LOCUS       Actinorhodin            23291 bp	DNA     linear     22-Dec-2016
DEFINITION  Actinorhodin biosynthesis cluster
ACCESSION   Actinorhodin
VERSION
KEYWORDS
SOURCE      Streptomyces coelicolor
FEATURES             Location/Qualifiers
     source          1..23291
                     /organism="Streptomyces coelicolor"
                     /mol_type="genomic DNA"
                     /strain_name="A3(2)"
                     /db_xref="taxon:100226"
     CDS             complement(29..1213)
                     /locus_tag="Actino_00010"
                     /product="hypothetical protein"
                     /note="original product:hydroxylacyl-CoA dehydrogenase"
                     /gene="actVI-ORFB"
                     /note="original gene:ORFB"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
     CDS             complement(1569..2009)
                     /locus_tag="Actino_00020"
                     /product="hypothetical protein"
                     /note="original product:hydroxylacyl-CoA dehydrogenase"
                     /gene="actVI-ORFA"
                     /note="original gene:ORFA"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
     CDS             2083..3006
                     /locus_tag="Actino_00030"
                     /product="C-3 ketoreductase"
                     /note="original product:hydroxylacyl-CoA dehydrogenase"
                     /gene="actVI-ORF1"
                     /note="original gene:ORF1"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR006176"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR008927"
                     /inferenece="InterPro:IPR006108"
                     /inferenece="InterPro:IPR013328"
                     /translation="MSTVTVIGAGTIGLGWINLFSARGLTVRVNSRRPDVRRVVHEAL
                     ELFSPGRVDELAARIEYEPDVGRAVAGADVVSENAPDDLPLKQRLFAEIGAAAPDHAL
                     VLSSTSKLLPDELSRDMPGPGRLVVAHPFNPPHIVPLVEVVRGERTDPEAVERTLAFL
                     ASVGRTPVVVRRALPGFAANRLQSALLRESIHLVLEGVVTVEELDRIVTDSIGLRWST
                     IGPFHAFHLGGGPGGLRKWLEHLGSGLEQGWRGLGQPALTPQAVEALVAQTEAAYGHR
                     PYAELVRDRDDRHLAVLAALERTEQPQEETK"
     CDS             3003..3992
                     /locus_tag="Actino_00040"
                     /product="putative oxidoreductase"
                     /gene="actVI-ORF2"
                     /note="original gene:ORF2"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR013149"
                     /inferenece="InterPro:IPR011032"
                     /inferenece="InterPro:IPR002364"
                     /inferenece="InterPro:IPR020843"
                     /inferenece="InterPro:IPR013154"
                     /translation="MMRAVQFDRYGDPDVLYVAERPVPEPGPGQVRIAVDAVSVGHAQ
                     TQMRREAFPAPMWRPVFPVVLGGDVVGRITAVGPGVTALRPGDRVGAFTLYGAYAEQV
                     VVDAVTVVPVPEELDAAEAAVLPGTGLIALGILRTGRLRKGETVLIHAAAGGVGHIAV
                     QLARAAGAGLIIGTAGAAAKREFARATGADAVVDHRSAHWADEVRELTGGRGPDLILD
                     GIGAEVLEQGVGLLAPGGRLVFYGSSGGELAIPKVSVMDLIGIKYVTGFALSAWRGGR
                     PQEYEAGVAELTRLLAEGQVTSAVHARLPLERAAEAHAVVEARAQLGRVVLVP"
     CDS             4059..4703
                     /locus_tag="Actino_00050"
                     /product="hypothetical protein"
                     /gene="actVI-ORF3"
                     /note="original gene:ORF3"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
     CDS             4737..5657
                     /locus_tag="Actino_00060"
                     /product="putative oxidoreductase"
                     /gene="actVI-ORF4"
                     /note="original gene:ORF4"
                     /note="category:5.1 general function"
                     /transl_table=11
                     /inferenece="InterPro:IPR013154"
                     /inferenece="InterPro:IPR002364"
                     /inferenece="InterPro:IPR011032"
                     /inferenece="InterPro:IPR016040"
                     /translation="MPKAVAIHQFGGPDVLGLVDVPEPVPGPGQVTVRVRAAGVNGFD
                     CRVRSGGMRGRYPVEFPQIIGNEFAGVVERTGPEATGFAPGDEVLGFAVLQSGTELLA
                     VGADQITVKPPELSWEVAGSLSAVGQTADIALAELRVGPGDTVLVHAAAGGVGSLAVQ
                     LVRERGGTAIGSAGEHNHDYLRSLGALPVAYGPGFADRVRALARTASTPPLDCHGGPE
                     ALAVSLELVADRARIATVANFRAAAQEGIVMPRVVRSAERLAALAALCAEGRLRPHVE
                     AVLPFAKAAEAHHRLEQGHVRGKLVLVPDL"
     CDS             5689..7290
                     /locus_tag="Actino_00070"
                     /product="drug resistance transporter"
                     /gene="actVA-ORF1"
                     /note="original gene:actVA 1"
                     /note="category:4.3 transport"
                     /transl_table=11
                     /inferenece="InterPro:IPR020846"
                     /inferenece="InterPro:IPR016196"
                     /inferenece="InterPro:IPR001411"
                     /inferenece="InterPro:IPR011701"
                     /translation="MTANPGRPGGPADQGHPRRWAILGVLVLSLVGIILDNTVLNVTL
                     RTLTDPEQGLGASHSQVEWVLSAYTLAFAATLFTWGVLGDRLGRRRVLLLGLGLFGLS
                     SLAGAYAGSPEQLIAARACMGVSGAAVLPSTLATIAAVFPLRERPKALGIWAASVGFA
                     LGIGPVTGGILLAHFWWGSVLLVNVPLMAGCLVAVVLVVPETRGTAGRRVDAAGLLLS
                     IAGVVPLVYAIIEAGRSGGVTRPAVWAAGLAGLGLLLVFLWHERRTPEPSLELGFFRM
                     KAFSTAVAAVGFVSFAMMGFLFFSAFYLQSVRGYTPLQAGGCTVALAVANVVCGPLST
                     VLVRSIGPRNVCAAGMLAVTASLCGVTFVTQHAPVWLILVLFAALGAGVACVMPTAAV
                     SIMNAIPREKAGVASAMNNTVRQLGGALGVAVLGSLMGAAYRRGIEDELAVLPPSARH
                     QAGESLDATLLAATRLGESGLVGPARQAFLDAMHLAAGAAAAVALVGALAVLRWLPSS
                     VTTPTPPAGAVPGREHSDHLKVQGS"
     CDS             7292..7687
                     /locus_tag="Actino_00080"
                     /product="pyridoxamine 5'-phosphate oxidase-like
                     FMN-binding domain protein"
                     /gene="actVA-ORF2"
                     /note="original gene:actVA 2"
                     /note="category:5.2 function unknown"
                     /transl_table=11
                     /inferenece="InterPro:IPR012349"
                     /inferenece="InterPro:IPR024031"
