LOCUS       Cosmomycin            14080 bp	DNA     linear     22-Jan-2015
DEFINITION  Cosmomycin biosynthesis cluster
ACCESSION   Cosmomycin
VERSION
KEYWORDS
SOURCE      Streptomyces olindensis
FEATURES             Location/Qualifiers
     source          1..14080
                     /organism="Streptomyces olindensis"
                     /mol_type="genomic DNA"
                     /strain_name="DAUFPE 5622"
                     /db_xref="taxon:358823"
     CDS             complement(3..365)
                     /locus_tag="Cosmo_00010"
                     /product="putative NDP-hexose C-4 ketoreductase(fragment)"
                     /note="original product:CosM"
                     /note="original gene:cosM"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR016040"
                     /translation="MSTTTQGGAAVGTVAVLGATGCVGRSVCDELSRTGHRVLAVARH
                     PAPHTRPHAFVPLDVAGTAPERLAALLDRYGVTAVVNATGGWGTTVEEMRRAHIDLLE
                     RLVDGCAATSRRLRVVQLG"
     CDS             complement(374..1000)
                     /locus_tag="Cosmo_00020"
                     /product="putative NDP-hexose epimerase"
                     /note="original product:CosL"
                     /note="original gene:cosL"
                     /note="category:2.3 modification addition of sugar moiety"
                     /EC_number="5.1.3.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR011051"
                     /inferenece="InterPro:IPR014710"
                     /inferenece="InterPro:IPR000888"
                     /translation="MQIRKLKVEGAYEFTPRQFRDHRGLFVSPFQLEAFQQALGRPHF
                     PVAQTNHSISRRGTVRGIHFTVTPPGTAKYVYCARGRALDIVVDLRVGSPTFMQWDAV
                     EMDQVHFRASYFPVGVGHAFVALEDDTVMSYLLTGPYVAENELAVDIFDRELGVRLPA
                     GLDTVQSERDAAALSFAAARAQGLLPDYAESAAVEERLWQSSGIGASS"
     CDS             complement(1074..2366)
                     /locus_tag="Cosmo_00030"
                     /product="L-2-deoxyfucose glycosyltransferase"
                     /note="original product:CosK"
                     /note="original gene:cosk"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR010610"
                     /inferenece="InterPro:IPR004276"
                     /translation="MRVLFTTFAAKSHMHAQVTLAWALKAAGHDVRIASHPDLADEIT
                     RTGLTAVGVGEELHLDEQMQETQENIGQDVDQLESQAQVGLDMSETRPERLTWDYTLG
                     VFTAMTSVVFQNCCSDQMVDELVEHCRSWKPDLVLWDTMTFAGAIAAMATGTAHGRLL
                     FGMDLAGKMRETFLEQLAARPPELRDDPLREWLTWSLERHGASFEEAAVTGDFTVCPL
                     PASMRFPLDLHYVPMRYVPYNGQSTVPQWLQEPPKRGRRVCITLGVAHREVLGADRAS
                     IGDLLEAVAGLDDVEVVATLNENQLKDFDTLPDNVRAVDFVPLDALLPTCDAVIHHGG
                     SGSFGTAMIHAVPQLIVVDGVWDTINKARYLERRQAGLYVPGKLSAKGLRELLVRLLE
                     EPVFKRNAEALRREALAAPAPAQVVPTLERLAAEHRRR"
     CDS             2613..3176
                     /locus_tag="Cosmo_00040"
                     /product="putative PadR family transcriptional regulator"
                     /note="original product:CosS"
                     /note="original gene:cosS"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR011991"
                     /inferenece="InterPro:IPR005149"
                     /translation="MSATRLLVLGVVRMHGRAHGYLVRSELLSWGADEWAHIKFGSIY
                     HALRQLAKDGLLKSTDIPDWPGRVDYEIAPPGEEEFFRLLRDALRQGNNRPDMLGAAL
                     VLLPALSREEAIALLRERIASLSAEQGELIAKVDETAGERPQRAHIRELLGLWEHSAA
                     SQAAWTEALIERLEAGAYVMAGEEKGA"
     CDS             3284..4261
                     /locus_tag="Cosmo_00050"
                     /product="hypothetical protein"
                     /note="original product:CosY"
                     /note="original gene:cosY"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR003462"
