LOCUS       Griseusin            5364 bp	DNA     linear     16-Jan-2013
DEFINITION  Griseusin biosynthesis cluster
ACCESSION   Griseusin
VERSION
KEYWORDS
SOURCE      Streptomyces griseus
FEATURES             Location/Qualifiers
     source          1..5364
                     /organism="Streptomyces griseus"
                     /mol_type="genomic DNA"
                     /strain_name="K-63"
                     /db_xref="taxon:1911"
     CDS             190..1458
                     /locus_tag="Griseu_00010"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /note="original product:ketosynthase"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR018201"
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR014031"
                     /translation="MERRAVITGIGVCAPGGTGVDSFWELMCDGRTATRGITLFDPSP
                     YRSRVAAEIDFDPRAHGLTPQEIRRMDRAAQFGVVTAREAFADSGLDGAALDPFRTGV
                     SLGTAIGAAGGLDAEYRVVSDDGRLELVDHRYATPHLYDLFVPSSFATEVAWAVGAEG
                     PATVVSTGCTAGIDAVGHAVEAIRDGSADVMVTGAVDAPITPLTMAAFDAIRATTSLN
                     DEADTASRPFDASRKGFVLGEGAAVFVLEEAEHARRRGAYVYAEIAGYASRGNAFHMT
                     GLRSDGAELAAAIRAALDEARLDASAVDYVNAHGSGTRQNDRHETVALKSALGQHAHR
                     VPVSAIKSMVGHSLGAIGSIEIAACALAMRHHVIPPTANLHTPDPECDLDYVPLTARA
                     QRTDAVLTIGSGFGGFQSAMVLARPDRSAA"
     CDS             1455..2693
                     /locus_tag="Griseu_00020"
                     /product="polyketide synthase chain length factor subunit"
                     /note="original product:putative chain length
                     determination factor"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR016039"
                     /translation="MSAPGGGDRGRTLITGMGLATPHGVDVEDFWAATRVGKNAIGPV
                     TRFDASGYPARLAGEIRGFSAADHLPGRLVAQTDRVTQLALVAADRAFRDAGVAPGDL
                     PANGMGVVTAAGSGGFEFGERELRKLWSLGANHVSAYQSFAWFPTANTGQIAIRSDSR
                     GPNGVVVGDQAGGLDALGQARRLIRRGTGLVAAGGFEASLTPLGWTARLSTGLMSTSD
                     DPDRAYLPFHPAARGYVPGEGGALLILEDERSALARGAATAHAELAGYSATLDPRPGS
                     GREPGLRRAIELALADAGVAPAEVDVVFADAAGSPEPDAVEVAAVAGVFGPRAVPVTA
                     PKTMIGRLQAGGAPVDVVTAVLAIREGLIPPTADAESATARELDLVVGRPRTASVGTA
                     LVLARGHGGFNSAVVLRAVD"
     CDS             2809..3078
                     /locus_tag="Griseu_00030"
                     /product="polyketide synthase acyl carrier protein
                     subunit"
                     /note="original product:acyl carrier protein"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR009081"
                     /inferenece="InterPro:IPR006162"
                     /translation="MSKQEFTLEDLKRILLEGAGADEGVDLDGDILDTDFEELGYESL
                     ALLETGGRIEREYGITLDDDVLADSRTPRSLIAAINAAFQGLVEA"
