LOCUS       Jadomycin B            30636 bp	DNA     linear     22-Dec-2016
DEFINITION  Jadomycin B biosynthesis cluster
ACCESSION   Jadomycin B
VERSION
KEYWORDS
SOURCE      Streptomyces venezuelae
FEATURES             Location/Qualifiers
     source          1..30636
                     /organism="Streptomyces venezuelae"
                     /mol_type="genomic DNA"
                     /strain_name="ISP5230"
                     /db_xref="taxon:54571"
     CDS             complement(1..48)
                     /locus_tag="Jado_00005"
                     /product="TetR family transcriptional regulator(fragment)"
                     /note="product synonym:gamma-butyrolactone
                     receptor(fragment)"
                     /gene="jadR3"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
     CDS             195..1124
                     /locus_tag="Jado_00010"
                     /product="putative gamma-butyrolactone biosynthesis
                     enzyme"
                     /note="original product:JadW1"
                     /note="product synonym:putative regulatory protein"
                     /note="original gene:jadW1"
                     /note="category:4.6 biosynthesis of butyrolactone"
                     /transl_table=11
                     /inferenece="InterPro:IPR005509"
                     /translation="MHTTSRGEFVHRADPADIIPTDWTQLRQNRFSVSARVACLRSLL
                     LSRAGARHDPMLVAETIPETSMLVAHAELGVPLDEQFVMWDLSYSADSEALTVDGLSS
                     DVTVDVVCSDITRRGSRLRNLRTTVVLTRDDRLLATGSGTARCTSALAYRRMRGERME
                     ALGRPVPLIPGVHPRLVGRARTEDVVLAPGNRPDQWQLRVNTAHTTLFRRPNDHVPGM
                     VLLEAARQAATATTGSAAYLPTDLSVSFLRYVELDSPCWIEAESVPTPDPSTTTIRVT
                     GHQDGSPVFRCTLTSPSRELSVATAGLDTRLAG"
     CDS             1139..2086
                     /locus_tag="Jado_00020"
                     /product="hypothetical protein"
                     /note="original product:JadW2"
                     /note="original gene:jadW2"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
                     /inferenece="InterPro:IPR016040"
                     /translation="MGPRILITGATGFIGGRVAAAAATAREPAHVRLLARGPLTGPAA
                     AAGPRTETAVGDLRDPASLRRACEGVDVLIHCASAIGGDAELARAVNDEGTRNLVDAA
                     VRAGATRIVGPEHRLRTRRGPFRAAAPGTLPLAPGSVTSSTRAAGERHVMDAGGTVLR
                     PHLVYGTGDRRLLPGLVRLLAALPGPLDGGSSLHSLIDVDSLAGALLGAALSPATEPG
                     PYYVDHPEPVPVGDLLAAAESLLTRTGLPRGRAVDLPTARRLLAGLPFAGHHLDMLAT
                     DHWFADDRPWRELGCDPGPGLPRGSRTTRRGTTDSSTIP"
     CDS             2109..2873
                     /locus_tag="Jado_00030"
                     /product="putative C-6 ketoreductase"
                     /note="original product:jadW3"
                     /gene="jadW3"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR020904"
                     /inferenece="InterPro:IPR002347"
                     /inferenece="InterPro:IPR002198"
                     /translation="MSALAGRTAIVTGASRGIGRGIAERLATDGALVAVHYGSNEKAA
                     LETVEIIEGRGGRAFAFRAELGAPDAVDTFYAALDAGLAERGAAREFDILVNNAAASG
                     SGRIHQLTTEVFDRLFAINVKAPLFLVQRGLDRLRDGGRIVNISSAATKHAFPDSVTY
                     AMTKGAVDTMTLALAKELGPRGITVNAVAPGYIATDMNARRRATPEASAALAAMSVFN
                     RIGTPAADVGRGRFPVSDEARWITGQYVDATGGTAL"
     CDS             complement(2953..3543)
                     /locus_tag="Jado_00040"
                     /product="TetR family transcriptional repressor"
                     /note="original product:JadR2"
                     /note="original gene:jadR2"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR001647"
                     /inferenece="InterPro:IPR011075"
                     /inferenece="InterPro:IPR009057"
                     /inferenece="InterPro:IPR015893"
                     /translation="MTKQERATRTRDALIKSAAREFDEHGYALAKLSAISSGAGVSPG
                     ALHFHFENKVAAAVEIDASTTLRRTARIVYHQRSNALQNLADTTHALARLVREDVVVR
                     AGFRLSCSQLCGTDLNLRQEWQSCVQQRLAEAADEGLLASDIGGQQDLARTIVAATIG
                     LEALCRDNGEWLSPGTVTGLWRTLLPIVAAPGRSPP"
     CDS             4113..4892
                     /locus_tag="Jado_00050"
                     /product="transcriptional regulator"
                     /note="original product:JadR1"
                     /note="original gene:jadR1"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR001867"
                     /inferenece="InterPro:IPR001789"
                     /inferenece="InterPro:IPR011991"
                     /inferenece="InterPro:IPR011006"
                     /translation="MSLTSVEVKEPHIPAPRLAGRASLSGVSVDTSARGGPVTAAGWR
                     VLVVESCGKEGEGLVQGLRRHGHEVDRVETGGAALQAYEEADLVLIDLELPDLDGLEV
                     CRGIRSAGDVPVIAVTSRGSELDRVLGLQAGADDYLVKPYGFRELMARMEAVMRRARP
                     RPSTARTITRGPLHIDAAARQVTLDGQDVDLTRKEFDLLYLLASHPDTVIPRKQLMQQ
                     VWGDSWSRRTVDTHVSSLRNKLGASDWVITIRGVGFRFGRG"
     CDS             6401..8155
                     /locus_tag="Jado_00060"
                     /product="putative acyl-CoA carboxylase alpha subunit"
                     /note="original product:JadJ"
                     /note="original gene:jadJ"
                     /note="category:2.1 modification addition of extender
                     units"
                     /EC_number="6.4.1.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR000089"
                     /inferenece="InterPro:IPR013816"
                     /inferenece="InterPro:IPR011761"
                     /inferenece="InterPro:IPR011764"
                     /inferenece="InterPro:IPR005481"
                     /inferenece="InterPro:IPR011054"
                     /inferenece="InterPro:IPR016185"
                     /inferenece="InterPro:IPR005479"
                     /inferenece="InterPro:IPR013815"
                     /inferenece="InterPro:IPR005482"
                     /inferenece="InterPro:IPR011053"
                     /inferenece="InterPro:IPR001882"
                     /translation="MRKVLIANRGEIAVRVARACRDAGIGSVAVYAEPDRDALHVRAA
                     DEAFALGGDTPATSYLDMAKVLQAAADSGADAVHPGYGFLSENAEFAQAVLDAGLTWI
                     GPPPQAIRDLGDKVAARHIAQRAGAPLVAGTPDPVSGADEVVAFAEEHGLPIAIKAAF
                     GGGGRGLKVARTLEEVPELYDSAVREAVAAFGRGECFVERYLDKPRHVETQCLADQHG
                     NVVVVSTRDCSLQRRHQKLVEEAPAPFLSEAQNAELYAASKAILKEAGYVGAGTVEFL
                     VGTDGTISFLEVNTRLQVEHPVTEEVTGIDLVREMFRIADGEELGYGDPEIRGHSFEF
                     RINGEDPGRGFLPAPGTVTEFTPPTGPGVRLDAGVESGSVIGPAWDSLLANVIVTGAS
                     REQALQRAARAVAEFRVEGMATAIPFHQAVVTDPDFTADPFRVHTRWIETEFVNEIKP
                     FAPAGEADEDEAGRETIVVEVGGKRLEVSLPSSLGMTLARTVLRRVPKPKRRASKKVR
                     ASAASGDTLASPMQGTIVKVAVEEGQEVKEGDLIVVLEAMKMEQPLNAHRSGTVKGLT
                     AEVGASVTSGATICDIKD"
     CDS             8268..8597
                     /locus_tag="Jado_00070"
                     /product="putative cyclase"
                     /note="original product:jadomycin polyketide synthase
                     cyclase"
                     /note="original gene:jadI"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR011008"
                     /inferenece="InterPro:IPR006765"
                     /translation="MHSTLIVARMEPGSSTDVAKLFAEFDASEMPHLMGTRRRQLFSY
                     RGLYFHLQDFDADNGGELIERAKTDPRFVGISEDLKPFIEAYDPATWRSPADAMATRF
                     YNWEANA"
     CDS             8594..9862
                     /locus_tag="Jado_00080"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /note="original product:jadomycin polyketide ketosynthase"
                     /note="original gene:jadA"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR018201"
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR016038"
                     /translation="MTARRVVITGIEVLAPGGTGSKAFWNLLSEGRTATRGITFFDPT
                     PFRSRVAAEIDFDPEAHGLSPQEIRRMDRAAQFAVVAARAVADSGIDLAAHDPYRVGV
                     TVGSAVGATMGLDEEYRVVSDGGRLDLVDHAYAVPHLYDYMVPSSFSAEVAWAVGAEG
                     PNTVVSTGCTSGLDSVGYARGELIREGSADVMIAGSSDAPISPITMACFDAIKATTNR
                     YDDPAHASRPFDGTRNGFVLGEGAAVFVLEELESARARGAHIYAEIAGYATRSNAYHM