                     /inferenece="InterPro:IPR011576"
                     /inferenece="InterPro:IPR009002"
                     /translation="MPFTPDELEYYASQNLGRLATVAPDGQPQANPVSFRVNTETGTI
                     DIGGHNLTASKKFRNVTKHDQVAFVVDDLISTQPWNVRGIEVRGRAEALTDAHAPHPY
                     FGTAMIRIHPKRIITWGLGGDAAQRGRDV"
     CDS             7782..8627
                     /locus_tag="Actino_00090"
                     /product="hypothetical protein"
                     /gene="actVA-ORF3"
                     /note="original gene:actVA 3"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
     CDS             8652..9536
                     /locus_tag="Actino_00100"
                     /product="hypothetical protein"
                     /gene="actVA-ORF4"
                     /note="original gene:actVA 4"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR008030"
                     /inferenece="InterPro:IPR016040"
                     /translation="MPDENKPVLVLGATGKQGGSAARYLLERGWTVRAFVRDPGAPKA
                     KELRELGASLHTGDLEDAGSVRAAMKGAYGVFSIQTPMTPAGVEGEERQGKICADAAR
                     DLGVQHYVHSSVGGAERPEGVNWRLSKLAIEQRIQENALRFTFLRPSYFMENLNHDMS
                     PLVMEDGVLTFRRGLGPANTLQMISGPDIGYFAADAFDDPDTFGGAKIELAGDELTGE
                     QIAAAFGRHTGLPARFVSVPIPELHRTGFEWQAISYTWLNGIGYHADIPTLRARFPQL
                     LTLDQWLARTGWTPRDPA"
     CDS             9533..10678
                     /locus_tag="Actino_00110"
                     /product="FMNH2-dependent monooxygenase"
                     /gene="actVA-ORF5"
                     /note="original gene:actVA 5"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR013107"
                     /inferenece="InterPro:IPR009075"
                     /inferenece="InterPro:IPR013786"
                     /inferenece="InterPro:IPR009100"
                     /inferenece="InterPro:IPR006091"
                     /translation="MSEDTMTQERPSLTAHARRIAELAGKRAADAEQQRRLSPDVVDA
                     VLRAGFAAHFVPVAHGGRAATFGELVEPVAVLGEACASTAWYASLTASLGRMAAYLPD
                     EGQAELWSDGPDALIVGALMPLGRAEKTPGGWHVSGTWPFVSVVDHSDWALICAKVGE
                     EPWFFAVPRQEYGIVDSWYPMGMRGTGSNTLVLDGVFVPDARACTRAAIAAGLGPDAE
                     AICHTVPMRAVNGLAFALPMLGAARGAAAVWTSWTAGRLAGPTGQNAVSSQDRVVYEH
                     TLARATGEIDAAQLLLERVAAVADAGSATGVLVGRGARDCALAAELLTAATDRLFASA
                     GTRAQAQDSPMQRLWRDVHAAGSHIGLQFGPGAALYAGELLRRSNDG"
     CDS             10671..11012
                     /locus_tag="Actino_00120"
                     /product="C-6 monooxygenase"
                     /gene="actVA-ORF6"
                     /note="original gene:actVA 6"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR007138"
                     /inferenece="InterPro:IPR011008"
                     /translation="MAEVNDPRVGFVAVVTFPVDGPATQHKLVELATGGVQEWIREVP
                     GFLSATYHASTDGTAVVNYAQWESEQAYRVNFGADPRSAELREALSSLPGLMGPPKAV
                     FMTPRGAILPS"
     CDS             complement(11263..12042)
                     /locus_tag="Actino_00130"
                     /product="TetR family transcriptional repressor"
                     /gene="actII-ORF1"
                     /note="original gene:actII"
                     /note="gene synonym:actR"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR004111"
                     /inferenece="InterPro:IPR009057"
                     /inferenece="InterPro:IPR015893"
                     /inferenece="InterPro:IPR011075"
                     /inferenece="InterPro:IPR001647"
                     /inferenece="InterPro:IPR003012"
                     /translation="MSRSEEGRPMPEEIPVPPWRRPKKAPPRMPLTQDRIVVTALGIL
                     DAEGLDALSMRRLAQELKTGHASLYAHVGNRDELLDLVFDIVLTEVEVPEPEPGRWAE
                     QVKEMCRSLRRMFLAHRDLARIAIDRVPLGPNGMVGMERTMNLLRSGGLHDELAAYGG
                     DLLSTFVTAEALEQSSRNPGTEQGREQAGVFADQLHGYLKSLPATSFPNLVHLAGPIT
                     SLDSDRRFELGLEIIIAGLLAGAGEAADDQVRTAGSPPAES"
     CDS             12153..13889
                     /locus_tag="Actino_00140"
                     /product="drug resistance transporter"
                     /gene="actII-ORF2"
                     /note="original gene:actII"
                     /note="gene synonym:actA"
                     /note="category:4.3 transport"
                     /transl_table=11
                     /inferenece="InterPro:IPR020846"
                     /inferenece="InterPro:IPR016196"
                     /inferenece="InterPro:IPR011701"
                     /translation="MSSVEADEPDRATAPPSALLPEDGPGPDGTAAGPPPYARRWAAL
                     GVILGAEIMDLLDGTVMNVAAPAVRADLGGSLSVIQWITVGYTLAFAVLLVVGGRLGD
                     IYGRKRMFVVGAVGFTAASVLCSVAAGPEMLTAARFLQGGLGALMIPQGLGLIKQMFP
                     PKETAAAFGAFGPAIGLGAVLGPIVAGFLVDADLFGTGWRSVFLINLPIGVAVIVGAV
                     LLLPEGKAPVRPKFDVVGMALVTSGLTLLIFPLVQGRERGWPAWAFVLMLAGAAVLVG
                     FVAHELRQERRGGATLIELSLLRRSRYAAGLAVALVFFTGVSGMSLLLALHLQIGLGF
                     SPTRAALTMTPWSVFLVVGAILTGAVLGSKFGRKALHGGLVVLALGVLIMLLTIGDQA
                     GGLTSWELVPGIAVAGLGMGIMIGLLFDIALADVDKQEAGTASGVLTAVQQLGFTVGV
                     AVLGTLFFGLLGSQATASVDDGASRARTELAAAGASTTEQDRLLADLRVCLRESASQQ
                     DSERTPDSCRNLQQARPAVAEATARAWRTAHTENFSTAMVRTLWVVIALLAVSFALAF
                     RLPPKPREEEGF"
     CDS             13889..16024
                     /locus_tag="Actino_00150"
                     /product="hypothetical protein"
                     /gene="actII-ORF3"
                     /note="original gene:actII"
                     /note="gene synonym:actB"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
                     /inferenece="InterPro:IPR000731"
                     /inferenece="InterPro:IPR004869"
                     /translation="MTRTLLSWPGGRRLKWLVLAAWIGLLIVLQPLAGKLGDVESNDA
                     AAWLPGNAESTEVLELSEKFQPADTSPTVIVYDRPSGITAADEAKARADATHFADGTG
                     VVGEPYGPVRSDDGKALRTVVNVHLGKDGWEGLNAAAKDMRAIARPSAPDGLGVHVTG
                     PTGYAADSAESFSSADFKLTLVTLLIVVTILVVTYRSPLLWLLPMISAGMSLVISQAI
                     VYLLAKNAGLTVNAQTAMILTVLVLGAATDYALLLVARYREELRRHEDRHEAMAVALR
