Salinomycin : Cluster information
Compound
| Entry name | Salinomycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 15 |
| Sugar Unit | none |
| Classification | Polyether |
| Activity | Antibacterial Antiprotozoal Antitumor Ionophore |
| Composition | C42H70O11 |
Original source
| Organism | Streptomyces albus subsp. albus |
|---|---|
| Strain | DSM 41398 |
| Contig | HE586118 |
PKS/NRPS Module
| Salino_00910 salAI | 0 |  | malonyl-CoA |
| 1 |  | ethylmalonyl-CoA | |
| 2 |  | malonyl-CoA | |
| Salino_00920 salAII | 3 | | methylmalonyl-CoA |
| 4 | | malonyl-CoA | |
| Salino_00930 salAIII | 5 |  | malonyl-CoA |
| 6 |  | malonyl-CoA | |
| Salino_00940 salAIV | 7 |  | methylmalonyl-CoA |
| Salino_00950 salAV | 8 | | methylmalonyl-CoA |
| 9 | | ethylmalonyl-CoA | |
| Salino_00960 salAVI | 10 |  | methylmalonyl-CoA |
| Salino_00970 salAVII | 11 | | methylmalonyl-CoA |
| Salino_00980 salAVIII | 12 | | methylmalonyl-CoA |
| 13 | | malonyl-CoA | |
| Salino_00990 salAIX | 14 | | ethylmalonyl-CoA |
| 15 |  |
Reference
- A late-stage intermediate in salinomycin biosynthesis is revealed by specific mutation in the biosynthetic gene cluster.
- Yurkovich ME, Tyrakis PA, Hong H, Sun Y, Samborskyy M, Kamiya K, Leadlay PF[PMID: 22076845]Chembiochem. 13 (2012) 66-71
- Site-specific modification of the anticancer and antituberculosis polyether salinomycin by biosynthetic engineering.
- Luhavaya H, Williams SR, Hong H, Gonzaga de Oliveira L, Leadlay PF[PMID: 25155178]Chembiochem. 15 (2014) 2081-5
- Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis.
- Luhavaya H, Dias MV, Williams SR, Hong H, de Oliveira LG, Leadlay PF[PMID: 26377145]Angew Chem Int Ed Engl. 54 (2015) 13622-5
- Direct cloning and heterologous expression of the salinomycin biosynthetic gene cluster from Streptomyces albus DSM41398 in Streptomyces coelicolor A3(2).
- Yin J, Hoffmann M, Bian X, Tu Q, Yan F, Xia L, Ding X, Stewart AF, Muller R, Fu J, Zhang Y[PMID: 26459865]Sci Rep. 5 (2015) 15081
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Salinomycin |
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History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2015-02-12[Update]
- 2014-03-10[Release]