                     TGLRPDGAEMAEAIRVALDEARMNPTEIDYINAHGSGTKQNDRHETAAFKKSLGDHAY
                     RTPVSSIKSMVGHSLGAIGSIEIAASALAMEHNVVPPTGNLHTPDPECDLDYVRSCRE
                     QLTDSVLTVGSGFGGFQSAMVLARPERKIA"
     CDS             9859..11073
                     /locus_tag="Jado_00090"
                     /product="polyketide synthase chain length factor subunit"
                     /note="original product:chain length determinant"
                     /gene="jadB"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR016038"
                     /translation="MSASVVVTGLGVAAPNGLGREDFWASTLGGKSGIGPLTRFDPTG
                     YPARLAGEVPGFAAEEHLPSRLLPQTDRMTRLALVAADWALADAGVRPEEQDDFDMGV
                     VTASASGGFEFGQGELQKLWSQGSQYVSAYQSFAWFYAVNSGQISIRNGMKGPSGVVV
                     SDQAGGLDAVAQARRQIRKGTRLIVSGGVDASLCPWGWVAHVASDRLSTSEEPARGYL
                     PFDREAQGHVPGEGGAILVMEAAEAARERGARIYGEIAGYGSTFDPRPGSGREPGLRK
                     AIELALADAGAAPGDIDVVFADAAAVPELDRVEAEALNAVFGTGAVPVTAPKTMTGRL
                     YSGAAPLDLAAAFLAMDEGVIPPTVNVEPDAAYGLDLVVGGPRTAEVNTALVIARGHG
                     GFNSAMVVRSAN"
     CDS             11116..11385
                     /locus_tag="Jado_00100"
                     /product="polyketide synthase acyl carrier protein
                     subunit"
                     /note="original product:acyl carrier protein"
                     /gene="jadC"
                     /note="original gene:acp"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR006162"
                     /inferenece="InterPro:IPR009081"
                     /translation="MSSKTFTLDDLKRILREGAGADEGVDLDGDILDTHFETLGYESL
                     ALLETGSRIEREYSITLDDDVLSDADTPRALIEAVNAHLSAVAAA"
     CDS             11459..12253
                     /locus_tag="Jado_00110"
                     /product="polyketide C-9 ketoreductase"
                     /note="original product:ketoreductase"
                     /gene="jadE"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR002347"
                     /inferenece="InterPro:IPR020904"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR002198"
                     /translation="MSQQEKQEKRVALVTGATSGIGLAVARLLASQNHRVFLGARNAE
                     NVAATVKQLQDEGLEVDGTTLDVRSGEDVKAFVQAAVDRFGTVELLVNNAGRSGAGVT
                     ADIADELWNDVIDTNLNCVFRLTREALTTGGMREKSRGRIINMASTAGKQGVVLGAPY
                     SASKHGVVGFTKALGNELAPTGITVNAVCPGYVETPMAQRVRQGYAAAYETSEDAILE
                     KFQSKIPLGRYSTPEEVAGLVGYLASDTAASITSQALNVCGGLGNF"
     CDS             12294..13226
                     /locus_tag="Jado_00120"
                     /product="cyclase/dehydratase"
                     /note="original product:bifunctional cyclase/dehydrase"
                     /gene="jadD"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR023393"
                     /inferenece="InterPro:IPR019587"
                     /translation="MTTREVEHEITVAAPAQAVYRLIAEVENWPRIFPPTLYVDHVER
                     GEREERIRIWATANGAPKNWTSKRTLDPDNLRITFRQEVSTPPVAAMATWIIEPVSAT
                     ESGSALLHDYRAIDDDPEGLKWVDEAVDRNSRSELAALKTNVELAHASEEITFSFEDT
                     VQIDGSAKDAYDFVNEANLWPERLPHVATVRFEEETPGLQSLEMDSRAKDGSTHTTKS
                     YRVTFPHHRIAYKQITLPALMTLHTGYWTFEENEDGVAASSQHTVVLNTENIARILGA
                     DATVADAREYVQTALSTNSRATLGYAKAYAEGKR"
     CDS             13313..14851
                     /locus_tag="Jado_00130"
                     /product="2,3-dehydratase"
                     /note="original product:JadF"
                     /note="original gene:jadF"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR002938"
                     /inferenece="InterPro:IPR003042"
                     /translation="MTEPRRAGAPAPESPDAPDTPVLLDADVVVIGAGPTGLMLAGEL
                     RLGGADVIVLESRETPTTESRASTLHARTMELLDDRGLLTPLGTPPSEPRGHFGGIPL
                     DLTLPGRHPGQWKVEQTRTEALLQEWATGLGADVRRGHTLRSLTVTETYAEAGATGPG
                     GRDVRVRARYAVGCDGERSTVRALAGAEFPGQEARRELLRADVAGIDVPDRRFQRLPG
                     GLAVAACRNGVTRVMVHEFGRPAVARTGEPEFAEVVDVWKRVTGEDISGGTPLWVNSF
                     HDANRQLTRYRDGRVLWAGDAAHQQMPIGGQALNLGLQDAVNLGWKLAAVVRGTAPDG
                     LLDTYHDERHAVGRQVLGNIRAQALLLLGGPEAEPVRSLLGPLIALDDVRAHLAGKVS
                     GLDIRYGAGAADVHPLTGTRLPRTALVDDGREAVDPSLRAGQGLFLTLDPSGTGPGTG
                     AAAAAAWAGRVGTAVARPVPGGVLDGLDAVLVRPDGYLAWTSADGAGPEAALHRWFGA
                     PTHL"
     CDS             14875..15552
                     /locus_tag="Jado_00140"
                     /product="dehydrorabelomycin C-5
                     hydroxylase/Baeyer-Villiger monooxygenase/decarboxylase"
                     /note="original product:JadG"
                     /note="original gene:jadG"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR011008"
                     /inferenece="InterPro:IPR007138"
                     /translation="MPLINPEDGYLTVFNLFETETYDGQARVVDEMKDIVDNATYPGW
                     ISSTVHAGVDTPGTLNYIQWRSLADLEARYQGQKFQKKTVPLFDQLATSVKLLKTELV
                     HAQHHPDLGAAAEVSPERDDYAVFILFEVKPDQQQELLDTLAKPDEWIKTVPGYRSHG
                     YYRGIDGTYVVNYAQWESKELYEAFHTLPEEQRPADIREGRLRARSLVTSRWANSFRA
                     VHSRSAE"
     CDS             15558..17183
                     /locus_tag="Jado_00150"
                     /product="4a,12b-dehydratase/C-12 hydroxylase"
                     /note="original product:JadH"
                     /note="original gene:jadH"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR003042"
                     /inferenece="InterPro:IPR002938"
                     /translation="MTTTPEAGFDADVIVVGAGPTGLMLAGERRLGGARVLVAERLER
                     PTGQSRGLGFTARAMEVFDQRGLLPRFGQGETLETSPMGHFGGVQFDYTVLEGAHFGA
                     RGIPQYTTESVLEEWATELGADIRRGWEFTGLDQDDDAVEITVRTPEGERRLRAAYVV
                     GCDGGHSPVRKAAGFDFPGTPATREMYLADVVGCGLKPRFLGERLPEGMVMAAPLAEG
                     VDRIIVCPHGTPPRDRRDAQAVSFAEVAAAWQRITGEDISGGSAEWVSSFTDTTRQAT
                     EYRRGRVLLVGDAAHIHLPAGGQGLSTGVQDAANLGWKLAAVVRGTAPDGLLDTYHGE
                     RHPVGQRLLMNTRAQGTVFLGGEESDPLRELFTELLAYDDVKRHLAGVVSGLDIRYDL
                     AGGADDPLVGARLAHRALTTAAGETSTTRLVHAGQGVLLDLADDPAVRDAAAAWKDRV
                     VTVTGTPLPVEGTDVLAGVTAVLVRPDGHVAWTARAAGADASDAGTEAGAAASLAGTD
                     AEGLGASLRRWFGEPASDASVTPGASADGGAAR"
     CDS             17305..18093
                     /locus_tag="Jado_00180"
                     /product="putative phosphopantetheinyl transferase"
                     /note="original product:phosphopantetheinyl transferase"
                     /note="original gene:jadM"
                     /note="category:1.4 Other"
                     /transl_table=11
                     /inferenece="InterPro:IPR008278"
                     /translation="MPLLRVADDELHLWTLRPPPPGSAAADALATGELDGAERRRAEA
                     YVRPRDRVQYLAAHLALRRVLARYTGVPAGRLRFGREAAGRPVLLGVAGPPSFSLSHS
                     HGLVLLGVARRPVGVDVQRVPPYATAEVCRGALHPAEREELAALPEDRLAAAFARLWT
                     RKEAYLKGLGTGLARGLATDFLGTPGHGGVRRPAGWTVLDLPGGPDHAAAAALHGDTA
                     PRVTTRALRPEDLTSTTHASHDTQTPHDTYDPYDTQTERGVGSA"
     CDS             18094..19671
                     /locus_tag="Jado_00190"
                     /product="putative acyl-CoA carboxylase beta subunit"
                     /note="original product:decarboxylase JadN"
                     /note="original gene:jadN"
                     /note="category:2.1 modification addition of extender
                     units"
                     /EC_number="6.4.1.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR011763"
                     /inferenece="InterPro:IPR011762"
                     /inferenece="InterPro:IPR000022"
                     /translation="MTTTSTAGGALADRLTELGRLRELAQEGPDPSGPPNASTAKGKL
                     TARERIELLLDKGSFTEIEQLRRHRAQGFGLEAKKPYTDGVITGWGTVEGRTVFVYAH
                     DFRIFGGALGEAHATKIHKIMDMAIAAGAPLVSLNDGAGARIQEGVSALAGYGGIFQR
                     NTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRETSQMFITGPDVVKAVTGEEIT
                     QNGLGGADVHAGVSGVSHFVYDDEETCLAEVRYLLSMLPQNNRDLPPVMPSSDPADRP
