LOCUS       Daunorubicin            21404 bp	DNA     linear     16-Jan-2013
DEFINITION  Daunorubicin biosynthesis cluster
ACCESSION   Daunorubicin
VERSION
KEYWORDS
SOURCE      Streptomyces sp.
FEATURES             Location/Qualifiers
     source          1..21404
                     /organism="Streptomyces sp."
                     /mol_type="genomic DNA"
                     /strain_name="C5"
                     /db_xref="taxon:1931"
     CDS             complement(1696..2523)
                     /locus_tag="Dauno_00200"
                     /product="putative doxorubicin biosynthesis protein"
                     /gene="dauV"
                     /note="original gene:orfA"
                     /note="category:5.2 function unknown"
                     /transl_table=11
                     /inferenece="InterPro:IPR025870"
                     /translation="MTRFAPGAPAWFDLGSPDVAASADFYTGLFGWTATVVSDPGAGG
                     YTTFSSDGKLVAAVARHQIDTPYHRPYGPGNDQHGMPAIWTVYFATNDADALTKRVET
                     AGGDVIMTPMDVLGLGRMAVFADPSGAAFAVWRKGVMEGAEVTGVPGSVGWVELVTDD
                     IGTARGFYRATLGLAPADTGRKGVTDPVWHIHDTPVAGTRELGTTGAVRPHWAVLFSV
                     HDCDATVRRAVELGGSVENEPVDTPRGRRADLLDPHGAGFSVVELREAYPAAADGAS"
     CDS             complement(431..1699)
                     /locus_tag="Dauno_00210"
                     /product="cytochrome P450"
                     /note="original product:daunomycin C-14 hydroxylase"
                     /note="original gene:doxA"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR001128"
                     /inferenece="InterPro:IPR017972"
                     /inferenece="InterPro:IPR002397"
                     /translation="MSGEAPRVAVDPFSCPMMTMQRKPEVHDAFREAGPVVEVNAPAG
                     GPAWVITDDALAREVLADPRFVKDPDLAPTAWRGVDDGLDIPVPELRPFTLIAVDGED
                     HRRLRRIHAPAFNPRRLAERTDRIAAIADRLLTELADSSDRSGEPAELIGGFAYHFPL
                     LVICELLGVPVTDPAMAREAVGVLKALGLGGPQSAGGDGTDPAGDVPDTSALESLLLE
                     AVHAARRKDTRTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAE
                     VLAGRLAADADGDAISRFVEEALRHHPPVPYTLWRFAATEVVIRGVRLPRGAPVLVDI
                     EGTNTDGRHHDAPHAFHPDRPSRRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPQ
                     ARLAVPYEELRWCRKGAQTARLTDLPVWLR"
     CDS             complement(1..147)
                     /locus_tag="Dauno_00220"
                     /product="putative transcriptional regulator(fragment)"
                     /note="original product:DauI"
                     /note="original gene:dauI"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR001867"
                     /translation="MQINMLGPLVAHHNGTSVTPIARKPRQVFSLLALQAGTVVPVPA
                     LMEEL"
     CDS             complement(3224..4087)
                     /locus_tag="Dauno_00010"
                     /product="putative oxidoreductase"
                     /note="original product:ketoreductase"
                     /gene="dauU"
                     /note="category:5.1 general function"
                     /transl_table=11
                     /inferenece="InterPro:IPR002347"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR002198"
                     /translation="MTVPTPRHGTPHGGLPGRTVLITGATSGIGRAAALAIARQGARV
                     VLVGRDPERLRTVTNEVARTAGPAPDAFRADFAELRQVRELGERLRDRYPRIDVMAGN
                     AGGMFWSRTTTQDGFEATLQVNHLAGFLLARLLRERLAGGRLILTSSDAYTQGRIDPD
                     DLNGDRHRYSAGQAYGTSKQANIMTATEAARRWPDVLTVSYHPGEVRTRIGRGTVAST
                     YFRFNPFLRSAAKGADTLVWLAAAPAEELTTGGYYSDRRLSPVSGPTADAGLAAKLWE
                     ASAAAVGDTAR"
     CDS             complement(4084..4338)
                     /locus_tag="Dauno_00020"
                     /product="polyketide synthase acyl carrier protein
                     subunit"
                     /note="original product:acyl carrier protein"
                     /gene="dpsG"
                     /note="original gene:dauA(g)"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR006162"
                     /inferenece="InterPro:IPR009081"
                     /translation="MAELSLAELREIMRQSLGEDEVPDLADADTVTFEDLGLDSLAVL
                     ETVNHIERTYGVKLPEEELAEIRTPHSMLIFVNERLRAAV"
     CDS             4566..5021
                     /locus_tag="Dauno_00030"
                     /product="hypothetical protein"
                     /note="category:5.3 hypothetical protein"
                     /transl_table=11
     CDS             5047..6597
                     /locus_tag="Dauno_00040"
                     /product="putative NDP-hexose 2,3-dehydratase"
                     /gene="dnmT"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR005212"
                     /translation="MRRHSAAATTVQIARSVLARDGLCSGMDRFWAWYAERSARVVHR
                     TERIPLDALKGWSRHPVTGTISHHTGRFFSIEGLDVHIPGAPVPRWSQPIVNQPEVGI
                     LGFLVKERGGILHCLVQAKFEPGNPGGLQLSPTVQATRSNYTRVPGGKTIPSWSTSAT
                     PPDRQVVADVLQSGQGSWFYRKRNRNMIVQVFDEVPLREDFHWLTLGQLHRLLGVENL
                     VNMDARTVLACLPSRARERARWPTRSPPELTAPGASAHPVVPSLGPTAAGLRWTPGFH
                     HSLVRSCAAAEGSLHSTVDIVSWIATCAAGPMWSPARQANSLPHWIERDGVIATRAGR
                     FLEVMAVDVTAASREVPGWSQPMIEPKGRGVAAFLVRRIDGVLHALGTARVEPGYVDV
                     VEIAPTVQCTPGSLHALPAGARPRFLDAVLEAPPEAACATTTDLAEEGGRFHHAVNTY
                     MIVEADDDIPDGGEFRWLTLHQLVELLRHSHYVNVQARTLVACLHSLSVGHRPSTRSA
