Landomycin : Cluster information
Compound
Entry name | Landomycin |
---|---|
PKS Type | TypeII |
Starter Unit | acetyl-CoA |
Chain Length | 10 |
Sugar Unit | D-olivose L-rhodinose |
Classification | Angucycline Benzanthraquinone |
Activity | Antitumor |
Composition | A: C55H74O22 |
Original source
Organism | Streptomyces cyanogenus |
---|---|
Strain | S136 |
Contig | AF080235 AY187683 |
PKS/NRPS Module
|
Reference
- Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis.
- Westrich L, Domann S, Faust B, Bedford D, Hopwood DA, Bechthold A[PMID: 9933932]FEMS Microbiol Lett. 170 (1999) 381-7
- Elucidation of the function of two glycosyltransferase genes (lanGT1 and lanGT4) involved in landomycin biosynthesis and generation of new oligosaccharide antibiotics.
- Trefzer A, Fischer C, Stockert S, Westrich L, Kunzel E, Girreser U, Rohr J, Bechthold A[PMID: 11755402]Chem Biol. 8 (2001) 1239-52
- Production of landomycins in Streptomyces globisporus 1912 and S cyanogenus S136 is regulated by genes encoding putative transcriptional activators.
- Rebets Y, Ostash B, Luzhetskyy A, Hoffmeister D, Brana A, Mendez C, Salas JA, Bechthold A, Fedorenko V[PMID: 12757959]FEMS Microbiol Lett. 222 (2003) 149-53
- Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis.
- Luzhetskyy A, Liu T, Fedoryshyn M, Ostash B, Fedorenko V, Rohr J, Bechthold A[PMID: 15515090]Chembiochem. 5 (2004) 1567-70
- Identification of the function of gene lndM2 encoding a bifunctional oxygenase-reductase involved in the biosynthesis of the antitumor antibiotic landomycin E by Streptomyces globisporus 1912 supports the originally assigned structure for landomycinone.
- Zhu L, Ostash B, Rix U, Nur-E-Alam M, Mayers A, Luzhetskyy A, Mendez C, Salas JA, Bechthold A, Fedorenko V, Rohr J[PMID: 15651811]J Org Chem. 70 (2005) 631-8
- Generation of novel landomycins M and O through targeted gene disruption.
- Luzhetskyy A, Zhu L, Gibson M, Fedoryshyn M, Durr C, Hofmann C, Hoffmeister D, Ostash B, Mattingly C, Adams V, Fedorenko V, Rohr J, Bechthold A[PMID: 15812784]Chembiochem. 6 (2005) 675-8
- LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis.
- Luzhetskyy A, Taguchi T, Fedoryshyn M, Durr C, Wohlert SE, Novikov V, Bechthold A[PMID: 15977274]Chembiochem. 6 (2005) 1406-10
- Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A.
- Luzhetskyy A, Fedoryshyn M, Durr C, Taguchi T, Novikov V, Bechthold A[PMID: 16039521]Chem Biol. 12 (2005) 725-9
- LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis.
- Mayer A, Taguchi T, Linnenbrink A, Hofmann C, Luzhetskyy A, Bechthold A[PMID: 16283688]Chembiochem. 6 (2005) 2312-5
- Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.
- Zhu L, Luzhetskyy A, Luzhetska M, Mattingly C, Adams V, Bechthold A, Rohr J[PMID: 17139690]Chembiochem. 8 (2007) 83-8
- Function of lanI in regulation of landomycin A biosynthesis in Streptomyces cyanogenus S136 and cross-complementation studies with Streptomyces antibiotic regulatory proteins encoding genes.
- Rebets Y, Dutko L, Ostash B, Luzhetskyy A, Kulachkovskyy O, Yamaguchi T, Nakamura T, Bechthold A, Fedorenko V[PMID: 17786405]Arch Microbiol. 189 (2008) 111-20
- Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136.
- Ostash I, Ostash B, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V[PMID: 18537830]FEMS Microbiol Lett. 285 (2008) 195-202
- Differences in the substrate specificity of glycosyltransferases involved in landomycins A and E biosynthesis.
- Erb A, Krauth C, Luzhetskyy A, Bechthold A[PMID: 19352642]Appl Microbiol Biotechnol. 83 (2009) 1067-76
- Properties of lanK-based regulatory circuit involved in landomycin biosynthesis in Streptomyces cyanogenus S136.
- Ostash B, Ostash I, Zhu L, Kharel MK, Luzhetskii A, Bechthold A, Walker S, Rohr J, Fedorenko V[PMID: 20583594]Genetika. 46 (2010) 604-9
- Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase.
- Harle J, Gunther S, Lauinger B, Weber M, Kammerer B, Zechel DL, Luzhetskyy A, Bechthold A[PMID: 21513888]Chem Biol. 18 (2011) 520-30
- Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis.
- Kharel MK, Pahari P, Shepherd MD, Tibrewal N, Nybo SE, Shaaban KA, Rohr J[PMID: 22186970]Nat Prod Rep. 29 (2012) 264-325
- Elucidation of post-PKS tailoring steps involved in landomycin biosynthesis.
- Kharel MK, Pahari P, Shaaban KA, Wang G, Morris C, Rohr J[PMID: 22454092]Org Biomol Chem. 10 (2012) 4256-65
- Tailoring enzymes involved in the biosynthesis of angucyclines contain latent context-dependent catalytic activities.
- Patrikainen P, Kallio P, Fan K, Klika KD, Shaaban KA, Mantsala P, Rohr J, Yang K, Niemi J, Metsa-Ketela M[PMID: 22633416]Chem Biol. 19 (2012) 647-55
- Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
- Paananen P, Patrikainen P, Kallio P, Mantsala P, Niemi J, Niiranen L, Metsa-Ketela M[PMID: 23848284]Biochemistry. 52 (2013) 5304-14
- Structure-based engineering of angucyclinone 6-ketoreductases.
- Patrikainen P, Niiranen L, Thapa K, Paananen P, Tahtinen P, Mantsala P, Niemi J, Metsa-Ketela M[PMID: 25200607]Chem Biol. 21 (2014) 1381-91
- Structural characterization of O- and C-glycosylating variants of the landomycin glycosyltransferase LanGT2.
- Tam HK, Harle J, Gerhardt S, Rohr J, Wang G, Thorson JS, Bigot A, Lutterbeck M, Seiche W, Breit B, Bechthold A, Einsle O[PMID: 25581707]Angew Chem Int Ed Engl. 54 (2015) 2811-5
Data download
History
- 2016-01-27[Update]
- 2015-02-12[Update]
- 2013-09-04[Update]
- 2013-01-16[Update]
- 2012-08-03[Release]