                     GDRLLDLVPADGNRSYDVREVIEELVDDSDYMEVHAAWAPNLVCAFARLDGHVVGIVA
                     NQPAAMAGVLDIKASEKGARFVQFCDAFNIPIITLVDVPGFLPGVDQEHDGIIRRGAK
                     LLYAYCNATVPRISVVLRKAYGGAYIVMDSRSIGADISLAWPTNEIAVMGAEGAANVV
                     FRREIAAADDPEAMRAQKIQEYREELVHPYYAAERGLVDDVIDPRETRQVLCRSVAML
                     AAKHADLPRRKHGNPPQ"
     CDS             19940..20458
                     /locus_tag="Jado_00200"
                     /product="jadomycins binding protein"
                     /note="original product:JadX"
                     /note="product synonym:chloramphenicol binding protein"
                     /note="original gene:jadX"
                     /note="category:5.3 uncharacterized protein (biosynthesis
                     involved)"
                     /transl_table=11
     CDS             20458..21882
                     /locus_tag="Jado_00210"
                     /product="putative NDP-hexose 2,3-dehydratase"
                     /note="original product:NDP-hexose 2,3-dehydratase"
                     /note="original gene:jadO"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR005212"
                     /translation="MSTGTTTPAPPSPPAGLAERIARSAATGRGAHLATEDFHDWLDG
                     RRRANTFRVDKIPFDALDGWSFDEEDGNLVHRSGRFFTVEGLHVVEEDGPYGDGPYRS
                     WYHPVIKQPEVGILGILAKEFDGVLHFLMQAKMEPGNPNLLQLSPTVQATRSNYTKAH
                     RGGDVKYIEYFTGAEHGTVIADSLQSEHGAWFFHKSNRNMIVEATGEVPLLDDFCWLT
                     LGQLGELLHQDNVINMDARTVLSCVPYEDADAGRALLSDVQLLSWFTGERSRHDVRAR
                     RVPLRELPGWKQGEETIEHEEGRHFKVVAVSVQAGNREVTSWTQPLIEPVGLGVAAFL
                     TRDFDGVPHYLVHARVEGGFLDTVELAPTVQYTPGNYAHLPTDERPPFLDLVLDTDPG
                     PRPATRPCTPRKAAAVSFKRREPLPSLVEADETQGPGPDPAARATPGRPAAQLTSLAP
                     GTGHYLNVQARTLLACVHAGAVRP"
     CDS             21912..22910
                     /locus_tag="Jado_00220"
                     /product="putative NDP-hexose C-3 ketoreductase"
                     /note="original product:NDP-hexose 3-ketoreductase"
                     /note="original gene:jadP"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR004104"
                     /inferenece="InterPro:IPR000683"
                     /inferenece="InterPro:IPR016040"
                     /translation="MLGCADIAVRRMMPAMAALPGTEVTAVASRDAAKAAVAAAPYGA
                     AAVEGYQELLRRPDVDAVYVPLPAALHAEWTEAALRAGKHVLAEKPLTTDPESTAALL
                     GLAAASGLALMETSCSSTTASTPTSRKLVADGAIGELRALHACSASPGCPTPTFRHDP
                     GLGGGALGDVGVYPLRAAQHLLGDELDVLGAHLVRGPGSRVETAGGALLATPAGVTAH
                     IAFGMDHGYRSAYELWGSQGRLVVERAYTPPADHRPVVRLETRTGVEALQKWVQGWFN
                     LVLDADDQVRNTVAAFAALVARTGAGHPGDGGAPDPEAPLRQARLLDAVRRRAALV"
     CDS             23016..23915
                     /locus_tag="Jado_00230"
                     /product="putative glucose-1-phosphate
                     thymidylyltransferase"
                     /note="original product:NDP-glucose phosphate
                     nucleotidyltransferase"
                     /note="product synonym:putative dTDP-glucose synthase"
                     /note="original gene:jadQ"
                     /note="category:2.3 modification addition of sugar moiety"
                     /EC_number="2.7.7.24"
                     /transl_table=11
                     /inferenece="InterPro:IPR005835"
                     /inferenece="InterPro:IPR005907"
                     /translation="MRLGTPEERTVKGIFLAGGHGTRLHPITLGTSKQMLPVYDKPMI
                     YYPLSVLMLAGIRDIQIISSPDDIENFRRLLGDGSPLGISLSYAVQEQPRGLAEAFLI
                     SADHIGDDSVALVLGDNIFHGPGFAGILQDKAVDVDGCVLFGYPVRDPERYGVGEVDA
                     DGRLVSLEEKPEHPRSDLAITGLYFYDNDVIDIAKNLTPSARGELEITDVNRIYLERG
                     KAELVSLGRGFVWLDAGTHDALTEAGQYVQILEHRQGVRLACLEEIAWRMGFIDREAC
                     LRLGEELSKSPYGQYVMEIARAG"
     CDS             23966..25156
                     /locus_tag="Jado_00240"
                     /product="putative glycosyltransferase"
                     /note="original product:glycosyltransferase"
                     /note="original gene:jadS"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR010610"
                     /translation="MRYLFTTIPGTSHTLPLVPLAHAALAAGHEVAFAASGPALRAAN
                     AAGLQTIAAAGDEAAEPYEELIAKVTTSDLRRVPGPKILPYVSGIFGEVGARLVEGVA
                     EAARTWRADAVVFPPNHVAGLLAARMTGLPAVLHGIGTPRPVFAPALAYLEPVAARSA
                     SDLPAPVADVEIDLNPASLTAPSLGGPGGGGPAAAHRLPMRYTSYNGGAEIPPGLLGR
                     GERPRVAVTLAPSPRCTARAPCLREIVDGSADLGIELVITTGGAELPALTGSLPPHVT
                     CVDWVPLRTLLASCDAIVHHGGMGSTFTAFDAGVPQLAIPLTGPESVSNGRVAADRGT
                     GIVLDPPLSVPLTAATVKSSLHELLSNPAHRTAAAEVAAEMREMPAPAATLVQLNALL
                     GGTA"
     CDS             25249..26187
                     /locus_tag="Jado_00250"
                     /product="putative dTDP-glucose 4,6-dehydratase"
                     /note="original product:NDP-hexose 4,6-dehydratase"
                     /note="original gene:jadT"
                     /note="category:2.3 modification addition of sugar moiety"
                     /EC_number="4.2.1.46"
                     /transl_table=11
                     /inferenece="InterPro:IPR001509"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR005888"
                     /translation="MHGSHYVRSLLDGAYGGDGTDTVTVLDKLTYAGNRDNLPASHER
                     LTFVRGDICDLPLLLDLLPGHDAVVHFAAESHVDRSLESAAEFVRTNVLGTQTVLEAA
                     LRTGVQRLVHVSTDEVYGTIDEGSWTEDFPLLPNSPYAASKASSDLVARSYWRTHGLD
                     LSITRCSNNYGPYQHPEKLIPRFVTNLLEGHPVPVYGDGRNVREWLHVDDHCRAIHLV
                     LPPAGRARRTTSASGNELTNLDLTERILDLCGADRSMIRYVEDRKGHDLRYSLSDAKI
                     REELGYTPRTSFEDGLRRTVDWYRDNPQWWKAGKEK"
     CDS             26196..26789
                     /locus_tag="Jado_00260"
                     /product="putative NDP-hexose epimerase"
                     /note="original product:NDP-4-keto-6-deoxyhexose
                     5-epimerase"
                     /note="original gene:jadU"
                     /note="category:2.3 modification addition of sugar moiety"
                     /EC_number="5.1.3.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR014710"
                     /inferenece="InterPro:IPR011051"
                     /inferenece="InterPro:IPR000888"
                     /translation="MQVTPLAIEGAFAFTPPVFKDSRGLFASPYQGDVFAGQLGRPLF
                     QVNQVSHNLSARGTLRGVHFTATPPGMAKYVYCPYGRLRDFLIDLRVGSPTFGQWVMN
                     ELDAETSRALYVPVGVGHAFVSLQDDSMCVYVMSQGYSPPTNWPCTRSTRRSDLPAGR
                     RRADPVRPDKIAPTLAEARDRGLLPDFDTCRKLEELL"
     CDS             26828..27805
                     /locus_tag="Jado_00270"
                     /product="putative NDP-hexose C-4 ketoreductase"
                     /note="original product:NDP-4-keto-6-deoxyhexose
                     4-ketoreductase"
                     /note="original gene:jadV"
                     /note="category:2.3 modification addition of sugar moiety"
                     /transl_table=11
                     /inferenece="InterPro:IPR001509"
                     /inferenece="InterPro:IPR016040"
                     /translation="MVVLGAAGFVGSAVLRELARHDLRVRAVSRRPVTVPAGARAEVE
                     TRSVDLTVPGAMAGAIEGADVVVHSIAYIAGSSTWRITDGDTGAERVNVGLVRDLVEA
                     VRASGRPDTAVLFTGSVSAAGPSERGVYDGTEPDEPQGEYDRQKLAAERVLLAASAEG
                     VLRGISLRLPTVFGYGPDSTARDKGIVSSMVRRAVAGEPITMWHDGTVRRDLLYVEDV
                     ARAIAAALGHLDALAGRHWVLGSGHGAELGPVFTTVARMVAERTGKPPVAVRSVEPPA
                     HAEARDFASVTVDPRAFHEVTGWRAEVPLDEALDRTTAFSASGAEEHFG"
     CDS             complement(27863..28477)
                     /locus_tag="Jado_00280"
                     /product="TetR family transcriptional repressor"
                     /note="original product:JadR*"
                     /note="original gene:jadR*"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR001647"
                     /inferenece="InterPro:IPR011075"
                     /inferenece="InterPro:IPR009057"
                     /inferenece="InterPro:IPR015893"
