Pladienolide : Cluster information
Compound
| Entry name | Pladienolide |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | methylmalonyl-CoA |
| Chain Length | 11 |
| Sugar Unit | none |
| Classification | Other Macrocyclic Lactone |
| Activity | Antitumor |
| Composition | A: C28H46O7 B: C30H48O8 |
Original source
| Organism | Streptomyces platensis |
|---|---|
| Strain | Mer-11107 |
| Contig | AB435553 |
PKS/NRPS Module
| Pladi_00010 pldAI | 0 |  | methylmalonyl-CoA not conserved YASHS(S->T) |
| 1 |  | methylmalonyl-CoA | |
| 2 |  | malonyl-CoA | |
| 3 |  | methylmalonyl-CoA not conserved YASHS(S->T) | |
| Pladi_00020 pldAII | 4 | | malonyl-CoA |
| 5 | | methylmalonyl-CoA not conserved YASHS(S->T) | |
| 6 | | methylmalonyl-CoA not conserved YASHS(S->T) | |
| 7 | | malonyl-CoA | |
| Pladi_00030 pldAIII | 8 | | methylmalonyl-CoA |
| 9 | | malonyl-CoA | |
| Pladi_00040 pldAIV | 10 |  | malonyl-CoA |
Reference
- Organization of the biosynthetic gene cluster for the polyketide antitumor macrolide, pladienolide, in Streptomyces platensis Mer-11107.
- Machida K, Arisawa A, Takeda S, Tsuchida T, Aritoku Y, Yoshida M, Ikeda H[PMID: 18997414]Biosci Biotechnol Biochem. 72 (2008) 2946-52
- Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism.
- Komatsu M, Uchiyama T, Omura S, Cane DE, Ikeda H[PMID: 20133795]Proc Natl Acad Sci U S A. 107 (2010) 2646-51
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Pladienolide |
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History
- 2013-05-28[Update]
- 2012-03-28[Release]
