Piericidin : Cluster information
Compound
| Entry name | Piericidin |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | acetyl-CoA |
| Chain Length | 9 |
| Sugar Unit | none |
| Classification | alpha-pyridone antibiotics |
| Activity | Antibacterial Antifungal Antitumor |
| Composition | A1: C25H37NO4 |
Original source
| Organism | Streptomyces piomogenus var. Hangzhouwanensis |
|---|---|
| Strain | |
| Contig | HQ840721 |
PKS/NRPS Module
| Pier_00020 pieA1 | 0 |  | acetyl-CoA |
| 1 |  | methylmalonyl-CoA | |
| Pier_00030 pieA2 | 2 |  | methylmalonyl-CoA |
| 3 | | methylmalonyl-CoA | |
| Pier_00040 pieA3 | 4 |  | |
| Pier_00045 pieA3 | 4 |  | |
| Pier_00050 pieA4 | 5 |  | methylmalonyl-CoA |
| Pier_00060 pieA5 | 6 | | malonyl-CoA |
| Pier_00070 pieA6 | 7 |  | methylmalonyl-CoA |
| 8 |  | malonyl-CoA |
Reference
- Elucidation of Piericidin A1 biosynthetic locus revealed a thioesterase-dependent mechanism of alpha-pyridone ring formation.
- Liu Q, Yao F, Chooi YH, Kang Q, Xu W, Li Y, Shao Y, Shi Y, Deng Z, Tang Y, You D[PMID: 22365607]Chem Biol. 19 (2012) 243-53
- The unique chemistry and biology of the piericidins.
- Zhou X, Fenical W[PMID: 27301663]J Antibiot (Tokyo). 69 (2016) 582-93
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Piericidin |
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History
- 2016-12-27[Update]
- 2014-03-10[Release]