                     RAGPAIVASAATVAVSMLVLLLAALNSTKGLGPVCAVGVLVGLLSMMTLLPALLVIFG
                     RWVFWPARPKHGTEPDVTRGLWSRIARLVSGRPRAVWVTTSLLLGAVATLAVTLNADG
                     LQQKDGFKTKPESVVGEEILTRHFPAGSGEPMVVIAKGASADQVHAALETVPGVIEVA
                     PPQVKDGLAYVEATLGAGADSPAAMRSVTAARETLARLDGAQARVGGSSAVVHDMREA
                     SSRDRGLIIPVILAVVFCILALLLRALVAPLLLIASVVLSFFTALGLAALFFNHVFDF
                     AGADSAFPLWVFVFLVALGVDYNIFLVTRIKEESDRLGTRQGALKGLTSTGGVITAAG
                     LVLAGTFAALATLPLVFIAELGFTVAVGVLLDTMIVRSVLVTALTLDVGRWMWWPHPL
                     ARREDPSEDPAVSGMPDSIDSEASTTASR"
     CDS             16174..16941
                     /locus_tag="Actino_00160"
                     /product="transcriptional activator"
                     /gene="actII-ORF4"
                     /note="original gene:actII"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR001867"
                     /inferenece="InterPro:IPR016032"
                     /inferenece="InterPro:IPR005158"
                     /inferenece="InterPro:IPR011990"
                     /inferenece="InterPro:IPR011991"
                     /translation="MRFNLLGRVHVITDAGCVIPLKSSKATQLLVLLLLRRHEVVGSG
                     VLIEELWADHPPRSAMTTLQTYVYHTRRLLGEHRVTSDDRELVLTQPPGYFALIDEDE
                     LDVAVAERLIRTGGRLLEENRLEEALASLDAGLDLWRGPALSTVPCGRVLESNIAHLE
                     ELRLFGMQLRIDANWRLGRIGPMIPELRSLVISHPLNETLHAKLMGALCQMGRRAEAL
                     ESYRNLRRILSDELGVDPTPEIQRMHMEILNGEKVLV"
     CDS             17080..17865
                     /locus_tag="Actino_00170"
                     /product="polyketide C-9 ketoreductase"
                     /gene="actIII"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR002347"
                     /inferenece="InterPro:IPR020904"
                     /inferenece="InterPro:IPR002198"
                     /translation="MATQDSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLR
                     TTLKELREAGVEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAEL
                     ADELWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGVVHAAPYSAS
                     KHGVVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHYSDIWEVSTEEAFDRIT
                     ARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQALNVCGGLGNY"
     CDS             18112..19386
                     /locus_tag="Actino_00180"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /note="original product:Beta-Ketoacyl synthase/Acyl
                     transferase"
                     /gene="actI-ORF1"
                     /note="original gene:actIORF1"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR018201"
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR020841"
                     /translation="MKRRVVITGVGVRAPGGNGTRQFWELLTSGRTATRRISFFDPSP
                     YRSQVAAEADFDPVAEGFGPRELDRMDRASQFAVACAREAFAASGLDPDTLDPARVGV
                     SLGSAVAAATSLEREYLLLSDSGRDWEVDAAWLSRHMFDYLVPSVMPAEVAWAVGAEG
                     PVTMVSTGCTSGLDSVGNAVRAIEEGSADVMFAGAADTPITPIVVACFDAIRATTARN
                     DDPEHASRPFDGTRDGFVLAEGAAMFVLEDYDSALARGARIHAEISGYATRCNAYHMT
                     GLKADGREMAETIRVALDESRTDATDIDYINAHGSGTRQNDRHETAAYKRALGEHARR
                     TPVSSIKSMVGHSLGAIGSLEIAACVLALEHGVVPPTANLRTSDPECDLDYVPLEARE
                     RKLRSVLTVGSGFGGFQSAMVLRDAETAGAAA"
     CDS             19383..20606
                     /locus_tag="Actino_00190"
                     /product="polyketide synthase chain length factor subunit"
                     /gene="actI-ORF2"
                     /note="original gene:actIORF2"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR014031"
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR016039"
                     /translation="MSVLITGVGVVAPNGLGLAPYWSAVLDGRHGLGPVTRFDVSRYP
                     ATLAGQIDDFHAPDHIPGRLLPQTDPSTRLALTAADWALQDAKADPESLTDYDMGVVT
                     ANACGGFDFTHREFRKLWSEGPKSVSVYESFAWFYAVNTGQISIRHGMRGPSSALVAE
                     QAGGLDALGHARRTIRRGTPLVVSGGVDSALDPWGWVSQIASGRISTATDPDRAYLPF
                     DERAAGYVPGEGGAILVLEDSAAAEARGRHDAYGELAGCASTFDPAPGSGRPAGLERA
                     IRLALNDAGTGPEDVDVVFADGAGVPELDAAEARAIGRVFGREGVPVTVPKTTTGRLY
                     SGGGPLDVVTALMSLREGVIAPTAGVTSVPREYGIDLVLGEPRSTAPRTALVLARGRW
                     GFNSAAVLRRFAPTP"
     CDS             20631..20891
                     /locus_tag="Actino_00200"
                     /product="polyketide synthase acyl carrier protein
                     subunit"
                     /note="original product:Acyl carrier protein"
                     /gene="actI-ORF3"
                     /note="original gene:actIORF3"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR006162"
                     /inferenece="InterPro:IPR009081"
                     /translation="MATLLTTDDLRRALVECAGETDGTDLSGDFLDLRFEDIGYDSLA
                     LMETAARLESRYGVSIPDDVAGRVDTPRELLDLINGALAEAA"
     CDS             20888..21838
                     /locus_tag="Actino_00210"
                     /product="cyclase/dehydratase"
                     /note="original product:Cyclase/dehydrase"
                     /gene="actVII"
                     /note="original gene:actIORF4"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR023393"
                     /inferenece="InterPro:IPR005031"
                     /translation="MSRPGEHRVVHTLRTQAPARRLYELVARVEDWPAVFEPTVHVQV
                     LERGPGTERFRIWARVGGRVKTWTSRRTLDPDTLRVTFRQELTQPPIASMGGSWEFRG
                     DGDGTEVVLTHDFAAVDEAALPGLREALDANSGKELAALVALAERRQPPEELVFTFED
                     TLRVPSGDDAYAFIERSDLWQERLPHVRKVTLTEEAAGTGPAETRDMTVQDMTMETVT
                     TDGGTHTTRSIRLCVPARSIVYKQLVPPALLSGHCGAWTFGEDTVTARHTVAIDPARV
                     EEVLGKGATVADARTHLREVLGANSRATLRHAAAAAGPAS"
     CDS             21835..22728
                     /locus_tag="Actino_00220"
                     /product="cyclase/dehydratase"
                     /note="original product:Dehydrase"
                     /gene="actIV"
                     /note="original gene:actIORF5"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR001279"