                     /translation="MPIMLTSEDVDDAFDDEAFMEERFSDVQRLLLGRGPALGPETPV
                     LLPATHCRLTVGPHTSGPFGRCFAVRLDPGADQSAPRVELLLADDGSLLGLVDAGALD
                     GWRSAIPSGLAARYLAPPAPSLLGLFGSGEPAWSCLLVLHHALPSLSEVHVVGRDPAQ
                     ARDLATAAALRTGLRVRTSEDARATAAGADVVATTGGHPRVRAEWLAAGALLIDQTAT
                     AATAATAAPTAAGPAVGQVGLVPPRGPAVRQVSLVPPRGPAEDTRHEPLPLAEIVAGR
                     ALPRRSGSDIVHYQGAELAGWSAIAAAAGLGHAWRRDVGTPVRLGRGSP"
     CDS             4360..4713
                     /locus_tag="Cosmo_00060"
                     /product="putative C-12 oxygenase"
                     /note="original product:CosX"
                     /note="original gene:cosX"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR011008"
                     /inferenece="InterPro:IPR007138"
                     /translation="MRSTDPMSADQPGPASGGPATFVNSFTLRTTPEEFEDVFARTAR
                     FMERQPGFLGYTLVRHLEQPHSYVNIARWADVASFRAAVGQSDFRPHAEALRAISTSS
                     SNLYLERRSATGEAR"
     CDS             4710..5978
                     /locus_tag="Cosmo_00070"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /note="original product:CosB"
                     /note="original gene:cosB"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR018201"
                     /inferenece="InterPro:IPR014030"
                     /translation="MTRRVVITGIGVVAPGGIGTKQFWETVTGGRTATRTISLFDPAP
                     FRSRIAAECDFDAAEQGLSPEDAERLDRAAQFALVALREAVTDSGLEPDPDTAHRTGV
                     SLGSAVGCTQKLEEEYVALSGGGQEWLVDHTAAGAHLYDHFVPSSMAAELAWEAGAEG
                     PCTVVSAGCTSGLDSVGHAAALIREGTADVMIAGATDAPISPITVACFDAIRATSPRN
                     DDPATALRPFDRTRNGFVLGEGAAVLVLEELTAARRRGAHVYAEIAGYASRGNAYHMT
                     GLRTDGRELAAAVDAALDEARLAPEALGYVNAHGTATKQNDVHETAALKRSLGSHAHR
                     VPVSSIKSMIGHSLGAIGSIEVAATALALEHGVIPPTANLTDPDPDLDLDYVPLHARE
                     RTMSAALTVGSGFGGFQSAVVLRRPEGRAA"
     CDS             5975..7219
                     /locus_tag="Cosmo_00080"
                     /product="polyketide synthase chain length factor subunit"
                     /note="original product:CosC"
                     /note="original gene:cosC"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR014030"
                     /translation="MTPVVVTGIGVVAPTGIGLDAYWAATLRGDDGIRRVQAFDPSRY
                     PTRRAGEVTGFEAGDHLPSRLIPQTDRMTQFALAAADWAVADAGIDLDAVPSLERGVV
                     TAGASGGFGFGQRELQHLWGESPKKVSAYMSFAWFYAVNTGQISIRHGMNGPTGVFVG
                     EQAGGLDALAHARRQIRAGARLMISGGMDCSLCPYGMAAQLAGGRLTADAYLPFDDQA
                     SGHLPGEGGALLTLESAEGARARGRGHYGEIAGFGATFDPRPGSGRPPALRRAVEQAL
                     ADAQAAPEDIAVVFADGAGVPELDAAEAAALTEVFGPGGVPVTVPKTATGRLYSGAGP
                     LDVVTALLTLRDGIAPPTVNVSRVPDTYGLDLVLGRPRPVSGTAALVLARGHHGFNSA
                     LVVRAPAPGDAVAHRPEERTAA"
     CDS             7216..8250
                     /locus_tag="Cosmo_00090"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /note="original product:CosE"
                     /note="original gene:cosE"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR013751"
                     /inferenece="InterPro:IPR013747"
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR016038"
                     /translation="MNDGALYIRATGTWLPPAERVADAVADGRCEAAVARSTRMESVT
                     VSAGEPAPEMAARAARTALERAAAEPGDIDLVLHASFYYQGFDLWAPASYVQRAAVGN
                     QCPAMEIRQVSNGGMAALDLAWAYLAADPARVAALLTTGDRFCPPGFDRWRSDPGTVY
                     GDGGTALVVSRHSGFARVRSIATVSAPDLEGMHRGDDPFGPAPFSHRDVVDLDAHKRD
                     FLARHGVAPTVARVAAAQEAVVKQALADAGLGLADIDRFVLPHLGHRRLHVAYFAKFG
                     IDPARSTWSWSRTIGHLGAGDPFAGLDHLATAGELGPGDTCLLFGVGAGFSWSCAVVE
                     ILDAPSWRDR"
     CDS             8247..9296
                     /locus_tag="Cosmo_00100"