                     VPSAPPRR"
     CDS             6604..7932
                     /locus_tag="Dauno_00050"
                     /product="putative glycosyltransferase"
                     /note="original product:glycosyltransferase"
                     /note="original gene:dauH"
                     /note="category:5.1 general function"
                     /transl_table=11
                     /inferenece="InterPro:IPR004276"
                     /inferenece="InterPro:IPR010610"
                     /translation="MRVLFATMAARSHVYAQVTLASALRTAGHEVLVASQPDVLDDIV
                     RAGLTRVRIGEDLNIEEETREANASFEDDRNLGGLAMSNTRDDPLPWDHALGMFTAMT
                     AMVFQNVCPEPMVDDLVGLARDWRPDLVVWDPLTLAGPVAARLSGAAHARLLFGPDQM
                     GRNRTAFRALLDRQRPSCVTTRCAEWLTWTLERWRRQRLDMSEELVLGQWTIDPTPPS
                     MRIPLDLPCVPVRYVPYNGPSLLPDWLREPPRHPRRLCLTLGVSLGEATGAGTVAASD
                     VLAAVDGLDVEVVATLSRNCQELGTLPANVRAVDFVRLNALLPSCSGIIHHGGSGTFM
                     TALAHATPQLIVPDMMWDAMEKAHGLARSGAGGYVDAKDVSPDLLRERVLDLFDDPSY
                     AAGARRVRAEIVGTPSPNDIVPVLERLTAEHQAGGPERSPALKSPSTGGA"
     CDS             7942..8697
                     /locus_tag="Dauno_00060"
                     /product="aklaviketone C-7 ketoreductase"
                     /note="original product:aklaviketone reductase"
                     /note="original gene:dauE"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR002198"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR002347"
                     /translation="MENTQRSVIVTGGGSGIGRAVARAFAARGDRVLVVGRTAGPLAE
                     TVDGHKEAHTLAVDITDPAAPQAVVREVRERLGGVVDVLVNNAATAVFGHLGELDRTA
                     VEAQVATNLVAPVLLTQALLDPLETASGLVVNIGSAGALGRRAWPGNAVYGAAKAGLD
                     LLTRSWAVELGPRGIRVIGVAPGVIETGAGVRAGMSQEAYDGFLEAMGQRVPLGRVGR
                     PEDVAWWVVRLADPEAAYASGAVLAVDGGLSVT"
     CDS             complement(9554..10501)
                     /locus_tag="Dauno_00130"
                     /product="putative cyclase/dehydratase"
                     /note="original product:cyclase/dehydrase"
                     /gene="dpsF"
                     /note="original gene:dauA"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR019587"
                     /inferenece="InterPro:IPR023393"
                     /translation="MSESPLQQTEHEIHTSAAPDAVFAVLADVRSWPAVFPPSVHVEQ
                     LECADSSERIRIWATANGSLRTWTSRRELDERVRRIRFRQETSAHPVAAMGGEWIVEE
                     AGDGGTRVRLTHDFRAVDDDPETIGWIHRAVDRNSEAELASLRTALEGPDGTAPTTFE
                     DTVVVRGSAEDIYRFLHRSDLWEKRLSHVARIAVKEEEPGLQHMEMDTLTADGSVHTT
                     ASVRVCFPERRLIVYKQLRTPPLLALHLGRWSVRPAGDGDGIAVTSAHTVSVARSAIP
                     GILGAGANETDAVDFVRRALGRNSLLTLEAARRYAESSA"
     CDS             complement(10531..11319)
                     /locus_tag="Dauno_00140"
                     /product="putative polyketide C-9 ketoreductase"
                     /note="original product:polyketide reductase"
                     /gene="dpsE"
                     /note="original gene:dauB"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR020904"
                     /inferenece="InterPro:IPR002347"
                     /inferenece="InterPro:IPR002198"
                     /inferenece="InterPro:IPR016040"
                     /translation="MSDAADRVALVTGGTSGIGLAVGRRKLALDGTRVFLCARDESAV
                     TGTVKELQASGLEVEGTSCDVRSTDAVDRLVRTARNPLRAIDIVVNNAGRGGGGVTAQ
                     ITDDLWSDVVDTNLGGAFRVTRAVLTGGGMQEHGWGRIINIASTGGKQGVALGAPYSA
                     SKSGLIGFTKAVALELARTGITVNAVCPGYVETPMAQGVRQRYAAFWGITEDDVLEKF
                     RAKIPLGRYSTSDEVAGMVHYLVSDSADSITAQAINVCGGLGSY"
     CDS             11498..11893
                     /locus_tag="Dauno_00150"
                     /product="putative C-12 oxygenase"
                     /note="original product:oxygenase"
                     /gene="dauG"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR011008"
                     /inferenece="InterPro:IPR007138"
                     /translation="MEQRCLWPEPNDAGSGSVTFVNRFTLSGSAEDFEAAFAETAEFL
                     CRRPGFRWHVLLAPTGSGSADVRPQYVNIAVWDDEASFRAAVAHPQFPAHAAVLRALS
                     TSEPTLYRSRQIRVAPGAPAMSRPEGRTT"
     CDS             11890..13146
                     /locus_tag="Dauno_00160"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /note="original product:polyketide synthase"
                     /gene="dpsA"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR018201"
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR016038"
                     /translation="MNRRVVITGMGVVAPGAIGIKSFWELLLSGTTATRAITTFDATP
                     FRSRIAAECDFDPVAAGLSAEQARRLDRAGQFALVAGQEALTDSGLRIGEDSAHRVGV
                     CVGTAVGCTQKLESEYVALSAGGANWVVDPHRGAPELYDYFVPSSLAAEVAWLAGAEG
                     PVNIVSAGCTSGIDSIGYACELIREGTVDVMLAGGVDAPIAPITVACFDAIRVTSDHN
                     DTPETLAPFSRSRNGFVLGEGGAIVVLEEAEAAVRRGARIYAEIGGYASRGNAYHMTG
                     LRADGAEMAAAITAALDEARRDPSDVDYVNAHGTATRQNDRHETSAFKRSLGDHAYRV
                     PISSVKSMIGHSLGAAGSLEVAATALAVEYGAIPPTANLHDPDPELDLDYVPLTAREK
                     RVRHALTVGSGFGGFQSAMLLSRPER"
     CDS             13233..14429
                     /locus_tag="Dauno_00170"
                     /product="polyketide synthase chain length factor subunit"