                     /translation="MTVEVREVAEGVYAYEQAPGGWCVSNAGIVVGGDGALVVDTLST
                     IPRARRLAEWVDKLAAGPGRTVVNTHFHGDHAFGNQVFAPGTRIIAHEDMRSAMVTTG
                     LALTGLWPRVDWGEIELRPPNVTFRDRLTLHVGERQVELICVGPAHTDHDVVVWLPEE
                     RVLFAGDVVMSGVTPFALFGSVAGTLAALDRLAELEPEVVVGGHGPVAGPEVIDANRD
                     YLRWVQRLAADAVDRRLTPLQAARRADLGAFAGLLDAERLVANLHRAHEELLGGHVRD
                     AMEIFAELVAYNGGQLPTCLA"
     CDS             22740..23273
                     /locus_tag="Actino_00230"
                     /product="NADH-dependent FMN reductase"
                     /note="original product:Dimerase"
                     /gene="actVB"
                     /note="original gene:actIORF6"
                     /note="category:3.3 modification reduction"
                     /EC_number="1.5.1.42"
                     /transl_table=11
                     /inferenece="InterPro:IPR009002"
                     /inferenece="InterPro:IPR012349"
                     /inferenece="InterPro:IPR002563"
                     /translation="MAADQGMLRDAMARVPAGVALVTAHDRGGVPHGFTASSFVSVSM
                     EPPLALVCLARTANSFPVFDSCGEFAVSVLREDHTDLAMRFARKSADKFAGGEFVRTA
                     RGATVLDGAVAVVECTVHERYPAGDHIILLGEVQSVHVEEKGVPAVYVDRRFAALCSA
                     AGACPSATGRGVPAHAG"
ORIGIN      
        1 ggatccccag gttcggcgcg gcagcgcgtc agggtgtcag cgcgcactcc gccgccgcca
       61 cgaccgtgcg ggcctggagt tccacctggg cgtgcacggg gacccagcgc agccgcaggg
      121 acgtctcgaa gtccgtgcac caggcggtga agagggcgtc cagctcgtgg tggagcccgg
      181 cggcggccgg ggcgtcggcc gcgtgcagca gccgcagcag gagtcccgcc gcgcgtagcg
      241 gctgacggcg cgcgacgacc tccagggcgc cgatccccgc cgtcgtcaac gcgggtgagc
      301 cgtcggtgcg cggtcccgcc tccgcctgcc ggaccagggg cccccaggag tcggccacca
      361 ggtcgtacag gtcctcggcc atccactcca gtacgcgtac gggtgggctg tcctcgggtg
      421 ccggcaggag gccgcgggcc ctctcgaaca cggcggtcac ctgccggccg ccctcccgca
      481 ccagcccgga cagcgcgcgc agggcccggg cggggtccgc gtgcggggtc gggtcgtccg
      541 ccggggcggt ggcccacagc ggtacctcga cgatcgccgt ggcaccgccg taccgctggg
      601 gcgcgcacca ggtggacagg ccgatgtcct cggacccggc cgccggccgc gcggtgctgc
      661 ccggcggcgg caggacatgg atgccggggg ccggattctc ccagtacagg gcgtcgtacg
      721 tgccgtgctg gaccgggacc cccagggcgg cggcggacgc cgcgaagggg gcggcgagtc
      781 cggggaggtc gcgggtcagc tgggcccagg tgccgcccgc gtcgacgttg tgcagggagc
      841 actggaggac ggggcgcagg tcgtcgatca cgtcgaacag ggcacggctc tccgggagtg
      901 gccggccgac gatcggggcc cactccggct gctccgcggc gaccgggcgg aaggcggcac
      961 ggtagtacga cgccagggac ggggcggggc cggccgtcgc ggtctcgatg ccctcgctca
     1021 gcgcggcgcc gtccgggtcg aggcacagga cgatgtccca ggtgacggcc tcggggtcgg
     1081 tcgccgggga gcgccggtcg ccgcctgcga ccagctccgc cagcgccagt gccgtcgcgc
     1141 cgcccaccgg ctcgtccggg tgcggccggg ccaccaccag gacgtgccgg ggtccgtggc
     1201 ccaccgacag catcaggagc ggccggcccg cccgggacgt gccgacacga cacaggcggc
     1261 ggtgcccggg aaacgggaga ccagccgtcg cgccgactcg gtgacctccg cgaccgtggg
     1321 gtatcggttc atcgggcgtg tccggtcagg ctccgccgtt gccgctctcg tccgccatgc
     1381 cgtctccttc cgacggtgcc cgtgggtacc cgtgggtacc tgtgctgctt ttcgcgcctg
     1441 tgctgcctgt ggtgtgcgag gcgcgtcgtg ccgctgtcag cgtccgttca ccggatcacc
     1501 gctgtcaatg gccggtgccg cccgcgcagt cgggggcggc gaagccggcg cgaaggcgag
     1561 ggtgcgcgtc aggccgggaa gacgtggtca tgggtgacgt ggcgggagcg cagcagcaac
     1621 tcgccgtccg ccccccggac caggacgtcg tgcacgaggc aactcggccc gaactccggc
     1681 gccttgacgt cggcgtggac ggtgagcacc aggcagtagc tggtcgccgt gatcgagccg
     1741 tcggacgcct ggctcagcgc cgtgtggtcg aaccagtgcc tgcgctggat tttgcgggcg
     1801 tcgaacttgc ggtggaagtc ctccaggacg gcggtgatcc cggcacgggt gtgggcggca
     1861 ggcagcgagg gcgagtgcct gaactcgccg tcctcggtga aggtcgcggc gtagccggcg
     1921 aagtcacggc cgtccagctt ctgcatctgg tggccgtaga acgacaggac ctcggcgtac
     1981 aggccggtgg gaagcgcggt gatggtcata cggccacggt cgcccggtgg cctcgaagtt
     2041 ccctcgagcc gggttcgagt gggcgctgcc aggctcgtcg ccatgagcac cgtgacagtg
     2101 atcggggcgg gcacgatcgg cctgggatgg atcaacctgt tcagcgcccg cgggctgacc
     2161 gtacgcgtca acagccgtcg gcccgacgtc cggcgcgtcg tgcacgaggc gctcgagctg
     2221 ttctccccgg ggcgggtgga cgagctggcg gcgcgcatcg agtacgagcc ggacgtcggc
     2281 cgggcggtgg ccggggcgga cgtcgtctcc gagaacgccc ccgacgacct gccgctcaag
     2341 cagcggttgt tcgcagagat cggagcggcc gccccggacc acgccctcgt gctgtcctcg
     2401 acgtcgaagc tgcttcccga cgagctgagt cgggacatgc cgggaccggg ccggctggtc
     2461 gtcgcgcatc cgttcaaccc accgcacatc gttccgctgg tcgaggtggt ccgcggcgag
     2521 cgcaccgacc cggaggccgt cgaacggaca ctggccttcc tggcgtcggt cgggcggacc
     2581 cccgtcgtgg tgcgcagggc gctgcccggc ttcgcggcca accggctgca gtcggcgctg
     2641 ctgcgcgaga gcatccacct cgtcctcgaa ggcgtggtga ccgtcgagga gctcgaccgg
     2701 atcgtcaccg actcgatcgg cctgcgctgg tccaccatcg ggccgttcca cgcgttccac
     2761 ctgggcggcg gtcccggcgg cctgcgcaag tggctcgagc acctcggcag cggcctcgaa
     2821 cagggctggc gtgggctcgg acagcccgcc ctcaccccgc aggccgtcga ggctctggtc
     2881 gcacagaccg aagccgccta cggacaccgg ccctacgccg aactggtccg ggaccgtgac
     2941 gaccggcacc tcgccgtact ggccgccctg gagcggaccg agcagcccca ggaggagacc
     3001 aagtgatgcg tgccgtgcag ttcgaccggt acggggaccc cgacgtgctg tacgtcgccg
     3061 agcgtcccgt ccccgaaccc ggccccggcc aggtgagaat cgccgtcgac gccgtgagcg
     3121 tcggccacgc gcagacccag atgcggcgcg aggccttccc cgcgccgatg tggcggcccg
     3181 tcttccccgt cgtcctcggc ggcgacgtgg tcggcaggat caccgcggtg ggaccgggcg
     3241 tcacggccct gcggccggga gaccgggtcg gtgcgttcac cctctacggc gcctacgccg
     3301 agcaggtcgt cgtcgacgcc gtcaccgtcg tacccgtgcc cgaggagctg gacgccgccg
     3361 aggccgcggt cctcccgggc accggactga tcgccctcgg catcctgcgg accggacgac
     3421 tgcgcaaggg cgagacggtg ctgatccacg cggcggccgg cggggtgggc cacatcgcgg
     3481 tccagctcgc ccgggcggcc ggcgccggcc tgatcatcgg caccgcgggc gcggccgcca
     3541 aacgcgagtt cgcccgcgcg acgggcgccg acgccgtcgt cgaccaccgc tccgcacact
     3601 gggccgacga ggtccgggaa ctcaccgggg ggcgtggccc cgacctgatc ctggacggca
     3661 tcggcgccga ggtcctggag cagggagtcg gtctgctcgc tccgggcggc cggctggtgt
     3721 tctacggctc gtccggcggc gagctggcga tcccgaaggt gtcggtgatg gacctcatcg
     3781 gcatcaagta cgtcaccggc ttcgccctgt cggcctggcg cggtggccgc ccgcaggagt
