Hedamycin : Cluster information
Compound
Entry name | Hedamycin |
---|---|
PKS Type | TypeI modular TypeII |
Starter Unit | 2,4-hexadienyl-ACP |
Chain Length | 12 |
Sugar Unit | alpha-L-N,N-dimethylvancosamine beta-D-angolosamine |
Classification | Pluramycin |
Activity | Antitumor |
Composition | C41H50N2O11 |
Original source
Organism | Streptomyces griseoruber |
---|---|
Strain | ATCC 15422 |
Contig | AY196994 |
PKS/NRPS Module
Heda_00020 hedT | 0 | malonyl-CoA | |
Heda_00010 hedU | 1 | malonyl-CoA | |
2 | |||
|
Reference
- The hedamycin locus implicates a novel aromatic PKS priming mechanism.
- Bililign T, Hyun CG, Williams JS, Czisny AM, Thorson JS[PMID: 15271354]Chem Biol. 11 (2004) 959-69
- In vivo and in vitro analysis of the hedamycin polyketide synthase.
- Das A, Khosla C[PMID: 19942143]Chem Biol. 16 (2009) 1197-207
- Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities.
- Javidpour P, Das A, Khosla C, Tsai SC[PMID: 21776967]Biochemistry. 50 (2011) 7426-39
Data download
History
- 2013-01-16[Update]
- 2012-10-02[Update]
- 2012-08-03[Release]