     CDS             3201..3986
                     /locus_tag="Griseu_00040"
                     /product="putative polyketide C-9 ketoreductase"
                     /note="original product:ketoreductase"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR002198"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR002347"
                     /inferenece="InterPro:IPR020904"
                     /translation="MSDQDKRVAVVTGATSGIGLSVARLLASQGHRVFIGARSAENVA
                     ATVKELVAEGLDVDGAVVDVRSDADVEAWIQAAVDRFGTVDVVVNNAGRSGGGVTADI
                     DPELWHDVIDTNLNSVFRVTRSALNTGGLRSKSRGRIINIASTAGKQGVVLGAPYSAS
                     KHGVVGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRQGYAAAYDATEDAILEKFQ
                     AKIPLGRYSTPDEVAGLVGYLASDTAASITSQALNVCGGLGNF"
     CDS             4051..5010
                     /locus_tag="Griseu_00050"
                     /product="cyclase/dehydratase"
                     /note="original product:putative cyclase/dehydrase"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR019587"
                     /inferenece="InterPro:IPR023393"
                     /translation="MSQPGLREVEHEITVSAPAAAVYRLIAEVRNWPRIFPPTIYVDH
                     VEENGDEERIRIWATANDEAKNWTSRRTLDPEGLRITFRQEVPAPPVAAMGGAWIIEP
                     LGDAESRIRLLHDYRAVDDDPAHLEWIDQAVDRNSRSELAALKGNVEKAHAEEGLTFS
                     FEDTVRVDGAAKDVYDFVNEADLWHERLPHVATVRLREDTPGLQELEMDTRAKDGSTH
                     TTKSYRVTFPHQRIAYKQTTLPALMTLHTGYWTFAEDDRGVLASSQHTVTINTANIAR
                     VLGPEATVEDAKAYVHTALSTNSTATLNHAKRFAEERAAGRRG"
ORIGIN      
        1 ggatccagaa ctcccgcaac gatccgcgct tcgtgcagat cagccatgaa ctcaagccgt
       61 tcatcgagcc gtacgacccg gagacctggc ggacgccggc cgacgcgatg gccacgcgct
      121 tctacgactg gtcggcaggc gagtgacctc ggcacggcac cgcaccggac cggaaggagg
      181 acggcagcag tggaacgccg ggcagtgatc acgggaatcg gtgtgtgcgc accgggcgga
      241 accggtgtgg acagcttctg ggagctgatg tgcgacggcc ggacggccac ccgcggcatc
      301 accctcttcg acccgtctcc gtaccgctcc agggtcgccg ccgagatcga cttcgacccg
      361 cgggcgcacg ggctgacgcc gcaggagatc cggcggatgg accgggccgc gcagttcggc
      421 gtggtgacgg cacgggaggc cttcgccgac agcgggctcg acggcgccgc gctcgatccg
      481 ttccgtacgg gagtcagcct cggcaccgcg atcggcgcgg ccggcggcct ggacgcggag
      541 taccgcgtgg tcagcgacga cggccggctg gagctggtcg accaccggta cgcgaccccg
      601 catctgtacg acctgttcgt gccgagctcc ttcgcgaccg aagtggcctg ggccgtcggc
      661 gcggaaggac cggcgacggt ggtgtccacc ggctgcaccg ccgggatcga cgcggtgggc
      721 cacgcggtgg aggcgatccg cgacggcagc gccgatgtga tggtcaccgg cgcggtggac
      781 gcgccgatca ccccgctcac gatggcggcc ttcgacgcga tccgcgccac cacgtccctc
      841 aacgacgagg cggacaccgc ctcccgcccc ttcgacgcgt cacgcaaggg cttcgtcctc
      901 ggtgaggggg cggcggtgtt cgtcctggag gaggcggagc acgcacggcg cagaggcgcg
