LOCUS       Oxytetracycline            25222 bp	DNA     linear     22-Dec-2016
DEFINITION  Oxytetracycline biosynthesis cluster
ACCESSION   Oxytetracycline
VERSION
KEYWORDS
SOURCE      Streptomyces rimosus
FEATURES             Location/Qualifiers
     source          1..25222
                     /organism="Streptomyces rimosus"
                     /mol_type="genomic DNA"
                     /strain_name="ATCC 10970"
                     /db_xref="taxon:1927"
     CDS             134..625
                     /locus_tag="Oxtet_00010"
                     /product="MarR family transcriptional repressor"
                     /note="original product:OxyTA1"
                     /gene="oxyTA1"
                     /note="original gene:oxyTA1"
                     /note="gene synonym:otrR"
                     /note="category:4.1 transcriptional regulator"
                     /transl_table=11
                     /inferenece="InterPro:IPR011991"
                     /inferenece="InterPro:IPR000835"
                     /translation="MDSSAPDLAALIEVTAEVFAVNGRLLREGDSLTAHAGLTSARWQ
                     VAGLLLSGPSTVARLARERGLRRQAVQQTVERLKAEGVVTTRPNPQDQRSPLVELTAR
                     GRQALDDLRPLERRWLEYLAEDIPVEDMRVAIAVLSRLREKLDARPATEFGTGAGSGR
                     QSA"
     CDS             770..2047
                     /locus_tag="Oxtet_00020"
                     /product="polyketide synthase beta-ketoacyl synthase
                     subunit"
                     /note="original product:OxyA"
                     /gene="oxyA"
                     /note="original gene:oxyA"
                     /note="gene synonym:otcY1-1"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR020841"
                     /inferenece="InterPro:IPR018201"
                     /inferenece="InterPro:IPR014031"
                     /translation="MSKIHDARRVVITGIGVVAPGDVGTKPFWEMLTAGRTATRPISS
                     FDASPFRSQVAAECDFDPAAEGLSQRQVRAWDRTMQFAYVAAREALADSGVTGEADPL
                     RTGVMAGTACGMTMSLDREYAVVSDEGRLWQVDDAHGVPYLYDYFVPSSMAAEIAWLA
                     EAEGPAGVVSAGCTSGIDVLTHAADLVRDGAAEVMVAGASDAAISPITVACFDAIKAT
                     TPRNDEPETASRPFDRTRNGFVLGEGAAFFVLEEYAHARRRGARAYAEIAGYAGRCNA
                     YSMTGLRSDGRELAEAVSRALDIARVDPSEVDYVNAHGSATKQNDLHETAAFKRSLGP
                     HAYSVPISSIKSMIGHSLGAICALEVAASALRIEHGVIPPTANLREPDPDCDLDYVPL
                     VAREAEVSTVVSVASGFGGFQSAIVLTEPGRQR"
     CDS             2044..3312
                     /locus_tag="Oxtet_00030"
                     /product="polyketide synthase chain length factor subunit"
                     /note="original product:OxyB"
                     /gene="oxyB"
                     /note="original gene:oxyB"
                     /note="gene synonym:otcY1-2"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR014030"
                     /inferenece="InterPro:IPR016038"
                     /inferenece="InterPro:IPR016039"
                     /inferenece="InterPro:IPR014031"
                     /translation="MTGQLAPAPETGTGRPGGSVRPVVTGLGVVAPNGLGTERYWAAT
                     LRGDSGIGRITRFDPSGYTSSLAGEIADFDPARLPNRLLPQTDLMTRLALVAAEEALD
                     DAGADPRTMPDFAAGVVTAASAGGFDFGQRELEALWSKGGAHVSAYQSFAWFYPVNSG
                     QISIRHDMRGPGGALVAEQAGGLDAVAKARRHVRDGTPLMLTGGVDGSLCPWGWLCMT
                     RSGALTTRTDPRRAYLPFSPDASGYVPGEGGALLVLEDPRAAAERGAPQVYGRIAGYA
                     ATFDPRPGSGREPGLRRALRLALDDAGIGPADVDVVFADAMGVPALDAVETQVLAAEF
                     GPRGVPVTAPKTMTGRLLAGGASLDLAAALLSLRDQVVPPTVHVDGGEIPDSLDLVTG
                     APRPARLRHALVLARGHGGFNSAMVVSGRD"
     CDS             3388..3675
                     /locus_tag="Oxtet_00040"
                     /product="polyketide synthase acyl carrier protein
                     subunit"
                     /note="original product:OxyC"
                     /gene="oxyC"
                     /note="original gene:oxyC"
                     /note="gene synonym:otcY1-3"
                     /note="category:1.1 PKS"
                     /transl_table=11
                     /inferenece="InterPro:IPR009081"
                     /inferenece="InterPro:IPR006162"
                     /translation="MTLLTLSDLLTLLRECAGEEESIDLGGDVEDVAFDALGYDSLAL
                     LNTVGRIERDYGVQLGDDAVEKATTPRALIEMTNASLTGASPSAGGAARDK"
     CDS             3686..5524
                     /locus_tag="Oxtet_00050"
                     /product="amide synthetase"
                     /note="original product:OxyD"
                     /gene="oxyD"
                     /note="original gene:oxyD"
                     /note="gene synonym:otcY1-4"
                     /note="category:2.2 modification addition of starter unit"
                     /transl_table=11
                     /inferenece="InterPro:IPR014729"
                     /inferenece="InterPro:IPR006426"
                     /inferenece="InterPro:IPR017932"
                     /inferenece="InterPro:IPR000583"
                     /inferenece="InterPro:IPR001962"
                     /translation="MCGIAGWIDFERNLAQERATAWAMTDTMACRGPDDAGLWTGGHA
                     ALGHRRLAVIDPAHGRQPMHSTLPDGTSHVITFSGEIYNFRELRVELESQGHRFRTHC
                     DTEVVLHGYTRWGRELVDRLNGMYAFAVWDEARQELLLVRDRMGVKPLYYHPTATGVL
                     FGSEPKAVLAHPSLRRRVTAEGLCEVLDMVKTPGRTVFSGMREVLPGEMVTVGRSGVA
                     RRRYWTLQAREHTDDLETTIATVRGLLTDRVRRQLVSDVPLCTLLSGGLDSSAVTALA
                     ARAGDGPVRTFSVDFSGAGTRFQPDAVRGNTDAPYVQEMVRHVAADHTEVVLDSADLA
                     APEVRAAVLGATDLPPAFWGDMWPSLYLFFRQVRQHCTVALSGEAADELFGGYRWFHR
                     TAAIDAGTFPWLTAGSARYFGGRGLFDRKLLDKLDLPGYQRDRYAEARKEVPVLPGED
                     AREAELRRVTYLNLTRFVQTLLDRKDRMSMATGLEVRVPFCDHRLVDYVFNVPWAMKS
                     FDGREKSLLRAAVRDLLPESVVTRVKTPYPATQDPVYERLLRDELAALLADSQAPVRE
                     LLDLGRARDLLRRPVGAVSQPYDRGSLELVLWMNTWLAEYGVSLEL"
     CDS             5521..6777
                     /locus_tag="Oxtet_00060"
                     /note="original product:OxyE"
                     /note="product synonym:C-4 hydroxylase"
                     /gene="oxyE"
                     /note="original gene:oxyE"
                     /note="gene synonym:otcY1-5"
                     /note="category:3.1 modification hydroxylation"
                     /transl_table=11
                     /inferenece="InterPro:IPR002938"
                     /inferenece="InterPro:IPR003042"
                     /translation="MTGHPRPPADGAHTDVCVVGGGPAGLTLALLMLRSGARVTLVER
                     SRSLDRAYRGEILQPGGQALLDALGVLEGARRRGCHEHDGFRLEERGRTLINGDYRRL
                     PGPYNCLLSLPQQHLLTDLLERCRAHPRFTCLTGTKVNGLVEEGGVVRGVVCGGGADG
                     LVVRADCVVGADGRYSTVRKLAGIPYDRIELFDQDVLWCKLTAPATRTVRIFRAGGNP
                     VLAYTSFPDCVQLGWTLPHKGYQALAERGFAHVKERIRAAVPEYADTVDQQLNSFKDV
                     SLLDVFAGSARRWARDGLLLIGDSAHTHSPIGAQGINLAIQDAVAAHPVLCEGLRRRD
                     LSERFLDAVAARRRPETERATRVQVMQSRMMLSTGRVSAAVRPKAAMLVSRTPAYRSV
