Oxazolomycin : Cluster information
Compound
Entry name | Oxazolomycin |
---|---|
PKS Type | Trans-AT PKS-NRPS hybrid |
Starter Unit | glycine |
Chain Length | 10 |
Sugar Unit | none |
Classification | Polyene-Type Alkaloid |
Activity | Antibacterial Antitumor Antivirus Ionophore |
Composition | A: C35H49N3O9 |
Original source
Organism | Streptomyces albus |
---|---|
Strain | JA3453 |
Contig | EF552687 |
PKS/NRPS Module
Oxzol_00200 ozmO | 0 | glycine | |
Oxzol_00220 ozmQ | 1 | ||
Oxzol_00190 ozmN | 2 | ||
3 | |||
4 | |||
Oxzol_00140 ozmH | 5 | ||
6 | glycine | ||
7 | |||
8 | |||
9 | |||
Oxzol_00150 ozmJ | 10 | ||
Oxzol_00160 ozmK | 11 | ||
Oxzol_00170 ozmL | 12 | serine | |
Oxzol_00180 ozmM | 13 | malonyl-CoA malonyl-CoA |
Reference
- Utilization of the methoxymalonyl-acyl carrier protein biosynthesis locus for cloning the oxazolomycin biosynthetic gene cluster from Streptomyces albus JA3453.
- Zhao C, Ju J, Christenson SD, Smith WC, Song D, Zhou X, Shen B, Deng Z[PMID: 16707707]J Bacteriol. 188 (2006) 4142-7
- The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis.
- Dorrestein PC, Van Lanen SG, Li W, Zhao C, Deng Z, Shen B, Kelleher NL[PMID: 16895402]J Am Chem Soc. 128 (2006) 10386-7
- Alternative method for site-directed mutagenesis of complex polyketide synthase in Streptomyces albus JA3453.
- Song D, Coughlin J, Ju J, Zhou X, Shen B, Zhao C, Deng Z[PMID: 18401530]Acta Biochim Biophys Sin (Shanghai). 40 (2008) 319-26
- Oxazolomycin biosynthesis in Streptomyces albus JA3453 featuring an "acyltransferase-less" type I polyketide synthase that incorporates two distinct extender units.
- Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z[PMID: 20406823]J Biol Chem. 285 (2010) 20097-108
Data download
History
- 2013-01-16[Update]
- 2012-10-02[Release]