      961 tacgtgtacg cggagatcgc cggatacgcc tcgcgcggca acgccttcca catgaccgga
     1021 ctgcggtccg acggagcgga gctggccgcc gcgatccggg cggcgctgga cgaggcccgg
     1081 ctcgacgcgt cggcggtgga ctacgtcaac gcgcacggtt ccggcacccg ccagaacgac
     1141 cggcacgaga cggtcgcgct caagtcggct ctgggacagc acgcccaccg ggtgccggtc
     1201 agcgcgatca agtcgatggt cgggcactcg ctcggggcga tcggctccat cgagatcgcc
     1261 gcctgcgcac tggccatgcg gcaccacgtc atccctccga ccgccaatct gcacaccccg
     1321 gatcccgagt gcgatctcga ctatgtcccg ctgacggccc gcgcgcagcg caccgatgcc
     1381 gtcctcacca tcggcagcgg attcggcggc ttccagagcg cgatggtgct ggcccgtccc
     1441 gacaggagcg ccgcgtgagc gccccgggcg gcggcgaccg cggccgcacg ttgatcaccg
     1501 gcatgggact ggccacaccg cacggcgtcg acgtggagga tttctgggcg gcgacacggg
     1561 tcggcaagaa cgccatcgga ccggtcaccc ggttcgacgc gtccggctac ccggcgcggc
     1621 tggcgggaga gatccgcgga ttctcggccg cggaccatct gccgggccgg ctggtggcgc
     1681 agaccgaccg ggtgacccaa ctggccctgg tcgccgcgga ccgcgcgttc cgggacgccg
     1741 gggtggctcc gggcgacctt cccgcgaacg ggatgggcgt ggtcacggcg gccggttccg
     1801 gcggtttcga gttcggcgag cgggagttgc gcaagctctg gagcctcggc gcgaaccacg
     1861 tgagcgccta ccagtcgttc gcctggttcc cgaccgccaa caccggccag atcgcgatcc
     1921 gcagcgacag ccgcggaccg aacggcgtgg tcgtcggcga ccaggccggc ggcctcgacg
     1981 cgctcggaca ggcccggcgg ctcatccgcc gcggcaccgg actggtcgcc gcgggcggct
     2041 tcgaggcgtc gctgacaccg ctcggctgga cggcacggct gtcgaccgga ctgatgtcga
     2101 ccagcgacga tcccgaccgc gcctatctgc cgttccatcc ggcggcgcgc ggctacgttc
     2161 ccggcgaggg cggcgcactg ctgatcctgg aggacgagcg cagcgccctg gcccgcggcg
     2221 cggccaccgc ccacgccgaa ctggccgggt acagcgcgac gctggatccg cgccccggca
     2281 gcgggcgcga gcccggtctg cggcgcgcca tcgaactggc gctggcggac gccggcgtcg
     2341 caccggccga ggtggacgtc gtcttcgccg acgccgccgg ctcaccggag ccggacgcgg
     2401 tggaagtggc ggccgtggcc ggtgtgttcg gaccgcgcgc ggtgccggtc accgcgccga
     2461 agaccatgat cggccggctc caggcgggcg gcgccccggt ggacgtggtg accgccgtcc
     2521 tcgccatccg cgaaggcctg atcccgccga ccgccgacgc ggagtccgcc acggcccgcg
     2581 agctggacct ggtcgtcgga cggccccgga ccgcctcggt cggcaccgcg ctggtgctcg
     2641 cgcgagggca cggcggattc aactcggccg tcgtgctgcg ggccgtcgac tgaggcgccc
     2701 gccaccccga agaccgcgcc cgcggccgtc tccccccgga cggtccgcgg gcgcctcatt
     2761 tcacccgtgg cccgtccggg cgtacgggag tcaaggaagg gatcgaccgt gtccaagcag
     2821 gagttcaccc tcgaagacct caagcgcatc cttctggaag gcgccggcgc ggacgagggc
     2881 gtcgacctcg acggcgacat cctcgacacc gatttcgagg aactcggcta cgagtcgctg
     2941 gcgttgctgg agaccggcgg ccggatcgag cgcgagtacg ggatcacgct cgacgacgac
     3001 gtgctcgccg acagccgcac gccgcgctcg ctgatagccg ccatcaacgc cgcgttccag
     3061 ggcctcgtcg aggcctgagc ccccctcgcg ccaccgcacc accacccctc tgtccggcgg
     3121 ggccgccgcc gcacctgtgc gcgacggccc cgccgaggcg taacagccca ctcttctctt
