Tautomycetin : Cluster information
Compound
Entry name | Tautomycetin |
---|---|
PKS Type | TypeI modular |
Starter Unit | malonyl-CoA |
Chain Length | 10 |
Sugar Unit | none |
Classification | Tetronic Acid Derivative |
Activity | Antifungal Antitumor Immunosuppressive |
Composition | C33H50O10 |
Original source
Organism | Streptomyces sp. |
---|---|
Strain | CK4412 |
Contig | DQ983361 |
PKS/NRPS Module
Tatmc_00080 tmcA | 0 | malonyl-CoA | |
1 | methylmalonyl-CoA | ||
2 | malonyl-CoA | ||
3 | methylmalonyl-CoA | ||
4 | malonyl-CoA | ||
5 | methylmalonyl-CoA | ||
Tatmc_00090 tmcB | 6 | methylmalonyl-CoA | |
7 | malonyl-CoA | ||
8 | ethylmalonyl-CoA not conserved XAGHS | ||
9 | malonyl-CoA |
Reference
- Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412.
- Choi SS, Hur YA, Sherman DH, Kim ES[PMID: 17379718]Microbiology. 153 (2007) 1095-102
- Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412.
- Hur YA, Choi SS, Sherman DH, Kim ES[PMID: 18832298]Microbiology. 154 (2008) 2912-9
- Functional expression of SCO7832 stimulates tautomycetin production via pathway-specific regulatory gene overexpression in Streptomyces sp. CK4412.
- Park SH, Choi SS, Kim YJ, Chang YK, Sherman DH, Kim ES[PMID: 19408025]J Ind Microbiol Biotechnol. 36 (2009) 993-8
- Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase.
- Scaglione JB, Akey DL, Sullivan R, Kittendorf JD, Rath CM, Kim ES, Smith JL, Sherman DH[PMID: 20623733]Angew Chem Int Ed Engl. 49 (2010) 5726-30
- Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412.
- Tripathi A, Choi SS, Sherman DH, Kim ES[PMID: 27277081]J Ind Microbiol Biotechnol. 43 (2016) 1189-93
Data download
History
- 2016-12-27[Update]
- 2012-06-04[Release]