     3841 acgaggcggg cgtcgccgaa ctcacccgac tgctggccga aggacaggtc acgtccgcgg
     3901 tgcacgcccg gctgccgctg gagcgggcgg ccgaggcgca cgccgtcgtc gaggccaggg
     3961 cccagctggg ccgggtcgtg ctcgtcccct gaaacgacca ggcattcctc cgaagtgtcc
     4021 aagcattcct gatccaagag cccgaaggag acctttccat gacctcgtcg ctgcaccacg
     4081 cgatacgtct gaccaccgcg tccgccatcg ccctgggcgg actcgtgacc ctggggacca
     4141 gcgcgcacgc cgcgagcgtc gccgtgccgt acgagtgccg cacctgggtg cagggcaaca
     4201 cgcacccggt ctacgactac gcgcgcggct tcgacgtcag cgtgcccgcc tcggtccgcg
     4261 cgggcaagaa cttcaaggcc acctacgatc ccgacccgat caccgccttc gccgagtaca
     4321 accagatcgt caacgacgtg cggatcgcct accggatccc ggacggcgcg aaggtccaca
     4381 aggtgcggct caccggcggc agcggtctcg gcgactccga cgtccgggtc caggtcaagg
     4441 gccgggacat cgtcgtcagc gcctccggcc ccttccaggg cggtgtcgag ttcgacctgc
     4501 cgacgctgaa ggtcacctac aaggcgccga agaccaccgg cccgctcaac ttcgtctcgg
     4561 gcggctcggg ttacgaggac cccggcttct actggtaccg ctaccagccg atcctggacg
     4621 agtggggccc cttcgagtgc ttccccgacc cggcgaagcc cgaggccgtc ctggccagca
     4681 cccaggtcaa gaagcacaag tagacacagc ggggtcggac gaacaatgga gaacgcatgc
     4741 ccaaggccgt agccatccac cagttcggcg ggccggacgt actgggcctc gtcgatgtcc
     4801 ccgagccggt gccgggaccg ggccaggtga ccgtccgagt gcgggccgcc ggagtcaacg
     4861 ggttcgactg ccgggtgcgc tccggcggca tgcgcggtcg ctatccggtc gagttcccgc
     4921 agatcatcgg caacgagttc gccggggtcg tcgagcggac cggaccggag gcgaccgggt
     4981 tcgcgcccgg cgacgaggtg ctcgggttcg ccgtgcttca gtccggcacc gagctgctcg
     5041 ccgtcggcgc ggaccagatc accgtgaaac cgccggagct gtcgtgggag gtcgcgggat
     5101 ccctctcggc cgtcggacag accgccgaca tcgccctggc cgaactgcgg gtcggccccg
     5161 gggacaccgt gctcgtgcac gccgcggccg gcggcgtcgg cagcctcgcc gtccagctcg
     5221 tccgggagcg gggcggcacg gcgatcggca gcgccggcga gcacaaccac gactacctgc
     5281 ggtcgttggg cgcactgccc gtcgcctacg gcccgggctt cgccgaccgg gtgcgggccc
     5341 tggcccgaac ggcgtcgacg ccgcccctcg actgccacgg cggaccggaa gccctcgccg
     5401 tgtcgctcga actcgtcgcg gaccgggccc ggatcgccac cgtcgccaac ttccgcgccg
     5461 cggcccagga gggcatcgtc atgccacggg tggtgcggtc cgccgagcgg ctcgccgcgc
     5521 tggccgcact ctgcgccgag ggccggctgc ggccgcacgt cgaggccgtc ctgcccttcg
     5581 ccaaggcggc cgaggcccat caccggctgg agcagggcca tgtccggggc aagctcgtcc
     5641 tggtgccgga cctgtgacgg cgaaccccgg NNcgtcctgg tgccggacct gtgacggcga
     5701 accccggccg tccgggcggc ccggcggacc agggccaccc gcgccgctgg gccatcctcg
     5761 gggtgctggt cctcagcctg gtcggcatca tcctcgacaa caccgtgctc aacgtgacgc
     5821 tgcgcaccct caccgacccc gagcagggcc tgggcgcctc gcacagccag gtggaatggg
     5881 tgctcagcgc ctacaccctg gccttcgcgg cgacgctgtt cacctgggga gtgctgggcg
     5941 accgactggg ccgcaggcgg gtactcctgc tgggcctcgg cctgttcgga ctgtcgtccc
     6001 tggccggggc ctacgccggg tcgccggagc agctcatcgc cgcccgtgcc tgcatggggg
     6061 tgagcggcgc ggcggtgctg ccgagcacac tcgccaccat cgccgccgtc ttcccgctgc
     6121 gcgagcggcc caaggccctc gggatctggg cggcctcggt cggcttcgcc ctcggcatcg
     6181 ggcccgtcac cggcgggata ctgctcgcgc acttctggtg gggctcggtc ctgctggtca
     6241 acgtgcccct catggccggg tgcctggtcg cggtggtgct ggtggtgccc gagacccggg
     6301 gcacggcggg caggcgcgtc gacgcggccg gactgctgct ctcgatcgcg ggtgtcgtgc
     6361 cgctcgtcta cgcgatcatc gaggccggcc ggagcggcgg ggtcacccgg cccgcggtct
     6421 gggcagccgg cctggcgggc ctcggcctgc tcctcgtgtt cctgtggcac gagcgccgta
     6481 ccccggaacc ctcgctggag ctcggcttct tccggatgaa ggccttctcc accgccgtcg
     6541 cggccgtcgg cttcgtcagc ttcgcgatga tgggcttcct cttcttcagc gccttctacc
     6601 tgcagagcgt gcgcggctac acacccctgc aggccggggg atgcaccgtg gcactggccg
     6661 tcgcgaacgt ggtctgcgga ccgctcagca cggtcctggt gcgttcgatc ggcccccgga
     6721 acgtgtgcgc ggcgggcatg ctggccgtca ccgcatcgct ctgcggggtc accttcgtga
     6781 cccagcacgc acccgtatgg ctgatcctcg tcctgttcgc cgcgctgggg gcgggcgtag
     6841 catgcgtcat gccgaccgcg gccgtgtcca tcatgaacgc gatcccacgc gagaaggcgg
     6901 gcgtcgcctc ggcgatgaac aacaccgtgc gccagctggg cggcgccctg ggcgtcgcgg
     6961 tgctcggttc cctcatgggc gccgcgtacc gccgcggcat cgaggacgag ctcgccgtac
     7021 tgccgccctc cgcgcggcac caggccggcg agtccctgga tgccaccctg ctggccgcga
     7081 ctaggctggg ggagagcgga cttgtcggcc ccgcgcgcca ggcattcctg gacgccatgc
     7141 acctggccgc cggggccgct gccgcggtgg cgctcgtggg ggcccttgcc gtgctccgct
     7201 ggctgccctc ctccgtcacg actccgacgc ccccggcagg ggccgtgccc ggccgggagc
     7261 attccgatca cctcaaggtc caaggaagct gacatgcctt tcactcctga cgagctcgag
     7321 tactacgcct cccagaacct cggccggctg gccaccgtgg cgcccgacgg ccagccccag
     7381 gccaacccgg tctcgttccg cgtcaacacc gagaccggca cgatcgacat cggcgggcac
     7441 aacctgaccg ccagcaagaa gttccgcaac gtcaccaagc acgaccaggt cgccttcgtc
     7501 gtcgacgacc tgatctccac gcagccgtgg aacgtacgcg gtatcgaagt gcgcggccgg
     7561 gccgaggcgc tgaccgacgc gcacgcgccg cacccctact tcggtaccgc gatgatccgt
     7621 atccacccca agcgcatcat cacctggggc ctcggcggcg acgccgccca gcgcggccgc
     7681 gacgtctgac ccagcaccct tcgactccgc ttcgagcgga cctcgacgcc ctcttgccaa
     7741 ggtggagccc gtaggacggg tacaccacgg ggagggcggc tggatgagta cagagatctt
     7801 ccatgaggag ttcgccgggg ggctggtgac cgaggggccg ggcgcgccgt ggcggcttcg
     7861 cccggtcgac ggtctcgagg cgggagacgg gctggtccgc gggggaccgg acggcctggt
     7921 ggtcgtgccg agcgccgccc acccggggac ccggcggccg gcgttcaccg agcccaagcc
     7981 cgggccggac ggcaccccgc tgcatctgcg gtggggtgcc ttcaccaccg gcggcaccac
     8041 cggcggcacc gccggcgcgc gggcggcgtt caccgccgtg cccggcgaac ggctctcggt
     8101 cagggccgag atggggctgc gcggcttcgg tctgcgctcc catccgtacg acgacgtgac
     8161 cgaacccgac gcggacgccc ggctcggcgc gggcggtctg atctcggtcg atctcgagtc
     8221 cgggatcatc ttcgacttct tcctcacaca cagccggctc tacgcggtct acgagcggct
     8281 cgcgctgcgg ccggacgccg agttcgcggc cttcacctca tgcgtcccgg tcgcggaccg
     8341 cacccccggc acgctccacc ggctcgaggt cggatacgac gtcgcggccg gcaccgccca
     8401 ctggacggcc gacgggcagg aggtcctgtc cgtggaccgg atcggcttcc gcgcactgga
     8461 cgcgcgctgg ctccggcggg acaacggcgg ccgcgaggag gccgtacggc cgcgcggact
     8521 cagcttcggc ctcgggctct tcctggagcg ccacttcggc cagggggtgc ggctgtcggt
     8581 gcgaaggctg tcggtgctca cctcgcccgc cggctcccgc gactcgtgac gacgaccaac
     8641 gaaaggcact gcgatgcccg atgagaacaa gcccgtactg gtcctcggcg ccaccggaaa
