Griseorhodin A : Cluster information
Compound
Entry name | Griseorhodin A |
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PKS Type | TypeII |
Starter Unit | acetyl-CoA |
Chain Length | 13 |
Sugar Unit | none |
Classification | Rubromycin |
Activity | Antibacterial human telomerase inhibitor |
Composition | C25H16O12 |
Original source
Organism | Streptomyces sp. |
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Strain | JP95 |
Contig | AF509565 |
PKS/NRPS Module
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Reference
- A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A.
- Li A, Piel J[PMID: 12323376]Chem Biol. 9 (2002) 1017-26
- Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways.
- Lackner G, Schenk A, Xu Z, Reinhardt K, Yunt ZS, Piel J, Hertweck C[PMID: 17625850]J Am Chem Soc. 129 (2007) 9306-12
- Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore.
- Yunt Z, Reinhardt K, Li A, Engeser M, Dahse HM, Gutschow M, Bruhn T, Bringmann G, Piel J[PMID: 19175308]J Am Chem Soc. 131 (2009) 2297-305
Data download
History
- 2013-01-16[Release]