Chalcomycin : Cluster information
Compound
Entry name | Chalcomycin |
---|---|
PKS Type | TypeI modular |
Starter Unit | malonyl-CoA |
Chain Length | 8 |
Sugar Unit | chalcose mycinose |
Classification | Macrolide |
Activity | Antibacterial |
Composition | C35H56O14 |
Original source
Organism | Streptomyces bikiniensis |
---|---|
Strain | NRRL 2737 |
Contig | AY509120 |
PKS/NRPS Module
Chalc_00210 chmGI | 0 | malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA | |
1 | methylmalonyl-CoA | ||
2 | malonyl-CoA not conserved HAFHS, conserved signature for methylmalonyl-CoA | ||
Chalc_00220 chmGII | 3 | malonyl-CoA | |
Chalc_00230 chmGIII | 4 | methylmalonyl-CoA | |
5 | methylmalonyl-CoA | ||
Chalc_00240 chmGIV | 6 | methylmalonyl-CoA | |
Chalc_00250 chmGV | 7 | malonyl-CoA |
Reference
- Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts.
- Reeves CD, Ward SL, Revill WP, Suzuki H, Marcus M, Petrakovsky OV, Marquez S, Fu H, Dong SD, Katz L[PMID: 15489173]Chem Biol. 11 (2004) 1465-72
- Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae.
- Ward SL, Hu Z, Schirmer A, Reid R, Revill WP, Reeves CD, Petrakovsky OV, Dong SD, Katz L[PMID: 15561847]Antimicrob Agents Chemother. 48 (2004) 4703-12
- Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose.
- Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM[PMID: 23116432]Biochemistry. 51 (2012) 9375-83
Data download
History
- 2013-05-28[Update]
- 2013-01-16[Update]
- 2012-10-02[Update]
- 2012-03-28[Release]