     3181 cttgttggga gaccagaaac atgtcggatc aggacaagcg cgtcgccgtc gtcaccggag
     3241 ccaccagcgg catcggactg tccgtcgcgc gcctgctggc ctcacagggc caccgtgtgt
     3301 tcatcggcgc gcgcagcgcg gagaacgtcg ccgcgaccgt caaggagctc gtggccgagg
     3361 gcctcgacgt cgacggcgcg gtggtggacg tccgcagcga cgccgatgtc gaggcctgga
     3421 tccaggccgc cgtggaccgc ttcggcaccg tcgacgtcgt cgtcaacaac gcgggccgct
     3481 ccggcggcgg cgtcaccgcg gacatcgacc cggagctgtg gcacgacgtc atcgacacca
     3541 atctcaactc ggtcttccgc gtcacgcgtt cggcgctgaa caccggcggc ctgcggtcca
     3601 agagccgcgg ccggatcatc aacatcgcct ccacggccgg caagcagggt gtggtgctcg
     3661 gtgcgccgta ctccgcgtcc aagcacggcg tggtcggctt caccaaggcg ctcggcaacg
     3721 agctggcgcc gaccggcatc accgtcaacg ccgtctgccc cggatacgtc gagacgccga
     3781 tggcgcagcg cgtgcggcag gggtacgccg cggcgtacga cgccaccgag gacgcgatcc
     3841 tggagaagtt ccaggcgaag atcccgctcg gccgctactc cacgccggac gaggtcgccg
     3901 gactcgtcgg ctacctggcc tcggacaccg cggcctccat cacctcgcag gcgctcaacg
     3961 tctgcggcgg actcggcaac ttctgagccg taccgatccg ggccgaagcg gtccggtacc
     4021 cacccgacac gaccaccgag gagtacgagc atgtcgcagc ccggcctgcg cgaggtggag
     4081 cacgagatca cggtctccgc tcccgccgcc gccgtctacc gtctgatcgc cgaggtccgc
     4141 aactggcccc ggatcttccc gccgaccatc tacgtcgacc acgtcgagga gaacggcgac
     4201 gaggagcgca tccgtatctg ggccacggcc aacgacgagg ccaagaactg gacctcgcgc
     4261 cgcacgctgg acccggaagg cctgcggatc accttccgcc aggaggttcc ggcgccgccg
     4321 gtcgccgcca tgggcggcgc ctggatcatc gagccgctcg gcgacgccga gtcacggatc
     4381 cgtctgctgc acgactaccg cgcggtcgac gacgacccgg cgcacctgga gtggatcgac
     4441 caggcggtcg accgcaactc ccgctccgaa ctggcggccc tgaagggcaa cgtcgagaag
     4501 gcgcacgccg aggaggggct gacgttctcc ttcgaggaca cggtgcgggt cgacggtgcg
     4561 gcgaaggacg tctacgactt cgtcaacgag gccgacctgt ggcacgagcg gctgccgcac
     4621 gtcgccaccg tacggctgcg cgaggacact cccggcctcc aggagctgga gatggacacc
     4681 cgggccaagg acggctcgac ccacaccacc aagtcgtacc gggtgacctt tccgcaccag
     4741 cggatcgcct acaagcagac cacgctgccg gcgctgatga ccctgcacac cggctactgg
     4801 accttcgccg aggacgaccg gggcgtgctg gcctcctccc agcacacggt caccatcaac
     4861 accgccaaca tcgcccgcgt cctcggcccg gaggccaccg tcgaggacgc caaggcgtat
     4921 gtgcacaccg cgctgtccac caacagcacg gccacgctga accacgccaa gcggttcgcc
     4981 gaggagcgtg ccgcgggccg gcggggctga ccgtgccgga ggacgacgac gcgcggatcg
     5041 tcgtggtcgg cgcgggcccg gtcgggctgc tgctcgccgg gctgctgcgc cggtccggcg
     5101 cggacgtggt cgtcctcgaa cagctcaccg cgcccaccac cgagtcccgc gcctccaccc
     5161 tgcacgcccg caccatggag atcctcgacg gctgcggtgt gcgggaccgg ctgggcgcgg
     5221 tggagcgcga gccgcgcggg cacttcggcg gcatcggcct cgacctgacg ctgcccgtcc
     5281 cccgtccggg ccagtggaag gtgccgcaga cgcggctgga ggaggtgctc gcgcggtggg
     5341 cacgggagct cggtgtgcgg atcc
//