                     /translation="MATRKYEQRLRAEAAAETRRRILDALYEQLRSAPSEAVGLDRIA
                     RTAGVSRSTVYTTFGSRSGLFDALGADLLHRGGFERMVREVLQPDAREGLRGGIRGNV
                     EMYAAHRDVMRALYSMAALDAEAVGGAVQRMETGRAAGMDDLARRLGAQGELREDVTV
                     AEAARRLWLFSAFDSFDLLYTGRSMTVEQVTSTLTTAAEHALCR"
     CDS             28522..29238
                     /locus_tag="Jado_00290"
                     /product="flavin reductase"
                     /note="original product:JadY"
                     /note="original gene:jadY"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR005025"
                     /translation="MLSDESAKTGCPRNRRQVHRAIHRAKPGSEAEGAPHDPDRRHHR
                     QHRPGRRSTAVAQWVEEAAGRHEAIKAGGATVELVDIAEFGLPLLDESVPAAFGQYAN
                     EHTKRWSEKIASFDAFVFVTPEYNRSVPAALKNAIDYLYAEWQNKSAGFVSYGVQGGT
                     RAIDHLRVTLAEVKVADVPTAVSLPVFTDFTFENPMDPTETGRVTPGPHQEPTLFKMF
                     DEIIAWAEALKPLRAAGAAV"
     CDS             29343..30635
                     /locus_tag="Jado_00300"
                     /product="putative oxidoreductase(fragment)"
                     /note="original product:JadZ"
                     /note="original gene:jadZ"
                     /note="category:5.1 general function"
                     /transl_table=11
                     /inferenece="InterPro:IPR011707"
                     /inferenece="InterPro:IPR001117"
                     /inferenece="InterPro:IPR008972"
                     /inferenece="InterPro:IPR006311"
                     /translation="MTTSRRELLKLMTAAGAALTASGLLISRTSLSDTRAGGPAGASP
                     FAAQPVAAQALAPIVTPFRTAMPIPPVARPVSVTSTTDTYSIPVTQTTAEIIPGVRTP
                     VLTYGGSFPGPTIKARSGRRVVVKQPNRITTGTSMHLHGAVVDPANDGGPMDLITPGG
                     QRTYTYPNPQVAATLWYHDHAHHMEAEHVYRGMSGFYLISDDNEDALPLPRGTYDVPI
                     VVRDIGLNPDGTLFFDHNFTPGRRSWSTGKPQPYFQVAARKYRLRILNGSNQRPFEFR
                     LSDGGEFTQIASDRGLLPAPYTTTTLPLSPAERADIVVDFSRYPVGSSVVLENAYFPE
                     PSNKEILRFDVVRSAYDPSSVPARLATLPPTAAPTQTRNYTLDFDVQTGAGSISGKTW
                     DEQRVDTTVRQGDTEVWEIKNTHPFIPHNFHIHLVDFRI"
ORIGIN      
        1 ctcgaggatc aaccggcggg ttcggattgc acgcgcttgc tgtgccaagg cgcctcctgc
       61 tgtctcgctg tctgtgctct acgtgtgacg tgaagcattg aaaagaaaac cgcgctgtac
      121 gtattctacg atcggcggtt ttcaccgccg gggggtggga acgcaagggg gattcatacc
      181 acagccatcg gggcgtgcac accacgtccc gaggggaatt cgttcaccgc gccgatcccg
      241 cggacatcat tcccacggac tggacgcagc tccggcagaa tcggttctcc gtatccgccc
      301 gcgtggcctg cctcagatcc cttcttctct cccgtgccgg ggcccggcac gaccccatgc
      361 tggtggccga gacgataccc gagaccagca tgctggtcgc tcacgccgag ctgggggtac
      421 ccctggacga acagttcgtc atgtgggacc tctcctacag cgccgactcc gaggcgctca
      481 cggtggacgg cctctcctcc gacgtcaccg tcgacgtcgt ctgctccgac atcacccgcc
      541 gcggcagccg cctccgcaac ctccgcacca ccgtggtgct cacccgcgac gaccggctcc
      601 tcgccaccgg cagcggcacg gcccgctgca cctccgccct ggcgtaccgc cggatgcgcg
      661 gcgagcggat ggaggcgctg ggcagacccg tgcccctcat acccggcgtg cacccgcgcc
      721 tcgtcggccg cgcgcggacc gaggacgtcg tcctcgcccc cggaaaccgg cccgaccagt
      781 ggcagttgcg cgtcaacacc gcgcacacca ccctcttccg ccgcccgaac gaccacgtgc
      841 ccgggatggt gctcctggag gcggcccggc aggcggcgac cgccacgacc ggcagcgcgg
      901 cctatctgcc caccgacctg agcgtctcct tcctgcgcta cgtcgagctc gacagcccct
      961 gctggatcga ggccgagtcc gtgcccaccc cggacccctc gacgaccacc atccgggtca
     1021 ccggccacca ggacggcagc cccgtcttcc gctgtacgct cacctccccg tcccgggaac
     1081 tgtcggtggc caccgccgga ctcgacaccc ggctggcggg ctgaaccgga tcggcacgat
     1141 gggccctcgc atcctgatca ccggcgccac cggattcatc ggcggccgcg tggccgccgc
     1201 ggccgccacc gcgcgggagc ccgcccacgt acggctgctc gcccgcggcc cgctcaccgg
     1261 cccggccgcg gccgccggac cgcggaccga gaccgccgtc ggcgacctcc gcgaccccgc
     1321 gtccctgcgc cgcgcctgcg agggcgtcga cgtactgatc cactgcgcct ccgcgatcgg
     1381 cggggacgcg gaactggccc gggcggtcaa cgacgagggc acccggaacc tcgtcgacgc
     1441 cgccgtccgc gccggggcga cccggatcgt cggccctgag caccgcctcc gtacacggcg
     1501 cggccccttc cgcgccgccg cccccggcac cttgccgctc gcccccggct cggtgaccag
     1561 cagcacccgg gcggccggcg agcggcacgt catggacgcc ggcgggaccg tactgcgacc
     1621 gcacctggtg tacggcaccg gggaccgccg gctgttgccc ggcctggtcc ggctcctcgc
     1681 cgcgctgccg ggaccgctcg acggcgggtc ctcgctgcac tccctgatcg acgtcgacag
     1741 cctggcgggc gcgctgctcg gcgcggccct ctccccggcg acggagccgg gaccgtacta
     1801 cgtcgaccat cccgaaccgg tgccggtcgg cgacctcctc gcggccgccg agtccctgct
     1861 gacccgcacg ggcctccccc ggggacgggc cgtggacctc ccgaccgccc gcaggctgct
     1921 cgccggcctc cccttcgcgg ggcaccacct ggacatgctc gccaccgacc actggttcgc
     1981 cgacgaccgc ccctggcggg agctcggctg cgacccgggg ccgggcttac cacggggttc
     2041 gcggaccacg cggcgtggta ccacggactc ctcgaccatt ccgtgaacag aaggtaggca
     2101 ccaccgacat gtccgcgctg gccggcagga ccgcgatcgt cacaggggcg agccgcggca
     2161 tcggaagagg catcgccgag cgacttgcca cggacggcgc cctggtcgcc gtccactacg
     2221 gcagcaacga gaaggcggcc ctggagacgg tggagatcat cgaggggcgg ggcggccgcg
     2281 ccttcgcgtt ccgcgcggaa ctcggggcgc cggacgccgt cgacaccttc tacgccgccc
     2341 tcgacgcggg cctcgcggag cggggcgcgg cgcgggagtt cgacatcctc gtcaacaacg
     2401 cggccgcgag cggctcgggc cgcatccacc agctcaccac cgaggtgttc gaccggctgt
     2461 tcgccatcaa tgtgaaagcc ccgctcttcc tggtccagcg gggcctcgac cggctgcggg
     2521 acggcggccg gatcgtcaac atctcctcgg cggccacgaa gcacgccttc cccgactccg
     2581 tcacctacgc gatgacgaag ggcgccgtcg acacgatgac cctcgccctc gccaaggagc
     2641 tggggccgcg ggggatcacc gtcaacgcgg tggcccccgg ctacatcgcg acggacatga
     2701 acgcccgccg cagggccacc ccggaggcga gcgcggccct cgcggcgatg tccgtcttca
     2761 accggatcgg cacgcccgcc gccgacgtcg gacgtggtcg gtttcctgtc tccgacgaag
     2821 cccggtggat caccggccag tacgtggacg ccaccggggg gacggcgctc tgagcgggcc
     2881 ggccggcggg cacgcgcggt caggcgaccg gcgtgtacgc ccgctcggcc atgcccgggc
     2941 tgcccgccgg tgtcagggcg gcgagcgccc gggggccgcg acgatgggga ggagggtccg
     3001 ccacaggccg gtgacggtgc cgggcgacag ccattcgccg ttgtcccggc agagggcctc
     3061 caggccgatg gtggcggcca cgatcgtgcg ggcgaggtcc tgttgaccac cgatgtccga
     3121 ggcgagcagg ccctcgtcgg cggcctccgc gagccgctgc tggacgcagc tctgccattc
     3181 ctggcgcagg ttgaggtccg taccgcagag ctgggagcag ctcagccgga accccgcgcg
     3241 cacgacgacg tcctcgcgga cgagccgggc cagcgcatgg gtggtgtcgg cgaggttctg
     3301 cagggcgttc gaccgctggt ggtacacgat cctggcggtc cggcgcagtg tggtggacgc
     3361 gtcgatctcg acggctgcgg ccaccttgtt ctcgaagtgg aagtggaggg cgccggggct
     3421 cacgcccgct cccgaactga tcgccgacaa cttggccagg gcgtagccgt gctcgtcgaa
     3481 ttctctggcc gccgacttga tcagggcgtc gcgcgtccgt gtggcccgct cttgtttggt
     3541 caccaatggc tccagtagca ccatgcgtcg cagcggcacg ggcttgcgcc ccgtcgcgcc
     3601 gtaccgctcg acgtctttaa accgactgct tggtattgta cgagtttttc gtgtgacctt
     3661 gggcgcatcg gtggggtagg gcgaggagac acccggggca accggaaccc ttcctcccgg
     3721 aaggagttgg gggcgcggcg tgagccggcg gacagtactc cggtaagtct ccccgaagtg
     3781 acgccgcctt aacaaaccga accagcggtt tgtcaagaag tggtcaagag tgcccgtggt
     3841 ctcccatgga ttcacctgac tgctgttatg tcgccccaag aaacggacat tcactgtcaa
     3901 gtgatgcgat ttcaatcatc acgatgtcaa ctccgtgtca aattttcgtt gcacgactct
     3961 cggaaaatct cacacgccgt ggtagagaaa tgaccttgac aaaccggcgc acgggtttgt
     4021 agcgttcccg ttggcgggat ccctacgggt cccggaactc cgggactctc caagggcccc
     4081 ggaaatgagt gacataggtg ctagggggaa ccgtgagcct gacgtccgta gaagtgaagg
     4141 agccccacat acctgcccca cgactcgccg ggagagcgag tctgtcgggc gtgagcgtgg
     4201 acacatcggc gaggggcggc ccggtcaccg cggccggctg gcgcgtcctg gtcgtggaga
     4261 gctgcggcaa ggagggggag gggctcgtac aggggctccg ccggcacggc cacgaggtcg
     4321 accgggtgga gacggggggc gccgccctcc aggcctacga agaggccgac ttggtcctga
     4381 tcgacctcga actgcccgac ctggacggct tggaggtctg ccgcggcatc cggtccgccg
     4441 gggacgtgcc ggtgatcgcc gtgacgagcc gcggcagcga actcgaccgc gtcctcggcc
     4501 tccaggccgg cgcggacgac tacctggtga agccctacgg cttccgtgaa ctgatggccc
     4561 ggatggaggc cgtcatgcgc cgggcccggc cccggccctc caccgcccgc acgatcaccc
     4621 gcggaccgct gcacatcgac gcggccgccc ggcaggtcac gctcgacggc caggacgtcg
     4681 acctgacccg caaggagttc gacctcctct atctgctcgc ctcccacccc gacacggtca
     4741 tcccgcgcaa gcagttgatg cagcaggtgt ggggggactc ctggtcgagg cggaccgtcg
