Dynemicin : Cluster information
Compound
Entry name | Dynemicin |
---|---|
PKS Type | TypeI iterative |
Starter Unit | acetyl-CoA |
Chain Length | 8 |
Sugar Unit | none |
Classification | Enediyne |
Activity | Antibiotic Antitumor |
Composition | A: C30H19NO9 |
Original source
Organism | Micromonospora chersina |
---|---|
Strain | ATCC 53710 (=NBRC 15963) |
Contig | EF552206 |
PKS/NRPS Module
Dynm_00180 dynE8 | 1 | acetyl-CoA malonyl-CoA |
Reference
- A genomics-guided approach for discovering and expressing cryptic metabolic pathways.
- Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM[PMID: 12536216]Nat Biotechnol. 21 (2003) 187-90
- The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710.
- Gao Q, Thorson JS[PMID: 18328078]FEMS Microbiol Lett. 282 (2008) 105-14
- Induced-fit upon ligand binding revealed by crystal structures of the hot-dog fold thioesterase in dynemicin biosynthesis.
- Liew CW, Sharff A, Kotaka M, Kong R, Sun H, Qureshi I, Bricogne G, Liang ZX, Lescar J[PMID: 20888341]J Mol Biol. 404 (2010) 291-306
- Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis.
- Liew CW, Nilsson M, Chen MW, Sun H, Cornvik T, Liang ZX, Lescar J[PMID: 22589546]J Biol Chem. 287 (2012) 23203-15
- Enediyne polyketide synthases stereoselectively reduce the beta-ketoacyl intermediates to beta-D-hydroxyacyl intermediates in enediyne core biosynthesis.
- Ge HM, Huang T, Rudolf JD, Lohman JR, Huang SX, Guo X, Shen B[PMID: 25019332]Org Lett. 16 (2014) 3958-61
Data download
History
- 2016-01-27[Update]
- 2014-03-10[Update]
- 2013-12-27[Release]