                     /product="putative acyl-ACP thioesterase"
                     /note="original product:CosF"
                     /note="original gene:cosF"
                     /note="category:1.4 Other"
                     /transl_table=11
                     /inferenece="InterPro:IPR001227"
                     /inferenece="InterPro:IPR014043"
                     /inferenece="InterPro:IPR016036"
                     /inferenece="InterPro:IPR016035"
                     /inferenece="InterPro:IPR020801"
                     /translation="MNDVRTAADGRDGGTRPVALLLPGQGAQHPRMAAGLLAAEPVFA
                     EAMDEALTALADAGGPGGHGTGLREDWLGSRDTALMDHVTRSQPLLFAVDYAIGRLVL
                     GWGVRPVALLGHSIGEVAAAVLSGVFTLPDAAAMVHDRVARLADAPPGGMVAVAATRE
                     EVAPFLTDGVVVGAVNAPRQTVLAGLDGPLRTVTAALADAGFVLQRVPASTAFHSPAL
                     APAMRGADERIAALPVGEPRIPVMSGYTGRFLTPAEAKDPAFWSRQPVAPVLFWPALD
                     ALLAQGDPVLVEAGPGQGLSQLARRHPAVRSGRSAVVPLLPARPGTAEDDVTAVRAAA
                     AALRERAGVPDARPV"
     CDS             9440..10690
                     /locus_tag="Cosmo_00110"
                     /product="putative glycosyltransferase helper protein"
                     /note="original product:CosT"
                     /note="original gene:cosT"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR001128"
                     /translation="MLTDQTNSELGRHLLTIRGVQFIFGAQGDPFAMILRAGDDDPLD
                     HGARAREQGLHESSIGAWVTAHRELGARILGDERFSPRHAEEGPQAHPGVDVWDNPLL
                     CHVVPLDDAQLNRDPADYRALARAAAPLLSAEALAARLPEIEAAYRQALAATGERFDL
                     YRDVAVPAALRVVADVLGLPEETRQRLPELHAGLATALDAGHCPQQLAAARALFTAVT
                     DLSTELTRLVGSGRATGLAALDGVSPEDAVAVGTLAVVVGVEVTATAVCNAVRVLLDH
                     REEWERIGREPERAGAAVREALRLAPPLRFESRIAREQAEFDGKTVEEGRRVVVLVDA
                     ANRDPEAFADPDAFVPGRADGDRSLTLLGGSAAPVTEALVRLQTEAAVRVLAELRPGL
                     RTGAEVLHRMRSAVLRGVLRFPVA"
     CDS             10725..12005
                     /locus_tag="Cosmo_00120"
                     /product="dTDP-L-rhodosamine glycosyltransferase"
                     /note="original product:CosG"
                     /note="original gene:cosG"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR004276"
                     /inferenece="InterPro:IPR010610"
                     /translation="MRVLLTAFAQDAHLNGIVPLAWALRTAGHEVRVAGQPAAVESIT
                     RAGLTAVPVGDDHRMDAVIPTVGPGMLMHHLDRDYLENRPERLSLDFLRASNAMLTAT
                     FYAQINNDSMIDALVDYARFWQPDLVLWEPFTFAGAVAAKATGAAHARLLAFPDLFAN
                     THLTLRRRQAELPAELRDDPLEEWLAYTLDRHGAAFDPDVVTGQWSVDQMPPGVRMEL
                     GLPTVPTRYVPYNGPGPAVVPDWLRRPPERRRVCLTLGLTIRDTEFPNAVDVDDVFAS
                     LADLDVEVVATLSEKELAQVSRVPDNTRVVDHVALLALLPSCSAIVHHGGAGTWATAA
                     AYGVPQVALGWMWDAIYRAQRVEELGAGLHLHSEGLTVEVLRDKLVRVLDDPSFTEGA
                     RRLRLAMLSAPSPNEVVPTLEKLTARHRSVAAAR"
     CDS             12028..13011
                     /locus_tag="Cosmo_00130"
                     /product="putative dTDP-glucose 4,6-dehydratase"
                     /note="original product:CosH"
                     /note="original gene:cosH"
                     /note="category:2.3 modification addition of sugar moiety"
                     /EC_number="4.2.1.46"
                     /transl_table=11
                     /inferenece="InterPro:IPR005888"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR001509"
                     /translation="MNILVTGAAGFIGSHFVRTLLSGGYPGHEDDRVTVLDKLTYAGT
                     LNNLPAHHPRLTFVHGDICDTTLLDKVFPGHEAVVHFAAESHVDRSVAGAEAFVRTNV
                     LGTQALLEAALRHGIGVFVQVSTDETYGSIAEGRWTEDEPLLPNSPYAASKASADLIA
                     RSYWRTHGLDVRITRCANNYGPGQHPEKLVPLFVTRLLDGQPVPLYGDGSNLREWLHV
