Streptolydigin : Cluster information --- DoBISCUIT

Entry name	Streptolydigin
PKS Type	PKS-NRPS hybrid
Starter Unit	malonyl-CoA
Chain Length	8
Sugar Unit	L-rhodinose
Classification	Tetramic Acid
Activity	Antibacterial
Composition	C₃₂H₄₄N₂O₉

Organism	Streptomyces lydicus
Strain	NRRL 2433 (=NBRC 13058)
Contig	FN433113

Strply_00310 slgA1	0	malonyl-CoA
	1	methylmalonyl-CoA
	2	malonyl-CoA
	3	methylmalonyl-CoA
Strply_00300 slgA2	4	methylmalonyl-CoA
Strply_00300 slgA2	5	methylmalonyl-CoA
Strply_00290 slgA3	6	malonyl-CoA
Strply_00290 slgA3	7	malonyl-CoA
Strply_00040 slgN2	8
Strply_00170 slgN1	8

KSQ	29..394

AT	559..870

ACP	954..1032

KS	1069..1445

AT	1610..1925

KR	2240..2418

ACP	2524..2594

KS	2622..2999

AT	3208..3519

KR	3807..3985

ACP	4096..4166

KS	4199..4576

AT	4743..5062

DH	5111..5302

KR	5693..5891

ACP	6014..6084

KS	51..426

AT	590..905

KR	1262..1442

ACP	1560..1630

KS	1656..2031

AT	2193..2508

DH	2557..2725

KR	3099..3270

ACP	3377..3447

KS	39..375

AT	546..871

DH	922..1089

KR	1458..1629

ACP	1736..1806

KS	1837..2213

AT	2377..2695

kr	3075..3253

ACP	3366..3436

C	17..298

A	497..552

PCP	636..703

A	99..496

Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives.: Olano C, Gomez C, Perez M, Palomino M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 19875077]Chem Biol. 16 (2009) 1031-44
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.: Horna DH, Gomez C, Olano C, Palomino-Schatzlein M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 21398531]J Bacteriol. 193 (2011) 2647-51
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.: Gomez C, Horna DH, Olano C, Palomino-Schatzlein M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 21665968]J Bacteriol. 193 (2011) 4214-23
Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin.: Gomez C, Olano C, Palomino-Schatzlein M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA
[PMID: 22569159]J Antibiot (Tokyo). (2012)
Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.: Gomez C, Horna DH, Olano C, Mendez C, Salas JA
[PMID: 22726958]Microb Biotechnol. 5 (2012) 663-7
Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.: Gomez C, Olano C, Mendez C, Salas JA
[PMID: 22820841]Microbiology. 158 (2012) 2504-14
Structural basis of the interaction of MbtH-like proteins, putative regulators of nonribosomal peptide biosynthesis, with adenylating enzymes.: Herbst DA, Boll B, Zocher G, Stehle T, Heide L
[PMID: 23192349]J Biol Chem. 288 (2013) 1991-2003
Discovery of a new family of Dieckmann cyclases essential to tetramic acid and pyridone-based natural products biosynthesis.: Gui C, Li Q, Mo X, Qin X, Ma J, Ju J
[PMID: 25621700]Org Lett. 17 (2015) 628-31