Alnumycin : Cluster information
Compound
Entry name | Alnumycin |
---|---|
PKS Type | TypeII |
Starter Unit | butyryl-ACP |
Chain Length | 8 |
Sugar Unit | none |
Classification | Naphthoquinone Benzoisochromanequinone (BIQ)-related |
Activity | Antitumor Gyrase inhibitory Topoisomerase inhibitory |
Composition | C22H24O8 |
Original source
Organism | Streptomyces sp. |
---|---|
Strain | CM020 |
Contig | EU852062 |
PKS/NRPS Module
|
|
Reference
- Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis.
- Oja T, Palmu K, Lehmussola H, Lepparanta O, Hannikainen K, Niemi J, Mantsala P, Metsa-Ketela M[PMID: 18940666]Chem Biol. 15 (2008) 1046-57
- Ketosynthase III as a gateway to engineering the biosynthesis of antitumoral benastatin derivatives.
- Xu Z, Metsa-Ketela M, Hertweck C[PMID: 19047004]J Biotechnol. 140 (2009) 107-13
- Characterization of the Two-Component Monooxygenase System AlnT/AlnH Reveals Early Timing of Quinone Formation in Alnumycin Biosynthesis.
- Grocholski T, Oja T, Humphrey L, Mantsala P, Niemi J, Metsa-Ketela M[PMID: 22467789]J Bacteriol. 194 (2012) 2829-36
- Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage.
- Oja T, Klika KD, Appassamy L, Sinkkonen J, Mantsala P, Niemi J, Metsa-Ketela M[PMID: 22474343]Proc Natl Acad Sci U S A. 109 (2012) 6024-9
- Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
- Oja T, Niiranen L, Sandalova T, Klika KD, Niemi J, Mantsala P, Schneider G, Metsa-Ketela M[PMID: 23297194]Proc Natl Acad Sci U S A. 110 (2013) 1291-6
- Biosynthetic conclusions from the functional dissection of oxygenases for biosynthesis of actinorhodin and related streptomyces antibiotics.
- Taguchi T, Yabe M, Odaki H, Shinozaki M, Metsa-Ketela M, Arai T, Okamoto S, Ichinose K[PMID: 23601640]Chem Biol. 20 (2013) 510-20
- Chemoenzymatic synthesis of novel C-ribosylated naphthoquinones.
- Blauenburg B, Oja T, Klika KD, Metsa-Ketela M[PMID: 24015959]ACS Chem Biol. 8 (2013) 2377-82
- Molecular evolution of the bacterial pseudouridine-5'-phosphate glycosidase protein family.
- Thapa K, Oja T, Metsa-Ketela M[PMID: 25081867]FEBS J. 281 (2014) 4439-49
Data download
History
- 2016-01-27[Update]
- 2013-05-28[Update]
- 2013-01-16[Update]
- 2012-08-03[Release]