Geldanamycin : Cluster information
Compound
Entry name | Geldanamycin |
---|---|
PKS Type | TypeI modular |
Starter Unit | 3-amino-5-hydroxybenzoic acid (AHBA) |
Chain Length | 8 |
Sugar Unit | none |
Classification | Ansamycin |
Activity | Antitumor Antivirus |
Composition | C29H40N2O9 |
Original source
Organism | Streptomyces hygroscopicus |
---|---|
Strain | 17997 |
Contig | AF521894 DQ914285 |
PKS/NRPS Module
Gelda_00010 gdmPKS | 6 | ||
7 | methylmalonyl-CoA |
Reference
- Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.
- He W, Wu L, Gao Q, Du Y, Wang Y[PMID: 16502293]Curr Microbiol. 52 (2006) 197-203
- The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997.
- He W, Lei J, Liu Y, Wang Y[PMID: 18214443]Arch Microbiol. 189 (2008) 501-10
- A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997.
- Li Y, He W, Wang Y, Wang Y, Shao R[PMID: 18667782]J Antibiot (Tokyo). 61 (2008) 347-55
- 7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997.
- Ni S, Wu L, Wang H, Wang Y, He W, Li Y, Jia C, Li S, Wang Y[PMID: 20683449]J Antibiot (Tokyo). 63 (2010) 623-5
- The missing C-17 O-methyltransferase in geldanamycin biosynthesis.
- Yin M, Lu T, Zhao LX, Chen Y, Huang SX, Lohman JR, Xu LH, Jiang CL, Shen B[PMID: 21682254]Org Lett. 13 (2011) 3726-9
- Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997.
- Lin L, Ni S, Wu L, Wang Y, Wang Y, Tao P, He W, Wang X[PMID: 21979086]Biosci Biotechnol Biochem. 75 (2011) 2042-5
- Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis.
- Li T, Ni S, Jia C, Wang H, Sun G, Wu L, Gan M, Shan G, He W, Lin L, Zhou H, Wang Y[PMID: 22849774]J Nat Prod. 75 (2012) 1480-4
- 19-[(1'S,4'R)-4'-Hydroxy-1'-methoxy-2'-oxopentyl]geldanamycin, a natural geldanamycin analogue from Streptomyces hygroscopicus 17997.
- Li S, Ni S, Wu L, Li L, Jiang B, Wang H, Sun G, Gan M, Li J, He W, Lin L, Wang Y, Bai S, Si S[PMID: 23656556]J Nat Prod. 76 (2013) 969-73
- Identification of 6-demethoxy-6-methylgeldanamycin and its implication of geldanamycin biosynthesis.
- Ni S, Jiang B, Wu L, Wang Y, Zhou H, He W, Wang H, Zhu J, Li S, Li T, Zhang K[PMID: 24105607]J Antibiot (Tokyo). 67 (2014) 183-5
Data download
History
- 2014-06-25[Update]
- 2013-12-27[Release]