Hectochlorin : Cluster information
Compound
| Entry name | Hectochlorin |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | hexanoic acid |
| Chain Length | 6 |
| Sugar Unit | none |
| Classification | |
| Activity | Antifungal Antitumor Toxic |
| Composition | C27H34Cl2N2O9S2 |
Original source
| Organism | Lyngbya majuscula |
|---|---|
| Strain | JHB |
| Contig | AY974560 |
PKS/NRPS Module
| 0 |
| ||
| Hecto_00040 hctD | 1 |  | malonyl-CoA |
| Hecto_00050 hctE | 2 |  | 2-oxoisovaleric acid |
| 3 |  | L-cysteine | |
| Hecto_00060 hctF | 4 |  | 2-oxoisovaleric acid |
| 5 |  | L-cysteine |
Reference
- Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula.
- Ramaswamy AV, Sorrels CM, Gerwick WH[PMID: 18001088]J Nat Prod. 70 (2007) 1977-86
- More than just a halogenase: modification of fatty acyl moieties by a trifunctional metal enzyme.
- Pratter SM, Ivkovic J, Birner-Gruenberger R, Breinbauer R, Zangger K, Straganz GD[PMID: 24497159]Chembiochem. 15 (2014) 567-74
- The role of chloride in the mechanism of O(2) activation at the mononuclear nonheme Fe(II) center of the halogenase HctB.
- Pratter SM, Light KM, Solomon EI, Straganz GD[PMID: 24847780]J Am Chem Soc. 136 (2014) 9385-95
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Hectochlorin |
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History
- 2014-06-25[Update]
- 2013-09-04[Release]