     4801 acacccatgt gagcagcctg cgcaacaagc tcggcgccag cgactgggtg atcaccatcc
     4861 gaggcgtggg tttccgcttc ggccgcggct gacgccgccc gcacattccc gtcctgtgat
     4921 ccaccgggca ccgccgacgc tgtccgagcg gacacctctc catcgcttcc cggcccgccc
     4981 cggtccggca ccgcctcagg tgccggcccg gggcgggcct tttcgtgccc ggccgcgccg
     5041 ctcgcgcccg accgggccgg ccgtgcctga ccggggtgtt tgacaccgtc ctgacattcg
     5101 cctggcgcat ttcccacact gccgccacgg gcttgtgaat tctgacggat ccctgaatcg
     5161 gtgagtcttg aacgaagtcc tggaccggaa caagcttgtc gtgaaggtcc ggtgcaccgt
     5221 cttcgagccc tttcgggaaa agcggaacgg gtacggagaa ggcgagtcga tcaggagttg
     5281 aaaccgtcgt gcgcaaggtg ctcatcgcca accgtggcga aatcgctgtc cgtgtggccc
     5341 gggcgtgccg ggacgcgggt atcggcagcg tggccgtgta cgccgagccg gaccgggatg
     5401 ctctgcatgt ccgggcggct gacgaggcgt tcgctctggg cggtgacact ccggcgacca
     5461 gttatctgga catggcgaag gtgttgcagg ccgccgcgga ctcgggtgcg gacgcggtcc
     5521 accccggtta cgggttcctt tcggagaacg cggagttcgc gcaggcggtc ctcgacgcgg
     5581 gtctgacgtg gatcggtccg ccgccgcagg cgatccggga tctgggtgac aaggtggcgg
     5641 cccgtcacat cgcccagcgt gccggggccc cgctggtggc cggcacgccc gacccggtct
     5701 cgggtgcgga cgaggtcgtg gcgttcgccg aggagcacgg tctgccgatc gcgatcaagg
     5761 cggcgttcgg tggcggtggc cgtggtctga aggtggcgcg gacgctggag gaggtcccgg
     5821 agctgtacga ctccgcggtc cgtgaggcgg tggcggcgtt cgggcggggc gagtgcttcg
     5881 tggagcggta cctggacaag ccgcggcacg tggagacgca gtgcctggcc gaccagcacg
     5941 gcaacgtggt cgtcgtctcg acgcgtgact gctcgctgca gcgccgtcac cagaagctgg
     6001 tggaggaggc tccggcgccg ttcctgtcgg aggctcagaa cgcggagctg tacgcggcgt
     6061 cgaaggcgat cctgaaggag gccggttacg tcggtgccgg cacggtggag ttcctcgtcg
     6121 gcacggacgg cacgatctcg ttcctcgagg tcaacacccg tctgcaggtg gagcacccgg
     6181 tgacggagga ggtcacgggg atcgacctgg tgcgggagat gttccggatc gcggacggtg
     6241 aggagctcNN gaattctgac ggatccctga atcggtgagt cttgaacgaa gtcctggacc
     6301 ggaacaagct tgtcgtgaag gtccggtgca ccgtcttcga gccctttcgg gaaaagcgga
     6361 acgggtacgg agaaggcgag tcgatcagga gttgaaaccg tcgtgcgcaa ggtgctcatc
     6421 gccaaccgtg gcgaaatcgc tgtccgtgtg gcccgggcgt gccgggacgc gggtatcggc
     6481 agcgtggccg tgtacgccga gccggaccgg gatgctctgc atgtccgggc ggctgacgag
     6541 gcgttcgctc tgggcggtga cactccggcg accagttatc tggacatggc gaaggtgttg
     6601 caggccgccg cggactcggg tgcggacgcg gtccaccccg gttacgggtt cctttcggag
     6661 aacgcggagt tcgcgcaggc ggtcctcgac gcgggtctga cgtggatcgg tccgccgccg
     6721 caggcgatcc gggatctggg tgacaaggtg gcggcccgtc acatcgccca gcgtgccggg
     6781 gccccgctgg tggccggcac gcccgacccg gtctcgggtg cggacgaggt cgtggcgttc
     6841 gccgaggagc acggtctgcc gatcgcgatc aaggcggcgt tcggtggcgg tggccgtggt
     6901 ctgaaggtgg cgcggacgct ggaggaggtc ccggagctgt acgactccgc ggtccgtgag
     6961 gcggtggcgg cgttcgggcg gggcgagtgc ttcgtggagc ggtacctgga caagccgcgg
     7021 cacgtggaga cgcagtgcct ggccgaccag cacggcaacg tggtcgtcgt ctcgacgcgt
     7081 gactgctcgc tgcagcgccg tcaccagaag ctggtggagg aggctccggc gccgttcctg
     7141 tcggaggctc agaacgcgga gctgtacgcg gcgtcgaagg cgatcctgaa ggaggccggt
     7201 tacgtcggtg ccggcacggt ggagttcctc gtcggcacgg acggcacgat ctcgttcctc
     7261 gaggtcaaca cccgtctgca ggtggagcac ccggtgacgg aggaggtcac ggggatcgac
     7321 ctggtgcggg agatgttccg gatcgcggac ggtgaggagc tcggctacgg cgacccggag
     7381 atccggggtc actccttcga gttccggatc aacggtgagg acccgggccg tggtttcctc
     7441 ccggcgcccg gcaccgtcac cgagttcacg ccgccgaccg gtccgggtgt ccgcctcgac
     7501 gcgggtgtgg agtcgggttc cgtgatcggc cccgcgtggg actcgctgct tgcgaacgtg
     7561 atcgtgaccg gtgcgagccg tgagcaggcg ctgcagcgtg cggcgcgtgc cgtggcggag
     7621 ttccgcgtcg agggcatggc gaccgcgatc cccttccacc aggcggtggt gaccgacccg
     7681 gacttcaccg cggacccgtt ccgggtgcac acgcggtgga tcgagacgga gttcgtcaac
     7741 gagatcaagc cgttcgcgcc ggcgggggag gcggacgagg acgaggccgg ccgcgagacg
     7801 atcgtggtcg aggtcggcgg caagcgtctt gaggtctccc tgccgtcctc gctcgggatg
     7861 acgctggccc ggacggtctt gcggcgggtg ccgaagccga agcggcgggc gtcgaagaag
     7921 gtccgggctt cggccgcctc gggtgacacc ctcgcctccc cgatgcaggg cacgatcgtg
     7981 aaggtcgcgg tcgaggaggg ccaggaggtc aaggaaggcg atctgatcgt cgtcctggag
     8041 gccatgaaga tggaacagcc cctcaacgcc caccgctccg gcaccgtgaa gggcctgacc
     8101 gccgaagtcg gcgcgtccgt cacctccggc gccaccatct gcgacatcaa ggactgaatt
     8161 cacccgccgc ccccgcgcgc cctttcgtac caccccgcta tttcccttcg ctttccctgc
     8221 cttcttcagc acgtcctttt ccaggacttc ttccggtgag gagaaacaca tgcacagcac
     8281 tctgatcgtg gcccgaatgg aacccggatc gagcaccgac gtggcgaagc tgttcgccga
     8341 attcgacgcc tccgagatgc cgcatctcat ggggacgcga cgccgtcagc tgttctcgta
     8401 ccgcggcctc tacttccacc tccaggactt cgacgccgac aacggcggcg agctcatcga
     8461 gcgggccaag accgaccccc gcttcgtggg catcagcgag gacctgaagc cgttcatcga
     8521 ggcctacgac ccggccacct ggcgctcgcc cgccgacgcc atggccaccc gcttctacaa
     8581 ctgggaggcg aacgcgtgac cgcgcgacgc gtcgtcatca ccggcatcga ggtcctcgcc
     8641 cccggtggca ccggatccaa ggccttctgg aacctgctca gcgagggccg cacggccacc
     8701 cggggcatca ccttcttcga cccgacgccg ttccgctccc gggtcgccgc cgagatcgac
     8761 ttcgacccgg aggcccacgg cctcagcccg caggagatcc gccgcatgga ccgggccgcc
     8821 cagttcgcgg tggtcgccgc gcgcgccgtc gccgacagcg gcatcgacct ggccgcccac
     8881 gacccgtacc gcgtcggcgt caccgtcggc agcgccgtcg gcgccaccat gggcctcgac
     8941 gaggagtacc gggtcgtcag cgacggcggc cggctcgacc tcgtcgacca cgcctacgcg
     9001 gtgccgcacc tctacgacta catggtgccc agctccttct ccgccgaggt cgcctgggcc
     9061 gtcggcgccg agggccccaa caccgtggtc tccaccggct gcacctccgg cctcgactcc
     9121 gtcggctacg cgcgtgggga gctgatccgc gagggctccg ccgacgtcat gatcgccggt
     9181 tcctcggacg ccccgatctc cccgatcacg atggcctgct tcgacgccat caaggcgacc
     9241 accaaccggt acgacgaccc ggcgcacgcc tcccggccct tcgacggcac ccgcaacggc
     9301 ttcgtgctcg gcgagggcgc ggccgtcttc gtcctggagg agctggagag cgcccgggcc
     9361 cgcggcgccc acatctacgc cgagatcgcc ggctacgcca cccgcagcaa cgcgtaccac
     9421 atgaccggtc tgcggccgga cggcgcggag atggcggagg cgatccgggt cgcgctcgac
     9481 gaggcgcgga tgaaccccac cgagatcgac tacatcaacg cgcacggctc cggcaccaag
     9541 cagaacgacc gccacgagac cgcagcgttc aagaagagcc tcggggacca cgcgtaccgc
     9601 accccggtca gctccatcaa gtcgatggtc gggcactccc tcggtgccat cggctccatc
     9661 gagatcgccg cctcggccct ggccatggag cacaacgtgg tcccgccgac gggcaacctg
     9721 cacaccccgg accccgagtg cgacctggac tacgtccgct cgtgccgcga gcagctcacg
     9781 gactcggtcc tgaccgtcgg cagcggattc ggcggcttcc agagcgccat ggtcctggcc
     9841 cgtcccgaga ggaagatcgc atgagcgcgt ccgtggtggt gaccggcctc ggtgtcgccg
     9901 cacccaacgg cctgggccgc gaggacttct gggcctcgac cctcggcggg aagagcggca
     9961 tcggcccgct cacccgcttc gaccccaccg gctacccggc gcgcctcgcc ggcgaggtgc
    10021 ccggcttcgc cgccgaggag cacctgccga gccggctgct gccgcagacc gaccggatga
    10081 cccgcctcgc gctggtcgcc gcggactggg cgctggccga cgcgggcgtc cgccccgagg
    10141 agcaggacga cttcgacatg ggcgtggtca cggccagcgc ctccggcggc ttcgagttcg
    10201 gccagggcga gctgcagaag ctgtggagcc agggcagcca gtacgtcagc gcgtaccagt
    10261 ccttcgcctg gttctacgcc gtcaacagcg gccagatctc catccgcaac ggcatgaagg
    10321 gccccagcgg cgtggtcgtc agcgaccagg ccggcggtct ggacgccgtc gcgcaggccc
    10381 gccgacagat ccgcaagggc acccggctca tcgtctccgg tggcgtcgac gcctcgctct
    10441 gcccctgggg ctgggtggcg cacgtcgcct ccgaccggct cagcaccagc gaggagcccg
    10501 cccggggcta cctgcccttc gaccgcgaag cccagggcca cgtgcccggc gagggtgggg
    10561 cgatcctcgt catggaggcc gccgaggcgg cccgggagcg cggggcccgg atctacggcg
    10621 agatcgccgg atacggctcc accttcgacc cccggccggg cagcgggcgc gagcccggcc
    10681 tgcgcaaggc catcgaactc gccctggccg acgccggagc ggcacccggt gacatcgacg
    10741 tcgtcttcgc ggacgcggcc gccgtccccg agctcgaccg cgtcgaggcc gaggccctca
    10801 acgccgtctt cggcaccggc gccgtcccgg tcaccgcgcc caagacgatg accggccggc
    10861 tgtactccgg cgccgcgccg ctcgacctgg ccgccgcgtt cctcgcgatg gacgagggcg
    10921 tcatcccgcc caccgtcaac gtcgagccgg acgccgcgta cggcctcgac ctggtcgtcg
    10981 gcgggccccg taccgccgag gtgaacaccg ccctggtgat cgcccgcggt cacggcggct
    11041 tcaactccgc gatggtcgtc cgttccgcga actgaccttt cccccgcagt acctcacagt
    11101 cacccaggag aagaaccatg agcagcaaga ccttcaccct cgacgacctc aagcggatcc
    11161 tgcgcgaggg cgccggcgcc gacgagggcg tcgacctcga cggcgacatc ctcgacaccc
    11221 acttcgagac gctcggctac gagtcgctcg ccctgctgga gaccggcagc cgcatcgagc
