Azinomycin B : Cluster information
Compound
| Entry name | Azinomycin B |
|---|---|
| Moiety description | A: 3-methoxy-5-methyl-naphthoic acid unit B: skeleton assembly |
| PKS Type | A: other B: NRPS |
| Starter Unit | A: acetyl-CoA |
| Chain Length | A: 6 |
| Sugar Unit | none |
| Classification | |
| Activity | Antitumor |
| Composition | C31H33N3O11 |
Original source
| Organism | Streptomyces sahachiroi |
|---|---|
| Strain | NRRL 2485 (=NBRC 13928) |
| Contig | EU240558 |
PKS/NRPS Module
| A | Azino_00260 aziB | 1 |  | acetyl-CoA malonyl-CoA |
|---|---|---|---|---|
| Azino_00140 aziG | 2 |  | ||
| B | Azino_00080 aziA1 | 1 |  | 3-methoxy-5-methyl-naphthoic acid |
| Azino_00100 aziA2 | 2 |  | ||
| 3 |  | |||
| Azino_00020 aziA3 | 3 |  | alpha-ketoisovaleric acid | |
| Azino_00040 aziA4 | 4 |  | aziridino[1, 2a]pyrrolidinyl amino acid | |
| Azino_00250 aziA5 | 5 |  | threonine |
Reference
- Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis.
- Zhao Q, He Q, Ding W, Tang M, Kang Q, Yu Y, Deng W, Zhang Q, Fang J, Tang G, Liu W[PMID: 18635006]Chem Biol. 15 (2008) 693-705
- Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B.
- Ding W, Deng W, Tang M, Zhang Q, Tang G, Bi Y, Liu W[PMID: 20485749]Mol Biosyst. 6 (2010) 1071-81
- Essential role of an unknown gene aziU3 in the production of antitumor antibiotic azinomycin B verified by utilizing optimized genetic manipulation systems for Streptomyces sahachiroi.
- Wang S, Zhao R, Liu K, Zhu M, Li A, He J[PMID: 23039858]FEMS Microbiol Lett. 337 (2012) 147-54
- Characterization of a novel DNA glycosylase from S. sahachiroi involved in the reduction and repair of azinomycin B induced DNA damage.
- Wang S, Liu K, Xiao L, Yang L, Li H, Zhang F, Lei L, Li S, Feng X, Li A, He J[PMID: 26400161]Nucleic Acids Res. 44 (2016) 187-97
- Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.
- Mori S, Simkhada D, Zhang H, Erb MS, Zhang Y, Williams H, Fedoseyenko D, Russell WK, Kim D, Fleer N, Ealick SE, Watanabe CM[PMID: 26731610]Biochemistry. 55 (2016) 704-14
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
 Azinomycin B |
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History
- 2016-12-27[Update]
- 2016-01-27[Update]
- 2015-02-12[Update]
- 2014-06-25[Update]
- 2014-03-10[Release]