                     LRRIAYGDQTLRVRSDLFEEGEPATV"
     CDS             complement(6809..7846)
                     /locus_tag="Oxtet_00070"
                     /product="C-6 C-methyltransferase"
                     /note="original product:OxyF"
                     /gene="oxyF"
                     /note="original gene:oxyF"
                     /note="gene synonym:otcY2-5"
                     /note="category:3.2 modification methylation"
                     /EC_number="2.1.1.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR011991"
                     /inferenece="InterPro:IPR016461"
                     /inferenece="InterPro:IPR001077"
                     /translation="MTSTSPTALPPAVMRLRELALSAACAAAVRAAASLGVADALGDE
                     PADAGTLAKAVRADADALERLLRALAAYDVFSELPDGRFEHTDASRLLREDAPRGLRY
                     SALWATEPWTWALWPHLADAVRTGREEFTALYGTEFFDWLHTAEARESAEVFDKAMTQ
                     SSVLSAKAIAEVLDLDGVGAMVDIAGGQGMVLATLLEKYPALRGTLFDLPKVVADADP
                     RLREGGALAGRAQLVGGDCRQSVPEGADLYLLKNILEWDDESTVRTLRNVAKSAPAGA
                     RVVVVENLVDGSPETRFTTAMDLMLLLNVGGKKHTKAGLSALVEQAGLQLEEVRAVNS
                     YLHMFVSTVPA"
     CDS             complement(7899..9833)
                     /locus_tag="Oxtet_00080"
                     /product="putative ligase/putative oxidoreductase"
                     /note="original product:OxyG"
                     /gene="oxyH/oxyG"
                     /note="original gene:oxyG"
                     /note="gene synonym:otcY2-3/otcY2-4"
                     /note="category:5.1 general function"
                     /transl_table=11
                     /inferenece="InterPro:IPR011008"
                     /inferenece="InterPro:IPR025110"
                     /inferenece="InterPro:IPR007138"
                     /inferenece="InterPro:IPR000873"
                     /inferenece="InterPro:IPR020845"
                     /translation="MAERHPEGPQDSTAEGPPLDVLAQLTGGPRIDDVLSRAARRAPR
                     RLALSGPSGDLTYAALEERATRCAAALRELDGEPGAVVGIAAVLDTSFAVAYFGASRA
                     RHVSAMFNPLLREERLTHVLRSAGARTVIVPPEMYARIQAVRGDLPALRTVVLTHREA
                     GFQEATADVPTLDELIDAAPATAPFAGRDPEGVANLQFTSGTTGAPKTVMLTHRNLTV
                     NAAQTAYTHRLTPESVLLNTLPSFHLMHLNIAVTVGATHLLRPGDDTVAALREGARHG
                     ATHLYSLPVRLARLAADDRLPELSVPSLRAVLSGGSALPARTADVLGGHFGVPVVQGY
                     GLAETAPSTHFDDLDHPVAGSSGRPVPGTACRIVDLRTRAVLPVGGRGEIQVKGPQLM
                     KGYLGRPREESVDPDGWFSTGDIGETDAEGRLFVVDRVKDVFKCDNWLVSPLEIENVL
                     ARCPGVTDCAVFDHPDELSGAVAHALVVLADEAADRDAVIRFVNDQLPYYQHIKYLDV
                     VRHIPRSPTGKIQRRDLREQTLGGTRKHATGATHHTKGTSTMFTFINRFTVQGDAAEF
                     EKRVGEITAHMSRQPGFRSHRLLRSAKDPQVYVEIAEWDDAESHGRALRTETFQQAVS
                     EVKKLASADPAPFVPVTAAG"
     CDS             complement(9872..10324)
                     /locus_tag="Oxtet_00090"
                     /product="hypothetical protein"
                     /note="original product:OxyI"
                     /gene="oxyI"
                     /note="original gene:oxyI"
                     /note="gene synonym:otcY2-2"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
     CDS             10593..11384
                     /locus_tag="Oxtet_00100"
                     /product="polyketide C-9 ketoreductase"
                     /note="original product:OxyJ"
                     /gene="oxyJ"
                     /note="original gene:oxyJ"
                     /note="gene synonym:otcY2-1"
                     /note="category:3.3 modification reduction"
                     /transl_table=11
                     /inferenece="InterPro:IPR002347"
                     /inferenece="InterPro:IPR020904"
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR002198"
                     /translation="MTTSATPRTALVTGGTSGIGLAVVKTLAARGLRVFLCARSRENV
                     DAVVKELRDQGLQVAGCEGDVRSRESVERVVRAAVDRFGPLSVLVNNAGRSGGGVTAR
                     IPDELWYDVIDTNLNSAFLVTREALTTGGLERAGVDGRIISIASTGGKQGVPLGAPYS
                     ASKAGLIGFTKALAKELAPTGVTVNAVCPGYVETPMAVRVRQAYAATWDTTEEDVLSR
                     FNDKIPLGRYSTPEEVAALVGHLAGDEAGSITAQALNVCGGLGIY"
     CDS             11443..12396
                     /locus_tag="Oxtet_00110"
                     /product="cyclase/dehydratase"
                     /note="original product:OxyK"
                     /gene="oxyK"
                     /note="original gene:oxyK"
                     /note="gene synonym:otcD1"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR019587"
                     /inferenece="InterPro:IPR023393"
                     /translation="MPAPTSHRAVHRTEIDAPADRVYALIRDAAEWPRHFTPTVHVER
                     AELDARSERLRIWATANGEVKHWTSHRALDPEGQSVRFRQEVCSPPVAAMSGEWVLRD
                     LPGGRCELTLHHTFAAVDDRPEDVEWITTATDRNSRTELANIKALAEAAGSDAELLFS
                     FEDSETVHAPAEAVYAFLAEAGKWPDRLPHVSRLDLTEPSDGVQVMTMVTRANDGSEH
                     TTESVRVCFPDELRIVYKQIGTPPLMTLHTGEWSIRDTGDGLLVTSQHTIRINESAIP
                     EILGADATAADARARVRAAVGGNSAATLALAKRFAEAPHAA"
     CDS             12386..14059
                     /locus_tag="Oxtet_00120"
                     /product="C-4/C-12a hydroxylase"
                     /note="original product:OxyL"
                     /gene="oxyL"
                     /note="original gene:oxyL"
                     /note="gene synonym:otcD2"
                     /note="category:3.1 modification hydroxylation"
                     /transl_table=11
                     /inferenece="InterPro:IPR002938"
                     /inferenece="InterPro:IPR003042"
                     /translation="MPPEADGPQVLIAGAGPVGLTLAHELTRRRVRVRVIDRADGPAT
                     TSRALAVHPRTLEACHQMGLADALVARGRPVVHFTVHLRGRQLIRFDTNYGRLPTAYP
                     FSLMLDQVRTEEILRERLAGLGVGIEWGVELADCAPCGDRVNAELRRDGRSEQVTVPW
                     LVGADGSRSTVRERLGLRLVGDATQTWLNADVVLDADLSRDSNHLVHTGSGTVLLVPF
                     PDPGKWRAVDTGYAGQGADPETVRRRLAGSLARGLGRPVAVSEPTWVSVFRVQQRMIT
                     AMRSGRCFVAGDAAHVHSPASGQGMNTGMQDAYNLAWKLADVVRGHAREELLDTYAAE
                     RIPVGGRLLSSTRTATALVALRNAVAPVAMPVGLSFLKAVRPLKRRVEHRIMAGMSGL
                     ALHYADSPLTYGTGDGAAGVHPGHLVACTEQDVARHPGLRALRQALTDPRWLLLLFAD
                     DGGAAELALRYGRAVQIRTVIPHEDEDGPALADPDDALRQTLGVPPGGWALIRPDGYL
                     AAKGQRSGTTTLTARLQALHLLPEDTAPGAGDSAGRPAPDGTRRGVTTE"
     CDS             14077..14835
                     /locus_tag="Oxtet_00130"
                     /product="putative oxidoreductase"
                     /note="original product:OxyM"
                     /gene="oxyM"
                     /note="original gene:oxyM"
                     /note="gene synonym:otcD3"
                     /note="category:5.1 general function"
                     /transl_table=11
                     /inferenece="InterPro:IPR016040"
                     /inferenece="InterPro:IPR002347"