                     DDHCHAVRLVLDRGRPGEVYNVGGGTHLTNKEMTGRLLALCGRDWDLVRRVADRKGHD
                     FRYAVDDSKIRRELGYAPRWSLEDGLRETVEWYAAHRDHWDAREEGADEGY"
     CDS             13087..14076
                     /locus_tag="Cosmo_00140"
                     /product="putative drug resistance ABC transporter
                     ATP-binding protein"
                     /note="original product:CosI"
                     /note="original gene:cosI"
                     /note="category:4.3 transport"
                     /transl_table=11
                     /inferenece="InterPro:IPR003593"
                     /inferenece="InterPro:IPR017871"
                     /inferenece="InterPro:IPR003439"
                     /inferenece="InterPro:IPR005894"
                     /translation="MGGADLAIQTEALKKKYGDKEALAGLDLEVPRGVVYGLLGPNGA
                     GKTTAVRILSTLLKYDEGTARVAGYDVATQSAQVRYSIGLLGQHAAVDEDLSGRQNLV
                     MFGRLYHIGKRNAQARADELLERFGLTEAAGKPAKQYSGGMRRRLDLAASLILAPSVL
                     FLDEPTTGLDPRGRNDVWESVRGLIAEGRTVLLTTQYLEEADQLADRIALIDNGRVVE
                     SGTPDQLKNKIGGDRIDVVLRRAHDLERATHTIGTLLRSEPETDADNRRISVVVDNRV
                     AALTAVARELDDAGIEAEDIALRRPTLDEVFLNLTGNGAATSAEQSLKEVAQS"
ORIGIN      
        1 gaccccagct ggacgacccg cagccgccgg gaggtcgcgg cacagccgtc gaccaggcgc
       61 tccaggaggt cgatgtgggc ccggcgcatc tcctcgacgg tggtgcccca gccgccggtg
      121 gcattgacca ccgcggtgac gccgtaccgg tcgaggagcg cggcgagacg ctccggcgcg
      181 gtcccggcga cgtcgagggg gacgaaggcg tgcgggcggg tgtggggcgc cgggtgccgg
      241 gccaccgcca gcacccggtg cccggtgcgc gacagttcgt cacagacgct gcggccgacg
      301 caccccgtgg cgccgagcac ggccacggtg ccgacggccg ccccgccctg cgtggtggtg
      361 gacatcgccg tgctcagctc gaggcgccga tgccggagga ctgccacagg cgctcctcga
      421 ccgccgcgga ctcggcgtag tcgggcagca gcccctgggc ccgggccgcg gcgaaggaca
      481 gcgccgcggc gtcccgctcc gactgcaccg tgtcgagacc ggcggggagc cgcacgccca
      541 gctcccggtc gaagatgtcg acggcgagct cgttctcggc cacgtacggg cccgtgagca
      601 ggtaggacat gacggtgtcg tcctccagcg cgacgaaggc gtggccgacg ccgaccggga
      661 agtacgaggc acggaagtgg acctggtcca tctcgaccgc gtcccactgc atgaaggtgg
      721 gcgagccgac ccgcaggtcg accacgatgt cgagggctcg gccgcgcgcg cagtacacgt
      781 acttcgcggt acctggtggg gtgacggtga agtggatgcc gcggaccgtg ccgcgccggg
      841 agatgctgtg gttggtctgc gcgaccggga agtgcggccg ccccagcgcc tgctggaacg
      901 cctccagctg gaagggcgag acgaacagcc cgcggtggtc gcggaactga cggggggtga
      961 actcgtaggc accctcgacc ttgagcttac ggatctgcat cgcttggttc accgtccggg
     1021 aggtaggggg gtacggcagg gccggtggcc ccggtgcggg tgtctcgcgc cggtcaccgg
     1081 cggcggtgct cggcggccag gcgctccagc gtggggacga cctgcgcggg ggcgggagcg
     1141 gcgagcgcct cgcgccgcag ggcctcggcg ttgcgcttga agaccggttc ctcgagcagg
     1201 cggacgagca gctcgcgcag tcccttcgcg ctgagcttgc cgggcacgta gagcccggcc
     1261 tggcgccgtt ccaggtagcg ggccttgttg atggtgtccc agacgccgtc gacgacgatg
     1321 agctggggca cggcgtggat catcgccgtg ccgaagctgc ccgacccgcc gtggtggatc
     1381 accgcgtcgc aggtgggcag cagcgcgtcg agcgggacga agtcgacggc ccgcacgttg
     1441 tccggcaggg tgtcgaagtc cttcagctgg ttctcgttga gcgtggcgac gacctcgacg
     1501 tcgtcgagcc ccgcgacggc ctccagcagg tcgccgatgg acgcccggtc ggcgcccagc
     1561 acctcgcggt gcgccacacc cagcgtgatg cacacccggc ggccccgctt cggcggttcc
     1621 tggagccact gcggcacggt ggactggccg ttgtacggca cgtaccgcat cggcacgtag
     1681 tgcaggtcca gcgggaaccg catggacgcc ggcagcgggc agacggtgaa gtcgcccgtc
     1741 accgcggcct cctcgaagga ggcgccgtgc cgctccaggc tccaggtgag ccactcgcgc
     1801 agcgggtcgt cccgcagctc cggcggacgc gccgccagct gctccaggaa ggtctcgcgc
     1861 atcttgcccg ccaggtccat cccgaagagc agccggccgt gcgccgtccc cgtggccatg
     1921 gcggcgatgg cgcccgcgaa ggtcatggtg tcccacagga ccaggtcggg cttccaggag
     1981 cggcagtgct ccaccagctc gtcgaccatc tggtcggagc agcagttctg gaagacgacc