                     /note="original product:polyketide synthase"
                     /gene="dpsB"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR016039"
                     /translation="MVTGLGIVAPNGLGVGAIWDAVLNGRNGIGPLRRFADDGRLGRL
                     AGEVSDFVPEDHLPKRLLVQTDPMTQMTALAAAEWALREAGCAPSSPLEAGVITASAS
                     GGFASGQRELQNLWSKGPAHVSAYMSFAWFYAVNTGQIAIRHDLRGPVGVVVAEQAGG
                     LDALAHARRKVRGGAELIVSGAMDSSLCPYGMAAQVRSGRLSGSDDPTAGYLPFDRRA
                     AGHVPGEGGAILAVEDAERVAERGGKVYGSIAGTASFDPPPGSGRPSALARAVETALA
                     DAGLDRSDIAVVFADGAAVGELDVAEAEALASVFGPHRVPVTVPKTLTGRLYSGAGPL
                     DVATGLLALRDEVVPATGHVHPDPDLPLDVVTGRPRAMADARAALVVARGHGGFNSAL
                     VVRGAA"
     CDS             14426..15484
                     /locus_tag="Dauno_00180"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /gene="dpsC"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR013751"
                     /inferenece="InterPro:IPR013747"
                     /translation="MSTLPGAPGDLYVAGCGVWLPPPVTTDQALAAGHCDRRLASSTR
                     MLSVAVADKETPAEMAASAARTAVDRSGVPPARIVLVLHASLYFQGHHLWAPASYVQR
                     VALGNRCPAMEVRQVSNGGMAALELARAYLLAAPDRTAALVTTGDRMSPPGFDRWNRP
                     RHVYADGGTALVLSRQGGFARLRSLVTVSEPVLEGMHRGGHPFGPPSAEEQRTVDLDA
                     HSGRTWPRREARSASPRVSAGQEEALAGALKAAGVGLDDISRVVLPHMGWRRLSASYF
                     GKWPVPPERTTWEFGRRTGHLGGGDPIAGFDHLVGSGRLAPGELCLLVSVGAGFSWSC
                     AVVELLDARRWAAAPAAR"
     CDS             15495..16511
                     /locus_tag="Dauno_00190"
                     /product="putative acyl-ACP thioesterase"
                     /note="original product:acyltransferase"
                     /gene="dpsD"
                     /note="category:1.4 Other"
                     /transl_table=11
                     /inferenece="InterPro:IPR001227"
                     /inferenece="InterPro:IPR016035"
                     /inferenece="InterPro:IPR014043"
                     /inferenece="InterPro:IPR016036"
                     /translation="MDVPAILLMFPGQGSQHARMAAGLYGSEPVFTAAMDEVLAAYDA
                     AGDCEGQRLRADWLSDRPAVPLDHVTRSQPLLFAVDYALGRMVLATTGRPWALLGHSV
                     GEMAGAALAGVFTLRDAACLLLDRVRRLAQAPPGGMLAVAAGEDVLGPYLVEGEVAVA
                     AVNSPRQTILAGPVAPLAAVARALREAGLTCREVPSLTAFHSPVLAPYTTGAAERFAS
                     TRVAAPSIPLRSGYRPGAVTGRLAADPSYWAGHPVETVRFWPALDAMLRSRTGVVCLE
                     TGPGQGLSTVARRHPTVRSGRNAVVSLLPPRAGTAEMDRTSVAAALTAVRERGAVLSG
                     RPGR"
     CDS             complement(17771..18433)
                     /locus_tag="Dauno_00080"
                     /product="aklanonic acid O-methyltransferase"
                     /note="original product:aklanonic acid methyltransferase"
                     /note="original gene:dauC"
                     /note="category:3.2 modification methylation"
                     /EC_number="2.1.1.-"
                     /transl_table=11
     CDS             18623..19108
                     /locus_tag="Dauno_00090"
                     /product="aklanonic acid methyl ester cyclase"
                     /note="original gene:dauD"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR009959"
                     /translation="MSPQIDLVRRMVEAYNTGKTDDVAEFILHEYLNPGALEHNPELR
                     GPEAFAAAVTWLKYAFSEEAHLEEIGYEENGPWVRAKLALYGRHVGNLVGMPATGRRF
                     SGEQIHLIRIVDGKIRDHRDWPDYLGTYRQLGEPWPTPEGWRPCPPPPRRRHDRSTDT
                     P"
     CDS             19105..20175
                     /locus_tag="Dauno_00100"
                     /product="C-4 O-methyltransferase"
                     /note="original product:carminomycin
                     4-O-methyltransferase"
                     /note="original gene:dauK"
                     /note="category:3.2 modification methylation"
                     /EC_number="2.1.1.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR011991"
                     /inferenece="InterPro:IPR016461"
                     /inferenece="InterPro:IPR001077"
                     /translation="MTAEPTVAARPQQIDALRTLIRLGSLHTPMVVRTAATLRLVDHI
                     LAGARTVKALAARTDTRPEALLRLIRHLVAIGLLEEDAPGEFAPTEVGKLLADDHPAA
                     QRAWHDLTQAVARADISFTRLPEAIRSGRPTYESVYGKPFYEDLAGRPDLRASFDSLL
                     ACDQDVAFDAPAAAHDWTNVRHVLDVGGGKGGFAAAIARRAPHVSATVLEMAGTVDTA
                     RSYLRDAGLSDRVDVVEGDFFEPLPRRADAIILSFVLLNWPDHDAVRILTRCAEALEP
                     GGRILIHERDDLHENSFNEQFTELDLRMLVFLGGALRTREKWDGLAASAGLVVEEVRQ
                     LPSPTIPYDLSLLVLAPASTGA"
     CDS             20206..21102
                     /locus_tag="Dauno_00110"
                     /product="rhodomycin D esterase"
                     /note="original product:esterase"
                     /note="original gene:dauP"
                     /note="category:3.4 other modification"
                     /transl_table=11
     CDS             21108..21404
                     /locus_tag="Dauno_00120"
                     /product="putative glycosyltransferase helper
                     protein(fragment)"
                     /note="original gene:dauQ"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
ORIGIN      
        1 ggtacccgcg catcgatgtc atggccggca acgccggcgg catgttctgg tcgcgcacca
       61 cgacccagga cgggttcgag gccaccctcc aggtcaatca tctcgcgggc ttcctgctgg