    11281 gcgagtactc catcaccctc gacgacgacg tgctgtccga cgccgacacc ccgcgcgccc
    11341 tcatcgaggc cgtcaacgcg cacctgtcgg ccgtcgccgc cgcctgaccc acccgaccga
    11401 caccggcgcc cgtacccgcc gccgtaccgc cgccccctgg cagagaagag acgacaccgc
    11461 atgtcccagc aggagaagca ggagaagagg gtcgccctcg tcaccggagc caccagtggc
    11521 atcggcctcg ccgtcgcccg gctcctggcg tcccagaacc accgggtgtt cctcggtgcc
    11581 cgcaacgccg agaacgtcgc cgccaccgtc aagcagctcc aggacgaggg ccttgaggtc
    11641 gacggcacca ccctcgacgt gcgctccggc gaggacgtca aggccttcgt ccaggccgcc
    11701 gtcgaccgct tcggcaccgt cgagctcctc gtgaacaacg cgggccgcag cggcgcgggc
    11761 gtcaccgccg acatcgccga cgagctgtgg aacgacgtca tcgacaccaa cctcaactgc
    11821 gtcttccggc tcacccgcga ggccctgacc accggcggca tgcgcgagaa gtcccgcggc
    11881 cggatcatca acatggcctc gaccgccggc aagcagggcg tcgtcctcgg cgccccctac
    11941 tcggcctcga agcacggcgt cgtcggcttc accaaggccc tcggcaacga gctcgccccg
    12001 accggcatca ccgtcaacgc ggtctgcccc ggttacgtcg agacgccgat ggcccagcgc
    12061 gtccgccagg gctacgccgc cgcgtacgag acctccgagg acgccatcct cgagaagttc
    12121 cagtcgaaga tcccgctcgg ccgctactcc acgcccgagg aggtcgccgg tctcgtcggc
    12181 tacctggcct ccgacaccgc ggcctccatc acctcgcagg cgctcaacgt ctgcggcggc
    12241 ctgggcaact tctgatcccc gcaccccctc tcgcaccgtc ccgaggagtt tcacgatgac
    12301 gacccgtgag gtcgagcacg agatcaccgt cgcggccccg gcccaggccg tgtaccggct
    12361 gatcgccgag gtggagaact ggccgcggat cttcccgccc accctctacg tcgaccacgt
    12421 cgagcgcggc gagcgggagg agcgcatccg gatctgggcg accgccaacg gcgccccgaa
    12481 gaactggacg tccaagcgga ccctggaccc ggacaacctc cggatcacct tccgccagga
    12541 ggtctccacc ccgccggtcg ccgccatggc gacctggatc atcgagccgg tctccgcgac
    12601 cgagtccgga tccgccttgc tgcacgacta ccgggcgatc gacgacgacc ccgagggcct
    12661 gaagtgggtc gacgaggccg tcgaccgcaa ctcgcgctcc gagctcgccg ccctcaagac
    12721 caacgtcgaa ctcgcccacg cctccgagga gatcaccttc tccttcgagg acaccgtgca
    12781 gatcgacggc tccgccaagg acgcctacga cttcgtcaac gaggcgaacc tctggccgga
    12841 gcggctgccg cacgtcgcca ccgtgcgctt cgaggaggag accccgggcc tgcagagcct
    12901 ggagatggac tcccgggcca aggacggctc cacccacacg acgaagtcgt accgggtgac
    12961 cttcccgcac caccggatcg cctacaagca gatcaccctg ccggcgctca tgaccctgca
    13021 caccggctac tggacgttcg aggagaacga ggacggcgtc gccgcctcct cgcagcacac
    13081 ggtcgtcctc aacaccgaga acatcgcccg gatcctcggc gccgacgcca ccgtcgccga
    13141 cgcccgcgag tacgtgcaga cggcgctcag caccaacagc cgggccaccc tcgggtacgc
    13201 caaggcctac gccgagggca agcgctgaca tgacggagcc ccgccgggca ggagcgcccg
    13261 caccggagtc cccggacgcc ccggacaccc cggtcctcct ggacgccgac gtccNNatga
    13321 cggagccccg ccgggcagga gcgcccgcac cggagtcccc ggacgccccg gacaccccgg
    13381 tcctcctgga cgccgacgtc gtcgtcatcg gcgccgggcc caccggcctg atgctcgccg
    13441 gcgaactgcg gctcggcggc gcggacgtga tcgtcctgga gagccgggag acccccacca
    13501 ccgagtcccg ggcctccacg ctgcacgccc gcacgatgga actgctcgac gaccgcgggc
    13561 tgctcacccc gctcggcact ccgccgtcgg agccccgcgg gcacttcggc ggcatcccgc
    13621 tcgacctgac cctgcccggt cggcaccccg ggcagtggaa ggtcgagcag acccggaccg
    13681 aggcgctgct ccaggagtgg gccaccggcc tcggggccga cgtccgacgc ggccacaccc
    13741 tgcgctccct cacggtgacg gagacgtacg ccgaggccgg agccaccggc cccggcggcc
    13801 gtgacgtgcg cgtgcgggcc cggtacgccg tgggctgcga cggggagcgg agcaccgtac
    13861 gggccctggc cggggcggag ttccccggcc aggaggcccg gcgcgaactg ctccgggccg
    13921 atgtggccgg gatcgacgtc cccgaccggc gcttccagcg gctgcccggc ggactggccg
    13981 tcgccgcgtg ccgcaacggc gtcacccggg tcatggtcca cgagttcggc aggcccgccg
    14041 tggccaggac cggcgagccg gagttcgccg aggtcgtgga cgtgtggaag cgggtcacgg
    14101 gggaggacat cagcggcggc acgccgctct gggtgaactc cttccacgac gccaaccggc
    14161 agctcacccg ctaccgggac gggcgcgtcc tgtgggcggg ggacgccgcc caccagcaga
    14221 tgccgatcgg cggccaggcc ctcaacctgg ggctccagga cgccgtcaac ctcggctgga
    14281 agctcgccgc cgtggtccgc ggcacggcgc cggacgggct gctcgacacc taccacgacg
    14341 agcggcacgc cgtcggccgc caggtcctcg gcaacatcag ggcccaggcc ctgctgctcc
    14401 tcggcgggcc cgaggcggag cccgtccgct ccctcctcgg cccgctcatc gccctggacg
    14461 acgtgcgggc gcacctggcc ggcaaggtct caggactcga catccggtac ggggccgggg
    14521 cggcggacgt gcatccgctg accggcaccc ggctgccccg cacggccctc gtggacgacg
    14581 gccgcgaggc cgtcgacccg tcgctgcggg ccggccaggg cctgttcctg acgctggacc
    14641 cgagcggcac cgggcccggg accggagcgg cggcggccgc cgcctgggcc ggccgggtcg
    14701 gcaccgccgt ggccaggccc gtgcccggcg gcgtcctcga cggactcgac gccgtcctcg
    14761 tacggcccga cggctacctc gcctggacct cggccgacgg cgcgggaccg gaagcggccc
    14821 tgcaccgctg gttcggcgcc cccacccacc tctgaacccc gacgaaggac cgagaaccat
    14881 gcctctgatc aaccccgaag acggctacct gaccgtcttc aacctcttcg agaccgagac
    14941 ctacgacggt caggcccgcg tcgtcgacga gatgaaggac atcgtcgaca acgccacgta
    15001 ccccggctgg atctcctcca ccgtgcacgc cggcgtcgac accccgggca ccctcaacta
    15061 catccagtgg cgcagcctcg ccgacctgga ggcgcgctac caggggcaga agttccagaa
    15121 gaagaccgtg ccgctcttcg accagctcgc cacctccgtg aagctgctca agacggagct
    15181 cgtgcacgcc cagcaccacc ccgacctggg cgccgccgcc gaggtctcgc ccgagcgcga
    15241 cgactacgcc gtcttcatcc tcttcgaggt gaagccggac cagcagcagg agctcctgga
    15301 caccctcgcc aagcccgacg agtggatcaa gaccgtcccg ggctaccgct cgcacggcta
    15361 ctaccgcggc atcgacggca cgtacgtcgt caactacgcc cagtgggaga gcaaggagct
    15421 ctacgaggcc ttccacaccc tgcccgagga gcagcgcccc gccgacatcc gcgagggccg
    15481 gctgcgcgcc cgctccctcg tcacctcccg ctgggccaac tccttccgcg cggtccactc
    15541 gcgctcggcg gagtaggcgc cgtgaccacc accccggaag ccggcttcga cgccgacgtg
    15601 atcgtcgtcg gcgcgggtcc caccggtctg atgctcgccg gtgaacggcg cctcggcggc
    15661 gcccgggtgc tcgtcgccga gcgccttgag cggcccaccg gccagtcccg cgggctcggc
    15721 ttcacggccc gcgccatgga ggtcttcgac cagcgcggac tgctgccgcg cttcggccag
    15781 ggggagaccc tggagaccag cccgatgggc cacttcggcg gtgtgcagtt cgactacacc
    15841 gtcctggagg gcgcccactt cggcgcccgc ggcatccccc agtacacgac cgagtcggtc
    15901 ctggaggagt gggccaccga gctcggcgcg gacatccggc gcggctggga gttcaccggc
    15961 ctcgaccagg acgacgacgc cgtggagatc accgtccgca cccccgaggg ggagcggcgg
    16021 ctgcgcgcgg cctacgtcgt cggctgcgac ggcggccaca gccccgtgcg caaggcggcc
    16081 ggcttcgact tccccggcac ccccgccacc cgcgagatgt acctcgcgga cgtcgtcggc
    16141 tgcgggctga agccccggtt cctcggcgag cggctgccgg agggcatggt catggcggcg
    16201 ccgctcgccg agggcgtcga ccggatcatc gtctgcccgc acggcacccc gccgcgcgac
    16261 cgcagggacg cccaggccgt cagcttcgcc gaggtggccg ccgcctggca gcgcatcacg
    16321 ggcgaggaca tcagcggcgg ttcggccgag tgggtcagct ccttcaccga caccacccgg
    16381 caggccaccg agtaccggcg cggccgggtg ctgctggtgg gcgacgccgc ccacatccac
    16441 ctcccggccg gcggccaggg gctgagcacc ggggtccagg acgcggccaa cctcggctgg
    16501 aagctggccg ccgtggtccg cggcacggcg cccgacgggc tgctcgacac ctaccacggc
    16561 gaacgccacc cggtggggca gcgcctgctg atgaacaccc gggcccaggg caccgtgttc
    16621 ctcggcggcg aggagtcgga cccgctgcgc gagctgttca ccgaactcct cgcgtacgac
    16681 gacgtgaagc ggcacctcgc cggagtcgtc agcggtctcg acatccgcta cgacctggca
    16741 ggcggcgccg acgacccgct ggtcggggcg cggctcgcgc accgggcgct caccacggcg
    16801 gcgggggaga ccagcacgac ccggctcgtc cacgccgggc agggcgtgct gctcgacctc
    16861 gccgacgacc cggcggtccg ggacgccgcg gcggcctgga aggaccgggt ggtcacggtg
    16921 acgggcaccc cgctgcccgt cgagggcacg gacgtgctcg cgggcgtcac ggccgtcctg
    16981 gtccggcccg acggccacgt ggcgtggacc gcgcgggccg ccggcgcgga cgcgtcggac
    17041 gccggcacgg aggccggtgc ggccgcctcc ctggccggta cggacgccga gggcctgggc
    17101 gcgagcctgc gccgctggtt cggcgagccc gcgtccgacg cgtccgtcac cccgggcgcc
    17161 tccgccgacg gcggcgcggc ccggtgaNNc tcgagtaccg cgggacgcgg ccggcccgta
    17221 cggccgccgc tcccgaccca tcccggggcc ccgactccga ctccccagac cccgactccg
    17281 accccgactc ccgcgaaagg ctggtccgcg atgccgctcc tgagggtcgc ggacgatgag
    17341 ctgcacctct ggaccctccg cccgcccccg ccggggtccg cggccgccga cgccctcgcg
    17401 accggggaac tcgacggtgc cgagcggcgc cgggcggagg cgtacgtacg cccccgggac
    17461 cgggtgcagt acctcgcggc gcacctcgcg ctgcgccggg tcctcgcccg ctacaccgga
    17521 gtcccggccg ggcggctgcg cttcggccgt gaggccgccg ggcggcccgt gctgctcggg
    17581 gtggcgggac cgccgtcctt ctcgctgtcg cacagccacg ggctggtgct gctcggggtg
    17641 gcccggcggc cggtgggcgt cgacgtccag cgcgtcccgc cgtacgccac cgcggaggtg