     2041 gaggtcatgg ccgtgaacac accgagtgtg tagtcccagg tgagccgctc cgggcgggtc
     2101 tcgctcatgt cgagaccgac ctgtgcctgg ctctccagct ggtcgacgtc ctggccgatg
     2161 ttctcctggg tctcctgcat ctgctcgtcg agatgcagtt cctccccgac cccgacggcg
     2221 gtcagcccgg tacgggtgat ctcgtcggcg agatcggggt gactggcgat cctgacgtcg
     2281 tggcccgccg ccttgagggc ccaggcgagt gtgacctggg cgtgcatgtg cgacttggcg
     2341 gcgaaggtgg tgaagagtac ccgcatccca acccctgttc cggcgaacga cccgtatgcg
     2401 atgggcctcc accctcgggc cgtgacctcg tgcgggagtc gagagtcgtt gcagcggcgc
     2461 tcgacgcggg gcggccggac gcggtcggtg cctcccgccc tcgcggagaa cagcaggtcg
     2521 tgtactaccg tgggatcagc cggcggggtc cggccgatgc gcggagcacc ggataccggt
     2581 ccgtgccgtg agggagattc agcagggaga cgatgtccgc cacgcgattg ctcgtcctgg
     2641 gggtcgtgcg gatgcacggc cgggcgcacg gctatctggt ccgctccgag ctgttgtcct
     2701 ggggtgccga cgaatgggcg cacatcaagt tcggctcgat ctaccacgcg ctcaggcagc
     2761 tggccaagga cggcctgctg aagtcgaccg acatccccga ctggcccggc cgcgtcgact
     2821 acgagatcgc gcccccgggc gaggaggagt tcttccggct gctgcgcgac gcgctgcgcc
     2881 aggggaacaa ccgaccggac atgctggggg cggcgctcgt cctgctgccg gcgctcagcc
     2941 gcgaggaggc gatcgccctg ttgcgggagc gcatcgcgtc gctctcggcg gagcagggtg
     3001 agctgatcgc gaaggtcgac gagacggcgg gcgagcggcc gcagcgggcc cacatccgcg
     3061 aactcctcgg cctctgggag cacagcgccg cgagccaggc cgcctggacc gaggcactga
     3121 tcgagcgcct ggaggcgggc gcctacgtca tggcggggga ggagaagggc gcctgacggg
     3181 cgggcccttc cggccgttga cgggagttcg gtggatgacc gcgcgcgccc cgtgatactc
     3241 aagtttgcat acccatcgtg cccgtcccga gaggacgacc gctgtgccga tcatgctgac
     3301 ctccgaagac gtggacgacg ccttcgacga cgaggccttc atggaggagc ggttctccga
     3361 cgtccagcga ctgctcctag gccgtgggcc ggcgctcggc cccgagaccc cggtcctgct
     3421 ccccgccacg cactgccggc tgaccgtggg accccacacc tccggcccct tcggccgctg
     3481 cttcgccgtc cgcctcgacc ccggcgccga ccagtccgcc ccgcgcgtgg aactgctgct
     3541 cgccgacgac ggatcactcc tcggcctggt cgacgccggc gccctggacg gctggcgcag
     3601 cgccatcccc tccgggctcg ccgcgcgcta cctcgccccg ccggccccct ccctgctcgg
     3661 cctcttcggc tccggcgaac cggcctggtc ctgcctgctc gtgctgcacc acgcgctgcc
     3721 ctcgctctcc gaggtgcacg tcgtcggccg ggacccggcc caggcccggg acctcgcgac
     3781 ggccgccgcc ctgcgcaccg gcctcagggt gcgcacgtcc gaggacgccc gcgccaccgc
     3841 agcgggcgcc gacgtcgtcg ccaccaccgg cggtcacccg cgcgtccgcg ccgaatggct
     3901 cgcggccggg gcgctcctga tcgaccagac cgccacggcc gccacggcgg ccacggccgc
     3961 gccgaccgcc gccggccccg ccgtcgggca ggtcggcctc gtgcccccgc gcggtcccgc
     4021 cgtacggcag gtcagcctcg tccctccgcg cggccccgcc gaggacaccc ggcacgaacc
     4081 cctgcccctc gccgagatcg tcgcgggccg ggcgctgccc cggcgcagcg gctccgacat
     4141 cgtccactac cagggcgccg aactggccgg ctggagcgcc atcgccgccg ccgcaggact
     4201 cggccacgcc tggcggcggg acgtcggcac ccccgtgcgg ctggggcgcg gcagtccctg
     4261 acccgggcgc gggatccagt cgtcttctag ggcaccgcga ggcacgccac cgagggtttc
     4321 agtccgacct cggcgtacgc gtcgccggac gcccggacga tgaggagcac cgatcccatg
     4381 tcagccgatc agcccggccc cgcctccggc ggcccggcca ccttcgtcaa cagcttcacc
     4441 ctccgcacca ccccggagga gttcgaggac gtcttcgccc gcacggcacg cttcatggag
     4501 cgccagcccg gcttcctcgg ctacaccctc gtacgccacc tggaacagcc gcacagctac
     4561 gtcaacatcg cccgctgggc cgacgtcgcc tccttccgcg ccgcggtcgg ccagagcgac
     4621 ttccggccgc acgccgaggc gctgcgggcg atcagcacca gcagctccaa cctctacctg
     4681 gagcggcgca gcgccaccgg ggaggcgcga tgacccggcg ggtcgtgatc accggcatcg
     4741 gggtggtggc ccccggcggc atcggcacca agcagttctg ggagaccgtc accggcggcc
     4801 gcaccgcgac ccggaccatc agcctgttcg accccgcccc gttccgctcc cggatcgcgg
     4861 ccgagtgcga cttcgacgcc gcggagcagg gcctgagccc cgaggacgcc gaacggctcg
     4921 accgggcggc gcagttcgcc ctggtcgcgc tgcgcgaggc cgtcaccgac agcggcttgg
     4981 agcccgaccc cgacaccgcc caccgcaccg gcgtcagcct cggcagcgcg gtcggctgca
