ML, Priestley ND, Strohl WR[PMID: 9864343]J Bacteriol. 181 (1999) 298-304
- The product of dpsC confers starter unit fidelity upon the daunorubicin polyketide synthase of Streptomyces sp. strain C5.
- Rajgarhia VB, Priestley ND, Strohl WR[PMID: 11162232]Metab Eng. 3 (2001) 49-63
Data download
History
- 2013-01-16[Update]
- 2012-10-02[Release]