                     /translation="MTAINGAPAAGGSVALVIGGTRGIGLAAARKLSAAGSEVLLNYA
                     HDEDGALAAERQLSEEGGKVRLMRADIGRPAGVVRLLEDIRRTHGRLDVLVHAAGSFH
                     PAPTASPHIGKYLGDGAVAVGPLLYGAARLGTLMTPDTGRIVAVSSIGARTVVPGYAG
                     LGMAKAALETLVRYLAVELAGKGVAVNAVAAGKIADGGPVPAQVLEGLLRRTPTGRLA
                     TAEEVADVVALLCRPEAGGLHGQVLTVDGGACLR"
     CDS             14855..15628
                     /locus_tag="Oxtet_00140"
                     /product="cyclase"
                     /note="original product:OxyN"
                     /gene="oxyN"
                     /note="original gene:oxyN"
                     /note="gene synonym:otcD4"
                     /note="category:3.4 other modification"
                     /transl_table=11
                     /inferenece="InterPro:IPR007325"
                     /translation="MRIIDLSTTVDAGRWEVDPVEHEILTPAEGGRHMAEGMRRHHGI
                     DFDPADLPDGELLSLDTLRLTTHTGTHVDAPSHYGSRARYGTPRHIDQMPLDWFLRPG
                     LKLDLTDEPVGAIGADRIRRALDEAGRDPRPYDIVLLHTGADRRAGKPEYFTEFAGLD
                     AAATHLLLDFGVRVIGTDAFSLDAPFGHMIKEYQRTGDRGVLWPAHFVGREREYCQIE
                     RLDNLGALPGPDGFLVSCFPFKIAGAGAGWTRAVAVVEE"
     CDS             15734..16795
                     /locus_tag="Oxtet_00150"
                     /product="hypothetical protein"
                     /note="original product:OxyO"
                     /gene="oxyO"
                     /note="original gene:oxyO"
                     /note="gene synonym:otcD5"
                     /note="category:5.4 hypothetical protein"
                     /transl_table=11
                     /inferenece="InterPro:IPR001646"
                     /translation="MRNRRSQQLHRVVRRASRAGNGPPPAGSVPPRPELGWARLIELT
                     SVLLASVVAVLSLWFSNRQVGNQLRIAQGELSTTREGQITERYTAAVGQLGEDSVDVR
                     LGGIYALQRNMEDLPRDHPTIADVLAAYIRTHAGTPPKGGKRVPPDVLAALDVISGRN
                     SAHDGSFVPDLRSTHLPGVELGWDRSSPVAADHKRAQLRGAILRDCDLRDARLSGADL
                     RGARLARADLADADLREADLREATPARANLRDADLSDANVRKADLRFADLRGVDLWGT
                     DLRGAVLYRAKLAGLELSEAHLDGADLRGADLTDAAVARSQVLASRIDAETRLPPDIA
                     RDPEVRARIAQAEAEDDGF"
     CDS             complement(16813..17835)
                     /locus_tag="Oxtet_00160"
                     /product="acyl-ACP thioesterase"
                     /note="original product:OxyP"
                     /gene="oxyP"
                     /note="original gene:oxyP"
                     /note="gene synonym:otcX3"
                     /note="category:1.4 Other"
                     /transl_table=11
                     /inferenece="InterPro:IPR016035"
                     /inferenece="InterPro:IPR014043"
                     /inferenece="InterPro:IPR020801"
                     /inferenece="InterPro:IPR001227"
                     /inferenece="InterPro:IPR016036"
                     /translation="MTADTKATGAPAARAPRPVALLLPGQGSQYRRMAAGLYAAEPVF
                     AEAVDEVLGAMGAEGARMHADWLAERPELPVDHVLRAQPLLFAVDYALGRLVTSWGIR
                     PVALLGHSIGEMAAATLAGVFTVRDAARVVLDRVTRLTAAPPGGMLAVAESAASLEPF
                     LGDGVVVGAVNAPRQTVLGGPEDALRAVGETLRARGITAQRVPALSPFHSPAIAPHAR
                     GAEAVLATVERRPPRTVVHSCYTAAPLTAQQVADPAYWAAHPVDQVRFWPALDGLLAP
                     GGLVVVEAGPGRTLSSLALRHPSVRRGDCMVVPLSPKRADGPEDDRVALGEAVDALRG
                     EGYRIP"
     CDS             complement(17832..18911)
                     /locus_tag="Oxtet_00170"
                     /product="C-4 aminotransferase"
                     /note="original product:OxyQ"
                     /gene="oxyQ"
                     /note="original gene:oxyQ"
                     /note="gene synonym:otcX2"
                     /note="category:3.4 other modification"
                     /EC_number="2.6.1.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR004839"
                     /inferenece="InterPro:IPR015422"
                     /inferenece="InterPro:IPR015424"
                     /inferenece="InterPro:IPR015421"
                     /inferenece="InterPro:IPR001176"
                     /inferenece="InterPro:IPR019880"
                     /translation="MRELPEFPWDVLLPYKKRAAAHPDGLVNLALGEPVDATPDVLRD
                     ALAAATDAPGYPPTEGTPALREAAAAWLRRRLGVTVDPSAVLPAVGTKELIAWLPAML
                     GTGPGDTVAFPRLAFPTFDVSARLAGARGRPVDSPLELGSEPVKVVWLNSPSNPEGRV
                     LSVPELREIVAWARDRGAVLVNDECYIEYGWDRRPVSLLDSAVCGGSHDGLLAVHSLS
                     KRSNLAGYRAGVCSGDPALIGRLLQVRKHAGHAVPAPVQAAMVAALEDDAHVERQRDR
                     YAYRRRVLRTALEGAGFRVEHSEGGLFLWATRGEPCWPAVQKLADLGILVAPGAFYGE
                     AGEQYVRIAFTATDERIAAAAARLT"
     CDS             complement(18908..19336)
                     /locus_tag="Oxtet_00180"
                     /product="pyridoxamine 5'-phosphate oxidase-like
                     FMN-binding domain protein"
                     /note="original product:OxyR"
                     /gene="oxyR"
                     /note="original gene:oxyR"
                     /note="gene synonym:otcX1"
                     /note="category:5.2 function unknown"
                     /transl_table=11
                     /inferenece="InterPro:IPR009002"
                     /inferenece="InterPro:IPR011576"
                     /inferenece="InterPro:IPR012349"
                     /inferenece="InterPro:IPR024031"
                     /translation="MPFTQKEITYLRAQGYGRLATVGAHGEPHNVPVSFEIDEERGTI
                     EITGRDMGRSRKFRNVAKSDRVAFVVDDVPCRDPEVVRAVVIHGTAQALPTGGRERRP
                     HCADEMIRIHPRRIVTWGIEGDLSTGVHARDITAEDGGRR"
     CDS             19492..21003
                     /locus_tag="Oxtet_00190"
                     /product="putative C-6 hydroxylase"
                     /note="original product:OxyS"
                     /gene="oxyS"
                     /note="original gene:oxyS"
                     /note="gene synonym:otcC"
                     /note="category:3.1 modification hydroxylation"
                     /transl_table=11
                     /inferenece="InterPro:IPR002938"
                     /inferenece="InterPro:IPR003042"
                     /translation="MRYDVVIAGAGPTGLMLACELRLAGARTLVLERLAEPVDFSKAL
                     GVHARTVELLDMRGLGEGFQAEAPKLRGGNFASLGVPLDFSSFDTRHPYALFVPQVRT
                     EELLTGRALELGAELRRGHAVTALEQDADGVTVSVTGPEGPYEVECAYLVGCDGGGST
                     VRKLLGIDFPGQDPHMFAVIADARFREELPHGEGMGPMRPYGVMRHDLRAWFAAFPLE
                     PDVYRATVAFFDRPYADRRAPVTEEDVRAALTEVAGSDFGMHDVRWLSRLTDTSRQAE
                     RYRDGRVLLAGDACHIHLPAGGQGLNLGFQDAVNLGWKLGATIAGTAPPELLDTYEAE
                     RRPIAAGVLRNTRAQAVLIDPDPRYEGLRELMIELLHVPETNRYLAGLISALDVRYPM
                     AGEHPLLGRRVPDLPLVTEDGTRQLSTYFHAARGVLLTLGCDQPLADEAAAWKDRVDL
                     VAAEGVADPGSAVDGLTALLVRPDGYICWTAAPETGTDGLTDALRTWFGPPAM"
     CDS             21064..22098
                     /locus_tag="Oxtet_00200"
