Alpha-lipomycin : Cluster information
Compound
| Entry name | Alpha-lipomycin |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | isobutyryl-CoA |
| Chain Length | 8 |
| Sugar Unit | D-digitoxose |
| Classification | Linear Polyene Peptide-Polyketide Hybrid |
| Activity | Antibacterial |
| Composition | C32H45NO9 |
Original source
| Organism | Streptomyces aureofaciens |
|---|---|
| Strain | Tü117 |
| Contig | DQ176871 |
PKS/NRPS Module
| Alip_00130 lipPks1 | 0 |  | isobutyryl-CoA |
| 1 |  | methylmalonyl-CoA | |
| Alip_00140 lipPks2 | 2 |  | methylmalonyl-CoA |
| 3 | | malonyl-CoA | |
| Alip_00150 lipPks3 | 4 | | malonyl-CoA |
| 5 | | malonyl-CoA | |
| Alip_00160 lipPks4 | 6 | | malonyl-CoA |
| 7 |  | malonyl-CoA | |
| Alip_00120 lipNrps | 8 |  |
Reference
- Biosynthetic gene cluster for the polyenoyltetramic acid alpha-lipomycin.
- Bihlmaier C, Welle E, Hofmann C, Welzel K, Vente A, Breitling E, Muller M, Glaser S, Bechthold A[PMID: 16723573]Antimicrob Agents Chemother. 50 (2006) 2113-21
- Characterization and analysis of the regulatory network involved in control of lipomycin biosynthesis in Streptomyces aureofaciens Tu117.
- Horbal L, Rebets Y, Rabyk M, Luzhetskyy A, Ostash B, Welle E, Nakamura T, Fedorenko V, Bechthold A[PMID: 19585113]Appl Microbiol Biotechnol. 85 (2010) 1069-79
- Broad substrate specificity of the loading didomain of the lipomycin polyketide synthase.
- Yuzawa S, Eng CH, Katz L, Keasling JD[PMID: 23692164]Biochemistry. 52 (2013) 3791-3
- Enzyme analysis of the polyketide synthase leads to the discovery of a novel analog of the antibiotic alpha-lipomycin.
- Yuzawa S, Eng CH, Katz L, Keasling JD[PMID: 24169801]J Antibiot (Tokyo). 67 (2014) 199-201
- Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis.
- Gui C, Li Q, Mo X, Qin X, Ma J, Ju J[PMID: 25621700]Org Lett. 17 (2015) 628-31
- Alteration of Polyketide Stereochemistry from anti to syn by a Ketoreductase Domain Exchange in a Type I Modular Polyketide Synthase Subunit.
- Eng CH, Yuzawa S, Wang G, Baidoo EE, Katz L, Keasling JD[PMID: 26976746]Biochemistry. 55 (2016) 1677-80
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Alpha-lipomycin |
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History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2014-06-25[Update]
- 2013-12-27[Update]
- 2012-10-02[Update]
- 2012-04-26[Release]