    17701 tgccgcggcg cgctccaccc ggccgagcgg gaggagctcg cggccctgcc ggaggaccgt
    17761 ctcgcggcgg ccttcgcccg gctgtggacc cggaaggagg cctacctcaa gggactcggc
    17821 acgggactcg cgcggggcct cgccaccgac ttcctcggca cgccgggcca cggcggcgtc
    17881 cggcggcccg ccggctggac ggtcctcgac ctgccgggcg gacccgacca cgcggcggcc
    17941 gccgccctgc acggcgacac cgcgccacgg gtcacgacga gggccctgcg ccccgaggac
    18001 ctgaccagca ccacacacgc atcgcacgac acgcagacac cgcacgacac gtacgacccg
    18061 tacgacacgc agaccgaaag gggagtggga agcgcatgaN Natgaccacg acgtccacgg
    18121 ccggaggagc cctcgcggac cgtctcaccg aactgggccg gctccgggag ctcgcccagg
    18181 agggccccga ccccagcggg ccaccgaacg ccagcaccgc gaagggcaag ctgaccgccc
    18241 gcgagcgcat cgaactgctc ctggacaagg ggagcttcac ggagatcgag cagctgcggc
    18301 ggcatcgtgc gcagggtttc ggtctggagg cgaagaagcc gtacaccgat ggtgtgatca
    18361 ccggttgggg gacggtggag ggccggacgg tcttcgtgta cgcgcatgat ttccggatct
    18421 tcggcggggc gctgggcgag gcgcacgcga cgaagatcca caaaatcatg gacatggcga
    18481 tcgcggcggg tgctccgctg gtctcgctga acgacggtgc gggtgcgcgt atccaggagg
    18541 gcgtctcggc gctggccggg tacggcggca tcttccagcg caacacccgg gcgtcgggtg
    18601 tgatcccgca gatctcggtg atgctcggcc cgtgcgcggg cggcgcggcc tacagtccgg
    18661 cgctgacgga cttcgtgttc atggtccgtg agacctcgca gatgttcatc accggtccgg
    18721 acgtcgtcaa ggcggtcacc ggcgaggaga tcacccagaa cggcctcggc ggcgccgacg
    18781 tccacgccgg cgtctccggc gtctcccact tcgtctacga cgacgaggag acctgcctgg
    18841 ccgaggtccg ctacctgctc tcgatgctcc cgcagaacaa ccgcgacctg ccgcccgtca
    18901 tgcccagctc cgaccccgcc gaccggcccg gcgaccggct gctcgacctc gtccccgccg
    18961 acggcaaccg ctcctacgac gtccgcgagg tcatcgagga actcgtcgac gacagcgact
    19021 acatggaggt ccacgcggcc tgggcgccca atctggtgtg cgccttcgcc cggctcgacg
    19081 ggcacgtcgt cggcatcgtc gccaaccagc cggccgccat ggccggggtg ctcgacatca
    19141 aggcctccga gaagggggcg cgcttcgtgc agttctgcga cgccttcaac atcccgatca
    19201 tcaccctcgt cgacgtgccc ggcttcctgc ccggcgtcga ccaggagcac gacggcatca
    19261 tccggcgcgg cgccaagctg ctctacgcct actgcaacgc gaccgtgccc cggatctccg
    19321 tcgtcctgcg caaggcctac ggcggcgcct acatcgtcat ggactcccgc tcgatcggcg
    19381 ccgacatctc cctcgcctgg cccaccaacg agatcgcggt catgggcgcc gaaggcgccg
    19441 ccaacgtggt cttccggcgg gagatcgccg ccgccgacga ccccgaggcg atgcgggccc
    19501 agaagatcca ggagtaccgc gaggagctcg tgcacccgta ctacgccgcc gagcgcggcc
    19561 tcgtcgacga cgtcatcgac ccgcgcgaga cccgccaggt gctgtgccgg tccgtcgcca
    19621 tgctcgccgc caagcacgcc gacctgccgc gccgcaagca cggcaacccg ccccagtgac
    19681 aggagcccgc cccgtgactc accgaagccc ggccgtccgg caccgaccgt ctgttccgcg
    19741 tcgagaaggg cgcgcccagc gccgaggagc tcgccgccgt caccgccgtc ctcctcgccc
    19801 gtacccagga gacgcaggcc ccggccccca ccgcccgtcc cgtcgccggc tggcgccgcc
    19861 tggagcgggc ccgcggcttc gacgggcccc gcacctggca ctccacgggc cacggccccc
    19921 actgaccccc gagaaaggcc tcccctcatg accaccaccg acctcaccgc cgtgaccacc
    19981 accgacggac cggccctcgc cgccgagctc gccgaactcc gcgccaccgt ccgcgagttg
    20041 tccgaccgcg ccgcgatatc cgcggtctgc gaccgctacg ccatgcacct cgacaaggac
    20101 cggggcagcg acgactggtt cggcgcggtg ttcaccgacg acgtccacct cgtcttcccg
    20161 atgggcgagt acaagggcat ggacggcctc gccgccttcc agcagatggc ccgcacgacc
    20221 ttcgcccgca cccaccacat cagcggcgcc tacgcgatcg acctgcgcgg cgacgaggcg
    20281 accgtacggg cccacctcac cgccttccac gtccgcgacg ccgccgcgcc ctccgcccac
    20341 ttcgccatcg gcgggcacta cgacgcccac gtcgtccgca cccccgaggg ctggcgcatc
    20401 cgctccttca ccttcgacct ggtgtggaac gccggcgagg cccccggcgc gaagggccac
    20461 tcctgatgag caccggcacc accacgcccg ccccgccctc accgcccgcc gggctcgccg
    20521 agcggatcgc ccgctcggcc gccaccggcc gcggcgccca cctggccacc gaggacttcc
    20581 acgactggct cgacggccgc cgccgcgcca acaccttccg cgtcgacaag atccccttcg
    20641 acgcgctcga cggctggtcc ttcgacgagg aggacggcaa cctcgtccac cgcagcggcc
    20701 gcttcttcac cgtcgagggc ctgcacgtcg tcgaggagga cggaccctac ggcgacggcc
    20761 cgtaccgctc ctggtaccac cccgtcatca agcagcccga ggtcggcatc ctcggcatcc
    20821 tcgccaagga gttcgacggc gtcctgcact tcctcatgca ggccaagatg gagcccggca
    20881 acccgaacct gctccagctg tcgccgaccg tccaggccac ccgcagcaac tacaccaagg
    20941 cgcaccgcgg cggcgacgtg aagtacatcg agtacttcac cggcgccgaa cacggcaccg
    21001 tcatcgccga ctccctccag tccgagcacg gcgcctggtt cttccacaag tccaaccgca
    21061 acatgatcgt cgaggccacc ggcgaggtcc cgctcctcga cgacttctgc tggctcaccc
    21121 tcggccagct cggcgagctc ctccaccagg acaacgtcat caacatggac gccaggaccg
    21181 tcctgtcctg cgtgccgtac gaggacgccg acgccgggcg ggcgctgctc tccgacgtcc
    21241 agctgctctc ctggttcacc ggcgagcgct cccgccacga cgtacgggcc cggcgcgtcc
    21301 cgctgcgcga gctgcccggc tggaagcagg gcgaggagac catcgagcac gaggagggcc
    21361 ggcacttcaa ggtcgtcgcc gtctccgtgc aggccgggaa ccgcgaagtg accagctgga
    21421 cccagccgct gatcgaaccg gtcggactcg gcgtcgccgc cttcctgacc cgcgacttcg
    21481 acggcgtccc gcactacctg gtgcacgccc gcgtcgaggg cggcttcctc gacaccgtgg
    21541 aactggcccc caccgtccag tacaccccgg gcaactacgc ccacctgccg accgacgagc
    21601 gcccgccctt cctcgacctc gtcctcgaca ccgaccccgg cccgcgtccg gctacgaggc
    21661 cgtgcactcc gaggaaggcg gccgcggttt ccttcaaacg ccgagagccg ctaccttcct
    21721 tggtggaggc cgacgagacg caaggccccg ggccggaccc cgccgcccgg gctacgcctg
    21781 ggcgacccgc cgcacagctc acctcccttg cacccggcac gggccactac ctcaacgtcc
    21841 aggcccgcac cctgctggcc tgcgtccacg ccggggcggt gcggccttga cgagcacccc
    21901 ggcgcccctg cggatcggtg tgctcggctg cgccgacatc gccgtccggc gcatgatgcc
    21961 cgcgatggcc gcgctccccg ggaccgaggt caccgccgtc gccagccgcg acgcggcgaa
    22021 ggccgccgtg gccgccgccc cgtacggcgc ggcggccgtc gagggctacc aggagctgct
    22081 gcgccgcccg gacgtcgacg ccgtctacgt accgctgccc gccgccctgc acgccgagtg
    22141 gaccgaggcc gccctgcggg ccggcaagca cgtcctggcc gagaagccgc tcaccacgga
    22201 cccggagagc accgccgcgc tgctcggcct ggccgccgcg tccgggctcg cgctgatgga
    22261 gacgtcatgt tcgtccacca ccgcctccac accgacgtcc cgcaagctcg tcgcggacgg
    22321 agccatcggc gaactccgcg ccctgcacgc ctgttcggca tcccccggct gcccgacacc
    22381 gacattccgg cacgaccccg ggctcggcgg cggcgccctc ggcgacgtcg gcgtctaccc
    22441 gctgcgagcc gcccagcacc tgctcggcga cgaactcgac gtcctcggcg cgcacctcgt
    22501 ccgggggccc ggcagccggg tcgagaccgc cggcggggcg ctgctcgcca ccccggcggg
    22561 cgtcaccgcg cacatcgcct tcggcatgga ccacggctac cgctcggcgt acgagctgtg
    22621 gggcagccag ggccggctcg tcgtcgagcg ggcctacacc ccgcccgccg accaccgccc
    22681 ggtggtgcgc ctggagaccc gcaccggcgt cgaggcgctt cagaagtggg ttcaaggatg
    22741 gttcaacctc gtcctcgacg ccgacgacca ggtccgcaac acggtggccg ccttcgccgc
    22801 cctcgtggcg cgcaccggag ccggccaccc cggggacggc ggcgcgcccg acccggaggc
    22861 cccgctgcgc caggcgcggc tgctcgacgc cgtgcggcgc cgggccgccc tcgtctgacc
    22921 cgcgcctgac attcacctgg cccgttgccg acgcagctga acagcgcgtg cagaacctga
    22981 ccaggccctg aaccgaggct ccttgaacgc cgcgccgcac ccggtgaggc tgggaacccc
    23041 agaggagaga actgtgaaag gcatcttcct ggccggaggc cacggcaccc ggctgcaccc
    23101 gatcaccctc ggcacgtcca agcagatgct gccggtctac gacaagccga tgatctacta
    23161 cccgctctcg gtgctgatgc tcgccgggat ccgggacatc cagatcatct cgtcccccga
    23221 cgacatcgag aacttccgcc ggctgctcgg cgacggctcc ccgctcggca tctcgctcag
    23281 ctacgccgtc caggagcagc cccgcggcct cgccgaggcc ttcctcatct ccgccgacca
    23341 catcggggac gactccgtcg ccctcgtcct cggcgacaac atcttccacg gccccggctt
    23401 cgccggaatc ctccaggaca aggccgtgga cgtggacggc tgcgtgctct tcggctaccc
    23461 ggtccgcgac cccgagcgct acggcgtcgg cgaggtcgac gcggacggcc ggctggtctc
    23521 cctggaggag aagccggagc acccgcgctc cgacctcgcc atcaccggcc tctacttcta
    23581 cgacaacgac gtcatcgaca tcgccaagaa cctcacgccc tcggcgcgcg gcgaactgga
    23641 gatcaccgac gtcaaccgga tctacctgga gcgcggcaag gccgaactgg tgtccctggg
    23701 acgcgggttc gtctggctcg acgccggaac gcacgacgcg ctgaccgagg ccggccagta
    23761 cgtgcagatc ctggagcacc gccagggcgt ccggctcgcc tgcctcgagg agatcgcctg
    23821 gcgcatgggg ttcatcgacc gggaggcctg cctgcggctc ggcgaggagc tctcgaagtc
    23881 cccgtacggc cagtacgtca tggagatagc ccgggccggc tgacccggcc gcccccaccg
    23941 cccgccacgc ccccgccccg cggagagaga accatgcgat atctgttcac caccatcccg
    24001 ggcacgtccc acacgctgcc cctggtcccg ctcgcccacg cggcgctcgc cgccgggcac
    24061 gaggtcgcct tcgccgcctc gggccccgcc ctgcgcgcgg ccaacgccgc cggtctccag
    24121 accatcgcgg ccgcgggcga cgaggccgcg gagccgtacg aggagctgat cgccaaggtc