                     /product="SAM-dependent N,N-dimethyltransferase"
                     /note="original product:OxyT"
                     /gene="oxyT"
                     /note="original gene:oxyT"
                     /note="gene synonym:otcZ"
                     /note="category:3.2 modification methylation"
                     /EC_number="2.1.1.-"
                     /transl_table=11
                     /inferenece="InterPro:IPR016461"
                     /inferenece="InterPro:IPR011991"
                     /inferenece="InterPro:IPR001077"
                     /translation="MTTTPLAPVAQARSLLQLTTAYHQAKALHSAVELGLFDLLADGP
                     ATAEEVKDRLRIVHPLAKEFLDALVALELLEADGDRYRNSPAAQAFLVSGASEYLGGT
                     VLQHARKHYHVWAGLTTALQEGEAGSGAEAHGPEAYPKHYEDPERARQVMAHFDTFSS
                     FTAEELARRVDWSGYGSFIDIGGARGNLATRVALAHPHLHGAVFDLPALAPLAGELIR
                     ERGLEGRVRFHGGDFLTDPLPSADAVVTGHVLPDWPVPQRRKLLARIHEALPSGGALV
                     VYDLMTDPATTTVHDVLQRLNHGLIRGDSSSSSVEEYRAEIEEAGFRVRQAERIDNLL
                     GDWLIVAVKP"
     CDS             22257..24248
                     /locus_tag="Oxtet_00210"
                     /product="putative oxytetracycline resistance protein"
                     /gene="otrA"
                     /note="category:4.4 resistance"
                     /transl_table=11
                     /inferenece="InterPro:IPR014721"
                     /inferenece="InterPro:IPR004161"
                     /inferenece="InterPro:IPR009022"
                     /inferenece="InterPro:IPR005517"
                     /inferenece="InterPro:IPR009000"
                     /inferenece="InterPro:IPR000795"
                     /inferenece="InterPro:IPR002127"
                     /inferenece="InterPro:IPR020568"
                     /inferenece="InterPro:IPR000640"
                     /inferenece="InterPro:IPR005225"
                     /translation="MNKLNLGILAHVDAGKTSLTERLLHRTGVIDEVGSVDAGTTTTD
                     SMELERQRGITIRSAVATFVLDDLKVNLIDTPGHSDFISEVERALGVLDGAVLVVSAV
                     EGVQPQTRILMRTLRRLGIPTLVFVNKIDRGGARPDGVLREIRDRLTPAAVALSAVAD
                     AGTPRARAIALGPDTDPDFAVRVGELLADHDDAFLTAYLDEEHVLTEKEYAEELAAQT
                     ARGLVHPVYFGSALTGEGLDHLVHGIRELLPSVHASQDAPLRATVFKVDRGARGEAVA
                     YLRLVSGTLGTRDSVTLHRVDHTGRVTEHAGRITALRVFEHGSATSETRATAGDIAQA
                     WGLKDVRVGDRAGHLDGPPPRNFFAPPSLETVIRPERPEEAGRLHAALRMLDEQDPSI
                     DLRQDEENAAGAVVRLYGEVQKEILGSTLAESFGVRVRFDPTRTVCIEKPVGTGEALI
                     ELDTRTHNYFWGAPWVCASDRPSPARAITFRLAVELGSLPLAFHKAIEETVHTTLRHG
                     LYGWQVTDCAVTLTRTGVRSPVSAADDFRKANARLVLMDALGRAGTEVHEPVSSFELE
                     VPAARLSPVLAKLAELGATPGVPTAEGDVFRLEGTMPTSLVHDFNQRVPGLTQGEGVF
                     LAEHRGYRPAVGQPPVRPRPEGPNPLNRDEYILHVLKRV"
ORIGIN      
        1 gcgcgcggct gggatccccc ccgtacacac acgcttgttc accatcggca ccgaggccgg
       61 gtgccgagcg taatcaccgc cgcggctttt gacaaggtct tgtcgttctc cggggagtac
      121 atacgctgtg gccatggatt cctcagcccc tgacctggcc gctctgatcg aggtgaccgc
      181 cgaggtcttc gcggtcaacg gccgcctgct ccgcgaaggc gacagcctca ccgcccacgc
      241 ggggctgacc tcggcgcgct ggcaggtggc cggactgctg ctgagcggcc cctcgacggt
      301 cgcccgcctg gcccgcgagc gggggctgcg gcggcaggcg gtccagcaga ccgtcgagcg
      361 gctgaaggcc gagggcgtcg tcacgacccg gcccaacccg caggaccagc gcagccccct
      421 ggtcgagctc accgcacgcg gccggcaggc gctggacgac ctgcgtcccc tggaacggcg
      481 gtggctggag tatctggccg aggacattcc ggtcgaggac atgcgcgtgg cgatcgcggt
      541 gctgagccgc ctgcgggaga agctggacgc ccgtccggcg acggagttcg ggaccggggc
      601 cgggtccggg cggcagtccg cctgagcggc cgccgccccg cccggccgtc tctccggagt
      661 ggcccgggcg tcgaatccgc ctccaaaccg ccttgaggtc cgaaggtcac tctgtgcctc
      721 gacgcgctcg tgccgccccc ggtggcgcga cgacggcaga ggagactcaa tgtccaagat
      781 ccatgacgcg cgacgcgtcg taatcacagg gatcggcgtg gtggctccgg gagacgtggg
      841 caccaaaccg ttctgggaga tgctcaccgc gggccgtacc gccacccgcc cgatctcgtc
      901 cttcgacgcc tcgcccttcc gctcccaggt ggcggcggag tgcgacttcg acccggcggc
      961 ggaggggctg agccagcggc aggtccgcgc ctgggaccgc accatgcagt tcgcttacgt
     1021 ggccgcgcgg gaggcgctgg cggacagcgg tgtgacgggc gaggcggacc cgctgcgcac
     1081 cggcgtcatg gccggcaccg cctgcggcat gacgatgagc ctggaccgcg agtacgcggt
     1141 ggtcagcgac gagggccggc tgtggcaggt ggacgacgcc catggggtgc cgtacctcta
     1201 cgactacttc gtgccctcgt cgatggcggc cgagatcgcc tggctggcgg aggcggaggg
     1261 cccggccggg gtggtctcgg ccggctgcac ctccggcatc gacgtgctca cccacgcggc
     1321 ggacctggta cgcgacggcg cggccgaggt gatggtggcc ggggcatcgg acgccgccat
     1381 ctcccccatc acggtggcgt gcttcgacgc gatcaaggcc accacgccgc gcaacgacga
     1441 gccggagacg gcgtcccgtc cgttcgaccg cacccgcaac ggcttcgtgc tgggcgaggg
     1501 ggcggcgttc ttcgtcctgg aggagtacgc gcacgccagg cggcgggggg cccgcgcgta
     1561 cgcggagatc gccgggtacg ccgggcggtg caacgcgtac agcatgaccg ggctgcgctc
     1621 ggacgggcgg gagctggccg aggcggtgag ccgcgcgctc gacatcgcgc gcgtcgatcc
     1681 gtcggaggtg gactacgtca acgcccacgg ttcggcgacc aagcagaacg atctccatga
     1741 gacggcggcg ttcaagcgga gcctgggtcc gcacgcctac tcggtcccga tcagctccat
     1801 caaatcgatg atcggccact cgctcggtgc catctgcgcg ctggaggtcg cggcgagcgc
     1861 gctgaggatc gagcacgggg tgatcccacc caccgcgaac ctgcgggagc cggaccccga
     1921 ctgcgacctg gactatgtgc cgctggtcgc cagggaggcc gaggtgtcca ccgtggtgtc
     1981 cgtggccagc ggattcggcg gcttccagag cgcgatcgtg ctcaccgagc cggggaggca
     2041 gcgatgaccg gccagctcgc ccccgctccc gaaaccggca ccggccgccc cggcggcagc
     2101 gtccggccgg tggtcaccgg cctcggtgtg gtcgcgccca acggcctggg caccgagcgg
     2161 tactgggccg cgacgctgcg cggcgacagc ggcatcggcc ggatcacccg gttcgacccg
     2221 tccggctaca cctcctcgct ggccggggag atcgcggact tcgaccccgc gcggctgccg
     2281 aaccggctgc tgccgcagac cgacctgatg acccggctcg cgctggtcgc ggccgaggag
     2341 gcgctggacg acgcgggcgc cgacccgcgc acgatgcccg acttcgccgc cggggtggtc
     2401 accgccgcgt cggcgggcgg cttcgacttc ggccagcggg agctggaggc cctgtggagc
     2461 aagggtggcg cgcacgtcag cgcgtatcag tccttcgcct ggttctatcc ggtcaactcc
     2521 ggtcagatct cgatccggca cgatatgcgg ggccccggcg gcgcgctggt ggccgagcag
     2581 gccggcgggc tggacgcggt ggccaaggcg cgccgccacg tacgggacgg gacgccgctg
     2641 atgctcaccg gcggtgtgga cggttcgctg tgcccgtggg gctggctgtg catgacccgt
     2701 tccggcgcgc tgaccacccg gaccgatccg cgccgcgcgt acctgccctt ctcccccgac
     2761 gcctccggat acgtgccggg tgagggcggg gcgctgctgg tcctggagga ccctcgggcc
     2821 gccgcggagc ggggtgcccc gcaggtctac gggcggatcg ccgggtacgc ggccaccttc
     2881 gacccccgtc cgggctccgg ccgggaaccg ggtctgcgca gagcgctccg gctggcgctg
     2941 gacgacgccg ggatcggacc ggcggacgtg gacgtggtct tcgccgacgc gatgggcgta
     3001 ccggcgctcg acgcggtgga aacacaggtg ctggccgccg agttcggccc gcgcggggtg
     3061 ccggtgacgg ctcccaagac gatgacggga cggctgctgg ccggcggcgc ctctctggac
     3121 ctggcggcgg cgctgctgtc gctgcgcgac caggtcgtac cgccgacggt gcacgtggac
     3181 ggcggcgaga tcccggactc gctggacctg gtgaccggcg ctccccggcc ggcgcgcctg
