Avilamycin : Cluster information
Compound
Entry name | Avilamycin |
---|---|
PKS Type | TypeI iterative |
Starter Unit | acetyl-CoA |
Chain Length | 4 |
Sugar Unit | 2,6-di-O-methyl-D-mannose 2-O-isobutyryl-L-lyxose 2-deoxy-D-evalose 4-O-methyl-D-fucose D-olivoses eurekanate |
Classification | Orthosomycin |
Activity | Antibacterial |
Composition | A: C61H88Cl2O32 |
Original source
Organism | Streptomyces viridochromogenes |
---|---|
Strain | Tü57 |
Contig | AF333038 |
PKS/NRPS Module
Avil_00210 aviM | 1 | acetyl-CoA malonyl-CoA |
Reference
- Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tu57.
- Gaisser S, Trefzer A, Stockert S, Kirschning A, Bechthold A[PMID: 9335272]J Bacteriol. 179 (1997) 6271-8
- An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57.
- Weitnauer G, Gaisser S, Trefzer A, Stockert S, Westrich L, Quiros LM, Mendez C, Salas JA, Bechthold A[PMID: 11181344]Antimicrob Agents Chemother. 45 (2001) 690-5
- Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tu57 and production of new antibiotics.
- Weitnauer G, Muhlenweg A, Trefzer A, Hoffmeister D, Sussmuth RD, Jung G, Welzel K, Vente A, Girreser U, Bechthold A[PMID: 11410376]Chem Biol. 8 (2001) 569-81
- Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tu57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1.
- Weitnauer G, Gaisser S, Kellenberger L, Leadlay PF, Bechthold A[PMID: 11832501]Microbiology. 148 (2002) 373-9
- Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes.
- Mosbacher TG, Bechthold A, Schulz GE[PMID: 12742024]J Mol Biol. 329 (2003) 147-57
- The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose.
- Treede I, Jakobsen L, Kirpekar F, Vester B, Weitnauer G, Bechthold A, Douthwaite S[PMID: 12828631]Mol Microbiol. 49 (2003) 309-18
- Novel avilamycin derivatives with improved polarity generated by targeted gene disruption.
- Weitnauer G, Hauser G, Hofmann C, Linder U, Boll R, Pelz K, Glaser SJ, Bechthold A[PMID: 15489167]Chem Biol. 11 (2004) 1403-11
- Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes.
- Mosbacher TG, Bechthold A, Schulz GE[PMID: 15581897]J Mol Biol. 345 (2005) 535-45
- Genes involved in formation and attachment of a two-carbon chain as a component of eurekanate, a branched-chain sugar moiety of avilamycin A.
- Treede I, Hauser G, Muhlenweg A, Hofmann C, Schmidt M, Weitnauer G, Glaser S, Bechthold A[PMID: 15640214]Appl Environ Microbiol. 71 (2005) 400-6
- Genes encoding enzymes responsible for biosynthesis of L-lyxose and attachment of eurekanate during avilamycin biosynthesis.
- Hofmann C, Boll R, Heitmann B, Hauser G, Durr C, Frerich A, Weitnauer G, Glaser SJ, Bechthold A[PMID: 16242656]Chem Biol. 12 (2005) 1137-43
- The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme.
- Boll R, Hofmann C, Heitmann B, Hauser G, Glaser S, Koslowski T, Friedrich T, Bechthold A[PMID: 16537546]J Biol Chem. 281 (2006) 14756-63
- Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4.
- Martinez-Fleites C, Proctor M, Roberts S, Bolam DN, Gilbert HJ, Davies GJ[PMID: 17113996]Chem Biol. 13 (2006) 1143-52
- Production of avilamycin A is regulated by AviC1 and AviC2, two transcriptional activators.
- Rebets Y, Boll R, Horbal L, Fedorenko V, Bechthold A[PMID: 19609289]J Antibiot (Tokyo). 62 (2009) 461-4
- Draft Genome Sequence of Streptomyces viridochromogenes Strain Tu57, Producer of Avilamycin.
- Gruning BA, Erxleben A, Hahnlein A, Gunther S[PMID: 23788550]Genome Announc. 1 (2013)
Data download
History
- 2015-02-12[Update]
- 2013-12-27[Release]