     8701 gcaaggcggc tccgcggccc ggtacctgct ggaacgcggc tggacagtcc gggccttcgt
     8761 ccgggacccc ggcgcgccca aggccaagga gctgcgtgag ctgggggcga gcctgcacac
     8821 cggcgacctg gaggacgccg gctcggtgcg cgccgcgatg aagggtgcgt acggcgtgtt
     8881 cagcatccaa acgccgatga caccggccgg cgtggagggc gaggagcggc agggcaagat
     8941 atgcgccgac gccgcccgcg acctcggcgt ccagcactac gtccacagct cggtgggcgg
     9001 cgcggaacgg ccggagggcg tgaactggcg gctgtccaag ctcgcgatcg agcagcggat
     9061 ccaggagaac gcgctccggt tcaccttcct gcggccgtcg tacttcatgg agaacctgaa
     9121 ccacgacatg tcgcccctcg tcatggagga cggcgtgctg accttccgga gggggctcgg
     9181 gccggccaac accctgcaga tgatcagcgg ccccgacatc gggtacttcg cggccgacgc
     9241 cttcgacgac cccgacacct tcggcggcgc caagatcgag ctggccgggg acgagctgac
     9301 cggcgagcag atcgcggccg cgttcggccg gcacaccggg ctgcccgccc gcttcgtgtc
     9361 ggtgccgata ccggagctgc accgcacggg gttcgagtgg caggcgatct cgtacacctg
     9421 gctcaacggc atcggctatc acgccgacat ccccacgctg cgcgcccggt tcccgcagct
     9481 gctcaccctc gaccagtggc tggccaggac cggctggacc ccgagggacc cggcatgagc
     9541 gaggacacga tgacccagga gcggccgtcc ctgacggcac acgcccgccg gatcgccgaa
     9601 ctcgccggga agcgggcggc cgacgccgaa cagcagcgcc ggctgagccc cgacgtcgtc
     9661 gacgcggtcc ttcgagccgg tttcgccgcc cacttcgtac cggtggcgca cggcggccgg
     9721 gccgcgacgt tcggggagct ggtggagccc gtcgcggtgc tcggcgaggc ctgtgcctcg
     9781 accgcctggt acgcctcgct cacggcgagc ctcggccgga tggccgccta cctgccggac
     9841 gagggccagg ccgagctgtg gtccgacggc cccgacgccc tgatcgtcgg tgccctgatg
     9901 ccgctgggcc gggccgagaa gaccccgggc ggctggcacg tgtcgggcac ctggccgttc
     9961 gtcagcgtcg tggatcactc cgactgggcg ctgatctgcg ccaaggtcgg cgaggagccg
    10021 tggttcttcg cggtgccgcg acaggagtac gggatcgtcg acagctggta cccgatgggt
    10081 atgcgcggaa cgggcagcaa cacgctcgtc ctcgacgggg tgttcgtgcc ggatgcgcgg
    10141 gcctgcaccc gtgcggccat cgcggcaggt ctcggtccgg atgccgaggc gatctgtcac
    10201 accgtgccca tgagggcggt caacgggctg gccttcgcac tgccgatgct cggcgcggcc
    10261 cgcggggccg cggccgtgtg gacctcgtgg accgccggaa gactggccgg gccgaccggg
    10321 cagaacgccg tctcgtccca ggaccgcgtg gtgtacgagc acacgctggc ccgggccacg
    10381 ggtgagatcg acgcggccca gctgctgttg gagcgggtcg cggcggtcgc cgacgccggc
    10441 tcggcgaccg gcgtactggt cggccgcggg gcgcgggact gcgccctggc ggcggagctg
    10501 ctgaccgccg cgaccgaccg gctgttcgcc tcggcgggca cccgggcaca ggcccaggac
    10561 agcccgatgc agcgcctgtg gcgcgatgtg cacgcggcgg gcagccatat cgggctgcag
    10621 ttcgggcccg gggcggcgct gtacgccgga gagctgttga ggaggagcaa cgatggctga
    10681 agtgaacgat ccccgggtgg gcttcgtcgc ggtcgtcacc ttcccggtgg acggccccgc
    10741 cacccagcac aagctggtgg agctggccac cggcggggtg caggagtgga tccgcgaggt
    10801 gcccggcttc ctgtcggcca cgtatcacgc gagcacggac gggaccgcgg tcgtcaacta
    10861 cgcccagtgg gagagcgagc aggcctaccg ggtgaacttc ggcgccgacc cgcgctcggc
    10921 ggagctgcgg gaggcgctga gctcgctgcc cgggctcatg gggccgccga aggccgtgtt
    10981 catgactccg cggggggcga tcctgccgtc ctgacctggt cgtccgcggc ctcgccggcc
    11041 ccggccagca ggccggcgat gatgatctcg agNNggatcc gcgaggtgcc cggcttcctg
    11101 tcggccacgt atcacgcgag cacggacggg accgcggtcg tcaactacgc ccagtgggag
    11161 agcgagcagg cctaccgggt gaacttcggc gccgacccgc gctcggcgga gctgcgggag
    11221 gcgctgagct cgctgcccgg gctcatgggg ccgccgaagg ccgtgttcat gactccgcgg
    11281 ggggcgatcc tgccgtcctg acctggtcgt ccgcggcctc gccggccccg gccagcaggc
    11341 cggcgatgat gatctcgagg ccgagctcga accggcggtc ggagtcgagc gaggtgatcg
    11401 ggccggccag gtggaccagg ttcgggaaac tggtggccgg cagtgacttc aggtagccgt
    11461 ggagctggtc ggcgaacacg ccggcctgct cccggccctg ttccgttccg gggttgcggg
    11521 acgactgctc cagggcctcc gccgtgacga aggtcgacag caggtcgccc ccgtaggcgg
    11581 cgagttcgtc gtgcaggccc ccggagcgca gcaggttcat ggtgcgctcc atccccacca
    11641 tcccgttggg tcccagcggc acccggtcga tcgcgatccg tgccaggtcc cggtgggcca
    11701 ggaacatcct ccgcagcgac cggcacatct ccttgacctg ctccgcccag cggccgggtt
    11761 ccggttccgg gacctccacc tcggtcagca cgatgtcgaa gacgaggtcg agcagctcgt
    11821 cccggttccc cacgtgcgcg tacagcgagg cgtgtccggt cttcagctcc tgcgcgagcc
    11881 gccgcatgct cagggcgtcg agtccctcgg cgtcgaggat gccgagcgcc gtgacgacga
    11941 tccggtcctg ggtcaggggc atgcgcggcg gcgccttctt cggccggcgc cacggaggca
    12001 cgggaatctc ctcgggcatg ggcctccctt cctcgcttcg cgacacgtgc tcctcatcgt
    12061 atggcatgaa cgggccaccg tttcttgacg cgaccaccgt tccattgtag aacggtggtc
    12121 gttcgtggac caatagtcga ggacccgggg gacgccatga gttccgttga agccgacgag
    12181 ccggacaggg ccacggcccc gccgtcggcg ttactgcccg aggacggccc cggaccggac
    12241 ggaaccgcgg ccggaccccc gccctacgcg cgccgttggg ccgcgctggg agtcatcctc
    12301 ggcgccgaga tcatggacct gctcgacggc acggtcatga acgtggccgc gcccgccgtc
    12361 cgcgcggacc tgggcggcag cctcagcgtc atccagtgga tcaccgtcgg gtacacgctc
    12421 gcgttcgccg tcctgctcgt ggtgggcggc cggctgggcg acatctacgg ccgcaagcgc
    12481 atgttcgtcg tcggcgccgt cggcttcacc gcggcctccg tgctgtgctc ggtggcggcc
    12541 ggtcccgaga tgctcaccgc ggcacgcttc cttcagggcg ggctcggcgc gctgatgatt
    12601 ccgcaagggc tcggtctcat caagcaaatg ttcccgccca aggagacggc ggcggcgttc
    12661 ggcgcgttcg gacccgccat cgggctgggc gccgtgctcg gcccgatcgt cgccgggttc
    12721 ctggtcgacg ccgacctgtt cggcacgggc tggcggtccg tcttcctgat caatctgccg
    12781 atcggcgtgg ccgtgatcgt cggcgcggtc ctgctgctgc ccgagggcaa ggcgcccgtg
    12841 cggccgaagt tcgacgtcgt cggcatggcg ctggtgacgt ccgggctcac cctgctcatc
    12901 ttcccgctcg tccaggggcg cgaacgcggc tggcccgcct gggcgttcgt gctgatgctg
    12961 gccggagcgg ccgtgctcgt cggcttcgtc gcccacgaac tgcggcagga gaggcgcggc
    13021 ggcgccacgc tcatcgagct cagcctgctg cgcaggtccc gctacgccgc gggactggcg
    13081 gtggcactgg tgttcttcac cggcgtctcc ggaatgtcgc tgctgctcgc cctgcacctg
    13141 cagatcggcc tgggcttcag ccccaccagg gccgcgctga ccatgacgcc ctggtcggtg
    13201 ttcctcgtcg tcggcgcgat cctgaccggg gcggtgctgg gatcgaagtt cggccgcaag
    13261 gccctgcacg gcgggctcgt ggtgctggcg ctgggcgtgc tgatcatgct gttgacgatc
    13321 ggcgaccagg ccggcgggct gaccagctgg gagctcgtcc ccggtatcgc cgttgccggg
    13381 ctcggcatgg gcatcatgat cggactgctc ttcgacatcg ccctggccga cgtcgacaag
    13441 caggaggccg gtaccgcctc cggcgtcctc accgcggtcc agcagctcgg cttcaccgtg
    13501 ggcgtcgcgg tgctcgggac cctgttcttc gggctgctcg gctcacaggc cacggcgagc
