Urdamycin : Cluster information
Compound
Entry name | Urdamycin |
---|---|
PKS Type | TypeII |
Starter Unit | acetyl-CoA |
Chain Length | 10 |
Sugar Unit | D-olivose L-rhodinose |
Classification | Angucycline Benzanthraquinone |
Activity | Antibacterial Antitumor |
Composition | A: C43H56O17 B: C37H44O13 |
Original source
Organism | Streptomyces fradiae |
---|---|
Strain | Tü2717 |
Contig | AF164961 X87093 AF164960 AF269227 |
PKS/NRPS Module
Reference
- Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae Tu2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation.
- Decker H, Haag S[PMID: 7592377]J Bacteriol. 177 (1995) 6126-36
- Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae Tu2717.
- Faust B, Hoffmeister D, Weitnauer G, Westrich L, Haag S, Schneider P, Decker H, Kunzel E, Rohr J, Bechthold A[PMID: 10658661]Microbiology. 146 ( Pt 1) (2000) 147-54
- Function of glycosyltransferase genes involved in urdamycin A biosynthesis.
- Trefzer A, Hoffmeister D, Kunzel E, Stockert S, Weitnauer G, Westrich L, Rix U, Fuchser J, Bindseil KU, Rohr J, Bechthold A[PMID: 10662691]Chem Biol. 7 (2000) 133-42
- The NDP-sugar co-substrate concentration and the enzyme expression level influence the substrate specificity of glycosyltransferases: cloning and characterization of deoxysugar biosynthetic genes of the urdamycin biosynthetic gene cluster.
- Hoffmeister D, Ichinose K, Domann S, Faust B, Trefzer A, Drager G, Kirschning A, Fischer C, Kunzel E, Bearden D, Rohr J, Bechthold A[PMID: 11094336]Chem Biol. 7 (2000) 821-31
- Two sequence elements of glycosyltransferases involved in urdamycin biosynthesis are responsible for substrate specificity and enzymatic activity.
- Hoffmeister D, Ichinose K, Bechthold A[PMID: 11410375]Chem Biol. 8 (2001) 557-67
- Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717.
- Rix U, Remsing LL, Hoffmeister D, Bechthold A, Rohr J[PMID: 12512084]Chembiochem. 4 (2003) 109-11
- The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses.
- Hoffmeister D, Drager G, Ichinose K, Rohr J, Bechthold A[PMID: 12696864]J Am Chem Soc. 125 (2003) 4678-9
- Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene.
- von Mulert U, Luzhetskyy A, Hofmann C, Mayer A, Bechthold A[PMID: 14734170]FEMS Microbiol Lett. 230 (2004) 91-7
- Surprising production of a new urdamycin derivative by S. fradiae Delta urdQ/R.
- Fedoryshyn M, Nur-e-Alam M, Zhu L, Luzhetskyy A, Rohr J, Bechthold A[PMID: 17434221]J Biotechnol. 130 (2007) 32-8
- Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin.
- Mittler M, Bechthold A, Schulz GE[PMID: 17640665]J Mol Biol. 372 (2007) 67-76
- Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.
- Patrikainen P, Kallio P, Fan K, Klika KD, Shaaban KA, Mantsala P, Rohr J, Yang K, Niemi J, Metsa-Ketela M[PMID: 22633416]Chem Biol. 19 (2012) 647-55
- Structure-based engineering of angucyclinone 6-ketoreductases.
- Patrikainen P, Niiranen L, Thapa K, Paananen P, Tahtinen P, Mantsala P, Niemi J, Metsa-Ketela M[PMID: 25200607]Chem Biol. 21 (2014) 1381-91
Data download
History
- 2015-02-12[Update]
- 2013-01-16[Update]
- 2012-08-03[Release]