Salinomycin : Cluster information
Compound
| Entry name | Salinomycin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 15 |
| Sugar Unit | none |
| Classification | Polyether |
| Activity | Antibacterial Antiprotozoal Antitumor Ionophore |
| Composition | C42H70O11 |
Original source
| Organism | Streptomyces albus |
|---|---|
| Strain | XM211 |
| Contig | JN033543 |
PKS/NRPS Module
| Salino3_00130 slnA1 | 0 |  | malonyl-CoA |
| 1 |  | ethylmalonyl-CoA | |
| 2 |  | malonyl-CoA | |
| Salino3_00140 slnA2 | 3 | | methylmalonyl-CoA |
| 4 | | malonyl-CoA | |
| Salino3_00150 slnA3 | 5 |  | malonyl-CoA |
| 6 |  | malonyl-CoA | |
| Salino3_00160 slnA4 | 7 |  | methylmalonyl-CoA |
| Salino3_00170 slnA5 | 8 | | methylmalonyl-CoA |
| 9 | | ethylmalonyl-CoA | |
| Salino3_00180 slnA6 | 10 |  | methylmalonyl-CoA |
| Salino3_00190 slnA7 | 11 | | methylmalonyl-CoA |
| Salino3_00200 slnA8 | 12 | | methylmalonyl-CoA |
| 13 | | malonyl-CoA | |
| Salino3_00210 slnA9 | 14 | | ethylmalonyl-CoA |
| 15 |  |
Reference
- Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211.
- Jiang C, Wang H, Kang Q, Liu J, Bai L[PMID: 22156425]Appl Environ Microbiol. 78 (2012) 994-1003
- Formation of the Delta(18,19) Double Bond and Bis(spiroacetal) in Salinomycin Is Atypically Catalyzed by SlnM, a Methyltransferase-like Enzyme.
- Jiang C, Qi Z, Kang Q, Liu J, Jiang M, Bai L[PMID: 26096919]Angew Chem Int Ed Engl. 54 (2015) 9097-100
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Salinomycin |
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History
- 2016-01-27[Update]
- 2014-03-10[Release]