    13561 gtcgacgacg gcgcgagccg ggcccgcacc gaactcgccg ccgccggggc gagcacgacc
    13621 gagcaggacc ggctcctggc cgacctgcgg gtgtgcctgc gggaatcggc gagtcagcag
    13681 gactccgaac ggacgccgga cagctgccga aacctccagc aggcccggcc ggcggtggcc
    13741 gaggccacgg cgcgggcctg gcggacggcc cacaccgaga acttcagcac cgcgatggtc
    13801 cgcacgctct gggtggtgat cgcactgctg gcggtctcct tcgcgctggc cttccggctg
    13861 ccgcccaagc cgcgtgagga agagggcttc tgatgacacg cacactgctg tcctggcccg
    13921 gcggacgccg gctcaagtgg ctggtgctcg cggcctggat cggtctgctg atcgtgctcc
    13981 agccgctggc agggaagctc ggcgacgtcg agtccaacga cgccgccgcc tggctccccg
    14041 gcaatgcgga gtcgaccgaa gtgctcgagc tgtccgagaa gttccagccg gccgacacca
    14101 gcccgaccgt gatcgtctac gaccgcccgt ccgggatcac ggccgccgac gaggcgaagg
    14161 cgcgggccga cgccacgcac ttcgcggacg gcaccggtgt ggtgggcgag ccctacggcc
    14221 cggtgcgctc ggacgacggc aaggccctgc gcaccgtcgt caacgtccac ctcggcaagg
    14281 acggctggga ggggctcaac gcggccgcga aggacatgcg ggcgatcgcc cggccgagcg
    14341 ccccggacgg tctcggcgtc cacgtcacgg gtccgaccgg ttacgccgcc gattccgcag
    14401 agtccttcag cagcgccgac ttcaagctca ccctggtcac cctcctcatc gtcgtgacga
    14461 tcctcgtcgt cacctatcgc agtcccttgc tctggctgct gccgatgatc tccgcgggca
    14521 tgtccctggt catctcgcag gccatcgtct acctgctggc caagaacgcg ggactcacgg
    14581 tcaacgccca gacggcgatg atcctcacgg tcctggtgct cggcgcggcc accgactacg
    14641 cgctgttgct cgtcgcccgc taccgcgagg agctgcggcg gcacgaggac cggcacgagg
    14701 ccatggccgt ggcgctgcgc cgggccggtc ccgccatcgt ggccagcgcc gccaccgtcg
    14761 ccgtcagcat gctcgtcctg ctgctggccg ctctgaactc caccaagggt ctcggcccgg
    14821 tctgcgccgt cggcgtgctg gtcggcctgc tgtcgatgat gacgttgctg cccgccctgc
    14881 tggtgatctt cggacgctgg gtcttctggc cggcccggcc gaagcacggt acggagcccg
    14941 acgtcacccg gggtctgtgg tcgcggatcg cccggctggt gtccggccgt ccgcgtgccg
    15001 tctgggtcac caccagcctg ctgctggggg cggtggccac gctggccgtc accctgaacg
    15061 ccgacggcct ccagcagaag gacggtttca agaccaagcc ggagtcggtg gtgggcgagg
    15121 agatcctgac ccggcacttc ccggccggct ccggtgaacc catggtcgtc atcgccaagg
    15181 gcgcctcggc ggaccaggtg cacgcagctc tggagaccgt gcccggcgtc atcgaggtcg
    15241 caccaccaca ggtgaaggac ggcctcgcct atgtcgaggc gacgctcggc gccggggcgg
    15301 actcgccggc ggccatgcgt tcggtcaccg cggcccgcga gacactcgcc cggctggacg
    15361 gtgcgcaggc acgggtgggc ggcagcagcg ccgtcgtgca cgacatgcgg gaggcgtcca
    15421 gccgcgaccg cggtctgatc attccggtga tcctcgccgt ggtgttctgc atcctcgcgc
    15481 tgctgctgcg agcactggtg gcgccgctgc tgctgatcgc gagcgtggtg ctgtccttct
    15541 tcaccgcgct cggcctcgcc gccctcttct tcaaccacgt cttcgacttc gcgggagccg
    15601 attcggcctt ccccctgtgg gtcttcgtct tcctggtcgc cctgggcgtc gactacaaca
    15661 tcttcctcgt cacccggatc aaggaggaga gcgaccggct cggcacccgg cagggcgcgc
    15721 tcaagggcct cacctcgacc ggtggcgtga tcaccgcggc cgggctggtg ctggccggga
    15781 ccttcgccgc gctggccacg ctgccgctgg tcttcatcgc cgagctcgga ttcacggtcg
    15841 cggtgggcgt cctgctcgac accatgatcg tgcgatcggt cctggtcacc gcgctcactc
    15901 tcgatgtcgg ccggtggatg tggtggccgc acccgctcgc ccggcgcgag gacccttccg
    15961 aggacccagc cgtatcagga atgccagatt ctattgattc ggaagcctcg accactgcct
    16021 ctcggtaaaa tccagcaaaa attaatcagt gcagctcgct gcactgatta atttttgatc
    16081 aataggagat cgcttgtgac ggcaagcaca ttgaaatctg ttgagtaggc ctgttattgt
    16141 cgcccccagg agacggagaa tctcgacggg ggcgcagatg agattcaact tattgggacg
    16201 tgtccatgta atcaccgatg cgggatgtgt aattccgctt aaatcctcga aggcgaccca
    16261 gctcctggtg ctgctgctcc tcaggcggca cgaggtggtg ggatcggggg tgctcatcga
    16321 ggagttgtgg gcggaccacc cgccccgcag cgccatgacg acgctgcaga cgtacgtgta
    16381 ccacacccgc cggctgctgg gggagcaccg ggtgacgagc gacgaccggg aattggtcct
    16441 gacccagccg cccggctact tcgccctgat cgacgaggac gaactcgacg tcgcggtcgc
    16501 cgagcgtctg atccgcaccg gcggccggct gctcgaggag aaccggctcg aggaggcgct
    16561 cgcctcgttg gacgcgggac tggatctctg gcgaggcccg gcgctgtcca ccgtaccgtg
    16621 cggccgggtg ctcgaaagca atatcgcgca cctggaagag ctgcggcttt ttggaatgca
    16681 gctccgtatc gacgcgaatt ggcggctggg cagaataggg ccgatgattc cggaactccg
    16741 gtccctggta atttcgcatc cgctgaacga gaccctgcac gccaaactga tgggcgcgct
    16801 ctgtcagatg ggcaggcgcg ccgaggcgct ggaatcgtat cggaatctcc ggcggatact
    16861 gtccgacgaa ctgggggtgg atccgacgcc ggaaatccag cgtatgcaca tggaaattct
    16921 caacggtgag aaggtgctcg tgtagcaccg gtccgtgaac gcggtggagc ccctNNggat
    16981 ccaccggcgc cgcgtccagc ggcaccccat ctcccttcga ccgccgctcg agccgggcgc
    17041 ccaaagctga gcgcgtgagg gaccacgagg cagggagggg aacacatggc cacgcaggac
    17101 tccgaagtcg cactggtgac gggtgcgacc agcggaatcg ggctggagat cgcccgcagg
    17161 ctcggtaagg aggggttgcg cgtgttcgtc tgcgcgcgcg gcgaagaagg actgcggacg
    17221 acgctgaagg agttgcggga ggcgggcgtg gaggcggacg ggcggacctg cgacgtccgc
    17281 tcggtcccgg agatcgaggc tctcgtggcg gcggtggtcg agcgttacgg tccggtcgac
    17341 gtgctggtga acaacgcggg ccggcccggc ggcggcgcca cggccgaact cgccgacgaa
    17401 ctctggctcg atgtcgtgga gaccaacctc accggcgtgt tccgggtgac caaacaggtc
    17461 ctcaaggcgg gcggcatgct cgaacggggc acgggccgaa tcgtcaacat cgcctcgacc
    17521 ggcggaaagc agggtgtggt gcacgccgcg ccctactccg cctcgaagca cggcgtggtc
    17581 ggcttcacca aggcgctcgg tctcgaactg gcgaggaccg gcatcacggt gaacgccgtc
    17641 tgccccggat tcgtcgagac gccgatggcc gcgtccgtgc gcgagcacta ctcggacatc
    17701 tgggaggtgt cgaccgagga ggccttcgac cggatcaccg cgcgcgtgcc gatcggccgg
    17761 tacgtgcagc cgtccgaggt ggcggagatg gtggcgtacc tgatcgggcc cggtgcggcc
    17821 gcggtcaccg cgcaggcgct gaacgtctgc ggcgggctgg ggaactactg acgccggccg
    17881 gtccgtgaac gcggtggagc ccctcgcagg ctgcgagggg ctccaccgcg ttcacggacc
    17941 ggtgctacac gagcaccttc tcaccgttga gaatttccat gtgcatacgc tggatttccg
    18001 gcgtcggatc cNNggatccg gcatcgaggg gtcccgtatc ggccttcgag cctccttcga
    18061 gccacggggc cgacgatgac gacgaccacc ggacgaacgc atcgaaggag ctgttcggat
    18121 tgaagcgcag agtcgtcatc acgggcgtcg gcgtccgcgc ccccggcggg aacggcaccc
    18181 ggcagttctg ggaactgctc acctcggggc ggacggcgac gcgccggatc tcgttcttcg
    18241 acccctcgcc ctaccgttca caggtcgcgg cggaggccga cttcgacccg gtcgccgagg
    18301 gcttcggccc gcgggagctc gaccggatgg accgggcctc gcagttcgcc gtggcctgtg
    18361 cccgggaggc gttcgccgcc agcgggctcg acccggacac cctcgacccc gcccgggtcg