     5041 cccagaaact cgaagaggag tacgtcgccc tgagcggcgg cggacaggag tggctcgtcg
     5101 accacaccgc cgccggcgcg cacctctacg accacttcgt gcccagctcc atggccgccg
     5161 aactcgcctg ggaggccggc gccgaaggcc cctgcaccgt cgtctccgcc ggctgcacct
     5221 ccggcctcga ctcggtcggg cacgcggccg ccctcatccg cgagggcacc gccgacgtga
     5281 tgatcgccgg ggccaccgac gcccccatct ccccgatcac cgtggcctgc ttcgacgcca
     5341 tccgcgccac ctcgccccgc aacgacgacc cggcgaccgc gctgcgcccc ttcgaccgca
     5401 cccgcaacgg cttcgtcctc ggcgagggcg ccgccgtcct ggtcctggag gagctgacgg
     5461 cggcccggcg ccggggcgcc cacgtgtacg ccgagatcgc cggctacgcc tcccggggca
     5521 acgcgtacca catgaccggg ctgcgcaccg acggacgcga gctcgccgcc gccgtcgacg
     5581 ccgccctcga cgaggcccgg ctcgcccccg aggcactcgg gtacgtcaac gcccacggca
     5641 ccgccaccaa gcagaacgac gtgcacgaga cggcggccct caagcgcagc ctcggatccc
     5701 acgcccaccg cgtcccggtc agctccatca agtcgatgat cgggcactcg ctcggcgcca
     5761 tcggctccat cgaggtcgcc gccaccgccc tggccctcga acacggcgtc atcccgccca
     5821 ccgccaacct gaccgacccc gaccccgacc tcgacctgga ctacgtcccc ctgcacgcca
     5881 gggagcggac catgtcggcc gcgctcaccg tgggcagcgg cttcggcggc ttccagagcg
     5941 cggtggtgct gcgccggccc gaggggcggg ccgcatgacc cccgtcgtgg tcacgggcat
     6001 cggcgtcgtc gcccccaccg gcatcggact cgacgcctac tgggcggcga ccctgcgcgg
     6061 cgacgacggc atccggcgcg tgcaggcgtt cgaccccagc cgctatccga cccgccgggc
     6121 cggggaggtg accgggttcg aggcgggcga ccacctgccg agccggctga tcccgcagac
     6181 cgaccgcatg acccagttcg ccctggccgc ggccgactgg gccgtcgccg acgccggcat
     6241 cgacctcgac gcggtgccgt cgctggaacg cggcgtcgtc acggccggtg cctccggcgg
     6301 cttcggcttc ggccagcgcg aactccagca cctgtggggc gagtccccca agaaggtcag
     6361 cgcctacatg tccttcgcct ggttctacgc cgtcaacacc ggccagatct ccatccggca
     6421 cggcatgaac gggccgaccg gcgtcttcgt cggcgagcag gccggcggcc tggacgccct
     6481 cgcccacgcc cggcgccaga tccgcgcggg ggcccggctg atgatctccg gcggcatgga
     6541 ctgctccctg tgcccgtacg gcatggccgc ccagctggcc ggcggacggc tcaccgccga
     6601 cgcctacctg cccttcgacg accaggcctc cggtcatctg cccggcgagg gcggggcgtt
     6661 gctcaccctg gagagcgccg agggggcccg ggcgcgcgga cgcggtcact acggcgagat
     6721 cgccgggttc ggcgccacct tcgacccgcg ccccgggtcc gggcgccccc cggccctgcg
     6781 ccgggccgtc gagcaggcgc tcgccgacgc ccaagccgcg ccggaggaca tcgccgtcgt
     6841 cttcgccgac ggtgccggcg tgcccgaact cgacgcggcc gaggccgcgg cgctcaccga
     6901 ggtcttcggc ccgggaggag tcccggtcac ggtgcccaag acggccaccg gccggctcta
     6961 ctccggtgcc gggccgctcg acgtggtcac cgccctgctg accctgcgcg acgggatcgc
     7021 cccgcccacg gtcaacgtct cgcgggtgcc cgacacgtac ggcctcgacc tcgtcctcgg
     7081 acggccccgg ccggtctccg gcacggcggc cctggtcctg gcccgcggcc accacggctt
     7141 caacagcgcc ctggtcgtcc gggcccccgc gcccggcgac gccgtcgcgc accggcccga
     7201 ggagaggacg gcggcgtgaa cgacggcgcg ttgtacatca gggccaccgg gacgtggctg
     7261 cccccggccg aacgggtcgc ggacgcggtc gcggacgggc gctgcgaggc cgccgtcgcc
     7321 cgctccaccc ggatggagtc ggtgacggtc tccgcgggcg agcccgcccc cgagatggcg
     7381 gcccgggccg cccggaccgc gctggagcgg gccgccgccg aaccgggcga catcgacctg
     7441 gtgctgcacg ccagcttcta ctaccagggc ttcgacctgt gggcccccgc ctcgtacgtc
     7501 cagcgggccg ccgtcggcaa ccagtgcccg gcgatggaga tccggcaggt ctccaacggc
     7561 ggcatggcgg cactcgatct ggcctgggcc tacctggccg ccgacccggc ccgggtggcg
     7621 gccctgctga ccaccgggga ccggttctgc ccgccggggt tcgaccggtg gcgcagcgac
     7681 ccgggaaccg tctacggcga cggcggcacc gccctcgtgg tgtcgcggca ctccgggttc
     7741 gcccgggtcc gcagcatcgc gaccgtgtcc gcacccgacc tggagggcat gcaccgcggc
     7801 gacgacccgt tcgggcccgc cccgttcagt caccgcgacg tcgtcgacct cgacgcgcac
     7861 aagcgggact tcctggcccg ccacggcgtg gcgccgaccg tggcccgggt cgccgcggcg
     7921 caggaggccg tcgtcaagca ggcgctcgcc gacgccgggc tgggcctcgc ggacatcgac
     7981 cggttcgtcc tgccgcacct gggtcaccgc cgcctgcacg tcgcgtactt cgcgaagttc
