Rimocidin : Cluster information

Compound

Entry name	Rimocidin
PKS Type	TypeI modular
Starter Unit	Rimocidin: butyryl-CoA CE-108: acetyl-CoA
Chain Length	14
Sugar Unit	mycosamine
Classification	Polyene Macrolide
Activity	Antifungal
Composition	C₃₉H₆₁NO₁₄

Rimoc_00080 rimA	0		acetyl-CoA for CE-108 butyryl-CoA for Rimocidin
Rimoc_00010 rimB	?

CoL	51..457

ACP	557..634

KS	661..1037

AT	1193..1517

ACP	1592..1662

KR	191..367

ACP	470..540

Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108, in Streptomyces diastaticus var. 108.: Seco EM, Perez-Zuniga FJ, Rolon MS, Malpartida F
[PMID: 15123265]Chem Biol. 11 (2004) 357-66
A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.: Seco EM, Fotso S, Laatsch H, Malpartida F
[PMID: 16242652]Chem Biol. 12 (2005) 1093-101
The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis.: Seco EM, Miranzo D, Nieto C, Malpartida F
[PMID: 19707755]Appl Microbiol Biotechnol. 85 (2010) 1797-807
Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.: Heia S, Borgos SE, Sletta H, Escudero L, Seco EM, Malpartida F, Ellingsen TE, Zotchev SB
[PMID: 21821762]Appl Environ Microbiol. 77 (2011) 6982-90
New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA.: Escudero L, Al-Refai M, Nieto C, Laatsch H, Malpartida F, Seco EM
[PMID: 26284936]PLoS One. 10 (2015) e0135891