     3241 cggcacgcgc tggtgctggc ccgcggtcac ggcgggttca actccgcgat ggtggtcagc
     3301 ggccgggact gagccgccgt cagctgctcg cttccggccc ggccggtctc atgaatcctc
     3361 tgcgactccc cgaaaggtag gactgtcatg accctgctca ccctctccga cctgctcacc
     3421 ctgctgcgcg agtgcgcggg cgaggaggaa tccatcgacc tgggagggga cgtcgaggac
     3481 gtcgccttcg acgccctcgg ctacgactcg ctggcgctgc tgaacaccgt gggacgcatc
     3541 gagcgcgact acggggtcca gctcggggac gacgcggtgg agaaggcgac cacgccgcgc
     3601 gccctgatcg agatgaccaa cgcgtcgctc accggcgcgt ccccgtccgc gggtggcgcc
     3661 gcgcgggaca agtgaggacc ggccgatgtg cggaatcgcc ggctggatcg atttcgaacg
     3721 caatctggcg caggagcggg cgacggcctg ggccatgacg gacaccatgg cctgccgggg
     3781 cccggacgac gcgggcctgt ggaccggtgg ccacgcggcg ctcggccacc gcaggctggc
     3841 cgtcatcgac ccggcgcacg ggcggcagcc gatgcacagc acgctgccgg acggcacgag
     3901 ccacgtcatc acgttcagcg gggagatcta caacttccgt gaactgcggg tcgagctgga
     3961 gtcccagggg caccgcttcc gtacccactg cgacacggag gtggtgctgc acggctacac
     4021 ccggtggggc cgggagctgg tggaccggct caacggcatg tacgcgttcg ccgtgtggga
     4081 cgaggcccgg caggaactgc tgctggtccg cgaccggatg ggggtcaagc cgctctacta
     4141 ccaccccacc gccaccggtg tgctgttcgg ctccgagccg aaggccgtgc tcgcgcaccc
     4201 ctcgctgcgg cggcgggtga cggccgaggg cctgtgcgag gtgctggaca tggtcaagac
     4261 ccccggccgg accgtcttct ccggtatgcg cgaggtgctg ccgggcgaga tggtcaccgt
     4321 cgggcgctcc ggtgtggccc gcaggcggta ctggacgctc caggcgcggg agcacaccga
     4381 cgatctggag accaccatcg ccacggtgcg cggcctgctg acggacaggg tgcgccggca
     4441 gctggtctcc gatgtgccgc tgtgcaccct gctctccggc gggctggact cgtcggcggt
     4501 gacggcgctg gcggcgcggg cgggcgacgg gccggtccgt acgttctcgg tggacttctc
     4561 cggcgcgggc acccggttcc agccggacgc cgtacggggc aacacggacg cgccgtacgt
     4621 ccaggagatg gtgcggcacg tggcggcgga ccatacggaa gtcgtgctgg acagcgccga
     4681 tctcgcggca cccgaggtgc gtgccgccgt cctgggggcc accgacctgc ccccggcgtt
     4741 ctggggcgac atgtggccct cgctgtacct gttcttccgg caggtgcggc agcactgcac
     4801 ggtggccctg tcgggcgagg cggcggacga actcttcggc ggttaccggt ggttccaccg
     4861 gacggcggcc atcgacgccg gtacgttccc ctggctgacc gccggctcgg cccggtactt
     4921 cggcggccgg ggcctgttcg accgcaagct gctggacaag ctcgacctgc cgggctacca
     4981 gcgcgaccgg tacgccgagg cccgtaagga agtccccgtc ctgcccggcg aggacgcgcg
     5041 ggaggcggag ctgcgccggg tgacctacct caacctcacc cgcttcgtgc agaccctgct
     5101 ggaccgcaag gaccggatga gcatggcgac cggcctggag gtgcgggtgc cgttctgcga
     5161 ccaccggctg gtcgactacg tcttcaacgt gccgtgggcc atgaagtcct tcgacggcag
     5221 ggagaagagc ctgctgcggg ccgcggtgcg cgacctgctg ccggagtcgg tggtcacccg
     5281 ggtcaagacg ccctaccccg ccacacagga cccggtctac gagcggctgt tgcgcgacga
     5341 actggccgcg ctgctggccg acagccaggc gccggtccgc gaactgctcg acctgggtcg
     5401 ggcgcgcgac ctgctgcggc ggccggtcgg cgccgtcagc caaccgtacg accgcggcag
     5461 tctggagctg gtcctgtgga tgaacacctg gctggcggag tacggcgtca gcctggagct
     5521 atgaccggcc acccgcggcc gccggccgac ggcgcgcaca ccgatgtgtg cgtcgtcggc
     5581 ggcggcccgg ccgggctgac cctggcgctg ctgatgctgc gctcgggggc gcgggtgacg
     5641 ctggtcgagc gcagccgctc actggaccgc gcctaccggg gcgagatcct ccagccgggc
     5701 gggcaggccc tgctcgacgc gctcggcgtc ctggagggtg cccggcggcg cggctgccac
     5761 gagcacgacg gtttccggct ggaggagcgc ggcaggaccc tgatcaacgg ggattaccgg
     5821 cggctgcccg gcccgtacaa ctgtctgctc agcctgccgc agcagcatct gctgaccgat
     5881 ctgctggagc gctgccgggc ccacccgcgc ttcacctgcc tgaccggcac caaggtcaac
     5941 gggctggtgg aggagggcgg cgtggtgcgc ggtgtggtgt gcggcggcgg ggcggacggg
     6001 ctcgtggtgc gcgcggactg cgtcgtcggt gcggacgggc ggtattcgac ggtccgcaag
     6061 ctggccggca ttccgtacga ccgcatcgag ctgttcgacc aggacgtgct gtggtgcaag
     6121 ctcaccgcgc ccgccacccg tacggtgcgg atcttccggg ccggcggcaa cccggtgctg
     6181 gcctacacgt ccttccccga ctgcgtacag ctcggctgga cgctgccgca caagggctac
     6241 caggcgctgg ccgagcgggg gttcgcgcac gtcaaggagc gtatccgggc agccgtgccc
     6301 gagtacgcgg acacggtgga ccagcagctg aacagcttca aggacgtgtc tctgctggat
     6361 gtgttcgccg gctccgcacg gcggtgggcg cgcgacgggc tgctgctcat cggcgacagc
     6421 gcgcacaccc acagcccgat cggggcccag ggcatcaacc tcgccatcca ggacgcggtc
     6481 gccgcgcacc cggtgctgtg cgagggcctg cggcgacggg acctgagcga gcggttcctc
     6541 gacgcggtcg cggcgcggcg ccgtccggag accgagcggg cgacccgcgt ccaggtgatg
     6601 cagagccgga tgatgctgtc gaccggacgc gtttcggcgg ccgtccgccc gaaggcggcg
     6661 atgctggtct cgcgtacccc ggcctaccgc tccgtcctgc ggcgcatcgc ctacggcgac
     6721 cagacactgc gggtccgctc cgacctgttc gaggagggcg agcccgccac cgtctgatcc
     6781 tcgtacgacg ccgtcgtacg tgtggcgact acgcgggcac cgtgctcacg aacatgtgca
     6841 ggtaggagtt gaccgcgcgt acctcctcca gctggagccc cgcctgctcc accagcgcgc
     6901 tcagccccgc cttggtgtgc ttcttgccgc cgacgttgag cagcagcatc aggtccatgg
     6961 cggtggtgaa ccgggtctcg ggactgccgt cgaccaggtt ctccaccacc acgacgcgcg
     7021 ccccggcggg ggccgacttg gcgacgttgc gcagggtgcg caccgtgctc tcgtcgtccc
     7081 actccaggat gttcttcagc agatacaggt cggcaccctc cggcaccgac tgccggcagt
     7141 caccgcccac cagctgcgcg cgcccggcga gcgcgccgcc ctcgcgcagc cgcgggtcgg
     7201 cgtcggcgac gaccttcggc aggtcgaaga gggtgccgcg cagcgccggg tacttctcca
     7261 gcagggtggc gagcaccatg ccctggcccc cggcgatgtc caccatggcg ccgacgccgt
     7321 ccaggtcgag cacctcggcg atggccttcg ccgacagcac gctggactgg gtcatggcct
     7381 tgtcgaacac ctcggccgac tcgcgggcct cggcggtgtg cagccagtcg aagaactcgg
     7441 tgccgtacag cgcggtgaac tcctcccggc cggtgcgcac ggcgtccgcc aggtgcggcc
     7501 acagcgccca ggtccacggc tcggtcgccc acagcgccga gtagcgcagg ccgcgcgggg
     7561 cgtcctcgcg cagcagccgg gaggcgtcgg tgtgctcgaa gcggccgtcg gggagttcgc
     7621 tgaagacgtc gtacgcggcg agggcgcgca gcaggcgctc cagcgcgtcc gcgtcggccc
     7681 gcaccgcctt cgcgagggtg ccggcgtccg cgggttcgtc cccgagggcg tccgcgacgc
     7741 ccaggctcgc cgcggcgcgg acggcggcgg cacaggcggc gctcagggcg agttcgcgca
     7801 gccgcatgac ggcgggggga agcgccgtgg gagaggtgct ggtcacggtg gactgccttt
     7861 ctgtttctgt gggtggggtc ggcgcggcgc agccgccgtc agccggccgc ggtgaccggg
     7921 acgaacgggg ccgggtcggc gctcgcgagc ttcttgacct cgctcacggc ctgctggaac
     7981 gtctcggtgc gcagcgcgcg gccgtgcgac tcggcgtcgt cccactcggc gatctcgaca
     8041 tagacctgcg ggtccttggc ggagcgcagc aggcggtgcg agcggaagcc gggctgccgc
     8101 gacatatggg cggtgatctc accgacccgc ttctcgaact cggcggcgtc gccctggacc
     8161 gtgaaccggt tgatgaaggt gaacatggtg gaggtgccct tcgtgtgatg ggtggcgccc
     8221 gtggcgtgct tccgggtgcc gccgagggtc tgctcccgca ggtcgcggcg ctggatcttg
     8281 ccggtgggcg agcgcgggat gtgccgtacg acgtcgaggt acttgatgtg ctggtagtag
     8341 ggcagctggt cgttgacgaa gcggatgacg gcgtcgcggt cggcggcctc gtccgccagg
     8401 accaccagcg cgtgcgcgac ggcgccgctc aactcgtccg ggtggtcgaa gaccgcgcag
     8461 tccgtcaccc cggggcagcg ggccagcacg ttctcgatct ccaggggcga gaccagccag
     8521 ttgtcgcact tgaagacgtc cttgacccgg tcgacgacga acagccgccc ctccgcgtcg
     8581 gtctcgccga tgtcgccggt cgagaaccag ccgtccgggt ccacggactc ctcccgcggc
     8641 cggccgaggt accccttcat cagctggggc cccttgacct ggatctcgcc gcggccgccc
     8701 accgggagga cggcgcgggt ccgcaggtcc acgatccggc aggcggtgcc cggtacgggc
