GHS Classification Result
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTES:
Updated date:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS number | 824-78-2 |
| Chemical name | Sodium p-nitrophenolate |
| Substance ID | 23A5159 |
| Fiscal year of classification conducted | FY2011 |
| Classifier(s) (Ministries) | Ministry of Health, Labour and Welfare （MHLW）, Ministry of the Environment （MOE） |
| New/Revised | New |
| Download in Excel format | Excel file |
| Item | Information |
|---|---|
| Guidance used for classification (External link) |
Physical Hazards & Health Hazards: GHS Classification Guidance by the Japanese Government （July, 2010）
Environmental Hazards: UN GHS Document （4th revised edition） |
| Definitions / Abbreviations (Excel file) | Definitions / Abbreviations |
| Model Label by MHLW (External link) | MHLW Website （in Japanese Only） |
| Model SDS by MHLW (External link) | MHLW Website （in Japanese Only） |
| OECD/eChemPortal (External link) | eChemPortal |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Explosives | Classification not possible | - | - | - | There is a chemical group associated with explosive properties (nitro group) but no data. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 3 | Aerosols | Not applicable | - | - | - | Not an aerosol product. |
| 4 | Oxidizing gases | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 5 | Gases under pressure | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 6 | Flammable liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 7 | Flammable solids | Classification not possible | - | - | - | No data. |
| 8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | The substance, which does not contain chemical groups associated with self-reactive properties but contains a chemical group associated with explosive properties (nitro group), has no data. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 10 | Pyrophoric solids | Classification not possible | - | - | - | No data. |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | No data. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | It contains sodium atom, but it is conceivable that it does not react vigorously with water from data on water solubility (13.9 g/L (pH7)) (PM (14th, 2006)). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 14 | Oxidizing solids | Classification not possible | - | - | - | The substance, which does not contain fluorine or chlorine but contains oxygen which is bonded to nitrogen, has no data. |
| 15 | Organic peroxides | Not applicable | - | - | - | An organic compound that does not contain -O-O- structure. |
| 16 | Corrosive to metals | Classification not possible | - | - | - | No established test method suitable for solid substances. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |  |
H302 |
P301+P312 P264 P270 P330 P501 |
From LD50 values of 550 mg/kg (males) and 467mg/kg (females) for rats (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Nov. 2011)), it was classified in Category 4. Refer to p-nitrophenol of an analog substance (CAS number 100-02-7). |
| 1 | Acute toxicity （Dermal） | Not classified | - | - | - | From an LD50 value of >5000 mg/kg for rabbits (RTECS (2003): original literature National Technical Information Service.: OTS0538646), it was classified as "Not classified." |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | "Solids" according to GHS definition. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | No data. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - |
The classification is not possible because a reported LC50 value of >4.7mg/L/4h for rats (CICAD (J) 20 (2004)) does not specify the Category. Besides, it was considered to be a test by dust because the test concentration is above the saturated vapour pressure concentration (3.49E-09 mg/L). |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | No data. |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | No data. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | No data. |
| 4 | Skin sensitization | Classification not possible | - | - | - | No data. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - |
There are no in vivo test data on this substance. But from a negative in a micronucleus test on p-nitrophenol of a free base using mice bone marrow cells (in vivo somatic cell mutagenicity test) (Regul. Toxicol. Pharmacol., 55, 33-42, 2009), it was classified as "Not classified." Besides, as in vitro tests on this substance, an Ames test reported a negative and a chromosomal aberration test using CHL cells reported a positive (both Report on Toxicity Tests of Chemical Substances, MHLW (Access on Nov. 2011)). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | No data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - |
In a preliminary reproductive toxicity test by oral administration prior to mating in rats, dead cases and decreased spontaneous motility were observed at 400 mg/kg of the highest dose as general toxicity in parent animals. But neither effects on reproductive function in both male and female parent animals nor dose-related change in newborns was observed. (Report on Toxicity Tests of Chemical Substances, MHW (Access on Nov. 2011)) But it was classified as "Classification not possible" due to lack of data on adverse effects on the development of the offspring including teratogenicity. |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system) |  |
H371 |
P309+P311 P260 P264 P270 P405 P501 |
In the oral administration in rats, decreased spontaneous motility and proneness/anaclisis at 250mg/kg or higher and tonic convulsions and deaths at 500mg/kg or higher were observed. And all signs shown in survived animals disappeared by 2 hours after administration, and no abnormality was observed in the necropsy of all animals including dead ones. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Nov. 2011)) In the above report, in addition to the signs of decreased spontaneous motility and proneness/anaclisis after administration, the tonic convulsions were observed at 500 mg/kg or higher corresponding to Category 2 in Guidance values and central nervous system was also listed as a target organ of this substance. (HSDB (2003)). From the above, it was classified in Category 2 (central nervous system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood system) | |
H373 |
P260 P314 P501 |
In a 2-week inhalation exposure test in rats (dust: 0.340 and 2.47 mg/L), a dose-dependent increase in methemoglobin value was still elevated after a 14-day recovery period in a part of animals and decreases in red blood cell number, hemoglobin, and hematocrit in an exposure period were indicated. (CICAD 20 (2000)) Furthermore, there is the information that blood is also listed as a target organ of this substance (HSDB (2003)), and the low dose of 0.340 mg/L in the above test (converted to a 90-day equivalent: 0.052 mg/L), corresponds to Category 2 in Guidance values. From the above, it was classified in Category 2 (blood system). Besides, in a 28-day oral repeated dose test, all reported findings such as death cases, decreases in spontaneous motility and respiratory rate, tonic convulsions (in a part of animals) at 1000 mg/kg/day, and a pathological change in the kidney at 400 mg/kg/day or higher were those above doses of a range of Guidance values. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on Nov. 2011)) |
| 10 | Aspiration hazard | Classification not possible | - | - | - | No data. |
| Hazard class | Classification |
Pictogram (Code: symbol) Signal word |
Code (Hazard statement) |
Code (Precautionary statement) |
Rationale for the classification | |
|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | No data. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | No data. |
| 12 | Hazardous to the ozone layer | Classification not possible | - | - | - | This substance is not listed in Annexes to the Montreal Protocol. |
NOTES:
|
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Updated date:
|
2016/11/16 Addition of Rationale for the classification |