A40926 : Cluster information
Compound
Entry name | A40926 |
---|---|
Moiety description | A: aglycone B: L-3,5-dihydroxyphenylglycine(Dpg) |
PKS Type | A: NRPS B: TypeIII |
Starter Unit | B: malonyl-CoA |
Chain Length | B: 4 |
Sugar Unit | N-acyl-aminoglucuronic acid 6'-O-acetyl-D-mannose |
Classification | Glycopeptide(teicoplanin-type) |
Activity | Antibacterial |
Composition | PA: C84H88Cl2N8O30 |
Original source
Organism | Nonomuraea sp. |
---|---|
Strain | ATCC 39727 |
Contig | AJ561198 |
PKS/NRPS Module
A | A4092_00310 dbv25 | 1 | L-4-hydroxyphenylglycine(Hpg) | |
---|---|---|---|---|
2 | tyrosine | |||
A4092_00320 dbv26 | 3 | L-3,5-dihydroxyphenylglycine(Dpg) | ||
A4092_00230 dbv17 | 4 | L-4-hydroxyphenylglycine(Hpg) | ||
5 | L-4-hydroxyphenylglycine(Hpg) | |||
6 | tyrosine | |||
A4092_00220 dbv16 | 7 | L-3,5-dihydroxyphenylglycine(Dpg) | ||
B | A4092_00370 dbv31 | 1 |
Reference
- The gene cluster for the biosynthesis of the glycopeptide antibiotic A40926 by nonomuraea species.
- Sosio M, Stinchi S, Beltrametti F, Lazzarini A, Donadio S[PMID: 12837387]Chem Biol. 10 (2003) 541-9
- Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons.
- Kruger RG, Lu W, Oberthur M, Tao J, Kahne D, Walsh CT[PMID: 15664522]Chem Biol. 12 (2005) 131-40
- Comparative analysis and insights into the evolution of gene clusters for glycopeptide antibiotic biosynthesis.
- Donadio S, Sosio M, Stegmann E, Weber T, Wohlleben W[PMID: 16007453]Mol Genet Genomics. 274 (2005) 40-50
- A derivative of the glycopeptide A40926 produced by inactivation of the beta-hydroxylase gene in Nonomuraea sp. ATCC39727.
- Stinchi S, Carrano L, Lazzarini A, Feroggio M, Grigoletto A, Sosio M, Donadio S[PMID: 16499611]FEMS Microbiol Lett. 256 (2006) 229-35
- Understanding and manipulating glycopeptide pathways: the example of the dalbavancin precursor A40926.
- Sosio M, Donadio S[PMID: 16761167]J Ind Microbiol Biotechnol. 33 (2006) 569-76
- Glycopeptide biosynthesis: Dbv21/Orf2 from dbv/tcp gene clusters are N-Ac-Glm teicoplanin pseudoaglycone deacetylases and Orf15 from cep gene cluster is a Glc-1-P thymidyltransferase.
- Ho JY, Huang YT, Wu CJ, Li YS, Tsai MD, Li TL[PMID: 17044690]J Am Chem Soc. 128 (2006) 13694-5
- Phosphate-controlled regulator for the biosynthesis of the dalbavancin precursor A40926.
- Alduina R, Lo Piccolo L, D'Alia D, Ferraro C, Gunnarsson N, Donadio S, Puglia AM[PMID: 17873036]J Bacteriol. 189 (2007) 8120-9
- A unique flavin mononucleotide-linked primary alcohol oxidase for glycopeptide A40926 maturation.
- Li YS, Ho JY, Huang CC, Lyu SY, Lee CY, Huang YT, Wu CJ, Chan HC, Huang CJ, Hsu NS, Tsai MD, Li TL[PMID: 17935335]J Am Chem Soc. 129 (2007) 13384-5
- Crystal structures of lipoglycopeptide antibiotic deacetylases: implications for the biosynthesis of A40926 and teicoplanin.
- Zou Y, Brunzelle JS, Nair SK[PMID: 18559264]Chem Biol. 15 (2008) 533-45
- Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.
- Marcone GL, Beltrametti F, Binda E, Carrano L, Foulston L, Hesketh A, Bibb M, Marinelli F[PMID: 20308385]Antimicrob Agents Chemother. 54 (2010) 2465-72
- Improved production of A40926 by Nonomuraea sp. through deletion of a pathway-specific acetyltransferase.
- Sosio M, Canavesi A, Stinchi S, Donadio S[PMID: 20414653]Appl Microbiol Biotechnol. 87 (2010) 1633-8
- Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.
- Liu YC, Li YS, Lyu SY, Hsu LJ, Chen YH, Huang YT, Chan HC, Huang CJ, Chen GH, Chou CC, Tsai MD, Li TL[PMID: 21478878]Nat Chem Biol. 7 (2011) 304-9
- Characterization of VanYn, a novel D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance in Nonomuraea sp. ATCC 39727.
- Binda E, Marcone GL, Pollegioni L, Marinelli F[PMID: 22788848]FEBS J. 279 (2012) 3203-13
- Streptomyces spp. as efficient expression system for a D,D-peptidase/D,D-carboxypeptidase involved in glycopeptide antibiotic resistance.
- Binda E, Marcone GL, Berini F, Pollegioni L, Marinelli F[PMID: 23497129]BMC Biotechnol. 13 (2013) 24
- Glycopeptide antibiotic biosynthesis.
- Yim G, Thaker MN, Koteva K, Wright G[PMID: 24220108]J Antibiot (Tokyo). 67 (2014) 31-41
- Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.
- Marcone GL, Binda E, Carrano L, Bibb M, Marinelli F[PMID: 24957828]Antimicrob Agents Chemother. 58 (2014) 5191-201
- Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus.
- Lyu SY, Liu YC, Chang CY, Huang CJ, Chiu YH, Huang CM, Hsu NS, Lin KH, Wu CJ, Tsai MD, Li TL[PMID: 25095906]J Am Chem Soc. 136 (2014) 10989-95
- Addendum: Interception of teicoplanin oxidation intermediates yields new antimicrobial scaffolds.
- Liu YC, Li YS, Lyu SY, Hsu LJ, Chen YH, Huang YT, Chan HC, Huang CJ, Chen GH, Chou CC, Tsai MD, Li TL[PMID: 25885959]Nat Chem Biol. 11 (2015) 361
- Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727.
- Lo Grasso L, Maffioli S, Sosio M, Bibb M, Puglia AM, Alduina R[PMID: 25986904]J Bacteriol. 197 (2015) 2536-44
Data download
History
- 2016-12-27[Release]