     8761 ctgcccgacg agccggccac cgggtggtcc aggtcgtcga agtgcgtgga cggcgcggtc
     8821 tcggccagtc cgtacccctg gacgaccggg acgccgaagt gcccgcccag gacatcggcg
     8881 gtccgcgcgg gcagggccga tccgccggag agcacggccc gcaggctggg cacggacagt
     8941 tccggcagcc ggtcgtccgc cgccagccgg gccagccgta ccggcaggct gtagaggtgc
     9001 gtcgcgccgt ggcgggcgcc ctcgcgcagt gcggccacgg tgtcgtcgcc gggccgcagc
     9061 aggtgggtgg cgccgacggt caccgcgatg ttcaggtgca tcaggtggaa cgacggcagg
     9121 gtgttgagca gcaccgactc gggggtgagc cggtgggtgt acgcggtctg ggccgcgttc
     9181 accgtcaggt tgcggtgggt gagcatgacg gtcttcgggg cgccggtggt gccgctggtg
     9241 aactggaggt tggccacgcc ctcggggtcg cggccggcga acggcgccgt ggcgggggcc
     9301 gcgtcgatca gctcgtcgag cgtgggcacg tcggccgtgg cctcctgaaa gccggcctcg
     9361 cggtgggtga gcaccacggt ccgcaacgcc ggcaggtccc ctcgtacggc ctggatacgc
     9421 gcgtacatct ccggcgggac gatcacggtc cgcgcgcccg ccgagcgcag cacgtgcgtc
     9481 aggcgctcct cgcgcagcag cgggttgaac atcgcgctga cgtgccgggc ccgggaggcg
     9541 ccgaagtacg ccacggcgaa cgaggtgtcc agtacggcgg cgatgcccac caccgcgccg
     9601 ggttcaccgt ccagttcgcg cagcgcggcg gcgcaccgcg tcgcccgctc ctccagggcc
     9661 gcgtaggtca ggtcccctga ggggccgctc agcgcgagcc gtctgggggc gcggcgggcc
     9721 gcccgcgaca gcacgtcgtc gatgcgcggg ccgcccgtca actgcgccag cacgtcgagc
     9781 ggcggcccct cggcggtgct gtcctgcggg ccctcggggt ggcgctcggc catgggcagg
     9841 gctcctctct cgctcgcggg tcggggctgc actactcggg ccgcaggtcg tcccggcgca
     9901 cctcgcggtg ccgtacgcgc agttggccgt cctcccgtac gagcacgtcg tcgcagctcg
     9961 tgctcaggtg caccgcggcc tggccgccgc gcggcgtgct gatgatcagg gcgtaggtgc
    10021 gggcgcggac ggtgccgtcg tcacaggcgt cggcgtccag catgccgagc cagtggcggc
    10081 gctggacgcc ctgctcggcc agcagggcgg cggccttgcg ggccccggcc gcgatggcgg
    10141 cccgcccgac ggacggctcg gggtgggcgt tggcgacgaa gacgccgtcc tcggtgaagg
    10201 tgccggccca ctcctcgacc cgcgcctcgt ccaggcagcg catctggcgt ccgtagaagt
    10261 gctggatctc ctggtagagc gcggtgtcca cggggacgcc cgagggctgt tccggggcgg
    10321 tcatacgact ctcctctccg gcggccgggc tgggggcggc cgctcggcgt gagcgtggca
    10381 gccggtcttc gaccgttctt cgagccgtgg tcggtccgtg atcgccccgc cgcgccgcac
    10441 ggagaccgcc ccaaccgcgg tcggtccagc ctcgaacggg cccttgcagg ctggggcgta
    10501 cgggacgggc gaggcagcgc ctgggtccgc ccggccggac gggcgccgcg cgagcgcgcc
    10561 caccgcagac cacaacaccg gaggacaagg ccatgactac cagtgccacg cccaggaccg
    10621 ccctggtgac gggcggcacc agcggcatcg ggctcgccgt ggtgaagacg ctcgccgccc
    10681 gcgggctgcg ggtgttcctg tgcgcccgca gccgcgagaa cgtcgacgcc gtggtcaagg
    10741 aactgcgcga ccaggggctt caggtggccg ggtgcgaggg ggacgtgcgg tcccgggagt
    10801 cggtggagcg ggtggtgcgc gccgcggtcg accggttcgg gccgctgagc gtcctggtga
    10861 acaacgcggg gcgcagcggc ggcggagtga ccgcgcgcat ccccgacgag ctctggtacg
    10921 acgtgatcga caccaacctc aacagcgcct tcctggtcac ccgtgaggcc ctgaccaccg
    10981 gcgggctgga gcgggcgggc gtcgacgggc ggatcatcag catcgcctcc accggcggca
    11041 agcagggcgt tccgctgggc gccccctact cggcctcgaa ggcgggcctg atcggtttca
    11101 ccaaggcgct ggccaaggag ctggccccca cgggggtcac cgtcaacgcc gtgtgcccgg
    11161 ggtacgtgga gacgccgatg gccgtccgcg tacggcaggc gtacgcggcc acctgggaca
    11221 ccaccgagga ggacgtgctg tcccgcttca acgacaagat cccgctgggg cgctactcca
    11281 cacccgagga ggtggccgcc ctggtcggcc acctggcggg cgacgaggcc gggtccatca
    11341 ccgcgcaggc cctcaacgtc tgcggcgggc tgggcattta ctgacccgcc cgccacagcc
    11401 ccgcccccgc tgctccgcac acccgagagg aaccgacgac gcatgcccgc acccacatcc
    11461 caccgcgccg tgcaccgcac ggagatcgac gccccggccg accgggtgta cgccctgatc
    11521 agggacgccg ccgagtggcc ccggcacttc accccgaccg tccacgtcga gcgcgcggag
    11581 ctcgacgccc gcagcgagcg gctgcggatc tgggccaccg ccaacggcga ggtcaagcac
    11641 tggacgtcgc accgcgccct ggaccccgaa gggcagagcg tccggttccg gcaggaggtg
    11701 tgttcgcctc cggtggccgc gatgagcggt gaatgggtcc tccgggacct tccgggcggg
    11761 cggtgcgagc tgacgctgca ccacacgttc gccgcggtgg acgaccgccc ggaggacgtg
    11821 gagtggatca ccaccgcgac cgaccgcaac agccgtaccg agctggcgaa catcaaggcg
    11881 ctggccgagg ccgcggggtc cgacgcggag ctgctgttct cgttcgagga ctccgagacg
    11941 gtgcacgccc cggccgaggc ggtgtacgcg ttcctcgcgg aggccgggaa gtggcccgac
    12001 cggctgccgc acgtctcccg gctcgacctc accgagccgt ccgacggcgt gcaggtgatg
    12061 accatggtca cccgggccaa cgacggctcg gagcacacga cggagtcggt gcgggtctgc
    12121 ttccccgacg aactgcgcat cgtctacaag cagatcggca ccccgccgct gatgaccctg
    12181 cacaccggtg agtggtcgat acgggacacc ggggacgggc tgctcgtcac ctcccagcac
    12241 accatccgga tcaacgaatc cgccatcccg gagatcctcg gcgcggacgc cacggcggcc
    12301 gacgcgcggg cccgggtgcg cgcggcggtc ggcggcaaca gcgcggccac cctggccctc
    12361 gccaagcgct tcgcggaggc cccgcatgcc gcctgaggcg gacggcccgc aggtgctgat
    12421 cgccggcgcc gggcccgtcg gcctgaccct ggcgcacgag ctgacccgcc ggcgcgtccg
    12481 cgtccgggtc atcgaccggg cggacggccc ggcgaccacc agccgggcgc tggccgtgca
    12541 tccgcgcacc ctggaggcgt gccaccagat gggcctggcg gacgccctgg tggcgcgggg
    12601 ccggccggtc gtccacttca ccgtgcacct gcgcggccgg cagctgatcc gcttcgacac
    12661 caactacggc aggctgccca cggcgtaccc gttcagcctg atgctcgacc aggtccgtac
    12721 ggaggagatc ctgcgcgagc gcctggccgg gctgggcgtc gggatcgagt ggggcgtgga
    12781 actggcggac tgcgcgccct gcggggaccg ggtcaacgcc gaactgcgcc gtgacggccg
    12841 ctccgaacag gtcaccgtgc cctggctggt gggcgcggac ggctcgcgca gcaccgtacg
    12901 cgagcggctg gggctgcggc tggtcggcga cgcgacgcag acctggctca acgcggacgt
    12961 ggtcctggac gccgacctgt cccgcgacag caaccacctg gtgcacaccg gttccgggac
    13021 ggtgctgctg gtgccgttcc ccgaccccgg caagtggcgt gcggtggaca ccgggtacgc
    13081 aggtcaggga gccgatccgg agacggtacg gcgccgcctc gccgggtccc tggcgcgcgg
    13141 tctcgggcgt ccggtggcgg tctcggagcc gacctgggtc tccgtcttcc gcgtacagca
    13201 gcgcatgatc accgccatgc gctccggccg ctgcttcgtg gccggggacg ccgcgcacgt
    13261 ccacagcccg gcctccggcc agggcatgaa caccggcatg caggacgcct acaacctggc
    13321 gtggaagctg gcggacgtgg tgcgcggaca cgcgcgggaa gagctgctgg acacctacgc
    13381 cgccgagcgc atcccggtgg gcggcaggct gctgtcctcg acgcgcacgg ccacggccct
    13441 ggtggcgctg cgcaacgccg tggcgccggt ggccatgccc gtgggcctgt ccttcctcaa
    13501 ggcggtgcgc ccgctcaaac gacgcgtcga gcaccggatc atggcgggaa tgtccggcct
    13561 cgccctgcac tacgcggaca gtccgctgac gtacggcacg ggcgacgggg cggcaggggt
    13621 acaccccggg cacctggtcg cgtgcacgga acaggacgtg gcgcgccacc ccggcctccg
    13681 ggcgctgcgg caggcgctca ccgatccccg gtggctgctt ctgctgttcg ctgatgatgg
    13741 cggcgccgcg gagctggcac tgcggtacgg ccgggccgta cagatacgca ccgtcatccc
    13801 tcacgaggac gaagacggcc ccgccctcgc cgaccccgac gacgctctgc ggcagaccct
    13861 cggcgtccct cccggcggct gggcgctgat caggccggac ggctatctgg ccgcgaaggg
    13921 gcagcggtcc ggcaccacca ccctgaccgc ccggctccag gcactgcacc tgctcccgga
    13981 ggacaccgcg cccggcgccg gtgactctgc cggccggccc gcgccggacg gcacacgccg
    14041 gggcgtgacg accgaatgac caaggaggac acgcgtatga cagcgatcaa cggcgcaccg
    14101 gcggcaggcg gttcggtggc actggtcatc ggcggcaccc gcggcatcgg gctggccgcc
    14161 gcccgcaaac tgagcgcggc gggcagcgag gtgctgctca actacgcgca cgacgaggac