      121 cacggctgct gcgggagcgg ctcgcgggcg ggcggttgat cctcacctcg tccgacgcgt
      181 acacccaggg ccggatcgac ccggacgatc tcaacggcga ccgtcaccgc tacagcgcgg
      241 gccaggcgta cggcacgtcc aaacaggcca acatcatgac cgccacggag gccgcccggc
      301 gctggccgga cgtgctgacg gtcagctacc accccggcga ggtccgcacc cgcatcgggc
      361 ggggcacagt cgcctcgacc tacttccggt tcaacccctt cctgcggtcc gcggccaagg
      421 gcgccgacac tctcgtgtgg ctggcggccg cgccggccga ggagttgacc acgggcggct
      481 actacagcga ccggcggctg tccccggtga gcggcccgac cgccgacgcc ggcctcgcgg
      541 ccaagctctg ggaggccagc gcggccgccg tcggcgacac cgcgcgctga ccgcggcggg
      601 cctccccgcc cgcatgcccg tctcatccgc gagcgcagac gctcgtgtgc cgatccgtcg
      661 aaaggaacga ttcgtgacca ggttcgcgcc cggcgccccc gcatggttcg acctcgggtc
      721 gcccgatgtc gccgcctcgg ccgacttcta caccggcctc ttcggctgga ccgcgaccgt
      781 ggtcagcgac ccgggtgccg ggggatacac gacgttcagc tccgacggga agctggtcgc
      841 cgcggtcgcc cgccatcaga tcgacacgcc ctaccaccgt ccgtacgggc ccggcaacga
      901 ccagcacggc atgccggcca tctggaccgt gtacttcgcc accaacgacg ccgacgcact
      961 gaccaaacgg gtcgagacgg cgggtggcga cgtcatcatg accccgatgg acgtcctcgg
     1021 tctcggccgg atggcggtct tcgccgaccc atcgggggcc gcgttcgcgg tgtggcgcaa
     1081 gggcgtcatg gagggcgcgg aggtgacggg cgtgcccggc tcggtcggct gggtggaact
     1141 ggtgaccgac gacatcggga ccgcccgtgg cttctaccgt gcgaccctcg gcctggctcc
     1201 ggccgacacc ggacgcaagg gcgtcaccga cccggtttgg cacatccatg acacaccggt
     1261 cgccggcacc cgggaactgg gcacgaccgg cgcggtacgg ccccactggg ccgtgctgtt
     1321 ctccgtgcac gactgcgacg cgacggtccg gcgggccgtc gaactcggcg gctccgtcga
     1381 gaacgagccc gtcgacaccc ccagggggcg gcgggcggac ctgctcgacc cgcacggggc
     1441 cggcttctcg gtggtcgaac tgcgggaggc gtaccccgcg gcggcggacg gtgcctcatg
     1501 agcggcgagg cgccgcgggt ggccgtcgac ccgttctcgt gtcccatgat gaccatgcag
     1561 cgcaaacccg aggtgcacga cgcattccga gaggcgggcc ccgtcgtcga ggtgaacgcc
     1621 cccgcgggcg gacccgcctg ggtcatcacc gatgacgccc tcgcccgcga ggtgctggcc
     1681 gatccccggt tcgtgaagga ccccgatctc gcgcccaccg cctggcgggg ggtggacgac
     1741 ggtctcgaca tccccgttcc ggagctgcgt ccgttcacgc tcatcgccgt ggacggtgag
     1801 gaccaccggc gtctgcgccg catccacgca ccggcgttca acccgcgccg gctggccgag
     1861 cggacggatc gcatcgccgc catcgccgac cggctgctca ccgaactcgc cgactcctcc
     1921 gaccggtcgg gcgaaccggc cgagctgatc ggcggcttcg cgtaccactt cccgctgttg
     1981 gtcatctgcg aactgctcgg cgtgccggtc accgatccgg caatggcccg cgaggccgtc
     2041 ggcgtgctca aggcactcgg cctcggcggc ccgcagagcg ccggcggtga cggcacggac
     2101 cctgccgggg acgtgccgga cacgtcggcg ctggagagcc ttctcctcga agccgtgcac
     2161 gcggcccggc ggaaagacac ccggaccatg acccgcgtgc tctatgaacg cgcacaggca
     2221 gagttcggct cggtctccga cgaccagctc gtctacatga tcaccggact catcttcgcc
     2281 ggccacgaca ccaccggctc gttcctgggc ttcctgcttg cggaggtcct ggcgggccgt
     2341 ctcgcggcgg acgccgacgg ggacgccatc tcccggttcg tggaggaggc gctgcgccac
     2401 cacccgccgg tgccctacac gttgtggagg ttcgctgcca cggaggtggt catccgcggt
     2461 gtccggctgc cccgcggagc gccggtactg gtggacatcg agggcaccaa caccgacggc
     2521 cgccatcacg acgccccgca cgctttccac ccggaccgcc cttcgaggcg gcggctcacc
     2581 ttcggcgacg ggccgcacta ctgcatcggg gagcagctcg cccagctgga atcgcgcacg
     2641 atgatcggcg tactgcgcag caggttcccc caagcccgac tggccgtgcc gtacgaggag
     2701 ttgcggtggt gcaggaaggg ggcccagaca gcgcggctca ctgacctgcc cgtctggctg
     2761 cgttgatggg ccgaccgcga cccggcacgg gaccgcccac cgcccatcgc gcggtgggcg
     2821 gtcccgtgcc ggtcgcccgg tgcggtcctc tcccgacgct cgctccccct gtgactttct
     2881 cacatcgaga cgtgacgaaa taatcccagc aagtgccatg cacactttca tggcggacat
     2941 tcacttgcga ggatggagtg agcacacggg gccgcccgag acaccctacg gccgccggaa
     3001 gtatgccacc tgttgacgcg aatggaacgc cacagaggga gcaccggcaa tgcagatcaa
     3061 tatgttgggc ccgctcgttg cacatcacaa tggcacgtcg gtgaccccga tagccagaaa
     3121 accccggcag gtattctcac tgctcgctct tcaggcagga accgtcgttc cggtccccgc
     3181 gctgatggag gagctcNNgc atgcgggcgg ggaggcccgc cgcggtcagc gcgcggtgtc
     3241 gccgacggcg gccgcgctgg cctcccagag cttggccgcg aggccggcgt cggcggtcgg
     3301 gccgctcacc ggggacagcc gccggtcgct gtagtagccg cccgtggtca actcctcggc
     3361 cggcgcggcc gccagccaca cgagagtgtc ggcgcccttg gccgcggacc gcaggaaggg
     3421 gttgaaccgg aagtaggtcg aggcgactgt gccccgcccg atgcgggtgc ggacctcgcc
     3481 ggggtggtag ctgaccgtca gcacgtccgg ccagcgccgg gcggcctccg tggcggtcat
     3541 gatgttggcc tgtttggacg tgccgtacgc ctggcccgcg ctgtagcggt gacggtcgcc
     3601 gttgagatcg tccgggtcga tccggccctg ggtgtacgcg tcggacgagg tgaggatcaa
     3661 ccgcccgccc gcgagccgct cccgcagcag ccgtgccagc aggaagcccg cgagatgatt
     3721 gacctggagg gtggcctcga acccgtcctg ggtcgtggtg cgcgaccaga acatgccgcc
     3781 ggcgttgccg gccatgacat cgatgcgcgg gtaccggtcc cgcagccgct ctcccagctc
     3841 gcgtacctgg cgcagctcgg cgaagtccgc gcggaaggcg tccggggccg ggccggcggt
     3901 ccgggccacc tcgttcgtga cggtccgaag acgctcgggg tcccggccga cgagcacgac
     3961 gcgggccccc tggcgggcga tcgcgagggc cgccgcccgg ccgatgccgg acgtggcccc
     4021 ggtgatcagc accgtccggc ccggcaggcc gccgtgtggt gtcccgtggc gcggggtggg
     4081 gaccgtcata ccgcggctcg cagcctctcg ttgacgaaaa tcagcatgct gtgaggcgtc
     4141 ctgatctccg ccagttcctc ctcgggcagc ttcacgccat aggtccgctc gatgtggttg
     4201 accgtttcca ggacggccag ggagtcgagc ccgagatcct cgaaggtcac ggtgtcggcg
     4261 tccgccaggt cggggacctc gtcctctccc aggctctgcc gcatgatctc ccgcagttcc
     4321 gccaggctga gctcagccat ccctgctcct ccgcaccggt tgctgcacga catgtacggc