     8041 ggcatcgacc ccgcgcgcag cacctggtcc tggagtcgga cgatcgggca cctgggcgcc
     8101 ggagacccct tcgccgggct cgaccacctg gccaccgccg gggagctcgg cccgggtgac
     8161 acgtgcctgc tcttcggcgt cggcgccggc ttcagctggt cctgcgccgt ggtcgagatc
     8221 ctcgacgcac cttcctggag ggaccgatga acgacgtccg cacggcagcg gacgggcggg
     8281 acggcggtac gcgcccggtc gccctgctgc tgcccggcca gggagcacag cacccgcgca
     8341 tggcggcggg cctcctggcc gccgagcccg tcttcgcgga ggcgatggac gaggccctga
     8401 ccgccctggc ggacgccggt gggccgggcg gccacggcac cggcctgcgc gaggactggc
     8461 tcgggtcccg cgacaccgcg ctgatggacc acgtcacgcg ctcccagccc ctgctcttcg
     8521 cggtggacta cgccatcggg cggctcgtgc tcggctgggg cgtgcggccc gtcgccctgc
     8581 tcggccacag catcggcgag gtggcggccg cggtcctctc cggcgtcttc acgctgccgg
     8641 acgccgccgc catggtgcac gaccgcgtcg cccggctggc ggacgcgccg cccggcggga
     8701 tggtcgccgt cgccgccacc cgggaggagg tggcgccctt cctcaccgac ggcgtggtcg
     8761 tcggcgccgt caacgccccg cggcagacgg tcctggccgg actcgacggc ccgctgcgca
     8821 ccgtcacggc ggcactggcc gacgccgggt tcgtgctcca gcgcgtaccc gcctccacgg
     8881 cgttccacag ccccgccctc gccccggcga tgcgcggtgc cgacgagcgg atcgccgccc
     8941 tgcccgtcgg cgagccccgg atcccggtca tgtccgggta cacgggccgg ttcctgacgc
     9001 ccgcggaggc gaaggacccg gccttctgga gcaggcagcc ggtggcgccg gtgctgttct
     9061 ggcccgccct cgacgccctc ctcgcccagg gcgacccggt gctcgtggag gccggtccgg
     9121 ggcaggggct gtcgcagctg gcccgccgcc acccggccgt gcgctccggc cgctccgccg
     9181 tcgtcccgct gctgccggcc cggccgggaa ccgccgagga cgacgtgacc gccgtacgcg
     9241 ccgccgccgc ggcgctacgg gaacgcgccg gcgtaccgga cgcgcggccc gtgtagcgcg
     9301 tgtcgagtgc ctttgtaggc acgcggccta gcgtcgcccg tggcgcttcg ccccttcctc
     9361 gtccgccgga tccacggccc tccgccggat ccgcgggcct ccctcacctt gtcaggactc
     9421 ttctcccaag gacggtgtca tgctgaccga tcagaccaac agcgagttgg gccggcatct
     9481 gctgaccatc cgaggcgtcc agttcatctt cggcgcccag ggcgacccct tcgccatgat
     9541 cctgcgcgcc ggggacgacg accccctcga ccacggggcg cgcgcccgcg aacagggcct
     9601 gcacgagagc agcatcggcg cgtgggtcac cgcgcaccgc gagctcggcg cccggatcct
     9661 cggcgacgag cggttctccc cgcgccacgc cgaggagggg ccgcaggccc acccgggtgt
     9721 cgacgtctgg gacaaccccc tgctgtgcca cgtcgtcccc ctcgacgacg cccagctcaa
     9781 ccgcgatccg gccgactacc gcgcgctggc ccgggccgcg gccccgctgc tgtcggccga
     9841 ggcgctcgcc gcgcggctgc cggagatcga ggcggcctac cgccaggcgc tcgccgcgac
     9901 cggcgaacgg ttcgacctgt accgggacgt cgccgtcccg gccgcgctgc gcgtggtggc
     9961 cgacgtgctc ggcctgcccg aggagacgcg gcagcgcctg cccgaactgc acgcgggtct
    10021 cgccaccgcc ctggacgccg gccactgccc gcagcaactg gcggccgccc gggcgctgtt
    10081 cacggccgtg acggacctct ccaccgagct gacccgcctg gtcggcagcg gccgcgccac
    10141 cggcctcgcc gcgctcgacg gcgtgtcgcc cgaggacgcg gtcgccgtcg ggacgctcgc
    10201 cgtcgtggtg ggcgtcgagg tcaccgcgac cgccgtgtgc aacgcggtgc gggtcctcct
    10261 ggaccaccgc gaggagtggg agcggatcgg gcgggagccc gaacgggccg gcgccgcggt
    10321 ccgcgaggcc ctgcggctgg ccccgccgct gcggttcgag agccgtatcg cgcgcgagca
    10381 ggccgagttc gacggcaaga ccgtcgagga gggccggcgc gtcgtggtgc tcgtcgacgc
    10441 ggccaaccgc gacccggagg ccttcgccga cccggacgcc ttcgtccccg gccgcgccga
    10501 cggcgaccgg tcgctcaccc tgctcggcgg ttccgccgcc ccggtcaccg aggcgctggt
    10561 ccgcctccag acggaagccg cggtgcgcgt cctcgccgag ctgcggcccg gcctgcgcac
    10621 gggcgccgag gtgctgcacc gcatgcgctc ggcggtgctg cgcggcgtcc tgcgcttccc
    10681 ggtcgcatga ccggaccgac catcaccagg ggaggagcac ctcggtgcgt gtactgctga
    10741 cagccttcgc acaggacgcc catctcaacg gcatcgttcc gctcgcctgg gcgctgcgga
    10801 ccgccgggca cgaggtccgg gtggccggcc agccggccgc ggtcgagagc atcacccggg
    10861 ccggtctgac ggccgtgccg gtgggcgacg accaccggat ggacgccgtc atccccaccg
    10921 tcggtcccgg gatgctcatg caccacctgg accgcgacta cctggagaac cgcccggagc
    10981 ggctgagcct cgacttcctg cgggcgtcga acgcgatgct gacggcgacc ttctacgcgc
    11041 agatcaacaa cgactcgatg atcgacgcgc tcgtcgacta cgcccggttc tggcagccgg