    14221 ggcgcgctgg cggccgaacg gcagctgtcc gaggagggcg gcaaggtacg gctgatgcgc
    14281 gcggacatcg gccgccccgc cggtgtggtg cggctgctgg aggacatccg gcgcacccac
    14341 ggccggctgg acgtcctggt gcacgcagcc ggttccttcc atccggcgcc gaccgcgtcc
    14401 ccgcacatcg gcaagtacct gggcgacggc gccgtggcgg tcggaccgct gctgtacggg
    14461 gcggcgcgcc tgggcaccct gatgaccccg gacacgggcc gtatcgtcgc cgtctccagc
    14521 atcggcgccc ggacggtcgt ccccggctac gcgggtctgg gcatggccaa ggcggccttg
    14581 gagacgctgg tgcggtacct ggcggtggaa ctcgccggga agggcgtcgc ggtgaacgcg
    14641 gtggccgcgg gcaagatcgc cgacggcggt cccgtaccgg cccaggtact ggagggcctg
    14701 ctgcggcgga ccccgacggg gcggctggcg actgccgaag aggtggccga cgtggtggcg
    14761 ctgctgtgcc gccccgaggc cggcggcctg cacggacagg tgctcaccgt ggacggcggg
    14821 gcctgcctgc ggtaggcgcc cggaagggac cgacatgcgc atcatcgatc tgtcgacaac
    14881 cgtggacgcc ggccggtggg aggtcgatcc ggtcgaacac gaaatcctca ccccggccga
    14941 gggcggccgg cacatggccg aggggatgcg gcgccaccac ggcatcgact tcgaccccgc
    15001 cgacctcccg gacggcgaac tgctgtccct cgacaccctg cggctgacca cccacaccgg
    15061 cacccacgtc gacgccccgt cgcactacgg gtcccgcgcg cgctacggca cgccgcgcca
    15121 catcgaccag atgccactgg actggtttct gcggccgggc ctcaagctcg accttaccga
    15181 cgagccggtg ggcgccatcg gagccgaccg gatacggcgg gccctcgacg aagcgggccg
    15241 cgacccgcgt ccgtacgaca tcgtgctgct gcacaccggc gcggaccggc gggccggaaa
    15301 gccggagtac ttcaccgagt tcgccggcct ggacgccgcg gcgacccacc tgctgctcga
    15361 cttcggcgtc cgggtcatcg gcaccgacgc cttcagcctc gacgccccgt tcgggcacat
    15421 gatcaaggag taccagcgca ccggcgaccg cggtgtgctg tggcccgccc acttcgtggg
    15481 acgggagcgc gagtactgcc agatcgagcg gctggacaac ctcggcgcgc tgcccggacc
    15541 ggacggcttc ttggtctcct gctttccgtt caagatcgcg ggagcggggg cggggtggac
    15601 gcgggcggtg gcggtggtgg aggagtaggg acggacgggt gaacgggcgc ccccggagca
    15661 tcctggggcg cccgtccgca cggcttccac ggaatccgcc acggcccacc tgcgatggcg
    15721 gtcgaatggc agtatgcgaa accggcggag tcagcagttg caccgcgtgg tccggcgcgc
    15781 ttcccgggcc gggaacggcc cgccaccggc cggcagcgtc cctccgcgtc cggagctggg
    15841 ctgggcccgt ctgatcgagc tgacttcggt actgctcgcc tcggtcgtcg ccgtgctgag
    15901 cctctggttc tccaaccgcc aggtgggcaa ccagttgcgg atcgcccagg gcgagctgag
    15961 caccaccagg gaaggtcaga tcaccgagcg gtacaccgcg gccgtgggcc agctgggcga
    16021 ggattcggtg gacgtgcgcc tgggcggcat ctacgccctg cagcgcaaca tggaggacct
    16081 cccccgcgac caccccacca tcgccgacgt cctggccgcc tatatccgca cccacgccgg
    16141 caccccgccg aaaggcggca aacgggtgcc acccgatgtc ctggccgcgc tcgacgtgat
    16201 cagcggccgg aactccgccc atgacggctc cttcgttccc gacctccgct ccacccacct
    16261 gcccggcgtc gaactggggt gggaccgttc gtctcccgtc gccgccgacc acaagcgggc
    16321 ccagttgcgc ggagcgatcc tccgtgactg cgacctgagg gacgcgcgtc tgagcggcgc
    16381 ggacctgcga ggcgcgaggc tcgcacgcgc cgatctggcc gacgcggatc tgcgcgaggc
    16441 ggacctccgg gaagccactc cggcgcgggc gaacctgcgc gacgcggact tgtccgacgc
    16501 caacgtgcgc aaggcggacc tgaggttcgc ggatcttcgc ggcgtggacc tgtggggcac
    16561 cgatctgcgc ggcgcggtcc tgtaccgggc gaaactggcc ggcctggagc tcagcgaggc
    16621 gcacctggac ggagccgacc tccgcggtgc tgatctcacg gacgcggcgg tggcacggag
    16681 ccaggtcctc gcgagccgca tcgacgcgga gaccaggctc ccaccggaca tcgcccgcga
    16741 tccggaggtg cgggcccgga tcgctcaggc cgaggcggag gacgatggtt tctgatcgcc
    16801 gcctcaccct cctcagggaa tccggtaccc ctcaccccgc aaggcgtcca ccgcctcccc
    16861 caaagccacc cggtcatcct ccggcccatc cgcccgctta ggtgacagcg gtacgaccat
    16921 gcagtcccca cggcgtacgg aggggtggcg cagggcgagg ctcgacagcg tacggccggg
    16981 tcccgcttcg accaccacca gtccgccggg cgccagcagc ccgtccagag cgggccagaa
    17041 gcgcacctgg tccacggggt gcgcggccca gtacgcgggg tcggcgacct gctgggccgt
    17101 cagtggtgcg gccgtgtagc aggagtggac cacggtgcgc ggcggccggc gttccaccgt
    17161 ggcgagcacc gcctcggcgc ccctggcgtg cggggcgatc gccgggctgt ggaacgggct
    17221 gagcgcgggg acccgctggg cggtgatgcc gcgggcccgc agggtctccc ccacggcgcg
    17281 cagcgcgtcc tccggccctc cgagtacggt ctgccgcggc gcgttgacgg cgccgaccac
    17341 cacgccgtcg ccgaggaaag gttccagcga cgcggcggac tccgccaccg ccagcatgcc
    17401 gcccgggggc gcggccgtca gccgcgtcac ccggtcgagc accacccgcg cggcgtcgcg
    17461 caccgtgaac accccggcga gcgtggcggc cgccatctcg ccgatgctgt ggccgagcag
    17521 cgccaccgga cggatgcccc agctcgtcac caggcggccg agcgcgtagt cgacggcgaa
    17581 cagcagcggc tgcgcccgca gtacgtggtc caccggcagc tccggccgct cggccagcca
    17641 gtcggcgtgc atacgggcgc cctcggcccc catcgcgccc agcacctcgt cgaccgcctc
    17701 ggcgaagacc ggctcggccg cgtacagccc cgccgccatc cgccggtact gggagccctg
    17761 gccgggcagc agcagcgcca ccggccgggg cgcccgtgcg gcgggcgccc cggtggcctt
    17821 cgtgtccgcc gtcatgtcag ccgggcggcg gccgcggcga tgcgttcgtc ggtcgccgtg
    17881 aacgcaatcc gtacgtactg ctcaccggcc tcgccgtaga aggcaccggg tgcgacgagg
    17941 atgccgagat cggccagctt ctgtacggcg ggccagcagg gctcaccccg ggtggcccac
    18001 aggaacaggc cgccttcgga atgctcgacg cggaacccgg ccccctccag ggccgtgcgc
    18061 agaacgcgcc gcctgtaggc gtaccggtct cgctgccgct ccacgtgggc gtcgtcctcc
    18121 agggcggcca ccatggccgc ctgtacgggg gccgggaccg cgtgcccggc gtgcttgcgt
    18181 acctggagga ggcgcccgat cagggccggg tcgccggagc agacgcccgc gcggtagccc
    18241 gcgaggttgg accgcttgga cagcgagtgc accgccagca gaccatcgtg actgccgccg
    18301 cacaccgccg agtccagcag cgacaccggc cgccggtccc acccgtattc gatgtagcac
    18361 tcgtcgttga cgaggacggc gccccggtcc cgcgcccagg ccacgatctc gcgcagctcg
    18421 ggtacggaca gcacccggcc ctccgggttg gacggcgagt tgagccagac caccttgacc
    18481 ggttcactgc cgagctccag cggtgaatcc accgggcgcc cccgcgcgcc cgcgaggcgc
    18541 gcgctgacgt cgaaggtggg aaacgccagc cggggaaagg ccaccgtgtc gccggggccg
    18601 gtgcccagca tcgccgggag ccaggcgatc agctccttgg tgccgaccgc gggcagtacg
    18661 gccgaggggt ccaccgtcac gcccaggcgg cggcgcagcc atgcggcggc cgcttcgcgg
    18721 agcgcgggcg tcccctccgt gggcgggtag ccgggcgcgt cggtcgccgc cgcgagggcg
    18781 tcgcgcagca cgtcgggcgt ggcgtcgacc ggttcgccca gcgccaggtt gaccagcccg
    18841 tcggggtggg ccgcggcgcg cttcttgtac ggcagcagca catcccacgg aaattcgggc
    18901 agttccctca tcgccgtcct ccgtcctcgg ccgtgatgtc gcgtgcgtgg accccggtgg
    18961 acaggtcccc ttcgatgccc caggtgacga tgcgccgggg gtggatgcgg atcatctcgt
    19021 cggcgcagtg cggccggcgc tccctgccgc cggtgggcag cgcctgggcc gtgccgtgga
    19081 tgacgacggc gcggaccacc tcggggtcgc ggcacggcac gtcgtccacg acgaaggcga
    19141 cccggtcgct cttcgccacg ttccggaact tgcggctgcg gcccatgtcc cggccggtga
    19201 tctcgatggt gccgcgctcc tcgtcgatct cgaacgagac gggcacgttg tggggttctc
    19261 catgggcgcc gaccgtcgcc agacggccgt agccctgcgc gcgcaggtag gtgatttcct
    19321 tctgggtgaa cggcatgaag cgtcctcggg gtccgtaggg tcgcggccac gctacgaagc
    19381 ccgcttcgag cacacttcga gccacccgct ccggattccg gctggacggc gcctttaatg
    19441 cccgcggtca gcatgctcgg cggcaaccca ctgatgatcc gaggagcgtg tatgcggtac
    19501 gacgtggtga tcgccggcgc cgggccgacc ggcctgatgc tcgcctgcga actgcgcctg
    19561 gccggtgcca ggaccctggt gctggaacgc ctggcggagc cggtcgactt ctccaaggcc
    19621 ctcggtgtgc acgcgcgcac cgtcgagctg ctggacatgc gcgggctggg cgaggggttc
    19681 caggccgagg cgccgaagct gcgcggcggg aacttcgcca gcctcggagt acccctggac