     4381 ccggtcagga ccgcggcgac caccctcggt tccgcaggtc cagtcgcact ggagcggtgg
     4441 tggaccggcg attgtccgtt ctgcctcgag acgcgcggaa caggttgggc acggcccggc
     4501 cggcaggcgc acgcgatcaa accgggaccg ggccacccga ggccatcaca cgaccctagg
     4561 ggcaaccatg gacgcgcttc cggcggacga cgcgccgacg acagagtcgg cggattctgc
     4621 ggaccccggc atttacctcc aggtacagcg gttctacgcc cgtcagatgc aactcctgga
     4681 cgacggcagg gccgaggact gggcgcgcac gttcgtgcac gacggtgtct tcgcggtggg
     4741 cggcgaggcc gtacgcgggg tcgcggacat cgcgcgtgcg gcacggcgga ccacggaccg
     4801 gttcgccgcc gaggggatta cccggcggca ctggatcggc atgctcaccg tcgacggcaa
     4861 gcccgacgag gtcacggccc ggagctacgc ggtggtgctg gagacgccgc ccgacggtga
     4921 cccggtgttc cggcgcagca cggtgtgcac ggacatcctg gtgcgggaag cgggcgagtg
     4981 gcgcgtcagg caccgcaccg tcacccggga cgggctggat tgaccatgcg tgctctccgg
     5041 ccctttccgt gcgccggcac agtgctgccg cgacgaccgt ccagatcgcc cgctccgtcc
     5101 tcgcccggga cggcctgtgc agcggcatgg accggttctg ggcgtggtac gccgagcgct
     5161 cggcgcgggt ggtgcaccgc accgagcgga ttccgctgga tgccctcaag gggtggagtc
     5221 gccacccggt caccgggacc atctcccatc acaccggaag gttcttcagc atcgagggac
     5281 tggacgtgca cattccgggc gccccggtgc cacgctggtc ccagccgatc gtgaaccagc
     5341 ccgaagtggg catcctgggc ttcctggtga aggaacgcgg cgggatcctc cactgcctcg
     5401 tccaggccaa gttcgagccg ggcaaccccg gcggacttca gctctccccc acggtccagg
     5461 ccacacggag caactacacg cgggtgcccg gcggcaagac catcccgtcc tggagcactt
     5521 ccgcgacacc tccggaccgg caggtggtcg ccgatgtgct ccagtcggga cagggctcct
     5581 ggttctaccg caaacgcaac cgcaacatga tcgtccaggt gttcgacgag gtcccgctgc
     5641 gcgaggactt ccactggctc acgctgggtc agctgcaccg gctgctgggg gtcgagaacc
     5701 tcgtgaacat ggacgccagg acggtgctgg cctgcctgcc gtcgcgagcg agggagcgcg
     5761 cccgctggcc gacgcggagc ccgccggagc tgacggcccc gggggcgtca gcccaccccg
     5821 tggtcccctc gctcggcccg acggcggcgg gtctccggtg gacgcccggt ttccaccact
     5881 ccctcgtgcg atcgtgcgcg gcggccgagg gcagcctgca cagcacggtg gacatcgtca
     5941 gctggatcgc gacctgcgca gccggaccga tgtggtcacc cgcccgacag gctaactcgc
     6001 tgccgcactg gatcgagcgg gacggcgtga tcgccacgag agccgggcgc ttcctggagg
     6061 tgatggccgt ggatgtgacg gccgcctcgc gagaggtgcc cggctggagt cagccgatga
     6121 tcgaacccaa gggccgaggg gtcgcggcct tcctggtccg gcggatcgac ggggttctcc
     6181 acgccctcgg gaccgcgcgc gtggagcccg gctacgtcga cgtggtggag atcgcgccga
     6241 ccgtgcagtg cacccccggc agtctgcacg ccctgccggc cggagccagg ccccgcttcc
     6301 tcgacgccgt cctggaggcg ccccccgaag cagcgtgcgc tacgacgacc gacctcgcgg
     6361 aggagggagg acgcttccac cacgcggtga acacttacat gatcgtcgaa gccgacgatg
     6421 acatcccgga cggtggtgag ttccggtggc tgacgctcca ccaactcgtc gagctgctgc
     6481 gtcactccca ctacgtcaac gtccaggccc gcaccctggt cgcctgcctg cacagcctgt
     6541 ccgtgggcca ccgcccgtcg acccgctcgg ccgtgccgtc cgccccgcct cggaggtgag
     6601 ttcccgtgcg cgtcctgttc gccaccatgg ccgcgcggtc ccacgtctac gcccaggtca
     6661 ccttggcgtc ggcactgcgg accgcggggc acgaggtgct cgtggccagc cagcccgacg
     6721 tcctcgacga catcgtccgg gccggtctca cgcgcgtgcg gatcggagag gacctcaaca
     6781 tcgaggagga gacccgggag gccaacgcca gcttcgagga cgaccgcaac ctcggcggcc
     6841 tcgctatgag caacacccgt gacgatccct taccgtggga ccacgccctc ggcatgttca
     6901 ccgcgatgac cgccatggtc ttccagaacg tgtgccccga acccatggtc gacgacctcg
     6961 tcggcctcgc ccgcgactgg cggccggacc tcgtggtctg ggatccgctg accctggccg
     7021 gaccggtggc agcccggctc agcggcgcgg cacacgcccg gctgctgttc ggcccggatc
     7081 agatgggccg gaacaggacg gcgttccgcg ccctgctcga ccggcaacgc ccgagctgcg
     7141 tgacgacccg ctgcgccgag tggctcacct ggacgctgga gcggtggcgg cggcagcgcc
     7201 tggacatgag cgaggaactg gtgctcgggc agtggacgat cgaccccaca ccaccgtcca
     7261 tgcgcattcc cctggacctg ccctgcgtgc cggtgcgcta cgtgccgtac aacgggccct
     7321 ccctgcttcc cgactggctg cgcgagccgc cccgccaccc gcggcgcctg tgcctgacgc
     7381 tcggtgtgtc cctcggcgag gcgacgggcg ccggtacggt cgccgcctcc gacgtcctgg
     7441 cagccgtgga cggcctggac gtggaggtcg tcgccaccct gtcgcggaac tgccaggaac
     7501 tcggcaccct gccggcgaac gtacgggcgg tggacttcgt ccggttgaac gccctgctgc
     7561 cgtcctgctc gggcattatc catcacggcg ggtccggcac gttcatgacg gccctggcgc
     7621 acgcgacgcc gcagctgatc gtgcccgaca tgatgtggga cgccatggag aaggcacacg
     7681 gcctggcccg cagcggtgcg ggcggttacg tggacgcgaa ggacgtctcg cccgacctgc
     7741 tgcgtgagcg cgtcctcgac ctgttcgacg atccgtccta tgccgccggg gcacgccgtg
     7801 tgcgcgccga gatcgtcgga acgccgagcc cgaacgacat cgtgcccgtg ctggaacggc
     7861 tgaccgccga gcaccaggcc ggcgggccgg agcggagccc ggcgctcaag tcgccttcca
     7921 ccggcggtgc ctagcctcgc cgtatggaga acacacagcg atccgtgatc gtgaccggcg
     7981 gcggctccgg catcggacga gccgtcgccc gcgctttcgc cgcccggggc gaccgcgtcc
     8041 tcgtcgtggg taggaccgcc ggtccgctgg ccgagacggt cgacgggcac aaggaggcgc
     8101 acacgctggc cgtggacatc accgaccccg cagcgccgca ggccgtcgtc cgggaggtgc
     8161 gcgagcggct cggcggcgtg gtcgacgtgc tcgtgaacaa tgccgccact gccgtcttcg
     8221 ggcacctggg ggagctggac cgcaccgcgg tggaggcgca ggtggccacg aacctcgtgg
     8281 cccccgtgct gctgacccaa gcactgctcg accccctgga gaccgcctcc gggctggtcg
     8341 tgaacatcgg ttcggcgggc gcgctgggcc ggcgggcctg gccggggaac gcggtgtacg
     8401 gagcggccaa ggccgggctg gacctgctga cgcggtcctg ggccgtggaa ctcggccccc
     8461 gcggaattcg cgtgatcggg gtcgccccgg gagtgatcga gacgggcgcg ggagtccggg
     8521 ccgggatgtc ccaggaggcg tacgacgggt tcctggaagc catgggacaa cgcgtcccgc
     8581 tcggccgggt gggccggccc gaggacgtcg cgtggtgggt ggtgcggctc gccgatcccg
