- Elucidation of anthracyclinone biosynthesis by stepwise cloning of genes for anthracyclines from three different Streptomyces spp.
Kantola J, Kunnari T, Hautala A, Hakala J, Ylihonko K, Mantsala P
[PMID: 10658662]Microbiology. 146 ( Pt 1) (2000) 155-63- A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.
Raty K, Kunnari T, Hakala J, Mantsala P, Ylihonko K
[PMID: 11016846]Mol Gen Genet. 264 (2000) 164-72- Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster.
Raty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mantsala P
[PMID: 12137949]Gene. 293 (2002) 115-22- Characterization of mutations in aclacinomycin A-non-producing Streptomyces galilaeus strains with altered glycosylation patterns.
Raty K, Hautala A, Torkkell S, Kantola J, Mantsala P, Hakala J, Ylihonko K
[PMID: 12427929]Microbiology. 148 (2002) 3375-84- Studies on a second and third ring cyclization in anthracycline biosynthesis.
Hautala A, Torkkell S, Raty K, Kunnari T, Kantola J, Mantsala P, Hakala J, Ylihonko K
[PMID: 12715874]J Antibiot (Tokyo). 56 (2003) 143-53- AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A.
Lu W, Leimkuhler C, Oberthur M, Kahne D, Walsh CT
[PMID: 15078101]Biochemistry. 43 (2004) 4548-58- AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A.
Lu W, Leimkuhler C, Gatto GJ Jr, Kruger RG, Oberthur M, Kahne D, Walsh CT
[PMID: 15911373]Chem Biol. 12 (2005) 527-34- Crystal structure of the polyketide cyclase AknH with bound substrate and product analogue: implications for catalytic mechanism and product stereoselectivity.
Kallio P, Sultana A, Niemi J, Mantsala P, Schneider G
[PMID: 16414075]J Mol Biol. 357 (2006) 210-20- Structure determination by multiwavelength anomalous diffraction of aclacinomycin oxidoreductase: indications of multidomain pseudomerohedral twinning.
Sultana A, Alexeev I, Kursula I, Mantsala P, Niemi J, Schneider G
[PMID: 17242508]Acta Crystallogr D Biol Crystallogr. 63 (2007) 149-59- Aclacinomycin oxidoreductase (AknOx) from the biosynthetic pathway of the antibiotic aclacinomycin is an unusual flavoenzyme with a dual active site.
Alexeev I, Sultana A, Mantsala P, Niemi J, Schneider G
[PMID: 17395717]Proc Natl Acad Sci U S A. 104 (2007) 6170-5- Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A.
Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D
[PMID: 17685523]J Am Chem Soc. 129 (2007) 10546-50
Compound
Aclacinomycin A