    19741 ttctcgtcgt tcgacacccg gcacccgtac gcgctgttcg tcccccaggt gcgtaccgag
    19801 gagctgctga ccgggcgggc cctggagctg ggggccgagc tgcggcgcgg gcacgcggtg
    19861 acggcgctgg agcaggacgc cgacggcgtg accgtctccg tcaccgggcc cgaggggccg
    19921 tacgaggtcg agtgcgcgta cctggtgggc tgcgacggcg gcggcagcac cgtacgcaag
    19981 ctgctcggca tcgacttccc cgggcaggac ccgcacatgt tcgcggtgat cgcggatgcc
    20041 cggttccgtg aggagctgcc gcacggggag ggcatgggac cgatgcggcc gtacggcgtc
    20101 atgcggcacg acctgcgcgc ctggttcgcc gccttcccgc tggagccgga cgtctaccgg
    20161 gccacggtcg ccttcttcga ccggccctac gccgaccgcc gggcgccggt caccgaggag
    20221 gacgtgcggg ccgcgctgac cgaggtggcc ggcagcgact tcgggatgca cgacgtgcgc
    20281 tggctctccc ggctcaccga cacctcacgc caggccgagc ggtaccgcga cggccgggtc
    20341 ctgctggccg gcgacgcctg ccacatccac ctgcccgcgg gcggccaggg cctcaacctg
    20401 ggcttccagg acgcggtgaa cctgggctgg aagctgggcg cgaccatcgc gggcacggct
    20461 ccgccggagc tgctggacac ctacgaggcc gagcgccgcc cgatcgccgc cggcgtactg
    20521 cgcaacaccc gcgcgcaagc cgtgctgatc gacccggacc cgcgttacga ggggctgcgg
    20581 gagctgatga tcgagctgct gcacgtcccg gagaccaacc gctatctggc gggcctcatc
    20641 tcggcgctgg acgtgcggta ccccatggcg ggcgagcacc cgctgctggg gcgccgcgta
    20701 ccggacctgc cgctcgtcac cgaggacggc acccggcagc tgagcacgta cttccacgcg
    20761 gcgcgcggcg tcctgctgac gctcggctgc gaccagccgc tcgccgacga ggccgcggcc
    20821 tggaaggacc gggtggacct ggtcgcggcc gagggcgtcg cggacccggg ctccgcggtc
    20881 gacgggctga ccgcgctgct cgtacgcccc gacggctaca tctgctggac cgcggctccg
    20941 gagacgggta cggacgggct caccgacgcc ctgcgcacct ggttcgggcc gcccgccatg
    21001 tgaggcaccc ccacccggtt ccctgccctt ccgcgcccgc cccttcccag gccaaggagt
    21061 cccatgacca ccacaccgct cgcccccgtg gcccaggccc gctcgctgct gcagctgacc
    21121 accgcgtacc accaggcgaa ggccctgcac agcgccgtgg agctgggcct gttcgacctg
    21181 ctcgccgacg ggcccgcgac cgccgaggag gtgaaggacc ggctgcggat cgtccatccg
    21241 ctggccaagg agttcctcga cgcgctcgtc gcgctggagt tgctggaagc ggacggcgac
    21301 cgctaccgca actcccccgc cgcccaggcg ttcctggtgt ccggcgcctc cgaatacctg
    21361 ggcggcaccg tcctccagca cgcccgcaag cactaccacg tatgggccgg gctgacgacg
    21421 gcgctccagg agggcgaggc gggttccggc gccgaagcgc acgggcccga ggcgtacccc
    21481 aagcactacg aggacccgga gcgggcccgt caggtcatgg cgcacttcga caccttcagc
    21541 tccttcacgg ccgaggagct ggcgcgccgc gtcgactgga gcgggtacgg gtccttcatc
    21601 gacatcggcg gcgcacgggg caacctcgcc acgcgggtgg ccctggccca cccgcacctg
    21661 cacggcgccg tgttcgacct gcccgcgctg gccccgctgg ccggcgagct gatccgtgag
    21721 cgcggcctcg aaggccgcgt ccgcttccac ggcggcgact tcctgaccga cccgctgccg
    21781 tccgcggacg ccgtggtcac cgggcacgta ctgcccgact ggccggtacc gcagcggcgc
    21841 aagctcctcg cgcgcatcca cgaggcgctg ccctccggcg gcgcgctggt ggtctacgac
    21901 ctgatgacgg atccggccac cacgacggtg cacgacgtac tgcaacggct caaccacggc
    21961 ctcatccgcg gcgacagctc gtccagcagc gtcgaggagt accgcgcgga gatcgaggag
    22021 gccggcttcc gggtgcggca ggcggagcgc atcgacaacc tcctcggtga ctggctgata
    22081 gtcgccgtca agccctgacc ctgcgtggcc gcccttgcta ccgtgatcat gcccgcgggt
    22141 gtgttcccgc cgggcggatc acagcgacgt cagagagggc ggaacgatgc ggcaggcgac
    22201 cacgaatccg gcaggaaagg tccgcatcac gacgctaagg aatccgaacc ccctccatga
    22261 acaagctgaa tctgggcatc ctggcccacg ttgacgccgg caagaccagc ctcaccgagc
    22321 gcctgctgca ccgcaccggt gtgatcgacg aggtcggcag cgtggacgcc ggcaccacga
    22381 cgaccgactc gatggagctg gagcggcagc gcggcatcac catccggtcc gccgtggcca
    22441 cgttcgtcct ggacgatctc aaggtcaacc tcatcgacac cccgggccac tccgacttca
    22501 tctccgaggt cgagcgggcg ctcggggtgc tcgacggcgc ggtcctggtg gtctcggccg
    22561 tcgagggcgt ccagccgcag acccgcatcc tgatgcggac cctgcgcagg ctgggcattc
    22621 ccacgctggt cttcgtcaac aagatcgacc ggggcggcgc gcgtcccgac ggtgtgctgc
    22681 gggagatccg cgaccggctc acccccgccg cggtggcact gtccgccgtg gcggacgccg
    22741 gcacgccgcg ggcccgcgcg atcgcgctcg gcccggacac cgacccggac ttcgccgtcc
    22801 gggtcggtga gctgctggcc gaccacgacg acgcgttcct caccgcctac ctggacgagg
    22861 aacacgtact gaccgagaag gagtacgcgg aggaactggc cgcgcagacc gcgcgcggtc
    22921 tggtgcaccc ggtgtacttc gggtccgcgc tgaccggcga gggcctggac catctggtgc
    22981 acggcatccg ggagttgctg ccgtccgtgc acgcgtcgca ggacgcgccg ctgcgggcca
    23041 ccgtgttcaa ggtggaccgt ggcgcgcgcg gcgaggccgt cgcgtacctg cggctggtct
    23101 ccggcacgct gggcacccgc gattcggtga cgctgcaccg cgtcgaccac accggccggg
    23161 tcaccgagca cgccggacgc atcaccgcgc tgcgggtctt cgagcacggg tcggccacca
    23221 gcgagacccg ggcgaccgcc ggggacatcg cgcaggcgtg gggcctgaag gacgtacggg
    23281 tcggtgaccg ggccgggcac ctcgacggtc ccccgccgcg caacttcttc gcgccgccca
    23341 gcctggagac cgtgatcagg ccggagcgcc cggaggaagc gggacggctg cacgccgcgc
    23401 tgcgcatgct ggacgagcag gacccctcga tcgacctgcg gcaggacgag gagaacgcgg
    23461 ccggcgcggt ggtccgcctc tacggggagg tgcagaagga gatcctcggc agcacgctcg
    23521 cggagtcctt cggcgtacgg gtgcgcttcg acccgacccg tacggtctgc atcgaaaagc
    23581 ccgtggggac cggcgaggcg ctgatcgagc tggacacgcg gacgcacaac tacttctggg
    23641 gcgcaccgtg ggtctgcgcg tcggaccggc cgagcccggc gcgggcgatc acgttccgtt
    23701 tggcggtgga actgggctcg ctccccctgg ccttccacaa ggccatcgag gagacggtgc
    23761 acaccaccct gcggcacggt ctgtacggct ggcaggtcac cgactgcgcc gtcaccctga
    23821 cccgtaccgg cgttcgcagt ccggtcagcg cggccgacga cttccgcaag gccaacgcgc
    23881 gcttggtcct gatggacgcg ctcggcaggg ccggtacgga ggtgcacgag ccggtcagct
    23941 ccttcgaact ggaggtgccc gccgcccggc tcagcccggt acttgcgaaa ctcgcggaac
    24001 tgggcgcgac gcccggtgtg cccacggccg agggggacgt cttccgcctg gagggcacga
    24061 tgccgaccag cctcgtgcac gacttcaacc agcgggttcc cggactgacc cagggcgagg
    24121 gcgtgttcct ggccgagcac cggggctacc ggcccgccgt cggacagccg cccgtgcggc
    24181 cgcggcccga ggggcccaac ccgctcaacc gcgacgagta catcctgcac gtgctcaagc
    24241 gcgtgtgaac cggcaccgga ccgcgccccg cgcggatttc cgcccggggc gcggtccggt
    24301 ggtttcaggt gccggcctgt acctggaggc ggacctcagg ccgtggatac gggctgtcct
    24361 gccgtgcgta cgggccggtg ttccgggaga ttccgaggat cagcatggat ttcgccttgt
    24421 tcacggcatc gatccgggaa accgcgccca gcttttcgaa aacattgctc aaatggcgtt
    24481 tcacggtcgc ttcggtgatg gtgagccggg cggcgatctg gctgttgctc agcccgcgcg
    24541 ccacgttctc cattatctgg agctcgcggg cggagagacg cgccgtggag gtatgcggca
    24601 gcgccgccat gctttctttt ggtacggaca tgaatatctg ccccgggtga ctggtcacgc
    24661 tgcggatggc ggcgagcacc tcggcgcgcc gtaaattctt ggtcagaaat ccgctcacgc
    24721 gcagttgcag cgcctgctgc acgagcgccg gatgatggaa cgaggtcaaa atgatgcact
    24781 gggaacgcgg tgacacccgg tgcatggcct cgacgccgga gacgactccg tacggctccg
    24841 acccgtccag cagaatgaca tcggggcgca gctcgccggc catgcgcacc gccgcctccc
    24901 cgttggccag gccgccgacc accttgatgt ccggctgggc ggcgagcacg tcgcacagcg
    24961 tctccctgag cagggtctgg tcgtcgacga cgaggacggt gatgactttg ttatccattc
    25021 gcccctccag cacacagaaa catttctgca ttctttggtc ggacccgcag gaaatttcgg
    25081 ccggggccgt cctgacggga caatcggaga ggggacgatc gaggagatgg cgagtcgcac
    25141 ggtccatgcg agcatcggca ccggaatgac ggaacccaaa agcttccccc gtgggggggg
    25201 agaggcaccc ccacgcacgc tt
//
