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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	95-94-3
Chemical Name	1,2,4,5-Tetrachlorobenzene
Substance ID	24A6074
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	- -	-	-	It is combustible (ICSC (J) (2003)), but the classification is not possible due to no data in the prescribed test.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There is a report on two LD50 values of 1,500 mg/kg and 3,105 mg/kg for rats (EHC 128 (1991)), one of them corresponds to Category 4, and the other corresponds to "Not classified." A more hazardous category was adopted, and it was classified in Category 4.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" because it is reported that no appreciable irritation was observed in a test by a repeated application of a 10% solution to the ear or abdominal skin of rabbits (BUA 86 (1991)), and it is described that this substance was concluded to be non-irritating in a skin irritation test (OECD TG 404) (BUA 86 (1991)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	It is reported that slight mucous membrane irritation was observed in a test in which a 1% or 10% solution was applied to the rabbit eye for three consecutive days (BUA 86 (1991)), while it is described that this substance was concluded to be non-irritating in an eye irritation test (OECD TG 405) (BUA 86 (1991)). Therefore, it was classified as "Not classified."
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	It is reported that a skin sensitization test with guinea pigs (a procedure similar to that of a Draize Test) gave a negative result (BUA 86 (1991)), but the test method was not the one approved by OECD, and the details are unknown. Therefore, it was classified as "Classification not possible" due to lack of data.
5	Germ cell mutagenicity	Not classified	- -	-	-	It was classified as "Not classified" based on negative results in a micronucleus test with peripheral blood after diet administration to mice and a chromosomal aberration test with bone marrow cells after intraperitoneal administration to mice (both in vivo somatic cell mutagenicity test) (NTP DB (Access on Aug. 2012)). Besides, it is reported that it was negative in a sister chromatid exchange test with bone marrow cells after intraperitoneal administration to mice (in vivo somatic cell genotoxicity test), and as for in vitro tests, there are reports on negative results in all of an Ames test (NTP DB (1981)), a chromosomal aberration test with CHO cells of Chinese hamsters (NTP DB (Access on Aug. 2012)), and a mouse lymphoma test (BUA 210 (1997)).
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Category 2, Additional category: Effects on or via lactation	Warning	H361 H362	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because a significant decrease in the number of live pups was observed at the dose where parent animals showed general toxicity such as increased weights and enlargement of the liver or kidney in a test by diet administration to mice from 7 days before mating and during a 92-day mating period according to the continuous breeding protocol (NTP Report # RACB89010 (1991)). And it is reported that in a two-generation reproductive test with rats, an analysis of the content of the stomach of offspring dying during lactation revealed that the substance that had accumulated in the fat of maternal animals was transferred to offspring via milk (BUA 86 (1991)). Therefore, it was classified in the Additional category: Effects on or via lactation. Besides, no teratogenicity of this substance is reported in tests by oral administration to rats or rabbits during the gestation period including the organogenesis period (EHC 128 (1991), BUA 86 (1991)).
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It was classified in Category 3 (narcotic effects) because signs such as depression, flaccid muscle tone, prostration, hypothermia, and coma were observed in a test by single oral administration of 200-4,000 mg/kg to rats (LD50 value: 3,105 mg/kg) (EHC 128 (1991)). Besides, oral administration of 30 or 300 mg/kg to male rats caused damage in the kidney, and diffuse interstitial nephritis was found (BUA 86 (1991)), but the finding in the kidney was not adopted for the rationale for classification because it was confirmed that it was alpha-2micro-globulin nephropathy specific to male rats (BUA 86 (1991)). And it is described that increased liver enzyme activity indicating live effects and slight anisokaryosis were seen at 300 mg/kg (BUA 86 (1991)), but these were not adopted for classification because there was no further information.
9	Specific target organ toxicity - Repeated exposure	Category 1 (kidney, thyroid), Category 2 (liver, blood)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	It was classified in Category 1 (kidney, thyroid), Category 2 (liver) because lesions in the kidney, liver, and thyroid were observed within the dose range of 30-2,000 ppm (1.5-100 mg/kg/day) corresponding to guidance values for Category 1 or 2 in a 13-week diet administration test with rats (doses: 0, 30, 100, 300, 1,000, 2,000 ppm) (NTP TOX 7 (1991)). As findings in the kidney, lesions consistent with hyaline droplet nephropathy (renal cortical tubular epithelial hyaline droplet formation) with medullary granular casts and mineralization were found in males at or above 30 ppm (1.5 mg/kg/day), but renal cortical tubular cell degeneration was seen in both males and females. As for the liver, only centrilobular hepatocellular hypertrophy was observed at or above 30 ppm, but there is a report on a significant increase in the incidence of liver lesions (basophilia, anisokaryosis, etc.) at or above 500 ppm (34 mg/kg/day) corresponding to Category 2 in another 13-week diet administration test with rats (Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005)). As for the thyroid, a decrease in thyroxine concentrations was found in females at or above 30 ppm, indicating hypothyroidism. On the other hand, as hematological findings, it is described that significant decreases in hematocrit values, hemoglobin concentration, and erythrocyte counts, suggesting poorly regenerative anemia, were observed at or above 1,000 ppm (50 mg/kg/day) corresponding to the guidance values for Category 2 (NTP TOX 7 (1991)), therefore it was classified in Category 2 (blood).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.33 mg/L for fish (Cyprinodon variegatus) (CICAD 60, 2004).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 21-day NOEC = 0.069 mg/L for fish (Jordanella floridae) (ECETOC TR91, 2003). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (not readily degradable, a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 96-hour LC50 = 0.33 mg/L for fish (Cyprinodon variegatus) (CICAD 60, 2004). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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