Lasalocid : Cluster information
Compound
| Entry name | Lasalocid |
|---|---|
| PKS Type | TypeI modular |
| Starter Unit | malonyl-CoA |
| Chain Length | 12 |
| Sugar Unit | none |
| Classification | Polyether |
| Activity | Antibacterial Ionophore |
| Composition | A: C34H54O8 |
Original source
| Organism | Streptomyces lasaliensis |
|---|---|
| Strain | ATCC 31180 |
| Contig | FM173265 |
PKS/NRPS Module
| Lasal2_00160 lasAI | 0 |  | malonyl-CoA |
| 1 |  | ethylmalonyl-CoA | |
| 2 |  | malonyl-CoA | |
| Lasal2_00170 lasAII | 3 | | ethylmalonyl-CoA |
| 4 | | methylmalonyl-CoA | |
| 5 |  | ethylmalonyl-CoA | |
| Lasal2_00180 lasAIII | 6 |  | methylmalonyl-CoA |
| Lasal2_00190 lasAIV | 7 | | methylmalonyl-CoA |
| Lasal2_00200 lasAV | 8 | | malonyl-CoA |
| 9 |  | malonyl-CoA | |
| Lasal2_00210 lasAVI | 10 |  | methylmalonyl-CoA |
| Lasal2_00220 lasAVII | 11 |  | malonyl-CoA |
Reference
- Analysis of specific mutants in the lasalocid gene cluster: evidence for enzymatic catalysis of a disfavoured polyether ring closure.
- Smith L, Hong H, Spencer JB, Leadlay PF[PMID: 19025863]Chembiochem. 9 (2008) 2967-75
- Insights into lasalocid A ring formation by chemical chain termination in vivo.
- Tosin M, Smith L, Leadlay PF[PMID: 22025396]Angew Chem Int Ed Engl. 50 (2011) 11930-3
Data download
| Compound name | Genomic nucleotide sequence |
Nucleotide sequences of the coding regions | Translation of the coding sequences | List of genes/ORFs | GBK | |||||||
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 Lasalocid |
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History
- 2014-06-25[Update]
- 2014-03-10[Release]