     8641 aagccgcgta cgccagcggt gccgtgctcg ccgtggacgg ggggctgtcg gtgacctgag
     8701 aggcccggtc ggacccgcac aggtcgccct cgctcgccgg agggcgacct gcggggtggt
     8761 gtcctgccgg ggacacggag gcccccgccc cgagggggtc gggacggggg ttccgtacgg
     8821 gtcgggacgc tcgtctcagg cgctggactc ggcgtaccgt ctggccgctt ccagggtcag
     8881 cagactgttg cggcccaggg cccggcggac gaagtccacg gcgtccgtct cattcgcccc
     8941 cgcacctagg atgccgggga tcgccgagcg ggccacggac acggtgtggg ccgacgtgac
     9001 ggcgatcccg tccccgtcgc cggcgggacg gaccgaccag cggccgagat ggagcgccag
     9061 cagcggcggc gtgcgcagtt gcttgtagac gatgaggcgg cgttcgggga agcacacgcg
     9121 caccgacgcg gtggtgtgta ccgagccgtc cgcggtgagg gtgtccatct ccatgtgctg
     9181 cagNNgaatt cgcgtgatcg gggtcgcccc gggagtgatc gagacgggcg cgggagtccg
     9241 ggccgggatg tcccaggagg cgtacgacgg gttcctggaa gccatgggac aacgcgtccc
     9301 gctcggccgg gtgggccggc ccgaggacgt cgcgtggtgg gtggtgcggc tcgccgatcc
     9361 cgaagccgcg tacgccagcg gtgccgtgct cgccgtggac ggggggctgt cggtgacctg
     9421 agaggcccgg tcggacccgc acaggtcgcc ctcgctcgcc ggagggcgac ctgcggggtg
     9481 gtgtcctgcc ggggacacgg aggcccccgc cccgaggggg tcgggacggg ggttccgtac
     9541 gggtcgggac gctcgtctca ggcgctggac tcggcgtacc gtctggccgc ttccagggtc
     9601 agcagactgt tgcggcccag ggcccggcgg acgaagtcca cggcgtccgt ctcattcgcc
     9661 cccgcaccta ggatgccggg gatcgccgag cgggccacgg acacggtgtg ggccgacgtg
     9721 acggcgatcc cgtccccgtc gccggcggga cggaccgacc agcggccgag atggagcgcc
     9781 agcagcggcg gcgtgcgcag ttgcttgtag acgatgaggc ggcgttcggg gaagcacacg
     9841 cgcaccgacg cggtggtgtg taccgagccg tccgcggtga gggtgtccat ctccatgtgc
     9901 tgcagacccg gttcctcctc cttgaccgcg atccgcgcga cgtgggagag ccgcttctcc
     9961 cagaggtcgc tgcgatggag gaagcggtag atgtcctcgg cactgccacg gacgacgacg
    10021 gtgtcctcga aggtcgtcgg agcggtgccg tcgggtcctt ccagcgcggt gcgcagcgac
    10081 gccagttcgg cttcgctgtt gcggtccacg gcccgatgga tccagccgat cgtctccggg
    10141 tcgtcgtcca cggcccggaa gtcgtgcgtc agccgcacgc gggtgccgcc gtcaccggct
    10201 tcctcgacga tccattcgcc gcccatggct gcgacggggt gggcggacgt ctcctgccgg
    10261 aaacggatgc gccggacccg ctcgtcgagc tcgcgccgcg acgtccaggt acgaagcgag
    10321 ccgttggcag tggcccagat gcggatgcgt tcgctggagt ccgcgcactc caactgttcg
    10381 acgtggacac tgggcgggaa cacggcgggc caggaccgca cgtcggccag cacggcgaac
    10441 acggcgtccg gcgcggccga ggtatggatc tcgtgctcgg tctgctgaag cggcgactcg
    10501 gacatctgcc ctcctgagct cgggtcgtgg acggtcagta actgccgagg ccaccacaga
    10561 cattgatggc ctgggccgtg atcgagtcgg cgctgtcgga gaccaggtag tgcaccattc
    10621 cggccacctc gtcggacgtc gagtagcgtc cgagcgggat cttcgcccgg aacttctcca
    10681 ggacgtcgtc ctcggtgatc ccccagaagg cggcgtatcg ctgccgcacg ccttgggcca
    10741 tgggcgtctc gacgtacccc gggcagacgg cgttgaccgt gatgcccgtc ctggccagct
    10801 ccagtgcgac agccttcgtg aagccgatca ggccgctctt ggaggcggag tagggagcgc
    10861 cgagggccac tccctgcttg ccgccggtag aggcgatgtt gatgatccgg ccccagccgt
    10921 gctcctgcat gccgccgccg gtgaggacgg cgcgggtgac ccggaaggcc ccgccgaggt
    10981 tggtgtcgac gacatcggac cacaggtcgt ccgtgatctg ggcggtcact cctccaccac
    11041 cgcggccggc gttgttgacg acgatgtcga tcgcccgaag cgggttccgg gccgttcgga
    11101 ccagccggtc gacagcgtcg gtgctccgca cgtcgcagga cgtgccctcc acctccagtc
    11161 ccgatgcctg aagttccttc acggtgccgg tgacggcgct ctcgtcacga gcgcacagga
    11221 acacccgggt cccgtccagg gcgagcttgc gtcgtcctac cgcgagaccg atgccgctgg
    11281 ttcccccggt gacaagtgcg acccggtcgg ctgcgtcgga catgatcctc ccttcgacgg
    11341 agggcccacc ctcacacctc gcgctcgagc cgcgcttgac gacccggctt ccagaggagg
    11401 tcgagcggcg ccgcagaacc tcggagtccg gcgtgaccgc acctgcggac gcggccgcac
    11461 cgtcgcaccg acgtccaccc cacacctgga ccaacggacc cgtggagcag cgatgcctct
    11521 ggccagaacc gaacgacgcc ggctccgggt cggtgacctt cgtcaaccga ttcaccctga
    11581 gcggatcagc cgaggacttc gaggcggcgt tcgccgaaac ggccgagttc ctgtgtcgcc
    11641 gacccggctt ccgctggcac gtcctgctgg cgccgaccgg ctccggctcg gccgacgtcc
    11701 gcccgcagta cgtgaacatc gcggtctggg acgacgaggc ctccttccgt gccgctgtgg
    11761 cgcacccgca gttcccggcc cacgcggccg tcctgcgggc gctgagcacc agcgaaccga
    11821 ccctgtaccg gtcccgtcag atccgtgtcg cgccgggcgc cccggccatg agcaggcccg
    11881 aagggcggac gacgtgaacc gacgggtcgt catcaccggg atgggtgtgg tggccccggg
    11941 agccatcggc atcaagtcgt tctgggagct gctgctgtcc gggaccaccg ccacccgggc
    12001 catcaccacg ttcgacgcca cgcccttccg ttcccggatc gccgccgagt gcgacttcga
    12061 tccggtcgcg gcagggctgt ccgcggagca ggcccggcgc ctcgaccggg ccgggcagtt
    12121 cgcgctggtc gccggtcagg aggcgctcac tgacagcggg ctgcgcatcg gggaggactc
    12181 cgcccaccgg gtcggggtgt gcgtgggtac cgctgtcggc tgcacgcaga aactggagtc
    12241 cgagtacgtg gctctcagcg cgggcggtgc gaactgggtc gtggaccccc accggggggc
    12301 gcccgagctg tacgactact tcgtgccgag ttccctcgcc gccgaagtgg cttggctcgc
    12361 cggggcggaa gggcccgtga acatcgtctc ggccgggtgc acctcgggga tcgactccat
    12421 cgggtacgcc tgcgaactca tccgcgaggg gacggtggac gtcatgctcg cgggaggcgt
    12481 ggacgccccc atcgcaccga tcactgtggc ctgcttcgac gccatcaggg tgacctccga
    12541 ccacaacgac acacccgaga cgctcgcgcc cttcagccgc agccgcaacg gcttcgtgct
    12601 gggcgagggt ggtgcgatcg tggttctgga agaggcagag gcggccgtgc gcaggggcgc
    12661 acgaatctac gccgagatcg gcgggtacgc ctcacgcggc aacgcatacc acatgacggg
    12721 gctgcgcgca gacggcgccg agatggctgc ggcgattacc gcggccctcg acgaagcccg
    12781 ccgcgacccc tcggacgtgg actatgtcaa cgcccacgga acagcgacgc gacagaacga
    12841 ccggcacgaa acctccgcgt tcaagcgctc gctgggggat cacgcgtacc gggttcccat