    24181 accacgagcg acctgcgcag agttcccggc ccgaagatcc tcccgtacgt ctccgggatc
    24241 ttcggcgagg tcggcgcgcg tctggtggag ggcgtcgcag aggcggcccg cacctggcgg
    24301 gccgacgccg tggtcttccc gcccaaccac gtcgcaggac tgctcgccgc ccggatgacc
    24361 ggcctgcccg ccgtgctgca cggcatcggc accccccgcc cggtcttcgc cccggccctc
    24421 gcgtacctgg agccggtcgc cgcccgctcg gcgtctgacc tcccggcccc ggtcgccgac
    24481 gtggagatcg acctcaaccc ggcctccctc accgcgccgt ccctcggcgg ccccggcggc
    24541 ggcggaccgg ccgccgcgca ccggctcccg atgcgctaca cctcgtacaa cggcggcgcg
    24601 gagatcccgc ccggcctgct cggccgcggc gagcggcccc gggtcgccgt gacgctggct
    24661 ccctcgccgc gctgtacggc gagggcacca tgcctccgcg agatcgtcga cggctcggcg
    24721 gacctcggca tcgaactggt catcaccacc ggcggcgccg aactgcccgc cctcaccggc
    24781 tcgttgcccc cgcacgtcac ctgcgtggac tgggtcccgc tgcgcaccct gctcgcgagc
    24841 tgcgacgcga tcgtccacca cggcggcatg ggcagcacct tcaccgcctt cgacgccggg
    24901 gtcccgcagc tggcgatccc gctcaccggc ccggagagcg tctccaacgg ccgggtcgcc
    24961 gccgaccgcg gcaccggcat cgtcctcgac ccgccgctgt ccgtcccgct caccgccgcg
    25021 accgtgaagt cctcgctgca cgagctgctc agcaaccccg cgcaccgcac ggcggccgcc
    25081 gaagtcgccg ccgagatgcg ggagatgccg gcgcccgccg ccaccctggt ccagctcaac
    25141 gcgctcctcg gagggacggc atgaggatcg agctcttcta tagtgtcacc taaatggcca
    25201 tttaggatcg aattcctgca gcccggggga tcctcgtcac cggcggtgcc ggcttcatgc
    25261 acggctccca ctacgtccgc tccctcctcg acggggcgta cggcggcgac ggcaccgaca
    25321 ccgtcaccgt cctcgacaag ctgacctacg cgggcaaccg ggacaacctg cccgcctccc
    25381 acgagcggct caccttcgtc cgcggcgaca tctgcgacct gccgctgctg ctcgacctcc
    25441 tccccgggca cgacgcggtc gtccacttcg ccgccgagtc gcacgtcgac cggtccctgg
    25501 agtcggccgc cgagttcgtc cgcaccaacg tcctcggcac ccagaccgtc ctggaggccg
    25561 cgctgcgcac cggcgtccag cggctcgtgc acgtctccac cgacgaggtg tacggcacga
    25621 tcgacgaggg ctcgtggacc gaggacttcc cgctcctgcc caactccccg tacgccgcct
    25681 ccaaggcgag ctcggacctg gtggcccgct cctactggcg cacccacggg ctcgacctgt
    25741 cgatcacccg ctgctccaac aactacgggc cgtaccagca ccccgagaag ctcatcccgc
    25801 gcttcgtcac caacctcctg gagggccacc cggtgccggt ctacggcgac gggcggaacg
    25861 tccgcgagtg gctgcacgtc gacgaccact gccgggcgat ccacctggtg ctaccaccgg
    25921 ccgggcgggc gagacgtaca acatcggcaa gcgggaacga gctcaccaac ctcgacctga
    25981 ccgaacgcat cctggacctc tgcggcgccg accgctcgat gatccggtac gtcgaggacc
    26041 gcaagggaca cgacctgcgg tactcgctct ccgacgccaa gatccgcgaa gagctgggct
    26101 acacgccccg gacctccttc gaggacggcc tgcgccggac cgtcgactgg taccgcgaca
    26161 acccccagtg gtggaaggcc ggcaaggaga agtgacgacg accatgcagg tgacccccct
    26221 ggccatcgag ggcgccttcg ccttcacgcc ccccgtcttc aaggacagcc gcggcctgtt
    26281 cgcctccccc taccaggggg acgtgttcgc cgggcagctc ggccgcccgc tcttccaggt
    26341 caatcaggtc agccacaacc tgtccgccag gggcaccctc cgcggcgtcc acttcaccgc
    26401 gaccccgccg ggcatggcga agtacgtcta ctgcccgtac ggcaggctcc gggacttcct
    26461 catcgacctc cgggtcggct caccgacctt cgggcagtgg gtgatgaacg aactcgacgc
    26521 ggagaccagc cgcgccctct acgtcccggt cggcgtcggc cacgcgttcg tctcgctcca
    26581 ggacgactcc atgtgcgtat acgtgatgtc gcaggggtac tccccgccaa cgaactggcc
    26641 ctgcacccgc tcgacccggc gctcggactt acctgccgga cgacgtcgag ctgatcctgt
    26701 ccgaccggac aagatcgccc ccaccctcgc cgaggcccgc gaccgcggcc tcctgcccga
    26761 cttcgacacc tgccgcaagc tggaggaact gctgtgaccg ccaccaccgg acagaccggg
    26821 gacacccgac ccctggtggt cgtcctcggc gccgccggct tcgtcggctc cgccgtcctg
    26881 cgcgaactcg cccgccacga cctgcgggtg cgggccgtct cccggcgccc ggtgaccgtc
    26941 ccggccggcg cccgcgccga ggtggagacc cgcagcgtcg acctcaccgt ccccggcgcg
    27001 atggccgggg cgatcgaggg cgccgacgtg gtcgtccact cgatcgccta catcgcgggc
    27061 tcctcgacct ggcgcatcac ggacggcgac accggcgccg agcgggtcaa cgtgggactc
    27121 gtacgggacc tggtcgaggc cgtgcgggcg agcggccgcc ccgacaccgc cgtcctgttc
    27181 accggctccg tctccgccgc cggaccctcg gagcggggcg tctacgacgg tacggagccg
    27241 gacgagccgc agggcgagta cgaccggcag aagctggcgg ccgagcgggt gctgctcgcg
    27301 gcgagcgccg agggcgtgct gcgcgggatc tcgctccggc tccccacggt cttcggctac
    27361 ggccccgact cgaccgcgcg ggacaagggc atcgtctcct cgatggtccg ccgggcggtg
    27421 gcgggcgagc cgatcaccat gtggcacgac ggcacggtcc gccgcgacct gctgtacgtg
    27481 gaggacgtgg cgcgcgctat cgcggcggcc ctcggccacc tcgacgcgct cgcgggacgg
    27541 cactgggtgc tcggcagcgg gcacggcgcc gagctcggcc cggtcttcac cacggtcgcc
    27601 cggatggtgg cggagcggac cggcaagccg ccggtggccg tgcgctcggt ggagccgccc
    27661 gcgcacgccg aggcccggga cttcgccagc gtcaccgtcg acccgcgcgc cttccacgag
    27721 gtcaccggct ggcgggccga ggtcccgctg gacgaggccc tggaccggac gacggccttc
    27781 agcgcgagcg gcgcggagga gcacttcggc tgaccccggc cgccgtgcgg gggcccgtcg
    27841 cgacgggccc cgtgatcggg ggagggccgg tcagcggcag agggcgtgtt cggcggcggt
    27901 ggtgagggtc gaggtgacct gctccaccgt catcgaacgg ccggtgtaga gcaggtcgaa
    27961 gctgtcgaag gccgagaaca gccagagacg gcgggccgcc tcggcgaccg tgacgtcctc
    28021 gcgcagctca ccctgcgcgc cgagccgccg ggcgaggtcg tccatcccgg cggcgcgtcc
    28081 ggtctccatc cgctggaccg cgccgccgac cgcctcggcg tcgagcgcgg ccatggagta
    28141 cagggcgcgc atgacgtcgc ggtgggccgc gtacatctcg acgttgcccc ggatgccgcc
    28201 gcggagccct tcgcgcgcgt cgggctggag cacctcgcgc accatccgct cgaagccgcc
    28261 gcggtgcagc aggtccgcgc cgagggcgtc gaagagcccg gagcgcgagc cgaaggtcgt
    28321 gtacacggtg gaccgcgaca cgcccgccgt gcgggcgatc cggtcgaggc cgacggcctc
    28381 ggagggggcc gatcggagct gctcgtacag cgcgtcgagg atgcgccggc gggtctcggc
    28441 tgccgcctcc gcccggaggc gctgttcgta cttcctggtg gccatgggcc gatcctagca
    28501 ttggcttgac agcctgtctg gtgaaagaca tgctgtccga cgaaagcgcg aagacaggct
    28561 gtccgcgaaa tcgccgccag gtccaccgcg ccatccaccg cgcaaaaccc ggatccgaag
    28621 cagagggagc accacatgac ccggatcgcc gtcatcatcg gcagcaccgt cccggccgcc
    28681 gctcgaccgc cgtcgcccag tgggtcgagg aggccgcggg ccgccacgag gcgatcaagg
    28741 ccggcggcgc caccgtcgag ctcgtcgaca tcgccgagtt cggcctgccg ctgctcgacg
    28801 agtccgtccc ggccgccttc ggccagtacg ccaacgagca caccaagcgc tggtccgaga
    28861 agatcgcgtc cttcgacgcc ttcgtcttcg tcaccccgga gtacaaccgc tccgtcccgg
    28921 ccgcgctcaa gaacgccatc gactacctgt acgccgagtg gcagaacaag tccgccggct
    28981 tcgtcagcta cggcgtccag ggcggcaccc gcgccatcga ccacctgcgg gtcaccctcg
    29041 ccgaggtcaa ggtcgccgac gtgccgaccg ccgtctcgct gccggtcttc accgacttca
    29101 ccttcgagaa ccccatggac ccgaccgaga ccggtcgcgt cacccccggc ccgcaccagg
    29161 agcccacgct cttcaagatg ttcgacgaga tcatcgcctg ggccgaggcc ctcaagccgc
    29221 tccgtgccgc gggggcggcc gtctgaccgg ccggttgtca acggaggaag gccttcgcct
    29281 cctcccacgg ggcctcccgc accaggaacc gccgggacgc cccgtaccga gaccacagga
    29341 gaaccaccgc atgaccacgt cccgacggga gctgctcaag ctgatgacgg ccgcgggggc
    29401 cgccctcacc gcgagcggac tcctcatcag ccggacctcg ctcagcgaca cccgggccgg
    29461 cggcccggcg ggcgcctcgc cgttcgccgc ccagccggtg gccgcccagg ccctcgcccc
    29521 gatcgtcacg cccttccgca ccgccatgcc catcccgccg gtggcccgcc cggtctccgt
    29581 cacctcgacc accgacacgt acagcatccc ggtcacccag accacggcgg agatcatccc
    29641 cggggtccgc acccccgtcc tcacctacgg cggcagcttc cccggcccca ccatcaaggc
    29701 gcgctccggt cggcgcgtgg tcgtcaagca gcccaaccgg atcaccaccg gcacctccat
    29761 gcacctgcac ggagcggtcg tcgaccccgc caacgacggc ggccccatgg acctgatcac
    29821 gcccggcggg cagcgcacgt acacctaccc caacccgcag gtggcggcca ccctctggta
    29881 ccacgaccac gcccaccaca tggaggccga gcacgtctac cgcggcatgt cgggcttcta
    29941 cctgatatcc gacgacaacg aggacgcgct gcccctgccg cgcggcacct acgacgtgcc
    30001 gatcgtcgtt cgcgacatcg ggctcaaccc cgacggcacc ctcttcttcg accacaactt
    30061 cacacccggc cgcagatcct ggtcaacggg caagccgcag ccctacttcc aggtcgccgc
    30121 ccgcaagtac cggctgcgca tcctcaacgg ctccaaccag cggcccttcg agttccggct
    30181 ctccgacggc ggcgagttca cccagatcgc ctccgaccgc ggcctgctcc ccgccccgta
    30241 cacgacgacg accctgccgc tctcgccggc cgaacgggcc gacatcgtcg tcgacttctc
    30301 gcgctacccc gtgggcagca gcgtcgtcct ggagaacgcc tacttcccgg agccctccaa
    30361 caaggagatc ctccgcttcg acgtcgtccg ctccgcctac gaccccagct cggtcccggc
    30421 ccggctcgcc accctgccgc cgaccgccgc gccgacccag acgcgcaact acacgctcga
    30481 cttcgacgtg cagaccggcg cgggctcgat cagcggcaag acctgggacg agcagcgcgt
    30541 cgacaccacg gtgcgccagg gggacaccga ggtctgggag atcaagaaca cccacccctt
    30601 catcccgcac aacttccaca tccacctggt ggacttccgg atcc
//
