R1128 : Cluster information

Compound

Entry name	R1128
PKS Type	TypeII
Starter Unit	R1128 A: butyryl-ACP R1128 B: pentanoyl-ACP R1128 C: isohexanoyl-ACP R1128 D: hexanoyl-ACP
Chain Length	8
Sugar Unit	none
Classification	Anthraquinone
Activity	Estrogen receptor antagonist
Composition	R1128 A: C₁₇H₁₄O₅ R1128 B: C₁₈H₁₆O₅ R1128 C: C₁₉H₁₈O₅ R1128 D: C₁₉H₁₈O₅

KS	10..331

ACP	5..78

KS	2..369

CLF	9..368

ACP	2..75

Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism.: Marti T, Hu Z, Pohl NL, Shah AN, Khosla C
[PMID: 10931852]J Biol Chem. 275 (2000) 33443-8
In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase.: Meadows ES, Khosla C
[PMID: 11732905]Biochemistry. 40 (2001) 14855-61
Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity.: Tang Y, Lee TS, Kobayashi S, Khosla C
[PMID: 12767243]Biochemistry. 42 (2003) 6588-95
The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units.: Tang Y, Koppisch AT, Khosla C
[PMID: 15260498]Biochemistry. 43 (2004) 9546-55
Biosynthesis of aromatic polyketides in bacteria.: Das A, Khosla C
[PMID: 19292437]Acc Chem Res. 42 (2009) 631-9
Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway.: Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC
[PMID: 21870821]Biochemistry. 50 (2011) 8392-406