    12901 cagctccgtg aagtcgatga tcggtcactc cctgggggcc gccggctcgc tcgaagtggc
    12961 ggcgaccgca ctggcggtgg agtacggggc gatcccgccg accgcgaatc tgcacgaccc
    13021 ggatcccgaa ctcgacctgg actacgtgcc gttgacggcg cgagaaaagc gggtgcggca
    13081 tgcgctgacg gtgggcagcg gcttcggcgg cttccagagc gccatgctgt tgagccgtcc
    13141 cgagaggtga gcgccatgac acgtccagct gaaggggccg catcctcgca gatccgcgca
    13201 tcatcctcgg gccggcggtg cctcaagggc cgcgcggtgg tgacgggtct cgggatcgtc
    13261 gcccccaacg ggctcggtgt gggcgcgatc tgggacgccg tcctgaacgg ccgcaacggc
    13321 atcggaccgc tgaggcggtt cgccgacgac ggtcgcctgg ggcggctggc cggtgaggtg
    13381 agcgacttcg tccccgagga ccatctgccg aagcggctgc tggtgcagac agatccgatg
    13441 acccagatga cggcgctggc cgccgccgag tgggccctgc gggaggccgg ctgcgcgccg
    13501 tcgtcgccgc tggaggcggg ggtgatcacg gccagcgctt ccggcggctt cgcgtccggc
    13561 cagcgggaat tgcagaacct gtggagcaag gggccggccc acgtcagcgc ctacatgtcg
    13621 ttcgcctggt tctacgccgt caacaccggg cagatcgcca tccgccacga cctgcgtggt
    13681 ccggtcggag tggtggtggc cgagcaggcg ggcggccttg acgccctcgc ccacgcccgc
    13741 cgcaaggtcc ggggcggagc cgagctgatc gtctcgggcg ccatggactc gtcattgtgc
    13801 ccgtacggta tggcggccca ggtgaggtcc ggtcggctga gcggctcgga cgacccgacg
    13861 gccgggtatc tgccgttcga ccggcgagcg gccggacacg tgcccggtga ggggggcgcg
    13921 atcctcgccg tcgaggacgc ggagcgcgtc gccgaacggg gcgggaaggt gtacgggtcg
    13981 atcgccggta cggcgagctt cgacccgccc cccggctccg gccgcccctc cgccctcgcc
    14041 cgtgccgtcg agacggcgct ggccgacgcg gggctggacc gatccgacat agccgtggtg
    14101 ttcgccgacg gcgcggccgt cggcgaactg gacgtggccg aggcggaggc cctggcgtcg
    14161 gtcttcggac cgcaccgggt cccggtgacc gtccccaaga cgctcaccgg ccgactgtac
    14221 tcgggagccg ggccgctgga cgtggccacc ggactgctgg cgctgcggga cgaggtggtc
    14281 ccggcgaccg ggcacgtcca cccggacccc gatctgccgc tggacgtggt gaccgggcgg
    14341 ccccgggcga tggccgacgc cagggcggct ctcgtcgtcg cccggggcca cgggggtttc
    14401 aacagcgctc tggtcgtccg gggggcggcg tgagcacgct gccgggagca cctggggacc
    14461 tctacgtggc cggttgcggt gtctggctgc ccccgccggt gaccacggat caggccctgg
    14521 ccgccggtca ctgcgaccgc aggctcgcct cctcgacgcg gatgctgtcg gtggcggtcg
    14581 ccgacaagga gacaccggcg gagatggcgg cctcggcggc ccggaccgct gtggaccgct
    14641 ccggcgtccc cccggcccgc atcgtcctcg tcctgcacgc cagcctgtac ttccaggggc
    14701 accatctgtg ggctcccgcc tcctacgtcc agcgggtggc cctcgggaac cgttgccccg
    14761 ccatggaggt gcggcaggtg tccaacggcg gcatggccgc cctggagctc gcccgcgcgt
    14821 acctgctcgc cgccccggac cggacggccg ctctcgtcac gacgggcgac cggatgagtc
    14881 cgccgggctt cgaccgctgg aacagacccc ggcacgtgta cgccgacggc ggcaccgccc
    14941 tcgtactgtc ccggcaggga ggcttcgccc ggctgcgtag cctggtgacg gtctccgaac
    15001 cggtgctgga gggcatgcac cggggcggac acccgttcgg cccgccgtcc gcggaggagc
    15061 agcggaccgt cgacctggac gcgcacagcg ggcgtacgtg gccgaggcgg gaggctcgtt
    15121 cagcgtcgcc gcgggtctcg gcgggccagg aggaggctct ggccggcgcg ctgaaggccg
    15181 ccggggtcgg actcgacgac atcagccggg tcgtgctgcc gcacatgggc tggcgcaggc
    15241 tgagcgcctc ctacttcgga aagtggccgg ttccgcccga gcggaccacg tgggagttcg
    15301 ggcgacggac cggccatctg ggcggcggcg acccgatcgc cgggttcgac cacctcgtgg
    15361 gctccggccg cctcgccccg ggggaattgt gtctgctggt cagcgtcggt gccggcttta
    15421 gctggtcgtg cgccgtcgtg gagttgctgg acgcccgtcg gtgggcggcc gccccggccg
    15481 cccggtgagg agaccgtcat ggacgtgccc gcgattctcc tgatgttccc ggggcagggg
    15541 tcccagcacg cgaggatggc agccgggctg tacggatccg aaccggtctt caccgctgcc
    15601 atggacgagg tcctcgccgc gtacgatgcc gccggcgact gtgagggcca gcggctgcgt
    15661 gccgactggc tgagcgaccg tccagccgtg ccgctggacc acgtcacccg gtcccagccg
    15721 ctgttgttcg cggtggacta cgccctcggc aggatggtac tggccacgac gggccggccg
    15781 tgggccctgc tcgggcacag tgtcggcgag atggcggggg ccgcgctcgc cggggtgttc
    15841 acgctgcgcg acgcggcctg cctcctgctg gaccgggtgc gacggctggc ccaggcaccg
    15901 cccgggggga tgctggcggt cgccgcgggc gaggacgtgc tgggcccgta tctcgtggag
    15961 ggggaggtgg cggtcgcggc cgtcaactcg ccccgccaga ccatcctcgc cggccccgtc
    16021 gcaccgctcg ccgcggtcgc ccgggcactg cgggaggcgg ggctcacatg ccgtgaggtg
    16081 ccctcgctga ccgcattcca cagtccggtg ctggccccgt acacgacggg ggcggccgag
    16141 cggttcgcat cgacgcgcgt ggcggcgccg tccatccctc tccgctccgg gtaccggccg
    16201 ggcgcggtga ccgggcgact ggccgccgac ccgtcctact gggccggaca tcccgtggag
    16261 acggtccgct tctggccggc actggacgcg atgctccgct cccgcacggg cgtcgtctgc
    16321 ctggagaccg ggccggggca ggggctcagc accgtcgccc gccgccatcc gacggtgcgg
    16381 tcggggagga acgcggtggt gtcgctgctg ccgccgcggg ccggcaccgc cgagatggac
    16441 cggacgtccg tggcggcggc gctgaccgca gtgcgcgagc ggggcgctgt gctcagtggg
    16501 cgacccgggc ggtgacgaag cggacaggca cgtcgatggc gagggccccg gtggcgtcgc
    16561 tcagcttgtc gagtccctcg acgagccgtg cgcgcagttc cgttcgctgc ggctgcggga
    16621 ggttctgcca cagcagacgc atgccctggg tgtgggacca gtccacccac gtctcgctgg
    16681 acggggccgt catccgcacc ggctcgtcga ctgacggaga cgagcgtaac cgcagccttc
    16741 aagggtacgg acaagatcct cggctcgctc cagccagctg ttgaaccgcc ggaccagcgc
    16801 ctcgggccgc cactgctcgg ggaggtgctc cagcaatgcc tgggggatga gcggggtgaa
    16861 ctccggcggc aggaacggga acgtgccggc acggaagacc gggctggtga acgcgatcct
    16921 gccgccgtgg tccaggatgt cggcgtagcg cgcgagggcc cccacggcat ccggcaggaa
    16981 aatgacgctg tagctcccca tgaccaggtc gaaggaacgc gccggaaatc cgggtgtctc
    17041 cgcatccatc accatgaggc tgatattccg cagaccgcgt tcggtggctt ccttgcgagc
    17101 ttcctcgatc attccgggag cgatgtcgat accgtggacg cacccctggg agccgacctt
