Chromomycin : Cluster information
Compound
Entry name | Chromomycin |
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PKS Type | TypeII |
Starter Unit | acetyl-CoA |
Chain Length | 10 |
Sugar Unit | D-olivose 4'-O-acetyl-D-oliose 4'-O-acetyl-L-chromose 4'-O-methyl-D-oliose |
Classification | Aureolic acid |
Activity | Antibacterial Antitumor Antiviral |
Composition | A3: C57H82O26 |
Original source
Organism | Streptomyces griseus |
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Strain | ATCC 13273 (=NBRC 3746) |
Contig | AJ578458 |
PKS/NRPS Module
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Reference
- Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.
- Menendez N, Nur-e-Alam M, Brana AF, Rohr J, Salas JA, Mendez C[PMID: 15112992]Chem Biol. 11 (2004) 21-32
- Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus.
- Menendez N, Nur-E-Alam M, Brana AF, Rohr J, Salas JA, Mendez C[PMID: 15255901]Mol Microbiol. 53 (2004) 903-15
- Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity.
- Menendez N, Nur-e-Alam M, Fischer C, Brana AF, Salas JA, Rohr J, Mendez C[PMID: 16391039]Appl Environ Microbiol. 72 (2006) 167-77
- Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis.
- Menendez N, Brana AF, Salas JA, Mendez C[PMID: 17768249]Microbiology. 153 (2007) 3061-70
- Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus.
- Bosserman MA, Florez AB, Shaaban KA, Brana AF, Salas JA, Mendez C, Rohr J[PMID: 21244022]Biochemistry. 50 (2011) 1421-8
- The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.
- Garcia B, Gonzalez-Sabin J, Menendez N, Brana AF, Nunez LE, Moris F, Salas JA, Mendez C[PMID: 21342468]Microb Biotechnol. 4 (2011) 226-38
Data download
History
- 2013-01-16[Release]