    11101 acctggtgct ctgggagccc ttcaccttcg ccggcgccgt cgccgccaag gcgaccgggg
    11161 ccgcccacgc ccggctcctg gccttccccg acctgttcgc gaacacccac ctgacgctgc
    11221 gccggcggca ggcggaactg cccgcggaac tgcgcgacga cccgctggag gagtggctgg
    11281 cgtacaccct cgaccggcac ggcgccgcct tcgaccccga cgtggtcacg gggcagtggt
    11341 cggtcgacca gatgcccccc ggcgtgcgga tggagctggg gctgccgacg gtgcccacgc
    11401 gttacgtgcc gtacaacggt ccgggtccgg ccgtcgtgcc ggactggctg cgccggccgc
    11461 cggagcgccg ccgggtctgc ctcaccctcg ggctcaccat ccgggacacg gagttcccca
    11521 acgccgtcga cgtcgacgac gtcttcgcct cgctggccga cctggacgtc gaggtggtgg
    11581 cgacgctgag cgagaaggaa ctcgcccagg tgtcgcgggt gccggacaac acgcgggtgg
    11641 tcgaccacgt ggccctgctg gccctgctgc ccagttgctc ggcgatcgtc caccacggcg
    11701 gtgccgggac gtgggcgacc gccgccgcgt acggggtgcc gcaggtggcg ctcggctgga
    11761 tgtgggacgc gatctaccgc gcgcagcggg tggaggagct gggggcgggg ctgcacctgc
    11821 actccgaggg cctgaccgtc gaggtcctgc gcgacaagct cgtgcgggtg ctcgacgacc
    11881 cctcgttcac ggaaggcgcc cgacggctgc gtctggccat gctgtcggcg ccgagcccca
    11941 acgaagtggt gcccacactc gagaaactga cggcgcgtca ccgctcggtg gccgcggccc
    12001 gctgactgag acgaggacgg gagaaccgtg aacatcctgg tgaccggtgc ggccggcttc
    12061 atcggctcgc acttcgtcag aacgctgctg agcggcgggt accccgggca cgaggacgac
    12121 cgggtgaccg tcctggacaa gctcacctac gcggggacgc tgaacaacct gccggcgcac
    12181 cacccgcggc tgaccttcgt gcacggcgac atctgcgaca ccaccctgct ggacaaggtg
    12241 ttcccgggcc acgaggcggt cgtccacttc gccgcggagt cgcacgtcga ccgctcggtg
    12301 gcgggcgccg aggccttcgt ccgcaccaac gtgctcggca cgcaggccct gctcgaagcg
    12361 gcgctgcggc acgggatcgg cgtcttcgtc caggtctcca cggacgagac gtacggttcc
    12421 atcgccgagg ggcgctggac ggaggacgag ccgctgctgc ccaactcgcc ctacgcggcg
    12481 tccaaggcgt cggccgacct catcgcccgg tcgtactggc gcacccacgg cctcgacgtg
    12541 cgcatcaccc gctgcgccaa caactacggc cccggccagc accccgagaa gctggtcccg
    12601 ctgttcgtca cccggctcct cgacgggcag ccggtcccgc tgtacgggga cggctcgaac
    12661 ctgcgcgagt ggctgcacgt ggacgaccac tgccacgcgg tgcggctggt gctggaccgg
    12721 ggccggccgg gggaggtcta caacgtcggc ggcggcaccc acctgaccaa caaggagatg
    12781 accggccgcc tcctcgcact ctgcggacgc gactgggacc tcgtgcggcg ggtggcggac
    12841 cgcaaggggc acgacttccg gtacgccgtg gacgactcca agatccgccg cgaactgggc
    12901 tacgcgcccc gctggtcgct cgaggacggg ctgcgcgaga cggtcgagtg gtacgccgcc
    12961 caccgtgacc actgggacgc ccgggaggaa ggcgccgacg aggggtacta aaacttgaat
    13021 atccgggccg ccctcctcta cgctcgccgg gtacacaaat ttgagcaccc gaaagaaggg
    13081 gcgggcatgg gcggcgccga cctggcgatc cagaccgaag ctctgaagaa gaaatacggc
    13141 gacaaggagg ccctcgcggg actcgacctg gaggtacccc gaggcgtcgt ctacgggctc
    13201 ctcggcccga acggcgccgg aaagaccacc gcggtccgca tcctctccac cctgctgaag
    13261 tacgacgagg gaacagcccg ggtcgccggc tacgacgtcg ccacccagtc ggcccaggtc
    13321 cgctacagca tcggactcct cggccagcac gccgcagtgg acgaggacct gagcggccgt
    13381 cagaacctcg tgatgttcgg gcgcttatac cacatcggta aacgcaacgc ccaggcccgg
    13441 gccgacgaac tgctggagcg cttcggcctc accgaggccg ccggcaagcc ggccaagcag
    13501 tactccggcg gtatgcgccg gcggctcgac ctcgccgcca gcctcatcct ggccccgtcc
    13561 gtgctgttcc tcgacgagcc caccaccggg ctcgacccgc ggggccgcaa cgacgtctgg
    13621 gagtccgtcc gaggcctgat cgccgagggc cgcacggtcc tgctgaccac ccagtacctg
    13681 gaggaggccg accagctcgc cgaccgcatc gccctgatcg acaacggcag ggtcgtcgag
    13741 tccggcaccc cggaccagct caagaacaag atcggcgggg accggatcga cgtcgtcctc
    13801 cgccgcgccc acgacctcga acgcgccacc cacacgatcg gcaccctgct gcgctccgag
    13861 cccgagacgg acgccgacaa ccggcgcatc agcgtcgtcg tcgacaaccg ggtcgccgcc
    13921 ctcaccgccg tcgcccgcga actcgacgac gccggcatcg aggccgagga catcgccctg
    13981 cgcaggccca ctctcgacga ggtgttcctg aacctgaccg gcaacggggc ggccacgtcc
    14041 gccgagcaga gcctcaagga ggtcgcccag tcatgaccgc
//