    17161 ttccgcagcc gggaaaaggc atgcgccgcg cccgcagccg atgtcgagca ctcgttcacc
    17221 cgtgaccggc tccgagatgt ccaccaggcg gcgacccatg ggcgtgaaga attcNNggta
    17281 ccggccgggc gcggtgaccg ggcgactggc cgccgacccg tcctactggg ccggacatcc
    17341 cgtggagacg gtccgcttct ggccggcact ggacgcgatg ctccgctccc gcacgggcgt
    17401 cgtctgcctg gagaccgggc cggggcaggg gctcagcacc gtcgcccgcc gccatccgac
    17461 ggtgcggtcg gggaggaacg cggtggtgtc gctgctgccg ccgcgggccg gcaccgccga
    17521 gatggaccgg acgtccgtgg cggcggcgct gaccgcagtg cgcgagcggg gcgctgtgct
    17581 cagtgggcga cccgggcggt gacgaagcgg acaggcacgt cgatggcgag ggccccggtg
    17641 gcgtcgctca gcttgtcgag tccctcgacg agccgtgcgc gcagttccgt tcgctgcggc
    17701 tgcgggaggt tctgccacag cagacgcatg ccctgggtgt gggaccagtc cacccacgtc
    17761 tcgctggacg gggccgtcat ccgcaccggc tcgtcgactg acggagacga gcgtaaccgc
    17821 agccttcaag ggtacggaca agatcctcgg ctcgctccag ccagctgttg aaccgccgga
    17881 ccagcgcctc gggccgccac tgctcgggga ggtgctccag caatgcctgg gggatgagcg
    17941 gggtgaactc cggcggcagg aacgggaacg tgccggcacg gaagaccggg ctggtgaacg
    18001 cgatcctgcc gccgtggtcc aggatgtcgg cgtagcgcgc gagggccccc acggcatccg
    18061 gcaggaaaat gacgctgtag ctccccatga ccaggtcgaa ggaacgcgcc ggaaatccgg
    18121 gtgtctccgc atccatcacc atgaggctga tattccgcag accgcgttcg gtggcttcct
    18181 tgcgagcttc ctcgatcatt ccgggagcga tgtcgatacc gtggacgcac ccctgggagc
    18241 cgaccttttc cgcagccggg aaaaggcatg cgccgcgccc gcagccgatg tcgagcactc
    18301 gttcacccgt gaccggctcc gagatgtcca ccaggcggcg acccatgggc gtgaagaatt
    18361 ccacccccag tcgatcataa gtggacgacg actggtcgaa ggcctgagtc acctgtttct
    18421 tgtaggacga atcctgcacc ttcggctcct gcctctgcga tgtgggctct tccctgatca
    18481 ccagtgttcg acctgcactt gaagggcggt ggagtgccgt tcgaggtgcc ccggaagcac
    18541 ttgtacgccg tccctggaag aaacaacaat cgctgacgcg gtcaccgctg gtgccgccgt
    18601 ttccgatacg gctttcggga gggaaaccat gagcccgcag atcgatctgg tccgccgcat
    18661 ggtggaggcg tacaacacgg gaaaaaccga tgatgtcgcg gagttcattc tacacgagta
    18721 cctgaacccc ggcgcgctgg agcacaaccc ggagctgcga ggcccggagg cgttcgcagc
    18781 tgccgtcacg tggctcaagt acgccttctc cgaggaggcg cacctggagg agatcgggta
    18841 cgaggagaac ggcccgtggg tccgcgcgaa gctcgccctc tacgggcggc acgtcggcaa
    18901 cctcgtcggc atgccggcaa cggggcgccg gttctccggt gagcagatcc acctcatccg
    18961 catcgtcgac ggcaagatcc gtgatcaccg cgactggccc gactatctcg gcacctaccg
    19021 ccagctcggc gagccctggc ccactcccga gggctggcga ccctgccccc caccgccccg
    19081 ccgacgccac gacaggagca cggacacacc atgacagccg aaccgacggt cgcggcccgg
    19141 ccgcagcaga tcgacgccct caggaccctg atccgcctcg gaagcctgca cacgcccatg
    19201 gtcgtccgga cggctgccac cctgcggctc gtcgaccaca tcctggcggg ggcccgcacc
    19261 gtgaaggccc tggcggccag aaccgacacg cggccggaag cactcctgcg actgatccgc
    19321 cacctggtgg cgatcggcct gctcgaggag gacgcaccgg gcgagttcgc cccgaccgag
    19381 gtcggcaagc tgctcgccga cgaccacccg gccgctcagc gtgcctggca cgacctgacg
    19441 caggccgtgg cgcgtgccga catctccttc acccgcctcc ccgaagccat ccgtagcggc
    19501 cgccccacgt acgagtccgt ctacggcaag ccgttctacg aagatctggc cggccgccct
    19561 gacctgcgcg cgtccttcga ctcgctgctc gcctgcgacc aggacgtcgc cttcgacgct
    19621 ccggccgccg ctcacgactg gacgaacgtc cggcacgtgc tcgacgtggg gggtggcaag
    19681 ggggggttcg ccgcggccat cgcgcgccgg gccccacatg tgtcggccac cgtgctggag
    19741 atggcgggca ccgtggacac cgcccgctcc tacctgaggg acgcgggcct ctccgaccgt
    19801 gtcgacgtcg tcgaagggga cttcttcgag ccgctgcccc gcagggcgga cgcgatcatc
    19861 ctctccttcg tcctcctcaa ctggccggat cacgatgctg tccgaatcct tacccgctgt
    19921 gccgaggccc tggagcccgg cgggcggatc ctgatccacg agcgcgacga cctccacgag
    19981 aactcgttca acgaacagtt caccgagctc gatctgcgga tgctggtctt cctcggcggt
    20041 gccctgcgca cccgcgagaa gtgggacggc ctggccgcgt cggcgggcct cgtggtcgag
    20101 gaggtacggc aactgccttc gccgaccatc ccgtacgacc tctcgctcct cgtcctcgcc
    20161 cccgcgtcca ccggcgcttg acacacgagg tacgggaagg agccatcagc aatgccgaca
    20221 cgcatgatca ccaaggacga ggtgaccttg tggagcgaag gaatcggcga tccggccgac
    20281 gctccgttgc tcctgatcgc cggcggcaac ctttcggcca ggtcatggcc ggacgagttc
    20341 gttgaacgcc tcgccgcggc cgggcacttc gtgatccgct acgaccaccg ggacacaggg
    20401 cgctcctccc ggtacgactt cgcgctccac ccctacggct tcgacgagct ggccaccgac
    20461 gcgctggccg tcctggacgc ctggcaggtc cgcgccgccc atgtggtggg catgtcgctg
    20521 ggcaacacca tcggccagtt gctcgccctg gacgctccgg agcgtctcct gacactcacc
    20581 gtcatgctgg ggggtgcgct cgatgtcgac ttcgacgccg acctggaggc ggcgctcaaa
    20641 ggtgagcctt ccgtcagcgg actgccggtg cccagccgac ggttcctcga catgatgatg
    20701 cttcttcagc agccggccgg gacggacgag gaactactgg agcgccgggt ggagaagtgg
    20761 cgcctgctca acggggaggg agtgcctttc gactccgacg agttccggcg ccgtgaactc
    20821 ctggccgccg gtcacgcggg aacgttcgac gagccgatcg tgcaccacat gatcccgcag
    20881 ccgccggtgt cgcggggggc ggagttggcc cgcatcacga caccggtact ggcgatccag
    20941 gcgatgtgcg accccgcggc cccgccgccg cacgcccggc acctggccga ccgaattccc
    21001 ggcgcccggg tcgtggagat cgagaacatg gggcacgcgc tgcccctcgc ggtccacgaa
    21061 ccgctggccg ccgccatctg cgcccatacc cgggccgcga ccgtgtgagg agcatgacga
    21121 tgcccacacc cacgtccgcg ccgccggccg ccccgaccaa cagcgagctg gggcgccatc
    21181 tgctgaccgt gcgcggcttc cacttcgtct tcggcgcgct gggcgacccc tatgcccggc
    21241 gactgcgcgg cgaagccgat catctgtctc tcggtgaact ggtccgcgac cgaggtccgc
    21301 tccaccgcag tgcgctgggc acctgggtga cggcggacgg agaaacatcg gccggcctgc
    21361 tggacgatcc gctgctgggc cctcggcacc ccgcctcgga agggctgcag
//