    18421 gggtcagcct cggcagcgcg gtggcagcgg cgaccagcct ggagcgcgag tatctgctgc
    18481 tgtcggactc cggccgtgac tgggaggtcg acgcggcctg gctgtcccgg cacatgttcg
    18541 actacctggt gcccagcgtc atgccggccg aggtcgcctg ggcggtcggc gccgagggcc
    18601 cggtcacgat ggtctccacc ggctgcacct cgggcctgga ctccgtcggc aacgcggtcc
    18661 gggcgatcga ggagggcagc gccgacgtga tgttcgcggg agccgccgac accccgatca
    18721 ccccgatcgt cgtcgcctgc ttcgacgcga tccgcgccac gacggcgcgc aacgacgacc
    18781 cggagcacgc ctcgcggccg ttcgacggta cgcgggacgg cttcgtgctg gccgaaggag
    18841 ccgcgatgtt cgtcctggag gactacgaca gcgcgctggc ccgcggagcc cgcatccacg
    18901 ccgagatctc ggggtacgcg acgcgctgca acgcgtacca catgacgggc ctgaaggccg
    18961 acggccgcga gatggccgag accatccggg tcgccctcga cgagtcccgc acggacgcga
    19021 cggacatcga ctacatcaac gcgcacggct ccggcacccg gcagaacgac cgccacgaga
    19081 cagcggcgta caagcgcgcc ctcggcgaac acgcccggcg cactccggtc agctcgatca
    19141 agtcgatggt cggccactcg ctgggcgcga tcggctcgct ggagatcgcg gcctgcgtac
    19201 tcgccctcga acacggcgtg gtgcccccga ccgccaacct gcgcaccagc gaccccgagt
    19261 gcgatctcga ctacgttccg ctggaggcca gggagcggaa gctgcggtcc gtactcaccg
    19321 tgggcagcgg cttcggcggc ttccagagcg cgatggtgct gcgcgacgcc gagaccgcgg
    19381 gggcggccgc atgagcgtcc tcatcaccgg agtcggcgtc gtcgcaccca acggcctcgg
    19441 cctggcgccg tactggtcgg cggtgctgga cggccgccac ggcctcggcc cggtcacccg
    19501 cttcgacgtg agccggtacc cggcgaccct cgccggccag atcgacgact tccacgcgcc
    19561 ggaccacatc ccgggccggt tgctgccgca gacggacccc tccacacggc tcgcgctgac
    19621 cgccgcggac tgggccctcc aggacgcgaa ggcggacccg gagtcgctga ccgactacga
    19681 catgggcgtg gtgaccgcca acgcctgcgg tgggttcgac ttcacccacc gggagttccg
    19741 caagctgtgg tccgagggcc ccaagtcggt cagcgtgtac gagtccttcg cctggttcta
    19801 cgcggtgaac accggccaga tctccatccg gcacggtatg cgcggtccga gcagtgccct
    19861 ggtcgccgag caggccgggg gcctggacgc cctgggccac gcccgccgta cgatccgccg
    19921 cggcacgccg ctggtggtct ccggcggggt ggactcggca ctcgacccgt ggggctgggt
    19981 ctcgcagatc gccagtggcc ggatcagcac ggccaccgat ccggaccggg cgtatctgcc
    20041 cttcgacgag cgggcggccg gctacgttcc gggcgagggc ggggccatcc tcgtcctgga
    20101 ggacagcgcc gcggccgagg cccgcggccg gcacgacgcg tacggcgaac tcgccggctg
    20161 cgcctccacc ttcgaccccg cccccggatc cggacggccc gcgggcctgg aacgcgcgat
    20221 ccggctggcg ctgaacgacg ccgggaccgg tcccgaggac gtcgacgtcg tgttcgccga
    20281 cggcgcgggc gtgcccgagc tggacgccgc cgaggcccgg gcgatcggcc gggtgttcgg
    20341 ccgcgaaggg gtgcccgtca ccgtccccaa gacgacgacg ggccgcctct actccggcgg
    20401 cggcccgctc gacgtggtca ccgccctgat gtccctgcgc gaaggggtga tcgcgccgac
    20461 cgcgggcgtg acgtccgtac cccgggagta cggcatcgac ctggtgctcg gcgaaccccg
    20521 cagcacggcc ccgcgcaccg cactggtcct ggccaggggc cgctggggct tcaactcggc
    20581 ggcggtcctg cgccgtttcg caccgacccc gtaacgaccc cgagaactgg agaaagccat
    20641 ggcaaccctg ctgaccaccg acgatctgcg ccgcgccctc gtggagtgcg ccggtgagac
    20701 ggacgggacg gacctgtccg gcgacttcct cgacctccgc ttcgaggaca tcgggtacga
    20761 ctcgctcgcc ctgatggaga ccgcggcgcg actcgagagc cggtacggcg tgtccatacc
    20821 cgacgacgtc gccggccgcg tcgacacgcc gcgagagctg ctcgacctga tcaacggcgc
    20881 actggccgag gcggcatgag ccggccggga gaacaccggg tggtccacac cctgaggacc
    20941 caggccccgg cgcggcggct ctacgagctg gtcgcacgcg tcgaagactg gccggccgtc
    21001 ttcgaaccca ccgtgcacgt acaggtcctg gagcgcggcc cgggcaccga acgcttccgg
    21061 atctgggcgc gcgtgggcgg ccgggtgaag acctggacgt cccgccggac gctggatccc
    21121 gacaccctga gggtgacgtt ccgccaggag ctcacccagc cgcccatcgc ctcgatgggc
    21181 gggagctggg agttccgggg cgacggcgac ggcaccgaag tcgtgctgac ccacgacttc
    21241 gccgcggtcg acgaagccgc cctgccggga ctgcgcgagg cgctggacgc gaacagcggg
    21301 aaggagctgg ccgcgctggt cgcgctggcg gagcgccggc agccgcccga ggagctggtc
    21361 ttcacgttcg aggacacgct ccgggtgccg tccggggacg acgcctacgc cttcatcgag
    21421 cgcagcgacc tgtggcagga acggctgccg cacgtgcgga aggtgacact caccgaggag
    21481 gcggcgggta ccggccccgc cgagacgcgg gacatgaccg tccaggacat gaccatggag
    21541 acggtgacca ccgacggcgg tacccacacc acccgttcga tccggctctg cgtccccgcg
    21601 aggagcatcg tgtacaagca gctcgtcccg cccgccctgc tctccgggca ctgcggcgcc
    21661 tggaccttcg gcgaggacac ggtcaccgcc cgccacaccg tggcgatcga cccggcccgc
    21721 gtggaagagg tcctgggcaa aggcgcgacc gtcgcggacg cccgtaccca tctgcgcgag
    21781 gtgctcggtg ccaacagccg ggccacgctc cgccacgcgg cggccgccgc cgggccggcg
    21841 tcatgacggt cgaggtccgt gaggtcgccg agggtgtcta cgcctacgag caggcccccg
    21901 gcggctggtg cgtcagcaac gcgggcatcg tggtgggcgg cgacggcgcg ctcgtcgtcg
    21961 acacgctgtc gacgatcccg agggcgcggc ggctggcgga gtgggtcgac aagctcgccg
    22021 cgggccccgg ccgtaccgtg gtcaacaccc acttccacgg cgaccacgcc ttcggcaacc
    22081 aggtcttcgc gccggggacg cggatcatcg cgcacgagga catgcggtcc gccatggtga
    22141 cgaccggcct ggccctcacc gggctctggc cgcgggtcga ctggggcgag atcgagctga
    22201 ggccgccgaa cgtgaccttc cgcgaccggt tgaccctgca cgtcggcgag cgacaggtcg
    22261 aactgatctg cgtcggcccc gcgcacaccg atcacgacgt ggtggtctgg ctgcccgagg
    22321 agcgggtgct gttcgcgggg gacgtcgtca tgtcgggcgt cactccgttc gccctcttcg
    22381 gttcggtggc cggcacgctg gccgcgctcg accggctggc ggagctggag cccgaggtgg
    22441 tcgtcggcgg gcacggcccg gtggcgggac ccgaggtgat cgacgccaac cgggactatc
    22501 tgcgctgggt ccagcgcctc gccgccgatg cggtcgaccg ccggctgaca ccgttgcagg
    22561 ccgcgcgccg ggcggacctc ggcgccttcg ccgggctgct ggacgcggag cgcctcgtcg
    22621 cgaacctgca ccgggcccac gaggagctgc tgggcgggca cgtgcgtgac gccatggaga
    22681 tcttcgcgga gctggtcgcc tacaacggtg ggcagctgcc cacctgcctc gcctagggag
    22741 ttcgaagatg gcagccgacc agggaatgct ccgggacgcc atggcccggg tgccggccgg
    22801 ggtggcgctc gtcaccgccc atgaccgcgg gggagtcccg cacggtttca ccgccagttc
    22861 gttcgtgtcc gtctcgatgg agccgccact ggcactggtc tgcctggctc gtacggccaa
    22921 ctccttcccg gtgttcgaca gttgcggcga gttcgcggtg agcgtgctgc gcgaggacca
    22981 cacggacctg gccatgcgct tcgcgcgcaa gtccgcggac aagttcgcgg gcggggagtt
    23041 cgtccgtacc gcgcggggag cgaccgtgct cgacggagcg gtcgcggtcg tcgagtgcac
    23101 ggtccacgag cgctacccgg cgggcgacca catcatcctg ctcggcgagg tccagtccgt
    23161 gcacgtcgag gagaagggcg taccggcggt ctacgtggac cgccggttcg ccgccctgtg
    23221 ctcggcggcg ggtgcctgcc cgtccgccac cgggcggggc gtgcccgcgc atgccggctg
    23281 aggccggccg ggaaggccg
//
