Meridamycin : Cluster information
Compound
| Entry name | Meridamycin |
|---|---|
| PKS Type | PKS-NRPS hybrid |
| Starter Unit | malonyl-CoA |
| Chain Length | 15 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Neuroprotective Non-immunosuppressive |
| Composition | C45H75NO12 |
Original source
| Organism | Streptomyces violaceusniger |
|---|---|
| Strain | DSM 4137 |
| Contig | DQ885223 |
PKS/NRPS Module
| Merid_00020 merA | 0 |  | malonyl-CoA |
| 1 |  | methylmalonyl-CoA | |
| 2 |  | methylmalonyl-CoA | |
| 3 | | malonyl-CoA | |
| Merid_00030 merB | 4 | | ethylmalonyl-CoA |
| 5 | | methylmalonyl-CoA | |
| 6 |  | methylmalonyl-CoA | |
| 7 | | methylmalonyl-CoA | |
| Merid_00040 merC | 8 | | malonyl-CoA |
| 9 | | malonyl-CoA | |
| 10 | | methylmalonyl-CoA | |
| 11 | | malonyl-CoA | |
| 12 | | malonyl-CoA | |
| 13 | | methylmalonyl-CoA | |
| 14 |  | malonyl-CoA | |
| Merid_00010 merP | 15 |  | |
| 16 |  |
Reference
- Organization of the biosynthetic gene cluster in Streptomyces sp. DSM 4137 for the novel neuroprotectant polyketide meridamycin.
- Sun Y, Hong H, Samborskyy M, Mironenko T, Leadlay PF, Haydock SF[PMID: 17159202]Microbiology. 152 (2006) 3507-15
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Meridamycin |
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History
- 2012-03-28[Release]
